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Drug Evaluations

Telmisartan: just an antihypertensive agent? A literature review

, MD, , MD, , MD, , MD, , MD, , MD & , MD show all
Pages 2719-2735 | Published online: 11 Nov 2011

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Masoomeh Fooladi, Alireza Shirazi, Peyman Sheikhzadeh, Mahsa Amirrashedi, Fatemeh Ghahramani, Mohsen Cheki & Mehdi Khoobi. (2023) Investigating the attenuating effect of telmisartan against radiation-induced intestinal injury using 18F-FDG micro-PET imaging. International Journal of Radiation Biology 99:3, pages 446-458.
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Di Zhao, Hui Liu & Pingshuan Dong. (2019) A Meta-analysis of antihypertensive effect of telmisartan versus candesartan in patients with essential hypertension. Clinical and Experimental Hypertension 41:1, pages 75-79.
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Geun Joo Choi, Hyun Min Kim, Hyun Kang & Jaetaek Kim. (2016) Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials. Current Medical Research and Opinion 32:7, pages 1303-1309.
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Articles from other publishers (36)

Abdullajon Odilov, Hongjian Qin, Emmanuel Mintah Bonku, Fuqiang Zhu, Feipu Yang & Jingshan Shen. (2023) An efficient synthesis of the last step key intermediate for telmisartan via Pd-catalyzed carbonylative cyclization. Tetrahedron 148, pages 133702.
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Facundo Galceran, Fabio A. Digirolamo, Marcos Rengifo, Chantal Reigada, Melisa Saye, Belen J. Maciel, Ivana G. Estecho, Andrea E. Errasti, Claudio A. Pereira & Mariana R. Miranda. (2023) Identifying inhibitors of Trypanosoma cruzi nucleoside diphosphate kinase 1 as potential repurposed drugs for Chagas’ disease. Biochemical Pharmacology 216, pages 115766.
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Lingxiang Ran, Zhixiang Gao, Qiu Chen, Yuanshuai Ran, Nengliang Duan, Guangmo Hu, Xingyu Lu, Renlan Xia, Qiaoqiao Li, Fengmei Cui, Xiaolong Liu & Boxin Xue. (2023) Improving effects of telmisartan on spermatogenic disorder induced by fractionated low-dose irradiation in mice. International Urology and Nephrology 55:6, pages 1427-1439.
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Shengsheng Qiang, Rong‐Bin Hu & Ying‐Yeung Yeung. (2023) Zwitterion‐Catalyzed Ring‐Opening of Epoxides with Carboxylic Acids. Asian Journal of Organic Chemistry 12:3.
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Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed & Ayman E. El-Sahar. (2022) Addressing Peroxisome Proliferator-Activated Receptor-gamma in 3-Nitropropionic Acid-Induced Striatal Neurotoxicity in Rats. Molecular Neurobiology 59:7, pages 4368-4383.
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B. Rudresh Gowda, N. Prakash, C. R. Santhosh, B. H. Pavithra, Rashmi Rajashekaraiah, M. L. Sathyanarayana, Suguna Rao, Prashantkumar Waghe, K. R. Anjan Kumar, G. R. Shivaprasad & Y. Muralidhar. (2021) Effect of Telmisartan on Arsenic-Induced (Sub-chronic) Perturbations in Redox Homeostasis, Pro-inflammatory Cascade and Aortic Dysfunction in Wistar Rats. Biological Trace Element Research 200:4, pages 1776-1790.
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Yanjun Cui, Ying Li, Xiao Li, Liju Fan, Xueru He, Yuhao Fu & Zhanjun Dong. (2022) A Simple UPLC/MS-MS Method for Simultaneous Determination of Lenvatinib and Telmisartan in Rat Plasma, and Its Application to Pharmacokinetic Drug-Drug Interaction Study. Molecules 27:4, pages 1291.
