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Dyslipidaemia in the metabolic syndrome and type 2 diabetes: pathogenesis, priorities, pharmacotherapies

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Pages 13-30 | Published online: 14 Jul 2010

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N.S. Nurmohamed, G.M. Dallinga – Thie & E.S.G. Stroes. (2020) Targeting apoC-III and ANGPTL3 in the treatment of hypertriglyceridemia. Expert Review of Cardiovascular Therapy 18:6, pages 355-361.
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Jose G Jimenez-Montero & Gregory Haft. (2015) Simvastatin/fenofibrate combination in the treatment of dyslipidemia: current evidence. Research and Reports in Endocrine Disorders 5, pages 1-13.
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Laia Salvadó, Lucía Serrano-Marco, Emma Barroso, Xavier Palomer & Manuel Vázquez-Carrera. (2012) Targeting PPARβ/δ for the treatment of type 2 diabetes mellitus. Expert Opinion on Therapeutic Targets 16:2, pages 209-223.
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David R Janero, Loren Lindsley, Venkata Kiran Vemuri & Alexandros Makriyannis. (2011) Cannabinoid 1 G protein-coupled receptor (periphero-)neutral antagonists: emerging therapeutics for treating obesity-driven metabolic disease and reducing cardiovascular risk. Expert Opinion on Drug Discovery 6:10, pages 995-1025.
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Gerald F Watts & Fredrik Karpe. (2011) Why, when and how should hypertriglyceridemia be treated in the high-risk cardiovascular patient?. Expert Review of Cardiovascular Therapy 9:8, pages 987-997.
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Altan Onat. (2011) Metabolic syndrome: nature, therapeutic solutions and options. Expert Opinion on Pharmacotherapy 12:12, pages 1887-1900.
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Articles from other publishers (43)

Nick S.R. Lan, Kharis Burns, Damon A. Bell & Gerald F. Watts. (2021) Best practice for treating dyslipidaemia in patients with diabetes based on current international guidelines. Current Opinion in Endocrinology, Diabetes & Obesity 28:2, pages 104-113.
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Darya S. Seryogina, Igor P. Nikolayenkov & Tatyana U. Kuzminykh. (2020) Obesity represents a strong pathogenetic link with the pathology of pregnancy and childbirth. Journal of obstetrics and women's diseases 69:2, pages 73-82.
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О. А. Бурка, М. І. Бобрик, В. М. Резниченко & Т. М. Тутченко. (2019) Modern approaches to diagnostics of hyperandrogenism distributed forms in reproductive aged women. Reproductive Endocrinology 0:47, pages 35-42.
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Aruna D. Pradhan, Nina P. Paynter, Brendan M. Everett, Robert J. Glynn, Pierre Amarenco, Marshall Elam, Henry Ginsberg, William R. Hiatt, Shun Ishibashi, Wolfgang Koenig, Børge G. Nordestgaard, Jean-Charles Fruchart, Peter Libby & Paul M Ridker. (2018) Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study. American Heart Journal 206, pages 80-93.
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Philip L.S.M. Gordts & Jeffrey D. Esko. (2018) The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis. Matrix Biology 71-72, pages 262-282.
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Adam J. Nelson & Stephen J. Nicholls. (2018) Treating Dyslipidemia in Type 2 Diabetes. Cardiology Clinics 36:2, pages 233-239.
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Adam J. Nelson, Simon K. Rochelau & Stephen J. Nicholls. (2018) Managing Dyslipidemia in Type 2 Diabetes. Endocrinology and Metabolism Clinics of North America 47:1, pages 153-173.
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Miguel Aguirre, Yajaira Briceño, Roald Gómez-Pérez, Yajaira Zerpa, Nolis Camacho & Mariela Paoli. (2018) Relación triglicéridos/colesterol de la lipoproteína de alta densidad como indicador de riesgo cardiometabólico en niños y adolescentes de la ciudad de Mérida, Venezuela. Endocrinología, Diabetes y Nutrición 65:2, pages 74-83.
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Miguel Aguirre, Yajaira Briceño, Roald Gómez-Pérez, Yajaira Zerpa, Nolis Camacho & Mariela Paoli. (2018) Triglycerides/High density lipoprotein cholesterol ratio as a cardiometabolic risk marker in children and adolescents from Mérida city, Venezuela. Endocrinología, Diabetes y Nutrición (English ed.) 65:2, pages 74-83.
