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Original Research

Role of aspirin in the primary prevention of cardiovascular disease in diabetes mellitus: a meta-analysis

, BSc MD MRCP, , &
Pages 1459-1466 | Published online: 29 Apr 2010

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Read on this site (4)

Niki Katsiki, Francesco Purrello, Costas Tsioufis & Dimitri P. Mikhailidis. (2017) Cardiovascular disease prevention strategies for type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 18:12, pages 1243-1260.
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David S. H. Bell. (2016) Aspirin in the prevention of cardiovascular events in patients with diabetes. Postgraduate Medicine 128:2, pages 180-190.
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Yabin Wang, Qiujun Yu, Daiming Fan & Feng Cao. (2012) Coronary heart disease in Type 2 diabetes: mechanisms and comprehensive prevention strategies. Expert Review of Cardiovascular Therapy 10:8, pages 1051-1060.
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Mario Bollati, Fiorenzo Gaita & Matteo Anselmino. (2011) Antiplatelet combinations for prevention of atherothrombotic events. Vascular Health and Risk Management 7, pages 23-30.
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A. Ruiz-García, V. Pallarés-Carratalá, A. Serrano-Cumplido, C. Escobar-Cervantes, A. Barquilla-García, J.A. Divisón-Garrote, M. Turégano-Yedro, M.A. Prieto-Díaz, S. Cinza-Sanjurjo, F.J. Alonso-Moreno, P. Beato-Fernández, L. García-Matarín, D. Rey-Aldana, E. Martín-Rioboó, A. Moyá-Amengual, R. Crespo-Sabarís, A. Piera-Carbonell, J.C. Romero-Vigara, E. Carrasco-Carrasco, S. Velilla-Zancada, M.C. Seoane-Vicente, J.L. Górriz-Teruel, J. Polo-García & V. Barrios. (2022) Evaluation of prophylaxis in primary prevention with acetylsalicylic acid in people with diabetes: A scoping review. Medicina de Familia. SEMERGEN 48:4, pages 275-292.
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Domingo Orozco-Beltrán, Carlos Brotons Cuixart, José Juan Alemán Sánchez, José Ramón Banegas Banegas, Ana M. Cebrián-Cuenca, Vicente F. Gil Guillen, Enrique Martín Rioboó & Jorge Navarro Pérez. (2020) Recomendaciones preventivas cardiovasculares. Actualización PAPPS 2020. Atención Primaria 52, pages 5-31.
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Dimitrios Patoulias, Konstantinos Stavropoulos, Konstantinos Imprialos, Vasilios Athyros, Michael Doumas & Asterios Karagiannis. (2020) Pharmacological Management of Cardiac Disease in Patients with Type 2 Diabetes: Insights into Clinical Practice. Current Vascular Pharmacology 18:2, pages 125-138.
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Livia Puljak, Nicoletta Riva, Elena Parmelli, Marien González-Lorenzo, Lorenzo Moja & Dawid Pieper. (2020) Data extraction methods: an analysis of internal reporting discrepancies in single manuscripts and practical advice. Journal of Clinical Epidemiology 117, pages 158-164.
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Ming-Hsun Lin, Chien-Hsing Lee, Chin Lin, Yi-Fen Zou, Chieh-Hua Lu, Chang-Hsun Hsieh & Cho-Hao Lee. (2019) Low-Dose Aspirin for the Primary Prevention of Cardiovascular Disease in Diabetic Individuals: A Meta-Analysis of Randomized Control Trials and Trial Sequential Analysis. Journal of Clinical Medicine 8:5, pages 609.
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Carlos Brotons Cuixart, José Juan Alemán Sánchez, José Ramón Banegas Banegas, Carlos Fondón León, José María Lobos-Bejarano, Enrique Martín Rioboó, Jorge Navarro Pérez, Domingo Orozco-Beltrán & Fernando Villar Álvarez. (2018) Recomendaciones preventivas cardiovasculares. Actualización PAPPS 2018. Atención Primaria 50, pages 4-28.
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Lianne A. Kokoska, Sheila M. Wilhelm, Candice L. Garwood & Helen D. Berlie. (2016) Aspirin for primary prevention of cardiovascular disease in patients with diabetes: A meta-analysis. Diabetes Research and Clinical Practice 120, pages 31-39.
