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Expert Opinion on Pharmacotherapy Volume 11, 2010 - Issue 12
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Original Research

Comparison of orlistat treatment and placebo in obese type 2 diabetic patients

Giuseppe Derosa University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, MD PhD,
Pamela Maffioli University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, MD,
Sibilla AT Salvadeo University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, MD,
Ilaria Ferrari University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, MD,
Alessia Gravina University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, MD,
Roberto Mereu University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, MD,
Angela D'Angelo University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, BD PhD,
Elena Fogari University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, MD,
Ilaria Palumbo University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, MD,
Sabrina Randazzo University of Pavia, Department of Internal Medicine and Therapeutics, P.le C. Golgi, 2, 27100 Pavia, Italy +39 0382 526217; +39 0382 526259; [email protected]
, MD &
Arrigo FG Cicero University of Bologna, ‘G. Descovich’ Atherosclerosis Study Center, Department of Internal Medicine, Aging and Kidney Diseases, Bologna, Italy
, MD PhD show all
Pages 1971-1982 | Published online: 23 Jun 2010

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Inger Smith, Emily Hardy, Stephen Mitchell & Sarah Batson. (2022) Semaglutide 2.4 Mg for the Management of Overweight and Obesity: Systematic Literature Review and Meta-Analysis. Diabetes, Metabolic Syndrome and Obesity 15, pages 3961-3987.
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Muqing Gu, Xiangyan Ruan, Yanqiu Li, Tianhe Li, Chenghong Yin & Alfred O. Mueck. (2022) Effect on the cardiovascular independent risk factor lipoprotein(a) in overweight or obese PCOS patients with ethinyl-estradiol/drospirenone alone or plus orlistat. Gynecological Endocrinology 38:7, pages 598-602.
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Awadhesh Kumar Singh & Ritu Singh. (2020) Pharmacotherapy in obesity: a systematic review and meta-analysis of randomized controlled trials of anti-obesity drugs. Expert Review of Clinical Pharmacology 13:1, pages 53-64.
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Robin L. Black, Ashley M. Higbea, Courtney Duval & Lisa M. Chastain. (2016) Pharmacological management of obesity in patients with type 2 diabetes. Expert Review of Endocrinology & Metabolism 11:5, pages 415-423.
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Ellen E Ladenheim. (2015) Liraglutide and obesity: a review of the data so far. Drug Design, Development and Therapy 9, pages 1867-1875.
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Giuseppe Derosa & Pamela Maffioli. (2012) Anti-obesity drugs: a review about their effects and their safety. Expert Opinion on Drug Safety 11:3, pages 459-471.
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Niki Katsiki, Dimitri P Mikhailidis, Anna Gotzamani-Psarrakou, John G Yovos & Dimitrios Karamitsos. (2011) Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus. Expert Opinion on Therapeutic Targets 15:4, pages 401-420.
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Nisrine I. Kawa & Souheil W. Adra. 2023. Inflammation and Obesity. Inflammation and Obesity 233 262 .
Eduardo Grunvald, Raj Shah, Ruben Hernaez, Apoorva Krishna Chandar, Octavia Pickett-Blakely, Levi M. Teigen, Tasma Harindhanavudhi, Shahnaz Sultan, Siddharth Singh & Perica Davitkov. (2022) AGA Clinical Practice Guideline on Pharmacological Interventions for Adults With Obesity. Gastroenterology 163:5, pages 1198-1225.
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Mobina Aghajani, Saleh Rahmati-Ahmadabad, Farhad Zamani, Behrouz Ghanbari & Mohammad-Ali Azarbayjani. (2021) The effects of high-intensity interval training and orlistat on selected adipokines and cytokines in obese womenAuswirkungen von Hochintensitätsintervalltraining und Orlistat auf ausgewählte Adipokine und Zytokine bei adipösen Frauen. German Journal of Exercise and Sport Research 52:1, pages 87-96.
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Chu Lin, Xiaoling Cai, Wenjia Yang, Fang Lv, Lin Nie & Linong Ji. (2020) The Body Weight Alteration and Incidence of Neoplasm in Patients With Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials. Frontiers in Endocrinology 11.
