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Expert Opinion on Pharmacotherapy Volume 13, 2012 - Issue 12
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Drug Evaluations

Retigabine/Ezogabine, a KCNQ/KV7 channel opener: pharmacological and clinical data

Gökce OrhanAbteilung Neurologie Mit Schwerpunkt Epileptologie, Hertie-Institut für Klinische Hirnforschung, Universität Tübingen, Tübingen, Germany
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Thomas V WuttkeAbteilung Neurologie Mit Schwerpunkt Epileptologie, Hertie-Institut für Klinische Hirnforschung, Universität Tübingen, Tübingen, Germany;Abteilung Neurochirurgie, Universität Tübingen, Tübingen, Germany
,
Anne T NiesDr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie Stuttgart, Germany;Universität Tübingen, Tübingen, Germany
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Matthias SchwabDr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie Stuttgart, Germany;Abteilung Klinische Pharmakologie, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universitätsklinikum Tübingen, Tübingen, Germany
&
Holger LercheAbteilung Neurologie Mit Schwerpunkt Epileptologie, Hertie-Institut für Klinische Hirnforschung, Universität Tübingen, Tübingen, Germany;Abteilung Neurologie mit Schwerpunkt Epileptologie, Hertie-Institut für Klinische Hirnforschung, Universität Tübingen, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany+49 7071 29 80442; +49 7071 29 4488; [email protected]
Pages 1807-1816 | Published online: 12 Jul 2012

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Slobodan Jankovic & Ivana Ilickovic. (2013) The preclinical discovery and development of ezogabine for the treatment of epilepsy. Expert Opinion on Drug Discovery 8:11, pages 1429-1437.
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Marbella Quiñonez, Marino DiFranco, Fenfen Wu & Stephen C Cannon. (2023) Retigabine suppresses loss of force in mouse models of hypokalaemic periodic paralysis. Brain 146:4, pages 1554-1560.
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Mark Estacion, Shujun Liu, Xiaoyang Cheng, Sulayman Dib-Hajj & Stephen G. Waxman. (2023) Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability. Frontiers in Pharmacology 14.
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Rostam Namdari, Constanza Luzon, Jay A. Cadieux, Jennifer Leung & Gregory N. Beatch. (2022) Pharmacokinetics of XEN496, a Novel Pediatric Formulation of Ezogabine, Under Fed and Fasted Conditions: A Phase 1 Trial. Neurology and Therapy 11:2, pages 781-796.
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Roberto Mandrioli, Michele Protti, Lorenzo Marincich & Laura Mercolini. (2021) Ion-Channel Antiepileptic Drugs: An Analytical Perspective on the Therapeutic Drug Monitoring (TDM) of Ezogabine, Lacosamide, and Zonisamide. Analytica 2:4, pages 171-194.
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Stephan Lauxmann, Lukas Sonnenberg, Nils A. Koch, Christian Bosselmann, Natalie Winter, Niklas Schwarz, Thomas V. Wuttke, Ulrike B. S. Hedrich, Yuanyuan Liu, Holger Lerche, Jan Benda & Josua Kegele. (2021) Therapeutic Potential of Sodium Channel Blockers as a Targeted Therapy Approach in KCNA1-Associated Episodic Ataxia and a Comprehensive Review of the Literature. Frontiers in Neurology 12.
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Michael C. Yau, Robin Y. Kim, Caroline K. Wang, Jingru Li, Tarek Ammar, Runying Y. Yang, Stephan A. Pless & Harley T. Kurata. (2018) One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels. Journal of General Physiology 150:10, pages 1421-1431.
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Ruhma Syeda, Jose S. Santos & Mauricio Montal. (2016) The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine. Journal of Biological Chemistry 291:6, pages 2931-2937.
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Robin Y. Kim, Michael C. Yau, Jason D. Galpin, Guiscard Seebohm, Christopher A. Ahern, Stephan A. Pless & Harley T. Kurata. (2015) Atomic basis for therapeutic activation of neuronal potassium channels. Nature Communications 6:1.
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Hongki Lee, Virginia De Vito, Mario Giorgi & Hyoin Yun. (2015) Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test. European Journal of Pharmacology 762, pages 350-356.
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Desiree Bailey, Brian P. Kirby, Jeffrey Atkinson, Solomon Fixon-Owoo, Martin C. Henman, Graham G. Shaw & Karen M. Doyle. (2015) Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation. Pharmacology Biochemistry and Behavior 133, pages 57-64.
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Han Li, Fei Wang, Xiaofeng Wang, Ran Sun, Jingqing Chen, Baicheng Chen & Yingze Zhang. (2015) Antinociceptive Efficacy of Retigabine in the Monosodium Lodoacetate Rat Model for Osteoarthritis Pain. Pharmacology 95:5-6, pages 251-257.
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Sheri Cotterman-Hart. 2015. Epilepsy and Brain Tumors. Epilepsy and Brain Tumors 171 193 .
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Niyathi Hegde Shah & Elias Aizenman. (2013) Voltage-Gated Potassium Channels at the Crossroads of Neuronal Function, Ischemic Tolerance, and Neurodegeneration. Translational Stroke Research 5:1, pages 38-58.
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Matthew B. Young & Steven A. Thomas. (2014) M 1 -Muscarinic Receptors Promote Fear Memory Consolidation via Phospholipase C and the M-Current . The Journal of Neuroscience 34:5, pages 1570-1578.
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Elinor Ben-Menachem. (2014) Medical management of refractory epilepsy-Practical treatment with novel antiepileptic drugs. Epilepsia 55, pages 3-8.
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Michael Strupp. (2013) Ion channel disorders: still a fascinating topic—news on episodic ataxia type 1. Journal of Neurology, Neurosurgery & Psychiatry 84:10, pages 1063-1064.
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Serge A. Y. Afeli, John Malysz & Georgi V. Petkov. (2013) Molecular Expression and Pharmacological Evidence for a Functional Role of Kv7 Channel Subtypes in Guinea Pig Urinary Bladder Smooth Muscle. PLoS ONE 8:9, pages e75875.
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Pingzheng Zhou, Haibo Yu, Min Gu, Fa-jun Nan, Zhaobing Gao & Min Li. (2013) Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. Proceedings of the National Academy of Sciences 110:21, pages 8726-8731.
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