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Kunal N. Karmali, Donald M. Lloyd-Jones, Mark A. Berendsen, David C. GoffJrJr, Darshak M. Sanghavi, Nina C. Brown, Liliya Korenovska & Mark D. Huffman. (2016) Drugs for Primary Prevention of Atherosclerotic Cardiovascular Disease. JAMA Cardiology 1:3, pages 341.
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Mariana GarciaSharon L. MulvaghC. Noel Bairey MerzJulie E. BuringJoAnn E. Manson. (2016) Cardiovascular Disease in Women. Circulation Research 118:8, pages 1273-1293.
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Shao-Xing Dai, Wen-Xing Li, Gong-Hua Li & Jing-Fei Huang. (2016) Proteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin. PeerJ 4, pages e1791.
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Judith G. Regensteiner, Sherita Golden, Amy G. Huebschmann, Elizabeth Barrett-Connor, Alice Y. Chang, Deborah Chyun, Caroline S. Fox, Catherine Kim, Nehal Mehta, Jane F. Reckelhoff, Jane E.B. Reusch, Kathryn M. Rexrode, Anne E. Sumner, Francine K. Welty, Nanette K. Wenger & Blair Anton. (2015) Sex Differences in the Cardiovascular Consequences of Diabetes Mellitus. Circulation 132:25, pages 2424-2447.
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Caroline S. Fox, Sherita Hill Golden, Cheryl Anderson, George A. Bray, Lora E. Burke, Ian H. de Boer, Prakash Deedwania, Robert H. Eckel, Abby G. Ershow, Judith Fradkin, Silvio E. Inzucchi, Mikhail Kosiborod, Robert G. Nelson, Mahesh J. Patel, Michael Pignone, Laurie Quinn, Philip R. Schauer, Elizabeth Selvin & Dorothea K. Vafiadis. (2015) Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association. Diabetes Care 38:9, pages 1777-1803.
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Caroline S. Fox, Sherita Hill Golden, Cheryl Anderson, George A. Bray, Lora E. Burke, Ian H. de Boer, Prakash Deedwania, Robert H. Eckel, Abby G. Ershow, Judith Fradkin, Silvio E. Inzucchi, Mikhail Kosiborod, Robert G. Nelson, Mahesh J. Patel, Michael Pignone, Laurie Quinn, Philip R. Schauer, Elizabeth Selvin & Dorothea K. Vafiadis. (2015) Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence. Circulation 132:8, pages 691-718.
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Yehuda Handelsman, Zachary T. Bloomgarden, George Grunberger, Guillermo Umpierrez, Robert S. Zimmerman, Timothy S. Bailey, Lawrence Blonde, George A. Bray, A. Jay Cohen, Samuel Dagogo-Jack, Jaime A. Davidson, Daniel Einhorn, Om P. Ganda, Alan J. Garber, W. Timothy Garvey, Robert R. Henry, Irl B. Hirsch, Edward S. Horton, Daniel L. Hurley, Paul S. Jellinger, Lois Jovanovič, Harold E. Lebovitz, Derek LeRoith, Philip Levy, Janet B. McGill, Jeffrey I. Mechanick, Jorge H. Mestman, Etie S. Moghissi, Eric A. Orzeck, Rachel Pessah-Pollack, Paul D. Rosenblit, Aaron I. Vinik, Kathleen Wyne & Farhad Zangeneh. (2015) American Association Of Clinical Endocrinologists And American College Of Endocrinology -Clinical Practice Guidelines For Developing A Diabetes Mellitus Comprehensive Care Plan – 2015. Endocrine Practice 21, pages 1-87.
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Yehuda Handelsman, Zachary T. Bloomgarden, George Grunberger, Guillermo Umpierrez, Robert S. Zimmerman, Timothy S. Bailey, Lawrence Blonde, George A. Bray, A. Jay Cohen, Samuel Dagogo-Jack, Jaime A. Davidson, Daniel Einhorn, Om P. Ganda, Alan J. Garber, W. Timothy Garvey, Robert R. Henry, Irl B. Hirsch, Edward S. Horton, Daniel L. Hurley, Paul S. Jellinger, Lois Jovanovič, Harold E. Lebovitz, Derek LeRoith, Philip Levy, Janet B. McGill, Jeffrey I. Mechanick, Jorge H. Mestman, Etie S. Moghissi, Eric A. Orzeck, Rachel Pessah-Pollack, Paul D. Rosenblit, Aaron I. Vinik, Kathleen Wyne & Farhad Zangeneh. (2015) American Association of Clinical Endocrinologists and American College of Endocrinology – Clinical Practice Guidelines for Developing A Diabetes Mellitus Comprehensive Care Plan – 2015 — Executive Summary. Endocrine Practice 21:4, pages 413-437.
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Carlos Brotons, Robert Benamouzig, Krzysztof J. Filipiak, Volker Limmroth & Claudio Borghi. (2014) A Systematic Review of Aspirin in Primary Prevention: Is It Time for a New Approach?. American Journal of Cardiovascular Drugs 15:2, pages 113-133.
