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Drug Evaluations

Dexamethasone for ocular inflammation

, MD & , MD
Pages 1127-1131 | Published online: 02 Apr 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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En Cao, Jun Xu, Yuanqi Gong, Jingjing Yuan, Anbang Chen, Jiayi Liu, Yunfei Fan, Xiangyang Fan & Xiaodong Kuang. (2023) Effect of the Lipoxin Receptor Agonist BML-111 on Cigarette Smoke Extract-Induced Macrophage Polarization and Inflammation in RAW264.7 Cells. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 919-932.
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Mustafa Gok, Hilal Altas & Hasan Burhanettin Kapti. (2019) The impact of intravitreal dexamethasone implant (Ozurdex®) on retrobulbar hemodynamics in patients with diabetic macular edema and retinal vein occlusions. Cutaneous and Ocular Toxicology 38:3, pages 240-248.
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Asima Bajwa, Travis Peck, Ashvini K Reddy, Peter A Netland & Yevgeniy Shildkrot. (2018) Dexamethasone implantation in birdshot chorioretinopathy – long-term outcome. International Medical Case Reports Journal 11, pages 349-358.
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J. Bradford Rice, Alan G. White, Lauren M. Scarpati, George J. Wan & Winnie W. Nelson. (2018) The burden of non-infectious intraocular inflammatory eye diseases: a systematic literature review. Current Medical Research and Opinion 34:12, pages 2095-2103.
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Aniruddha Agarwal, Sabia Handa, Kanika Aggarwal, Mansi Sharma, Ramandeep Singh, Aman Sharma, Rupesh Agrawal, Kusum Sharma & Vishali Gupta. (2018) The Role of Dexamethasone Implant in the Management of Tubercular Uveitis. Ocular Immunology and Inflammation 26:6, pages 884-892.
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Uwe Pleyer & Stephan R. Thurau. (2016) Sirolimus for the treatment of noninfectious uveitis. Expert Opinion on Pharmacotherapy 17:1, pages 127-135.
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Su Jin Lim, Sang Eun Lee, Sun Hyun Kim, Sung-Hee Hong, Yong Sung You, Oh Woong Kwon & Hyeun Seung Kim. (2015) Prevalence of Toxoplasma gondii and Toxocara canis among Patients with Uveitis. Ocular Immunology and Inflammation 23:2, pages 111-117.
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Su Jin Lim, Sang Eun Lee, Sun Hyun Kim, Sung-Hee Hong, Yong Sung You, Oh Woong Kwon & Hyeun Seung Kim. (2014) Prevalence of Toxoplasma gondii and Toxocara canis among Patients with Uveitis. Ocular Immunology and Inflammation 22:5, pages 360-366.
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Kyungmin Lee, Asima Bajwa, Clovis A Freitas-Neto, Jamie Lynne Metzinger, Bailey A Wentworth & C Stephen Foster. (2014) A comprehensive review and update on the non-biologic treatment of adult noninfectious uveitis: part I. Expert Opinion on Pharmacotherapy 15:15, pages 2141-2154.
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Nisha R. Acharya, Albert T. Vitale, Elizabeth A. Sugar, Janet T. Holbrook, Alyce E. Burke, Jennifer E. Thorne, Michael M. Altaweel, John H. Kempen & Douglas A. Jabs. (2023) Intravitreal Therapy for Uveitic Macular Edema—Ranibizumab versus Methotrexate versus the Dexamethasone Implant. Ophthalmology 130:9, pages 914-923.
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Blessing C. Ilochonwu, Simone A. van der Lugt, Ada Annala, Greta Di Marco, Thibault Sampon, Juergen Siepmann, Florence Siepmann, Wim E. Hennink & Tina Vermonden. (2023) Thermo-responsive Diels-Alder stabilized hydrogels for ocular drug delivery of a corticosteroid and an anti-VEGF fab fragment. Journal of Controlled Release 361, pages 334-349.
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Eloy Pena-Rodríguez, Teresa García-Berrocoso, Ezequiel Vázquez Fernández, Francisco J. Otero-Espinar, Joaquin Abian & Francisco Fernández-Campos. (2023) Monitoring dexamethasone skin biodistribution with ex vivo MALDI-TOF mass spectrometry imaging and confocal Raman microscopy. International Journal of Pharmaceutics 636, pages 122808.
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Verónica Castro-Navarro, Clara Monferrer-Adsuara, Catalina Navarro-Palop, Javier Montero-Hernández & Enrique Cervera-Taulet. (2022) Optical coherence tomography biomarkers in patients with macular edema secondary to retinal vein occlusion treated with dexamethasone implant. BMC Ophthalmology 22:1.
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Yi Tan, Xutao Zhang & Wai San Cheang. (2022) Isoflavones daidzin and daidzein inhibit lipopolysaccharide-induced inflammation in RAW264.7 macrophages. Chinese Medicine 17:1.
