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Drug Evaluations

Topical capsaicin. The fire of a ‘hot’ medicine is reignited

, MD PhD & , MD
Pages 1359-1371 | Published online: 06 May 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Elham Karimi-Sales, Gisou Mohaddes & Mohammad Reza Alipour. (2021) Hepatoprotection of capsaicin in alcoholic and non-alcoholic fatty liver diseases. Archives of Physiology and Biochemistry 0:0, pages 1-11.
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Asia Fernández-Carvajal, Rosario González-Muñiz, Gregorio Fernández-Ballester & Antonio Ferrer-Montiel. (2020) Investigational drugs in early phase clinical trials targeting thermotransient receptor potential (thermoTRP) channels. Expert Opinion on Investigational Drugs 29:11, pages 1209-1222.
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Kayla Fourzali & Gil Yosipovitch. (2020) Safety considerations when using drugs to treat pruritus. Expert Opinion on Drug Safety 19:4, pages 467-477.
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Eleni Kollia, Charalampos Proestos, Panagiotis Zoumpoulakis & Panagiota Markaki. (2019) Capsaicin, an inhibitor of Ochratoxin A production by Aspergillus section Nigri strains in grapes (Vitis vinifera L.). Food Additives & Contaminants: Part A 36:11, pages 1709-1721.
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Lian Duan, Huaidong Peng, Guangcan Li, Ruolun Wang & Yanfang Chen. (2018) Utility of in vitro and in vivo systems for studying the permeability of capsaicin and nonivamide through different intestinal regions. Xenobiotica 48:6, pages 541-545.
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Kinga Sałat, Anna Jakubowska & Katarzyna Kulig. (2014) Zucapsaicin for the treatment of neuropathic pain. Expert Opinion on Investigational Drugs 23:10, pages 1433-1440.
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Kinga Sałat, Paula Kowalczyk, Beata Gryzło, Anna Jakubowska & Katarzyna Kulig. (2014) New investigational drugs for the treatment of neuropathic pain. Expert Opinion on Investigational Drugs 23:8, pages 1093-1104.
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Articles from other publishers (63)

Areej Hazem Younes & Yasser Fakri Mustafa. (2023) Sweet Bell Pepper: A Focus on Its Nutritional Qualities and Illness-Alleviated Properties. Indian Journal of Clinical Biochemistry.
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Gianmarco Gualtieri, Annalisa Maruca, Roberta Rocca, Fabrizio Carta, Emanuela Berrino, Alessandro Salatino, Carolina Brescia, Roberta Torcasio, Manuel Crispo, Francesco Trapasso, Stefano Alcaro, Claudiu T. Supuran & Giosuè Costa. (2023) Uncovering Novel Capsaicin Inhibitory Activity towards Human Carbonic Anhydrase Isoforms IX and XII by Combining In Silico and In Vitro Studies. Antioxidants 12:5, pages 1115.
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Mei-Ju Ko, Yu-Sen Peng & Hon-Yen Wu. (2023) Uremic pruritus: pathophysiology, clinical presentation, and treatments. Kidney Research and Clinical Practice 42:1, pages 39-52.
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Christina Kursewicz, Kayla Fourzali & Gil Yosipovitch. 2023. Atopic Dermatitis : Inside Out Or Outside in. Atopic Dermatitis : Inside Out Or Outside in 264 275 .
Magda Blessmann Weber, Fernanda Oliveira Camozzato & Júlia Kanaan Recuero. 2023. Dermatology in Public Health Environments. Dermatology in Public Health Environments 1607 1636 .
Omar Mahmoud, Georgia Biazus Soares & Gil Yosipovitch. (2022) Transient Receptor Potential Channels and Itch. International Journal of Molecular Sciences 24:1, pages 420.
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Valdir Florencio da Veiga, Jr, Larissa Silveira Moreira Wiedemann, Claudio Pereira de Araujo, Jr & Ananda da Silva Antonio. 2022. Chemistry and Nutritional Effects of Capsicum. Chemistry and Nutritional Effects of Capsicum 93 112 .
Hao-Jui Weng, Quoc Thao Trang Pham, Chia-Wei Chang & Tsen-Fang Tsai. (2022) Druggable Targets and Compounds with Both Antinociceptive and Antipruritic Effects. Pharmaceuticals 15:7, pages 892.
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Gloria E. Barboza, Carolina Carrizo García, Luciano de Bem Bianchetti, María V. Romero & Marisel Scaldaferro. (2022) Monograph of wild and cultivated chili peppers (Capsicum L., Solanaceae). PhytoKeys 200, pages 1-423.
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Joseph A. Ayariga, Daniel A. Abugri, Balagopal Amrutha & Robert Villafane. (2022) Capsaicin Potently Blocks Salmonella typhimurium Invasion of Vero Cells. Antibiotics 11:5, pages 666.
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Lisa B Shields, Vasudeva G Iyer, Yi Ping Zhang & Christopher B Shields. (2022) Brachioradial Pruritus: Clinical, Electromyographic, and Cervical MRI Features in Nine Patients. Cureus.
