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Drug Evaluations

Dimethyl fumarate: a Janus-faced substance?

, PhD
Pages 1559-1567 | Published online: 22 May 2013

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Francesco Panza, Davide Seripa, Vincenzo Solfrizzi, Bruno P. Imbimbo, Andrea Santamato, Madia Lozupone, Rosa Capozzo, Camilla Prete, Alberto Pilotto, Antonio Greco & Giancarlo Logroscino. (2016) Tau aggregation inhibitors: the future of Alzheimer’s pharmacotherapy?. Expert Opinion on Pharmacotherapy 17:4, pages 457-461.
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A Scott Nielsen. (2015) Advances in the management of relapsing–remitting multiple sclerosis: role of oral dimethyl fumarate (BG-12). Degenerative Neurological and Neuromuscular Disease 5, pages 51-61.
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Articles from other publishers (17)

Federico Manai, Lisa Zanoletti, Davide Arfini, Simone Giorgio De Micco, Arolda Gjyzeli, Sergio Comincini & Marialaura Amadio. (2023) Dimethyl Fumarate and Intestine: From Main Suspect to Potential Ally against Gut Disorders. International Journal of Molecular Sciences 24:12, pages 9912.
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Panagiotis Theodosis-Nobelos & Eleni A. Rekka. (2022) Efforts Towards Repurposing of Antioxidant Drugs and Active Compounds for Multiple Sclerosis Control. Neurochemical Research 48:3, pages 725-744.
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Federico Manai, Stefano Govoni & Marialaura Amadio. (2022) The Challenge of Dimethyl Fumarate Repurposing in Eye Pathologies. Cells 11:24, pages 4061.
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Shilu Deepa Thomas, Niraj Kumar Jha, Bassem Sadek & Shreesh Ojha. (2022) Repurposing Dimethyl Fumarate for Cardiovascular Diseases: Pharmacological Effects, Molecular Mechanisms, and Therapeutic Promise. Pharmaceuticals 15:5, pages 497.
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Khadijeh Mousavi, Hossein Niknahad, Huifeng Li, Zhipeng Jia, Ram Kumar Manthari, Yangfei Zhao, Xiong Shi, Yuanyu Chen, Asrin Ahmadi, Negar Azarpira, Bahman Khalvati, Mohammad Mehdi Ommati & Reza Heidari. (2021) The activation of nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling blunts cholestasis-induced liver and kidney injury. Toxicology Research 10:4, pages 911-927.
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Mithun Singh Rajput, Nilesh Prakash Nirmal, Devashish Rathore & Rashmi Dahima. (2020) Dimethyl Fumarate Mitigates Tauopathy in Aβ-Induced Neuroblastoma SH-SY5Y Cells. Neurochemical Research 45:11, pages 2641-2652.
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Valentina Pegoretti, Kathryn A. Swanson, John R. Bethea, Lesley Probert, Ulrich L. M. Eisel & Roman Fischer. (2020) Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development. Oxidative Medicine and Cellular Longevity 2020, pages 1-19.
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Hugo Gonzalo, Lara Nogueras, Anna Gil-Sánchez, José Vicente Hervás, Petya Valcheva, Cristina González-Mingot, Meritxell Martin-Gari, Marc Canudes, Silvia Peralta, Maria José Solana, Reinald Pamplona, Manuel Portero-Otin, Jordi Boada, Jose Carlos Enrique Serrano & Luis Brieva. (2019) Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients. Frontiers in Neuroscience 13.
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Gaojian Lian, JN Rashida Gnanaprakasam, Tingting Wang, Ruohan Wu, Xuyong Chen, Lingling Liu, Yuqing Shen, Mao Yang, Jun Yang, Ying Chen, Vasilis Vasiliou, Teresa A Cassel, Douglas R Green, Yusen Liu, Teresa WM Fan & Ruoning Wang. (2018) Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. eLife 7.
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Amanda Pedder. (2018) Treating Psoriasis: What Is New About Fumaric Acid Esters?. European Medical Journal, pages 25-33.
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Jürgen Brück, Ralf Dringen, Adriana Amasuno, Ignasi Pau-Charles & Kamran Ghoreschi. (2018) A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis. Experimental Dermatology 27:6, pages 611-624.
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Martha Garstkiewicz, Gerhard E. Strittmatter, Serena Grossi, Jennifer Sand, Gabriele Fenini, Sabine Werner, Lars E. French & Hans-Dietmar Beer. (2017) Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression. European Journal of Immunology 47:5, pages 806-817.
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Francesco Panza, Vincenzo Solfrizzi, Davide Seripa, Bruno P Imbimbo, Madia Lozupone, Andrea Santamato, Rosanna Tortelli, Ilaria Galizia, Camilla Prete, Antonio Daniele, Alberto Pilotto, Antonio Greco & Giancarlo Logroscino. (2016) Tau-based therapeutics for Alzheimer’s disease: active and passive immunotherapy. Immunotherapy 8:9, pages 1119-1134.
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Wen-Xian Zhang, Jian-Hong Zhao, Fu-Min Ping, Zhi-Jun Liu, Jun-Xia Gu & Xin-Qing Lu. (2016) Effect of dimethyl fumarate on rats with chronic pancreatitis. Asian Pacific Journal of Tropical Medicine 9:3, pages 261-264.
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Francesco Panza, Vincenzo Solfrizzi, Davide Seripa, Bruno P. Imbimbo, Madia Lozupone, Andrea Santamato, Chiara Zecca, Maria Rosaria Barulli, Antonello Bellomo, Alberto Pilotto, Antonio Daniele, Antonio Greco & Giancarlo Logroscino. (2016) Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease. BioMed Research International 2016, pages 1-15.
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Bożena Adamczyk & Monika Adamczyk-Sowa. (2016) New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis. Oxidative Medicine and Cellular Longevity 2016, pages 1-18.
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Hui Chen, Julian C. Assmann, Antje Krenz, Mahbubur Rahman, Myriam Grimm, Christian M. Karsten, Jörg Köhl, Stefan Offermanns, Nina Wettschureck & Markus Schwaninger. (2014) Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE. Journal of Clinical Investigation 124:5, pages 2188-2192.
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