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Drug Evaluations

Morphine sulfate and naltrexone hydrochloride extended release capsules for the management of chronic, moderate-to-severe pain, while reducing morphine-induced subjective effects upon tampering by crushing

, MD
Pages 1111-1125 | Published online: 07 Apr 2011

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Robert B Raffa, Robert Taylor$suffix/text()$suffix/text() & Joseph V Pergolizzi$suffix/text()$suffix/text(). (2014) Sequestered naltrexone in sustained release morphine or oxycodone – a way to inhibit illicit use?. Expert Opinion on Drug Safety 13:2, pages 181-190.
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Mark R. Jones, Martin J. Carney, Rachel J. Kaye, Amit Prabhakar & Alan D. Kaye. (2016) Drug Formulation Advances in Extended-Release Medications for Pain Control. Current Pain and Headache Reports 20:6.
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Richard L. Rauck, Martin E. Hale, Almasa Bass, Candace Bramson, Glenn Pixton, Jacquelyn G. Wilson, Beatrice Setnik, Paul Meisner, Kenneth W. Sommerville, Bimal K. Malhotra & Gernot Wolfram. (2015) A randomized double-blind, placebo-controlled efficacy and safety study of ALO-02 (extended-release oxycodone surrounding sequestered naltrexone) for moderate-to-severe chronic low back pain treatment. Pain 156:9, pages 1660-1669.
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Jeffrey Vietri, Ashish V. Joshi, Alexandra I. Barsdorf & Jack Mardekian. (2014) Prescription Opioid Abuse and Tampering in the United States: Results of a Self-Report Survey. Pain Medicine 15:12, pages 2064-2074.
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Katsuhisa Kurogi, Andriy Chepak, Michael T. Hanrahan, Ming-Yih Liu, Yoichi Sakakibara, Masahito Suiko & Ming-Cheh Liu. (2014) Sulfation of opioid drugs by human cytosolic sulfotransferases: Metabolic labeling study and enzymatic analysis. European Journal of Pharmaceutical Sciences 62, pages 40-48.
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Edward M Sellers, Peter J Perrino, Salvatore V Colucci & Stephen C Harris. (2013) Attractiveness of reformulated OxyContin ® tablets: assessing comparative preferences and tampering potential . Journal of Psychopharmacology 27:9, pages 808-816.
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Beatrice Setnik, Kenneth Sommerville, Veeraindar Goli, Ling Han & Lynn Webster. (2013) Assessment of Pharmacodynamic Effects Following Oral Administration of Crushed Morphine Sulfate and Naltrexone Hydrochloride Extended-Release Capsules Compared with Crushed Morphine Sulfate Controlled-Release Tablets and Placebo in Nondependent Recreational Opioid Users. Pain Medicine 14:8, pages 1173-1186.
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Hélène Peyriere, Céline Eiden, Joëlle Micallef, Maryse Lapeyre-Mestre, Jean-Luc Faillie & Jean-Pierre Blayac. (2013) Slow-Release Oral Morphine Sulfate Abuse: Results of the Postmarketing Surveillance Systems for Psychoactive Prescription Drug Abuse in France. European Addiction Research 19:5, pages 235-244.
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Suzanne K. Vosburg, Jermaine D. Jones, Jeanne M. Manubay, Judy B. Ashworth, Irma H. Benedek & Sandra D. Comer. (2012) Assessment of a formulation designed to be crush-resistant in prescription opioid abusers. Drug and Alcohol Dependence 126:1-2, pages 206-215.
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. (2012) Current World Literature. Current Opinion in Anaesthesiology 25:5, pages 629-638.
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Howard S. Smith & Marco Pappagallo. 2012. Essential Pain Pharmacology. Essential Pain Pharmacology 331 339 .
Bernard Bannwarth. (2012) Will Abuse-Deterrent Formulations of Opioid Analgesics Be Successful in Achieving Their Purpose?. Drugs 72:13, pages 1713-1723.
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