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Key Paper Evaluation

Oral BG-12 (dimethyl fumarate) for relapsing–remitting multiple sclerosis: a review of DEFINE and CONFIRM

Evaluation of: Gold R, Kappos L, Arnold D, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 2012;367:1098-107; and Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med 2012;367:1087-97

, MD PhD, , MD, , PhD, , MS, , MD PhD, , MD & , MD show all
Pages 2145-2156 | Published online: 24 Aug 2013

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Lin Xu, Chi-Chi Peng, Kate Dawson, Scott Stecher, James Woodworth & Chandra Prakash. (2023) Metabolism, pharmacokinetics and excretion of [14C]dimethyl fumarate in healthy volunteers: an example of xenobiotic biotransformation following endogenous metabolic pathways. Xenobiotica 53:3, pages 163-172.
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Ramachandrapuram KiranjyothiMahalingam BalakrishnanKothapalli Bannoth Chandrasekhar. (2021) Stability Indicating RP-HPLC Method Development and Validation for Estimation of Diroximel Fumarate in bulk and its dosage forms. Research Journal of Pharmacy and Technology, pages 2603-2607.
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Chiara Zecca, Adam Czaplinski, Christophe Henny, Liliane Petrini, Andreas Beeler & Claudio Gobbi. (2020) SwissTecLive: effectiveness and safety of dimethyl fumarate in the treatment of RRMS in the Swiss clinical practice setting. Heliyon 6:12, pages e05819.
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Patrycja Michalska & Rafael León. (2020) When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration. Antioxidants 9:8, pages 740.
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Farinaz SafaviRodolfo ThomeZichen LiGuang-Xian ZhangAbdolmohamad Rostami. (2020) Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor–producing Th1 cells in CNS neuroinflammation. Neurology Neuroimmunology & Neuroinflammation 7:4.
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Mehrdad Gholamzad, Masoumeh Ebtekar, Mehdi Shafiee Ardestani, Maryam Azimi, Zeinab Mahmodi, Mohammad Javad Mousavi & Saeed Aslani. (2018) A comprehensive review on the treatment approaches of multiple sclerosis: currently and in the future. Inflammation Research 68:1, pages 25-38.
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Robbert-Jan Gieselbach, Annemarie H. Muller-Hansma, Martijn T. Wijburg, Marjolein S. de Bruin-Weller, Bob W. van Oosten, Dennis J. Nieuwkamp, Frank E. Coenjaerts, Mike P. Wattjes & Jean-Luc Murk. (2017) Progressive multifocal leukoencephalopathy in patients treated with fumaric acid esters: a review of 19 cases. Journal of Neurology 264:6, pages 1155-1164.
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Rui Li, Ayman Rezk, Mathab Ghadiri, Felix Luessi, Frauke Zipp, Hulun Li, Paul S. Giacomini, Jack Antel & Amit Bar-Or. (2017) Dimethyl Fumarate Treatment Mediates an Anti-Inflammatory Shift in B Cell Subsets of Patients with Multiple Sclerosis. The Journal of Immunology 198:2, pages 691-698.
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Giulio Disanto, Pascal Benkert, Johannes Lorscheider, Stefanie Mueller, Jochen Vehoff, Chiara Zecca, Simon Ramseier, Lutz Achtnichts, Oliver Findling, Krassen Nedeltchev, Ernst-Wilhelm Radue, Till Sprenger, Christoph Stippich, Tobias Derfuss, Jean-François Louvion, Christian P. Kamm, Heinrich P. Mattle, Christoph Lotter, Renaud Du Pasquier, Myriam Schluep, Caroline Pot, Patrice H. Lalive, Özgür Yaldizli, Claudio Gobbi, Ludwig Kappos & Jens Kuhle. (2016) The Swiss Multiple Sclerosis Cohort-Study (SMSC): A Prospective Swiss Wide Investigation of Key Phases in Disease Evolution and New Treatment Options. PLOS ONE 11:3, pages e0152347.
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Fiona E. MutterB. Kevin ParkIan M. Copple. (2015) Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress. Biochemical Society Transactions 43:4, pages 657-662.
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S.G. Meuth. (2015) Zeigen die neuen oralen Therapien Vorteile in der Basistherapie der Multiplen Sklerose? ProDo new oral therapies show advantages in the basal therapy of multiple sclerosis? Pro. Der Nervenarzt 86:4, pages 491-491.
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J. Havla, T. Kümpfel & R. Hohlfeld. (2015) Immuntherapie der multiplen SkleroseImmunotherapies for multiple sclerosis. Der Internist 56:4, pages 432-445.
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Roberto Bomprezzi. (2015) Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview. Therapeutic Advances in Neurological Disorders 8:1, pages 20-30.
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Oscar Fernandez. (2014) BG-12 (dimethyl fumarate) in the treatment of multiple sclerosis. Clinical Investigation 4:5, pages 441-451.
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