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Beyond efficacy: pharmacokinetic differences between clopidogrel, prasugrel and ticagrelor

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Pages 1285-1295 | Published online: 22 Jan 2011

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André J Scheen. (2011) Cytochrome P450-mediated cardiovascular drug interactions. Expert Opinion on Drug Metabolism & Toxicology 7:9, pages 1065-1082.
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James E. Tcheng & Steven M. Mackay. (2012) Prasugrel versus Clopidogrel Antiplatelet Therapy after Acute Coronary Syndrome. American Journal Cardiovascular Drugs 12:2, pages 83-91.
Crossref
Michael Camilleri. (2012) The role of pharmacogenetics in nonmalignant gastrointestinal diseases. Nature Reviews Gastroenterology & Hepatology 9:3, pages 173-184.
Crossref
Kathleen A. Packard, Jennifer A. Campbell, Jon T. Knezevich & Estella M. Davis. (2012) Emerging Antiplatelet Therapy for Coronary Artery Disease and Acute Coronary Syndrome. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 32:3, pages 244-273.
Crossref

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