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Valeria Albano, Silvana Guerriero, Claudio Furino, Giancarlo Sborgia, Alessandra Sborgia, Rosanna Dammacco, Francesco Boscia & Giovanni Alessio. (2022) Microvascular changes in the recurrent cystoid macular edema secondary to posterior noninfectious uveitis on optical coherence tomography angiography. International Ophthalmology 42:11, pages 3285-3293.
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Yun Guan, Haibing Lu, Ming Ma, Yanhong Yan & Beizhan Jiang. (2022) Effect of Mesoporous Silica-Encapsulated Dexamethasone-Loaded na-HAp on the Property and Odontoblastic Differentiation of Human Dental Pulp Stem Cells. Science of Advanced Materials 14:2, pages 414-422.
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Marco Brugnera, Marta Vicario-de-la-Torre, Vanessa Andrés-Guerrero, Irene Bravo-Osuna, Irene Teresa Molina-Martínez & Rocío Herrero-Vanrell. (2022) Validation of a Rapid and Easy-to-Apply Method to Simultaneously Quantify Co-Loaded Dexamethasone and Melatonin PLGA Microspheres by HPLC-UV: Encapsulation Efficiency and In Vitro Release. Pharmaceutics 14:2, pages 288.
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Patil Shivprasad Suresh, Anmol & Upendra Sharma. 2022. Pharmaceutical Applications of Supramolecules. Pharmaceutical Applications of Supramolecules 157 177 .
Rocco Luigi Modugno, Ilaria Testi & Carlos Pavesio. (2021) Intraocular therapy in noninfectious uveitis. Journal of Ophthalmic Inflammation and Infection 11:1.
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Eloy Pena-Rodríguez, Maria Lajarin-Reinares, Aida Mata-Ventosa, Sandra Pérez-Torras & Francisco Fernández-Campos. (2021) Dexamethasone-Loaded Lipomers: Development, Characterization, and Skin Biodistribution Studies. Pharmaceutics 13:4, pages 533.
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Verónica Castro-Navarro, Clara Monferrer-Adsuara, Catalina Navarro-Palop, Javier Montero-Hernández & Enrique Cervera-Taulet. (2021) Effect of Dexamethasone Intravitreal Implant on Visual Acuity and Foveal Photoreceptor Integrity in Macular Edema Secondary to Retinal Vascular Disease. Ophthalmologica 244:1, pages 83-92.
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Xue Pan, Xuan Liu, Xianli Zhuang, Yanping Liu & Shujie Li. (2020) Co-delivery of dexamethasone and melatonin by drugs laden PLGA nanoparticles for the treatment of glaucoma. Journal of Drug Delivery Science and Technology 60, pages 102086.
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Claudio Iovino, Rodolfo Mastropasqua, Marco Lupidi, Daniela Bacherini, Marco Pellegrini, Federico Bernabei, Enrico Borrelli, Riccardo Sacconi, Adriano Carnevali, Rossella D’Aloisio, Alessio Cerquaglia, Lucia Finocchio, Andrea Govetto, Stefano Erba, Giacinto Triolo, Antonio Di Zazzo, Matteo Forlini, Aldo Vagge & Giuseppe Giannaccare. (2020) Intravitreal Dexamethasone Implant as a Sustained Release Drug Delivery Device for the Treatment of Ocular Diseases: A Comprehensive Review of the Literature. Pharmaceutics 12:8, pages 703.
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RathiniLilian David & Parveen Sen. (2020) Secondary ocular hypertension post intravitreal dexamethasone implant (OZURDEX) managed by pars plana implant removal along with trabeculectomy in a young patient. Oman Journal of Ophthalmology 13:2, pages 92.
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Dewi & O’Connor. (2019) Use of Human Pluripotent Stem Cells to Define Initiating Molecular Mechanisms of Cataract for Anti-Cataract Drug Discovery. Cells 8:10, pages 1269.
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A. Arranz-Romera, B.M. Davis, I. Bravo-Osuna, S. Esteban-Pérez, I.T. Molina-Martínez, E. Shamsher, N. Ravindran, L. Guo, M.F. Cordeiro & R. Herrero-Vanrell. (2019) Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma. Journal of Controlled Release 297, pages 26-38.
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Jennifer E. Thorne, Elizabeth A. Sugar, Janet T. Holbrook, Alyce E. Burke, Michael M. Altaweel, Albert T. Vitale, Nisha R. Acharya, John H. Kempen & Douglas A. Jabs. (2019) Periocular Triamcinolone vs. Intravitreal Triamcinolone vs. Intravitreal Dexamethasone Implant for the Treatment of Uveitic Macular Edema. Ophthalmology 126:2, pages 283-295.