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Mohamed A. Morsy, Seham A. Abdel-Gaber, Rehab A. Rifaai, Mostafa M. Mohammed, Anroop B. Nair & Walaa Yehia Abdelzaher. (2022) Protective mechanisms of telmisartan against hepatic ischemia/reperfusion injury in rats may involve PPARγ-induced TLR4/NF-κB suppression. Biomedicine & Pharmacotherapy 145, pages 112374.
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Leidyanne Ferreira Gonçalves & Caroline Fernandes‐Santos. (2020) Telmisartan detection by UV spectrophotometry in mice drinking water. Analytical Science Advances 2:7-8, pages 408-415.
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Yun-Jin Hwang & Du-Hyong Cho. (2020) Activation of AMPK/proteasome/MLCK degradation signaling axis by telmisartan inhibits VSMC contractility and vessel contraction. Biochemical and Biophysical Research Communications 524:4, pages 853-860.
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Marta Mariniello, Raffaella Petruzzelli, Luca G. Wanderlingh, Raffaele La Montagna, Annamaria Carissimo, Francesca Pane, Angela Amoresano, Ekaterina Y. Ilyechova, Michael M. Galagudza, Federico Catalano, Roberta Crispino, Ludmila V. Puchkova, Diego L. Medina & Roman S. Polishchuk. (2020) Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin. Cancers 12:3, pages 608.
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Yun-Jin Hwang, Jung-Hyun Park & Du-Hyong Cho. (2020) Activation of Adenosine Monophosphate-activated Protein Kinase by Telmisartan Decreases Basal and Platelet-derived Growth Factor-stimulated Vascular Smooth Muscle Cell Proliferation via Inhibiting the Mammalian Target of Rapamycin/p70 S6 Kinase Signaling Axis. Journal of Korean Medical Science 35:35.
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Abdel G. Elkahloun, Yara Rodriguez, Seham Alaiyed, Erin Wenzel & Juan M. Saavedra. (2018) Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARγ Activation. Molecular Neurobiology 56:5, pages 3193-3210.
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Mitsuhide Naruse, Yasuhiro Koike, Nozomu Kamei, Ryuichi Sakamoto, Yuko Yambe & Michinori Arimitsu. (2019) Effects of azilsartan compared with telmisartan on insulin resistance in patients with essential hypertension and type 2 diabetes mellitus: An open-label, randomized clinical trial. PLOS ONE 14:4, pages e0214727.
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Tony M. Glaus, Jonathan Elliott, Esther Herberich, Tanja Zimmering & Balazs Albrecht. (2018) Efficacy of long‐term oral telmisartan treatment in cats with hypertension: Results of a prospective European clinical trial. Journal of Veterinary Internal Medicine 33:2, pages 413-422.
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Du-Hyong Cho. (2019) Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser 1179 Dephosphorylation . Journal of Korean Medical Science 34:42.
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Yan WangShun QiaoDe-Wu HanXin-Ren RongYi-Xiao Wang, Jing-jing XueJing Yang. (2018) Telmisartan Improves Insulin Resistance: A Meta-Analysis. American Journal of Therapeutics 25:6, pages e642-e651.
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Alicia Caro‐Vadillo, Maria Angeles Daza‐González, Elisa Gonzalez‐Alonso‐Alegre, Alfonso Rodríguez & José Gómez‐García. (2018) Effect of a combination of telmisartan and amlodipine in hypertensive dogs. Veterinary Record Case Reports 6:2.
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Kee-Ho Song, Sun-Ju Bae, Jiyeon Chang, Jung-Hyun Park, Inho Jo, Kae Won Cho & Du-Hyong Cho. (2017) Telmisartan mitigates hyperglycemia-induced vascular inflammation by increasing GSK3β-Ser9 phosphorylation in endothelial cells and mouse aortas. Biochemical and Biophysical Research Communications 491:4, pages 903-911.
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Lu Han, Wen-Jun Shen, Stefanie Bittner, Fredric B Kraemer & Salman Azhar. (2017) PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-β/δ and PPAR-γ. Future Cardiology 13:3, pages 279-296.