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Chee Hae Kim, Kyung Ah Han, Jaemyung Yu, Sang Hak Lee, Hui Kyung Jeon, Sang Hyun Kim, Seok Yeon Kim, Ki Hoon Han, Kyungheon Won, Dong-Bin Kim, Kwang-Jae Lee, Kyungwan Min, Dong Won Byun, Sang-Wook Lim, Chul Woo Ahn, SeongHwan Kim, Young Joon Hong, Jidong Sung, Seung-Ho Hur, Soon Jun Hong, Hong-Seok Lim, Ie Byung Park, In Joo Kim, Hyoungwoo Lee & Hyo-Soo Kim. (2018) Efficacy and Safety of Adding Omega-3 Fatty Acids in Statin-treated Patients with Residual Hypertriglyceridemia: ROMANTIC (Rosuvastatin-OMAcor iN residual hyperTrIglyCeridemia), a Randomized, Double-blind, and Placebo-controlled Trial. Clinical Therapeutics 40:1, pages 83-94.
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Štefan Tóth, Matej Šajty, Tímea Pekárová, Adil Mughees, Peter Štefanič, Matan Katz, Katarína Spišáková, Jozef Pella & Daniel Pella. (2017) Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia. Journal of Basic and Clinical Physiology and Pharmacology 28:4, pages 327-336.
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A. Palomäki, V. Hällberg, M. Ala-Korpela, P. T. Kovanen & K. Malminiemi. (2016) Prompt impact of first prospective statin mega-trials on postoperative lipid management of CABG patients: a 20-year follow-up in a single hospital. Lipids in Health and Disease 15:1.
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H.-S. Kim, H. Kim, Y. J. Jeong, S. J. Yang, S. J. Baik, H. Lee, S.-H. Lee, J. H. Cho, I.-Y. Choi, H. W. Yim & K.-H. Yoon. (2016) Comparative analysis of the efficacy of omega-3 fatty acids for hypertriglyceridaemia management in Korea. Journal of Clinical Pharmacy and Therapeutics 41:5, pages 508-514.
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D. John Betteridge & Rafael Carmena. (2015) The diabetogenic action of statins — mechanisms and clinical implications. Nature Reviews Endocrinology 12:2, pages 99-110.
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Fatima Al Hannan & Kevin Gerard Culligan. (2015) Human resistin and the RELM of Inflammation in diabesity. Diabetology & Metabolic Syndrome 7:1.
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Jeffrey B. Rosen, Christie M. Ballantyne, Willa A. Hsueh, Jianxin Lin, Arvind K. Shah, Robert S. Lowe & Andrew M. Tershakovec. (2015) Influence of metabolic syndrome factors and insulin resistance on the efficacy of ezetimibe/simvastatin and atorvastatin in patients with metabolic syndrome and atherosclerotic coronary heart disease risk. Lipids in Health and Disease 14:1.
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Anna Montali, Gessica Truglio, Francesco Martino, Fabrizio Ceci, Giampiero Ferraguti, Ester Ciociola, Marianna Maranghi, Francesco Gianfagna, Licia Iacoviello, Roberto Strom, Marco Lucarelli & Marcello Arca. (2015) Atherogenic Dyslipidemia in Children: Evaluation of Clinical, Biochemical and Genetic Aspects. PLOS ONE 10:4, pages e0120099.
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Lorenzo Arnaboldi & Alberto Corsini. (2015) Could changes in adiponectin drive the effect of statins on the risk of new-onset diabetes? The case of pitavastatin. Atherosclerosis Supplements 16, pages 1-27.
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Marcello Arca. 2015. Multidisciplinary Approach to Obesity. Multidisciplinary Approach to Obesity 121 130 .
Henna Cederberg & Markku Laakso. 2015. Dyslipidemias. Dyslipidemias 99 113 .
T. W. K. Ng, E. M. M. Ooi, G. F. Watts, D. C. Chan & P. H. R. Barrett. (2014) Atorvastatin plus omega-3 fatty acid ethyl ester decreases very-low-density lipoprotein triglyceride production in insulin resistant obese men. Diabetes, Obesity and Metabolism 16:6, pages 519-526.