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Ashleigh Laurin Levison. 2019. Posterior Uveitis. Posterior Uveitis 159 174 .
Han SongHee Jun SongJi Ho YangDo Gyun Kim. (2018) A Comparison of Three Intravitreal Modalities of Branch Retinal Vein Occlusion Macular Edema. Journal of the Korean Ophthalmological Society 59:9, pages 834.
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Fang Bian, Changjun Wang, Johanna Tukler-Henriksson, Stephen C. Pflugfelder, Caterina Camodeca, Elisa Nuti, Armando Rossello, De-Quan Li & Cintia S. de Paiva. (2016) MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. Journal of Cellular Physiology 231:11, pages 2506-2516.
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Tae Hoon KimChang Ki YoonJi Eun LeeJoo Eun LeeIn Young ChungMin SagongKun Hyung KimHyun Woong Kim. (2016) One-year Outcome of Intravitreal Dexamethasone Implant for Macular Edema Secondary to Central Retinal Vein Occlusion. Journal of the Korean Ophthalmological Society 57:12, pages 1918.
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Olga A. Kost, Olga V. Beznos, Nina G. Davydova, Devika S. Manickam, Irina I. Nikolskaya, Anna E. Guller, Petr V. Binevski, Natalia B. Chesnokova, Anatoly B. Shekhter, Natalia L. Klyachko & Alexander V. Kabanov. (2016) Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation. Oxidative Medicine and Cellular Longevity 2016, pages 1-13.
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Xingyi Li, Guojuan Pu, Xinxin Yu, Shuai Shi, Jing Yu, Wenguang Zhao, Zichao Luo, Zhifen He & Hao Chen. (2016) Supramolecular hydrogel of non-steroidal anti-inflammatory drugs: preparation, characterization and ocular biocompatibility. RSC Advances 6:67, pages 62434-62438.
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Pravin U. Dugel, Antonio CaponeJrJr, Michael A. Singer, Richard F. Dreyer, David G. Dodwell, Daniel B. Roth, Rui Shi, John G. Walt, Lanita C. Scott & David A. Hollander. (2015) Two or more dexamethasone intravitreal implants in treatment-naïve patients with macular edema due to retinal vein occlusion: subgroup analysis of a retrospective chart review study. BMC Ophthalmology 15:1.
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Waseem M. Al Zamil. (2015) Short-term safety and efficacy of intravitreal 0.7-mg dexamethasone implants for pseudophakic cystoid macular edema. Saudi Journal of Ophthalmology 29:2, pages 130-134.
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Daniel J. Ozzello & Alan G. Palestine. (2015) Factors Affecting Therapeutic Decisions in Intermediate and Posterior Uveitis. American Journal of Ophthalmology 159:2, pages 213-220.e3.
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Marco Dutra MedeirosMicol AlkabesRafael NavarroJosé Garcia-ArumíCarlos MateoBorja Corcóstegui. (2014) Dexamethasone Intravitreal Implant in Vitrectomized Versus Nonvitrectomized Eyes for Treatment of Patients with Persistent Diabetic Macular Edema. Journal of Ocular Pharmacology and Therapeutics 30:9, pages 709-716.
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Ravi D. Vaishya, Mitan Gokulgandhi, Sulabh Patel, Mukul Minocha & Ashim K. Mitra. (2014) Novel Dexamethasone-Loaded Nanomicelles for the Intermediate and Posterior Segment Uveitis. AAPS PharmSciTech 15:5, pages 1238-1251.
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Sophie J. Bakri, David S. Boyer, Thomas A. Albini, Nancy M. Holekamp, Philip J. Ferrone, Rahul Bhagat & Zoran Novakovic. (2014) Comparison of the Tissue Penetration and Glide Force of 22-Gauge Thin-Wall Needles for Intravitreal Implant Administration. Ophthalmic Surgery, Lasers and Imaging Retina 45:5, pages 430-435.
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Marco Dutra Medeiros, Maurizio Postorino, Rafael Navarro, José Garcia-Arumí, Carlos Mateo & Borja Corcóstegui. (2014) Dexamethasone Intravitreal Implant for Treatment of Patients with Persistent Diabetic Macular Edema. Ophthalmologica 231:3, pages 141-146.
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Poonam Chopra, Jinsong Hao & S. Kevin Li. (2013) Influence of Drug Lipophilicity on Drug Release from Sclera After Iontophoretic Delivery of Mixed Micellar Carrier System to Human Sclera. Journal of Pharmaceutical Sciences 102:2, pages 480-488.
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Reema Bansal, Pooja Bansal, Pandurang Kulkarni, Vishali Gupta, Aman Sharma & Amod Gupta. (2011) Wandering Ozurdex® implant. Journal of Ophthalmic Inflammation and Infection 2:1, pages 1-5.
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