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Zoe M. Lipman, Giuseppe Ingrasci & Gil Yosipovitch. (2021) Approach to the Patient with Chronic Pruritus. Medical Clinics of North America 105:4, pages 699-721.
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Janne D. Christensen, Silvia Lo Vecchio, Hjalte H. Andersen, Jesper Elberling & Lars Arendt-Nielsen. (2021) Effect of Topical Analgesia on Desensitization Following 8% Topical Capsaicin Application. The Journal of Pain 22:7, pages 778-788.
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Magdalena Nikolaeva-Koleva, Laura Butron, Sara González-Rodríguez, Isabel Devesa, Pierluigi Valente, Marta Serafini, Armando A. Genazzani, Tracey Pirali, Gregorio Fernández Ballester, Asia Fernández-Carvajal & Antonio Ferrer-Montiel. (2021) A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability. Scientific Reports 11:1.
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Talía Hernández‐Pérez, María del Rocío Gómez‐García, María Elena Valverde & Octavio Paredes‐López. (2020) Capsicum annuum (hot pepper): An ancient Latin‐American crop with outstanding bioactive compounds and nutraceutical potential. A review . Comprehensive Reviews in Food Science and Food Safety 19:6, pages 2972-2993.
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Patricia Batista Deroco, Orlando Fatibello-Filho, Fabiana Arduini & Danila Moscone. (2020) Electrochemical determination of capsaicin in pepper samples using sustainable paper-based screen-printed bulk modified with carbon black. Electrochimica Acta 354, pages 136628.
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Ji Hye Hwang, Jaseung Ku & Chul Jung. (2020) Evaluation of the Single-Dose Toxicity of Capsaicin Pharmacopuncture in Rats. Journal of Acupuncture Research 37:3, pages 167-172.
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Gloria E. Barboza, Luciano de Bem Bianchetti & João Renato Stehmann. (2020) Capsicum carassense (Solanaceae), a new species from the Brazilian Atlantic Forest. PhytoKeys 140, pages 125-138.
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Donatella Bagetta, Annalisa Maruca, Antonio Lupia, Francesco Mesiti, Raffaella Catalano, Isabella Romeo, Federica Moraca, Francesca Alessandra Ambrosio, Giosuè Costa, Anna Artese, Francesco Ortuso, Stefano Alcaro & Roberta Rocca. (2020) Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome. European Journal of Medicinal Chemistry 186, pages 111903.
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Emilie Fowler & Gil Yosipovitch. (2019) Chronic itch management: therapies beyond those targeting the immune system. Annals of Allergy, Asthma & Immunology 123:2, pages 158-165.
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Gloria E. Barboza, Carolina Carrizo García, Segundo Leiva González, Marisel Scaldaferro & Ximena Reyes. (2019) Four new species of Capsicum (Solanaceae) from the tropical Andes and an update on the phylogeny of the genus. PLOS ONE 14:1, pages e0209792.
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Gil Yosipovitch, Jordan Daniel Rosen & Takashi Hashimoto. (2018) Itch: From mechanism to (novel) therapeutic approaches. Journal of Allergy and Clinical Immunology 142:5, pages 1375-1390.
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G. Yosipovitch. (2018) The 8% capsaicin - a hot medicine for neuropathic itch. Journal of the European Academy of Dermatology and Venereology 32:9, pages 1403-1403.
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Jordan Daniel Rosen, Anna Chiara Fostini & Gil Yosipovitch. (2018) Diagnosis and Management of Neuropathic Itch. Dermatologic Clinics 36:3, pages 213-224.
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Taige Cao, Hong Liang Tey & Gil Yosipovitch. (2018) Chronic Pruritus in the Geriatric Population. Dermatologic Clinics 36:3, pages 199-211.
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Janelle Pavlis & Gil Yosipovitch. (2017) Management of Itch in Atopic Dermatitis. American Journal of Clinical Dermatology 19:3, pages 319-332.
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Luigino Calzetta, Paola Rogliani, Elena Pistocchini, Maurizio Mattei, Giuseppe Cito, Pietro Alfonsi, Clive Page & Maria Gabriella Matera. (2018) Effect of lipopolysaccharide on the responsiveness of equine bronchial tissue. Pulmonary Pharmacology & Therapeutics 49, pages 88-94.
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Zongmin Zhao, Anvay Ukidve, Anshuman Dasgupta & Samir Mitragotri. (2018) Transdermal immunomodulation: Principles, advances and perspectives. Advanced Drug Delivery Reviews 127, pages 3-19.
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Min Je Jung, Yong Won ChoiBo Young Chung, Chun Wook Park & Hye One Kim. (2018) Pathophysiology and new treatment of itch. Journal of the Korean Medical Association 61:11, pages 670.
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Magda Blessmann Weber & Fernanda Oliveira Camozzato. 2018. Dermatology in Public Health Environments. Dermatology in Public Health Environments 1279 1298 .
Simona-Roxana Georgescu, Maria-Isabela Sârbu, Clara Matei, Mihaela Ilie, Constantin Caruntu, Carolina Constantin, Monica Neagu & Mircea Tampa. (2017) Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?. Nutrients 9:12, pages 1365.