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James L. Wilson. (2014) Clinical perspective on stress, cortisol and adrenal fatigue. Advances in Integrative Medicine 1:2, pages 93-96.
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WenWen Li, QuanHui Wang, JianJun Chen, Jian Zhou, XinYu Zhou & Peng Xie. (2013) A multiple-reaction-monitoring mass spectrometric method for simultaneous quantitative analysis of five plasma apolipoproteins. Science China Chemistry 57:5, pages 723-731.
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Sandra J. Hamilton & Gerald F. Watts. 2014. Lipoproteins in Diabetes Mellitus. Lipoproteins in Diabetes Mellitus 239 278 .
Jenq-Wen Huang, Chung-Yi Yang, Hon-Yen Wu, Kao-Lang Liu, Chi-Ting Su, Cho-Kai Wu, Jen-Kuang Lee, Chih-Kang Chiang, Hui-Teng Cheng, Yu-Chung Lien & Kuan-Yu Hung. (2013) Metabolic syndrome and abdominal fat are associated with inflammation, but not with clinical outcomes, in peritoneal dialysis patients. Cardiovascular Diabetology 12:1.
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Gerald F. Watts, Esther M. M. Ooi & Dick C. Chan. (2013) Demystifying the management of hypertriglyceridaemia. Nature Reviews Cardiology 10:11, pages 648-661.
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Boudewijn Klop, Jan Elte & Manuel Cabezas. (2013) Dyslipidemia in Obesity: Mechanisms and Potential Targets. Nutrients 5:4, pages 1218-1240.
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Migle Baceviciene, Dalia Luksiene, Vida Cesnaitiene, Sandra Raubaite, Anne Peasey & Abdonas Tamosiunas. (2013) Dose-response association between physical activity and metabolic syndrome. Open Medicine 8:2, pages 273-282.
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Myung-A Kim. (2013) Triglyceride and Cardiovascular Disease. Journal of Lipid and Atherosclerosis 2:1, pages 1.
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Caroline SchmidtGöran M.L Bergström. (2012) The Metabolic Syndrome Predicts Cardiovascular Events: Results of a 13-Year Follow-Up in Initially Healthy 58-Year-Old Men. Metabolic Syndrome and Related Disorders 10:6, pages 394-399.
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Niina Matikainen & Marja-Riitta Taskinen. (2012) Management of Dyslipidemias in the Presence of the Metabolic Syndrome or Type 2 Diabetes. Current Cardiology Reports 14:6, pages 721-731.
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Sandra Parra, Gloria Vives, Raimon Ferré, Marta González, Montse Guardiola, Josep Ribalta & Antoni Castro. (2012) Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients. Atherosclerosis 225:1, pages 224-230.
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Göran Bergström, CarlJohan Behre & Caroline Schmidt. (2011) Increased Leisure-Time Physical Activity is Associated With Lower Prevalence of the Metabolic Syndrome in 64-Year Old Women With Impaired Glucose Tolerance. Angiology 63:4, pages 297-301.
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A.C.I. Boullart, J. de Graaf & A.F. Stalenhoef. (2012) Serum triglycerides and risk of cardiovascular disease. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821:5, pages 867-875.
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Anna Cabré, Nancy Babio, Iolanda Lázaro, Mònica Bulló, Ana Garcia-Arellano, Lluís Masana & Jordi Salas-Salvadó. (2012) FABP4 predicts atherogenic dyslipidemia development. The PREDIMED study. Atherosclerosis 222:1, pages 229-234.
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Gerald F Watts & Fredrik Karpe. (2011) Republished review: Triglycerides and atherogenic dyslipidaemia: extending treatment beyond statins in the high-risk cardiovascular patient. Postgraduate Medical Journal 87:1033, pages 776-782.
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Jennifer G. Robinson, Christie M. Ballantyne, Willa Hsueh, Jeffrey Rosen, Jianxin Lin, Arvind Shah, Robert S. Lowe, Mary E. Hanson & Andrew M. Tershakovec. (2011) Achievement of specified low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol apolipoprotein B, and high-sensitivity C-reactive protein levels with ezetimibe/simvastatin or atorvastatin in metabolic syndrome patients with and without atherosclerotic vascular disease (from the VYMET study). Journal of Clinical Lipidology 5:6, pages 474-482.
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