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Expert Opinion on Pharmacotherapy Volume 11, 2010 - Issue 1
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Drug Evaluations

Zoledronic acid: an unending tale for an antiresorptive agent

Michele Caraglia II University of Naples, Department of Biochemistry and Biophysics, Via S. M. Costantinopoli 16, 80138 Naples, Italy +39 08 1566 5871; +39 08 1566 5863; [email protected]
,
Monica Marra II University of Naples, Department of Biochemistry and Biophysics, Via S. M. Costantinopoli 16, 80138 Naples, Italy +39 08 1566 5871; +39 08 1566 5863; [email protected]
,
Silvio Naviglio II University of Naples, Department of Biochemistry and Biophysics, Via S. M. Costantinopoli 16, 80138 Naples, Italy +39 08 1566 5871; +39 08 1566 5863; [email protected]
,
Gerardo Botti Istituto Nazionale dei Tumori Fondazione ‘G. Pascale’, Pathology Unit, Naples, Italy
,
Raffaele Addeo ‘S. Giovanni di Dio’ Hospital, U.O.C. Oncologia, ASL Napoli 3, Frattaminore, Naples, Italy
&
Alberto Abbruzzese II University of Naples, Department of Biochemistry and Biophysics, Via S. M. Costantinopoli 16, 80138 Naples, Italy +39 08 1566 5871; +39 08 1566 5863; [email protected]
Pages 141-154 | Published online: 10 Dec 2009

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Chiara Schiraldi, Silvia Zappavigna, Antonella D' Agostino, Stefania Porto, Ornella Gaito, Sara Lusa, Monica Lamberti, Mario De Rosa, Giuseppe De Rosa & Michele Caraglia. (2014) Nanoparticles for the delivery of zoledronic acid to prostate cancer cells: A comparative analysis through time lapse video-microscopy technique. Cancer Biology & Therapy 15:11, pages 1524-1532.
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Li Chen, Yunfei Ding, Yongzhong Wang, Xingrong Liu, RJ Babu, WR Ravis & Weili Yan. (2013) Codelivery of zoledronic acid and doublestranded RNA from core-shell nanoparticles. International Journal of Nanomedicine 8, pages 137-145.
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Gabriella Misso, Silvia Zappavigna, Maria Castellano, Giuseppe De Rosa, Maria Teresa Di Martino, Pierosandro Tagliaferri, Pierfrancesco Tassone & Michele Caraglia. (2013) Emerging pathways as individualized therapeutic target of multiple myeloma. Expert Opinion on Biological Therapy 13:sup1, pages S95-S109.
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Carlo Buonerba, Michele Caraglia, Simona Malgieri, Francesco Perri, Davide Bosso, Piera Federico, Matteo Ferro, Mimma Rizzo, Giovannella Palmieri & Giuseppe Di Lorenzo. (2013) Calcitriol: a better option than vitamin D in denosumab-treated patients with kidney failure?. Expert Opinion on Biological Therapy 13:2, pages 149-151.
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Gabriella Misso, Manuela Porru, Antonella Stoppacciaro, Maria Castellano, Federica De Cicco, Carlo Leonetti, Daniele Santini & Michele Caraglia. (2012) Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid. Cancer Biology & Therapy 13:14, pages 1491-1500.
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Sigrun Ressler, Brigitte Mlineritsch & Richard Greil. (2011) Zoledronic acid for adjuvant use in patients with breast cancer. Expert Review of Anticancer Therapy 11:3, pages 333-349.
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Robin Epplen, Michael Stöckle, Udo Engelmann, Axel Heidenreich & Carsten-Henning Ohlmann. (2011) Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta Oncologica 50:1, pages 127-133.
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Lianwei Wang, Dengyang Fang, Jinming Xu & Runlan Luo. (2020) Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review. BMC Cancer 20:1.
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Xin-Jun Cai, Zeng Wang, Jia-Wei Cao, Jian-Jun Ni, Ying-Ying Xu, Jun Yao, Hong Xu, Fang Liu & Gao-Yi Yang. (2017) Anti-angiogenic and anti-tumor effects of metronomic use of novel liposomal zoledronic acid depletes tumor-associated macrophages in triple negative breast cancer. Oncotarget 8:48, pages 84248-84257.
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S. Ishtiaq, S. Edwards, A. Sankaralingam, B.A.J. Evans, C. Elford, M.L. Frost, I. Fogelman & G. Hampson. (2015) The effect of nitrogen containing bisphosphonates, zoledronate and alendronate, on the production of pro-angiogenic factors by osteoblastic cells. Cytokine 71:2, pages 154-160.
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I-Te Wang, Shou-Chu Chou & Ying-Chin Lin. (2014) Zoledronic acid induces apoptosis and autophagy in cervical cancer cells. Tumor Biology 35:12, pages 11913-11920.
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Carlo Palmieri, John R. Fullarton & Janet Brown. (2013) Comparative Efficacy of Bisphosphonates in Metastatic Breast and Prostate Cancer and Multiple Myeloma: A Mixed-Treatment Meta-analysis. Clinical Cancer Research 19:24, pages 6863-6872.
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Dikla Gutman, Hila Epstein-Barash, Moshe Tsuriel & Gershon Golomb. 2012. Nano-Biotechnology for Biomedical and Diagnostic Research. Nano-Biotechnology for Biomedical and Diagnostic Research 165 179 .
Monica Marra, Giuseppina Salzano, Carlo Leonetti, Pierfrancesco Tassone, Marco Scarsella, Silvia Zappavigna, Teresa Calimeri, Renato Franco, Giuseppina Liguori, Giovanni Cigliana, Roberta Ascani, Maria Immacolata La Rotonda, Alberto Abbruzzese, Pierosandro Tagliaferri, Michele Caraglia & Giuseppe De Rosa. (2011) Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes. Nanomedicine: Nanotechnology, Biology and Medicine 7:6, pages 955-964.
Crossref
Rakesh K. Goyal, G. Singh & A. K. Madan. (2011) Models for anti-tumor activity of bisphosphonates using refined topochemical descriptors. Naturwissenschaften 98:10, pages 871-887.
Crossref
G. Salzano, M. Marra, M. Porru, S. Zappavigna, A. Abbruzzese, M.I. La Rotonda, C. Leonetti, M. Caraglia & G. De Rosa. (2011) Self-assembly nanoparticles for the delivery of bisphosphonates into tumors. International Journal of Pharmaceutics 403:1-2, pages 292-297.
Crossref
. (2010) Current World Literature. Current Opinion in Supportive & Palliative Care 4:3, pages 207-227.
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