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Mohammad A. Tabrizi, Joanne Mckeown & Kelvin Siew. (2017) Management of persistent pruritus in carcinoma erysipeloides associated with oesophageal cancer. Internal Medicine Journal 47:7, pages 829-831.
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Vianey de la Rosa-Lugo, Macdiel Acevedo-Quiroz, Myrna Déciga-Campos & María Yolanda Rios. (2017) Antinociceptive effect of natural and synthetic alkamides involves TRPV1 receptors. Journal of Pharmacy and Pharmacology 69:7, pages 884-895.
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Helena Kuhn, Constance Mennella, Michelle Magid, Caroline Stamu-O’Brien & George Kroumpouzos. (2017) Psychocutaneous disease. Journal of the American Academy of Dermatology 76:5, pages 795-808.
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Jerrold Scott Petrofsky. 2017. Textbook of Aging Skin. Textbook of Aging Skin 1081 1090 .
Carolyn Stull, Shoshana Grossman & Gil Yosipovitch. (2016) Current and Emerging Therapies for Itch Management in Psoriasis. American Journal of Clinical Dermatology 17:6, pages 617-624.
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Nicholas K. Mollanazar, Peter K. Smith & Gil Yosipovitch. (2015) Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?. Clinical Reviews in Allergy & Immunology 51:3, pages 263-292.
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Shaherin Basith, Minghua Cui, Sunhye Hong & Sun Choi. (2016) Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases. Molecules 21:8, pages 966.
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Víctor Gómez-Calvario, María Luisa Garduño-Ramírez, Ismael León-Rivera & María Yolanda Rios. (2016) 1 H and 13 C NMR data on natural and synthetic capsaicinoids . Magnetic Resonance in Chemistry 54:4, pages 268-290.
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Mojtaba Heydari, Kaynoosh Homayouni, Mohammad Hashem Hashempur & Mesbah Shams. (2016) Topical Citrullus colocynthis (bitter apple) extract oil in painful diabetic neuropathy: A double-blind randomized placebo-controlled clinical trial . Journal of Diabetes 8:2, pages 246-252.
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Lindsey M. Snyder, Huizhen Huang & Sarah E. Ross. 2015. TRP Channels as Therapeutic Targets. TRP Channels as Therapeutic Targets 279 291 .
Marilù Giacalone, Francesco Forfori & Francesco Giunta. 2015. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease 187 195 .
Tabi Anika Leslie, Malcolm W. Greaves & Gil Yosipovitch. 2015. Pharmacology of Itch. Pharmacology of Itch 337 356 .
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Bernd Nilius & Arpad Szallasi. (2014) Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine. Pharmacological Reviews 66:3, pages 676-814.
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Judy H. Borovicka, Jennifer R.S. Gordon, Ann Cameron Haley, Nicole E. Larsen & Dennis P. West. 2013. Dermatologic Principles and Practice in Oncology. Dermatologic Principles and Practice in Oncology 384 400 .
Nilufer Ercan, Mecit Orhan Uludag, Erol Rauf Agis & Emine Demirel-Yilmaz. (2013) The anti-inflammatory effect of diclofenac is considerably augmented by topical capsaicinoids-containing patch in carrageenan-induced paw oedema of rat. Inflammopharmacology 21:6, pages 413-419.
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Gil Yosipovitch & Jeffrey D. Bernhard. (2013) Chronic Pruritus. New England Journal of Medicine 368:17, pages 1625-1634.
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Sébastien Talbot, Jenny Pena Dias, Karim Lahjouji, Maurício Reis Bogo, Maria Martha Campos, Pierrette Gaudreau & Réjean Couture. (2012) Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia. Journal of Neuroinflammation 9:1.
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Jennifer Sayanlar, Nilufer Guleyupoglu, Russell Portenoy & Sait Ashina. (2012) Trigeminal postherpetic neuralgia responsive to treatment with capsaicin 8 % topical patch: a case report. The Journal of Headache and Pain 13:7, pages 587-589.
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Rodrigo Valdes-Rodriguez, Shawn G. Kwatra & Gil Yosipovitch. (2018) Itch in Psoriasis: From Basic Mechanisms to Practical Treatments. Psoriasis Forum 18a:3, pages 110-117.
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Till WagnerAndrea Roth-Daniek, Angela Sell, Janice England & Kai-Uwe Kern. (2012) Capsaicin 8% patch for peripheral neuropathic pain: review of treatment best practice from ‘real-world’ clinical experience. Pain Management 2:3, pages 239-250.
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M. Metz, K. Krause, M. Maurer & M. Magerl. (2011) Treatment of notalgia paraesthetica with an 8% capsaicin patch. British Journal of Dermatology 165:6, pages 1359-1361.
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H. Bai, H. Li, W. Zhang, K. A. Matkowskyj, J. Liao, S. K. Srivastava & G.-Y. Yang. (2011) Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice. Carcinogenesis 32:11, pages 1689-1696.
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P. Anand & K. Bley. (2011) Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. British Journal of Anaesthesia 107:4, pages 490-502.
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