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Anja Zaletel, Polona Knavs Vrhunec & Breda Barbič-Žagar. (2016) Achieving Blood Pressure Control with Telmisartan and Fixed Dose Combination of Telmisartan and Hydrochlorothiazide. Cardiologia Croatica 11:10-11, pages 598-601.
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Nageh Ahmed El-Mahdy, Magda El-Sayed El-Sayad & Aya Hassan El-Kadem. (2016) Combination of telmisartan with sildenafil ameliorate progression of diabetic nephropathy in streptozotocin-induced diabetic model. Biomedicine & Pharmacotherapy 81, pages 136-144.
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Keizo Matsushita, Hai-Chun Yang, Manu M Mysore, Jianyong Zhong, Yu Shyr, Li-Jun Ma & Agnes B Fogo. (2016) Effects of combination PPARγ agonist and angiotensin receptor blocker on glomerulosclerosis. Laboratory Investigation 96:6, pages 602-609.
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Kee-Ho Song, Jung-Hyun Park, Inho Jo, Joong-Yeol Park, Jungwon Seo, Soon Ae Kim & Du-Hyong Cho. (2016) Telmisartan attenuates hyperglycemia-exacerbated VCAM-1 expression and monocytes adhesion in TNFα-stimulated endothelial cells by inhibiting IKKβ expression. Vascular Pharmacology 78, pages 43-52.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 329 356 .
Dnyandev Radhu Gund, Balivada Venkata Satyasai Rao, Pandurang Narayanrao Mandhare & Sanjay Dashrath Vaidya. (2015) Synthesis of some novel benzimidazole derivatives and their biological evaluation. European Journal of Chemistry 6:3, pages 270-274.
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P. IyngkaranM. Thomas. (2015) Bedside–to-Bench Translational Research for Chronic Heart Failure: Creating an Agenda for Clients who do Not Meet Trial Enrollment Criteria. Clinical Medicine Insights: Cardiology 9s1, pages CMC.S18737.
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Hany H. Arab, Muhammad Y. Al-Shorbagy, Dalaal M. Abdallah & Noha N. Nassar. (2014) Telmisartan Attenuates Colon Inflammation, Oxidative Perturbations and Apoptosis in a Rat Model of Experimental Inflammatory Bowel Disease. PLoS ONE 9:5, pages e97193.
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Damien Noone & Christoph Licht. (2013) Chronic kidney disease: a new look at pathogenetic mechanisms and treatment options. Pediatric Nephrology 29:5, pages 779-792.
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Maria Giulia Marini, Chiara Sonnino, Marco Previtero & Luigi M. Biasucci. (2013) Targeting Inflammation: Impact on Atherothrombosis. Journal of Cardiovascular Translational Research 7:1, pages 9-18.
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Habib Eslami, Ali M. Sharifi, Hamzeh Rahimi & Maryam Rahati. (2014) Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell. Neuroscience Letters 558, pages 31-36.
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Yan Zhao, Songji Zhao, Yuji Kuge, H. William Strauss, Francis G. Blankenberg & Nagara Tamaki. (2013) Attenuation of Apoptosis by Telmisartan in Atherosclerotic Plaques of Apolipoprotein E −/− Mice: Evaluation Using Technetium 99m–Annexin A5 . Molecular Imaging 12:5, pages 7290.2012.00045.
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S. Kushwaha & G.B. Jena. (2013) Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: Studies on possible molecular mechanisms. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 755:1, pages 11-23.
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Fernando Lizcano & Diana Vargas. (2013) Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism. Genetics and Molecular Biology 36:1, pages 134-139.
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Christian Delles & Anna F. Dominiczak. 2013. Resistant Hypertension. Resistant Hypertension 23 37 .
Akihiro Noda, Hiroshi Fushiki, Yoshihiro Murakami, Hiroshi Sasaki, Sosuke Miyoshi, Hirotoshi Kakuta & Shintaro Nishimura. (2012) Brain penetration of telmisartan, a unique centrally acting angiotensin II type 1 receptor blocker, studied by PET in conscious rhesus macaques. Nuclear Medicine and Biology 39:8, pages 1232-1235.
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