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Expert Opinion on Pharmacotherapy Volume 11, 2010 - Issue 8
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Drug Evaluations

Optimal airway antimicrobial therapy for cystic fibrosis: the role of inhaled aztreonam lysine

J Stuart Elborn Queen's University of Belfast, Centre for Infection and Immunity, Belfast, Northern Ireland, UK; Adult Cystic Fibrosis Center, Belfast Health and Social Care Trust, Belfast BT9 7AB, Northern Ireland, UK
, MD &
Noreen R Henig PAH and Respiratory Therapeutics, Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA +1 650 522 5267; +1 650 522 1834; [email protected]
, MD
Pages 1373-1385 | Published online: 29 Apr 2010

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Yagmur Akdag Cayli, Selma Sahin, Francesca Buttini, Anna Giulia Balducci, Serena Montanari, Imran Vural & Levent Oner. (2017) Dry powders for the inhalation of ciprofloxacin or levofloxacin combined with a mucolytic agent for cystic fibrosis patients. Drug Development and Industrial Pharmacy 43:8, pages 1378-1389.
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Articles from other publishers (14)

Sandra Anderson, Paul Atkins, Per Bäckman, David Cipolla, Andrew Clark, Evangelia Daviskas, Bernd Disse, Plamena Entcheva-Dimitrov, Rick Fuller, Igor Gonda, Hans Lundbäck, Bo Olsson & Jeffry Weers. (2022) Inhaled Medicines: Past, Present, and Future. Pharmacological Reviews 74:1, pages 48-118.
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Kathryn McLean, Duankun Lee, Elizabeth A. Holmes, Kelsi Penewit, Adam Waalkes, Mingxin Ren, Samuel A. Lee, Joseph Gasper, Colin Manoil & Stephen J. Salipante. (2019) Genomic Analysis Identifies Novel Pseudomonas aeruginosa Resistance Genes under Selection during Inhaled Aztreonam Therapy In Vivo . Antimicrobial Agents and Chemotherapy 63:9.
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Arcadia Woods & Khondaker Miraz Rahman. (2018) Antimicrobial molecules in the lung: formulation challenges and future directions for innovation. Future Medicinal Chemistry 10:5, pages 575-604.
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George A. O'Toole. (2018) Cystic Fibrosis Airway Microbiome: Overturning the Old, Opening the Way for the New. Journal of Bacteriology 200:4.
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Jeffry Weers. (2015) Inhaled antimicrobial therapy – Barriers to effective treatment. Advanced Drug Delivery Reviews 85, pages 24-43.
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Aukje C. Bos, Cedric van Holsbeke, Jan W. de Backer, Mireille van Westreenen, Hettie M. Janssens, Wim G. Vos & Harm A. W. M. Tiddens. (2015) Patient-Specific Modeling of Regional Antibiotic Concentration Levels in Airways of Patients with Cystic Fibrosis: Are We Dosing High Enough?. PLOS ONE 10:3, pages e0118454.
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Axel Dalhoff. (2014) Pharmacokinetics and Pharmacodynamics of Aerosolized Antibacterial Agents in Chronically Infected Cystic Fibrosis Patients. Clinical Microbiology Reviews 27:4, pages 753-782.
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J.-C. Dubus, L. Bassinet, F. Chedevergne, B. Delaisi, N. Desmazes-Dufeu, G. Reychler & L. Vecellio. (2014) Mucoviscidose et traitements inhal?s?: quoi de neuf en 2013??. Revue des Maladies Respiratoires 31:4, pages 336-346.
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Q. Yu, E. F. Griffin, S. Moreau-Marquis, J. D. Schwartzman, B. A. Stanton & G. A. O'Toole. (2012) In vitro evaluation of tobramycin and aztreonam versus Pseudomonas aeruginosa biofilms on cystic fibrosis-derived human airway epithelial cells. Journal of Antimicrobial Chemotherapy 67:11, pages 2673-2681.
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Lev Ruzer & Naomi HarleyStephen Marek, Hugh Smyth, Lucila Garcia-Contreras, Daniel Cooney, Robert Garmise, Latarsha Jones & Anthony Hickey. 2012. Aerosols Handbook. Aerosols Handbook 1 30 .
Kristen Zeitler, Brian Salvas, Vanessa Stevens & Jack Brown. (2012) Aztreonam lysine for inhalation: New formulation of an old antibiotic. American Journal of Health-System Pharmacy 69:2, pages 107-115.
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Ryan Hudson & Brooke Olson Blair. (2011) Inhaled antibiotics for Gram-negative respiratory infections. Future Medicinal Chemistry 3:13, pages 1663-1677.
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HELEN K. REDDEL, T. K. LIM, MICHIAKI MISHIMA, CLAIRE E. WAINWRIGHT & DARRYL A. KNIGHT. (2011) Year-in-review 2010: Asthma, COPD, cystic fibrosis and airway biology. Respirology 16:3, pages 540-552.
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David Berlana, Josep Manel Llop, Frederic Manresa & Ramón Jódar. (2012) Outpatient Treatment of Pseudomonas aeruginosa Bronchial Colonization with Long‐term Inhaled Colistin, Tobramycin, or Both in Adults without Cystic Fibrosis . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 31:2, pages 146-157.
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