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Drug Evaluations

Intravenous acetylcysteine for the treatment of acetaminophen overdose

, PharmD MPH & , MD
Pages 119-130 | Published online: 02 Dec 2010

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Read on this site (4)

Hai-Bo Wang, Hong-Yu Bai, An-Li Mao & Yan-Ming Liu. (2019) Poly(adenine) DNA-Templated Gold Nanocluster-Based Fluorescent Strategy for the Determination of Thiol-Containing Pharmaceuticals. Analytical Letters 52:14, pages 2300-2311.
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M. L. A. Sivilotti, D. N. Juurlink, J. S. Garland, I. Lenga, R. Poley, L. N. Hanly & M. Thompson. (2013) Antidote removal during haemodialysis for massive acetaminophen overdose. Clinical Toxicology 51:9, pages 855-863.
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Misagh Alipour, Caroline Buonocore, Abdelwahab Omri, Mary Szabo, Kresimir Pucaj & Zacharias E. Suntres. (2013) Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity. Journal of Drug Targeting 21:5, pages 466-473.
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W Stephen Waring. (2012) Criteria for acetylcysteine treatment and clinical outcomes after paracetamol poisoning. Expert Review of Clinical Pharmacology 5:3, pages 311-318.
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Babatunde Oluwafemi Adetuyi, Oluwaseun Abraham Adebisi, Oluwatosin Adefunke Adetuyi, Olubanke Olujoke Ogunlana, Pere-Ebi Toloyai, Chukwuebuka Egbuna, Chukwuemelie Zedech Uche, Johra Khan, Obinna Chukwuemeka Uchenna Adumanya & Kingsley C. Patrick-Iwuanyanwu. (2022) Ficus exasperata Attenuates Acetaminophen-Induced Hepatic Damage via NF-κB Signaling Mechanism in Experimental Rat Model. BioMed Research International 2022, pages 1-10.
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Funda YILMAZ. (2022) Management of Paracetamol (Acetaminophen) IntoxicationParasetamol (Asetaminofen) Zehirlenmesinin Yönetimi. Eurasian Journal of Toxicology 4:1, pages 17-22.
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Jephte Y. Akakpo, Anup Ramachandran, Steven C. Curry, Barry H. Rumack & Hartmut Jaeschke. (2022) Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of Toxicology 96:2, pages 453-465.
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Gonul Koc, Serife Mehlika Kuskonmaz, Koray Demirel, Gokhan Koca, Aylin Akbulut, Nihat Yumusak, Mehmet Senes, Gul Kirtil, Meliha Korkmaz & Cavit Culha. (2021) Ameliorating effects of N-acetyl cysteine against early liver damage of radioiodine in rats. Nuclear Medicine Communications 42:11, pages 1195-1201.
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Lanting Qian, Reem Elmahdy, Antony Raj Thiruppathi & Aicheng Chen. (2021) An ultrasensitive electrochemical sensor for the detection of acetaminophen via a three-dimensional hierarchical nanoporous gold wire electrode . The Analyst 146:14, pages 4525-4534.
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Sean Cuninghame, Khaled Lotfy & Paul Cameron. (2021) Massive acetaminophen overdose with metabolic acidosis refractory to N-acetylcysteine, fomepizole, and renal replacement therapy. Toxicology Reports 8, pages 804-807.
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Min Wang, Chun-Yu Liu, Tian Wang, Hong-Min Yu, Shu-Hua Ouyang, Yan-Ping Wu, Hai-Biao Gong, Xiao-Hui Ma, Gen-Long Jiao, Lei-Lei Fu, Qiong-Shi Wu, Hiroshi Kurihara, Yi-Fang Li, Tao Shen & Rong-Rong He. (2020) (+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis. Cell Death & Disease 11:9.
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Yan Hong, Rui Wang, Zhuoran Jiang, Zisong Cong & Heng Song. (2020) Rapid SERS Detection of Thiol-Containing Natural Products in Culturing Complex. International Journal of Analytical Chemistry 2020, pages 1-10.
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Amit S. Kalgutkar. (2019) Designing around Structural Alerts in Drug Discovery. Journal of Medicinal Chemistry 63:12, pages 6276-6302.
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Runyu Yang, Changqin Song, Jiaxi Chen, Lvqi Zhou, Xiubo Jiang, Xiaomei Cao, Yang Sun & Qi Zhang. (2020) Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1. Phytomedicine 69, pages 153211.
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Nadia I. Awad, Ann-Jeannette Geib, Akshay Roy, Craig Cocchio & Patrick J. Bridgeman. (2020) Protocol deviations in intravenous acetylcysteine therapy for acetaminophen toxicity. The American Journal of Emergency Medicine 38:4, pages 830-833.
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Jeanette Gaydos, Alicia McNally & Ellen L. Burnham. (2019) The impact of alcohol use disorders on pulmonary immune cell inflammatory responses to Streptococcus pneumoniae. Alcohol 80, pages 119-130.
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Fawzia Abd Elfatah Aly, Ayman Ali Farghaly, Asmaa Saad Salman, Emad Mohamed Hassan, Entesar Elsayed Hassan, Enayat Abdel Aziz Omara & Adel Bayoumi Salama. (2019) Protective Effect of Rosmarinus officinalis Essential Oil Against Genotoxic and Histopathological Alterations Induced by Paracetamol. International Journal of Pharmacology 15:6, pages 686-695.
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Ting Hu, Hang Sun, Wan-Yan Deng, Wen-Qi Huang & Qi Liu. (2019) Augmenter of Liver Regeneration Protects Against Acetaminophen-Induced Acute Liver Injury in Mice by Promoting Autophagy. Shock 52:2, pages 274-283.
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İ. İpek Boşgelmez & Gülin Güvendik. (2018) Beneficial Effects of N-Acetyl-L-cysteine or Taurine Pre- or Post-treatments in the Heart, Spleen, Lung, and Testis of Hexavalent Chromium-Exposed Mice. Biological Trace Element Research 190:2, pages 437-445.
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Jing Leng, Zi Wang, Cheng-lin Fu, Jing Zhang, Shen Ren, Jun-nan Hu, Shuang Jiang, Ying-ping Wang, Chen Chen & Wei Li. (2018) NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice . Phytotherapy Research 32:11, pages 2235-2246.
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