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Manling Xie, Zhilei Shan, Yan Zhang, Sijing Chen, Wei Yang, Wei Bao, Ying Rong, Xuefeng Yu, Frank B. Hu & Liegang Liu. (2014) Aspirin for Primary Prevention of Cardiovascular Events: Meta-Analysis of Randomized Controlled Trials and Subgroup Analysis by Sex and Diabetes Status. PLoS ONE 9:10, pages e90286.
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Frederik Matthys, Tine De Backer, Guy De Backer & Robert Vander Stichele. (2012) Review of guidelines on primary prevention of cardiovascular disease with aspirin: how much evidence is needed to turn a tanker?. European Journal of Preventive Cardiology 21:3, pages 354-365.
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Paul Sutcliffe, Martin Connock, Tara Gurung, Karoline Freeman, Samantha Johnson, Kandala Ngianga-Bakwin, Amy Grove, Binu Gurung, Sarah Morrow, Saverio Stranges & Aileen Clarke. (2013) Aspirin in Primary Prevention of Cardiovascular Disease and Cancer: A Systematic Review of the Balance of Evidence from Reviews of Randomized Trials. PLoS ONE 8:12, pages e81970.
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Joseph A. Delaney, Nils Lehmann, Karl-Heinz Jöckel, Sammy Elmariah, Bruce M. Psaty, Amir A. Mahabadi, Matt Budoff, Richard A. Kronmal, Khurram Nasir, Kevin D. O’Brien, Stefan Möhlenkamp, Susanne Moebus, Nico Dragano, Almut G. Winterstein, Raimund Erbel & Hagen Kälsch. (2013) Associations between aspirin and other non-steroidal anti-inflammatory drugs and aortic valve or coronary artery calcification: The Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study. Atherosclerosis 229:2, pages 310-316.
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Caroline J. Magri & Stephen Fava. (2012) Should diabetes still be considered a coronary artery disease equivalent?. Journal of Cardiovascular Medicine 13:11, pages 760-765.
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Scot H. Simpson, John-Michael Gamble, Laurie Mereu & Thane Chambers. (2011) Effect of Aspirin Dose on Mortality and Cardiovascular Events in People with Diabetes: A Meta-Analysis. Journal of General Internal Medicine 26:11, pages 1336-1344.
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Yehuda Handelsman, Jeffrey I. Mechanick, Lawrence Blonde, George Grunberger, Zachary T. Bloomgarden, George A. Bray, Samuel Dagogo-Jack, Jaime A. Davidson, Daniel Einhorn, Om Ganda, Alan J. Garber, Irl B. Hirsch, Edward S. Horton, Faramarz Ismail-Beigi, Paul S. Jellinger, Kenneth L. Jones, Lois Jovanovič, Harold Lebovitz, Philip Levy, Etie S. Moghissi, Eric A. Orzeck, Aaron I. Vinik, Kathleen L. Wyne, Alan J. Garber, Daniel L. Hurley & Farhad Zangeneh. (2011) American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for Developing a Diabetes Mellitus Comprehensive Care Plan. Endocrine Practice 17, pages 1-53.
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Yehuda Handelsman, Jeffrey I. Mechanick, Lawrence Blonde, George Grunberger, Zachary T. Bloomgarden, George A. Bray, Samuel Dagogo-Jack, Jaime A. Davidson, Daniel Einhorn, Om Ganda, Alan J. Garber, Irl B. Hirsch, Edward S. Horton, Faramarz Ismail-Beigi, Paul S. Jellinger, Kenneth L. Jones, Lois Jovanovič, Harold Lebovitz, Philip Levy, Etie S. Moghissi, Eric A. Orzeck, Aaron I. Vinik & Kathleen L. Wyne. (2011) American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for Developing a Diabetes Mellitus Comprehensive Care Plan: Executive Summary. Endocrine Practice 17:2, pages 287-302.
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Sonia Butalia, Alexander A Leung, William A Ghali & Doreen M Rabi. (2011) Aspirin effect on the incidence of major adverse cardiovascular events in patients with diabetes mellitus: a systematic review and meta-analysis. Cardiovascular Diabetology 10:1, pages 25.
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S. N. Murthy, P. J. Kadowitz & D. B. McNamara. 2011. Molecular Defects in Cardiovascular Disease. Molecular Defects in Cardiovascular Disease 305 314 .

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