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Anna Casu, Anika Bilal & Richard E. Pratley. (2020) Pharmacological therapies to address obesity in type 1 diabetes. Current Opinion in Endocrinology, Diabetes & Obesity 27:4, pages 194-206.
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Kazim Sahin, Cemal Orhan, Osman Kucuk, Nurhan Sahin, Mehmet Tuzcu, Besir Er, Shane Durkee & Aouatef Bellamine. (2020) A Dose-Dependent Effect of Carnipure® Tartrate Supplementation on Endurance Capacity, Recovery, and Body Composition in an Exercise Rat Model. Nutrients 12:5, pages 1519.
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Minyi Lee, Brianna N. Lauren, Tiannan Zhan, Jin Choi, Matthew Klebanoff, Barham Abu Dayyeh, Elsie M. Taveras, Kathleen Corey, Lee Kaplan & Chin Hur. (2020) The cost‐effectiveness of pharmacotherapy and lifestyle intervention in the treatment of obesity. Obesity Science & Practice 6:2, pages 162-170.
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David W. Hudgel, Sanjay R. Patel, Amy M. Ahasic, Susan J. Bartlett, Daniel H. Bessesen, Melisa A. Coaker, P. Michelle Fiander, Ronald R. Grunstein, Indira Gurubhagavatula, Vishesh K. Kapur, Christopher J. Lettieri, Matthew T. Naughton, Robert L. Owens, Jean-Louis D. Pepin, Henri Tuomilehto & Kevin C. Wilson. (2018) The Role of Weight Management in the Treatment of Adult Obstructive Sleep Apnea. An Official American Thoracic Society Clinical Practice Guideline. American Journal of Respiratory and Critical Care Medicine 198:6, pages e70-e87.
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Ali Nazary-vannani, Ehsan Ghaedi, Seyed Mohammad Mousavi, Alireza Teymouri, Jamal Rahmani & Hamed Kord Varkaneh. (2018) The effect of l-carnitine supplementation on serum leptin concentrations: a systematic review and meta-analysis of randomized controlled trials. Endocrine 60:3, pages 386-394.
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F. B. Del Vecchio, V. S. Coswig & L. M. Galliano. (2017) Comment on ‘The effect of ( l -)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials’ . Obesity Reviews 18:2, pages 277-278.
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M. Pooyandjoo, M. Nouhi, S. Shab-Bidar, K. Djafarian & A. Olyaeemanesh. (2016) The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obesity Reviews 17:10, pages 970-976.
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Giuseppe Derosa, Pamela Maffioli & Amirhossein Sahebkar. (2016) Improvement of plasma adiponectin, leptin and C-reactive protein concentrations by orlistat: a systematic review and meta-analysis. British Journal of Clinical Pharmacology 81:5, pages 819-834.
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Vladimír Pavlík, Jana Fajfrová, Jan M. Horáček, Václav Šafka, Pavla Krutišová, Miroslav Urban, Peter Urban, Jana Gazdačková & Petr Navrátil. (2016) ORLISTAT AND PHENTERMINE IN WEIGHT LOSS IN SELECTED CZECH POPULATION. Military Medical Science Letters 85:1, pages 13-18.
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Kieren J. Mather & Ronald B. Goldberg. (2014) Clinical use of adiponectin as a marker of metabolic dysregulation. Best Practice & Research Clinical Endocrinology & Metabolism 28:1, pages 107-117.
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Giuseppe Derosa & Pamela Maffioli. 2014. Integrative Weight Management. Integrative Weight Management 261 277 .
Vladimír Pavlík, Jana Fajfrová & Eva Drahokoupilová. (2013) The effect of orlistat on body weight in obese Czech adults. Open Medicine 8:5, pages 553-557.
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Marietta Charakida, Dimitris Tousoulis & Nicholas Finer. (2013) Drug treatment of obesity in the cardiovascular patient. Current Opinion in Cardiology 28:5, pages 584-591.
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G. Derosa, A. F. G. Cicero, A. D’Angelo, E. Fogari & P. Maffioli. (2012) Effects of 1-year orlistat treatment compared to placebo on insulin resistance parameters in patients with type 2 diabetes. Journal of Clinical Pharmacy and Therapeutics 37:2, pages 187-195.
Crossref
Giuseppe Derosa, Pamela Maffioli, Ilaria Ferrari, Angela D’Angelo, Elena Fogari, Ilaria Palumbo, Sabrina Randazzo & Arrigo F.G. Cicero. (2011) Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients. Fundamental & Clinical Pharmacology 25:5, pages 642-651.
Crossref

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