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New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease

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Amirhossein Sahebkar, Luis E. Simental-Mendía, Matteo Pirro, Fabrizio Montecucco, Federico Carbone, Maciej Banach, George E. Barreto & Alexandra E. Butler. (2018) Impact of fibrates on circulating cystatin C levels: a systematic review and meta-analysis of clinical trials. Annals of Medicine 50:6, pages 485-493.
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Michael Leutner, Christian Göbl, Oliver Schlager, Silvia Charwat-Resl, Alice Wielandner, Eleonora Howorka, Marlies Prünner, Latife Bozkurt, Katharina Maruszczak, Hacer Geyik, Helmut Prosch, Giovanni Pacini & Alexandra Kautzky-Willer. (2017) The Fatty Liver Index (FLI) Relates to Diabetes-Specific Parameters and an Adverse Lipid Profile in a Cohort of Nondiabetic, Dyslipidemic Patients. Journal of the American College of Nutrition 36:4, pages 287-294.
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Amirhossein Sahebkar. (2017) Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition 57:4, pages 666-676.
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Paola Dongiovanni, Raffaela Rametta, Marica Meroni & Luca Valenti. (2016) The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development – a potential therapeutic target?. Expert Review of Gastroenterology & Hepatology 10:2, pages 229-242.
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Zhong-Min Liu, Miao Hu, Paul Chan & Brian Tomlinson. (2015) Early investigational drugs targeting PPAR-α for the treatment of metabolic disease. Expert Opinion on Investigational Drugs 24:5, pages 611-621.
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Anthony S Wierzbicki & Adie Viljoen. (2014) Fibrates and niacin: is there a place for them in clinical practice?. Expert Opinion on Pharmacotherapy 15:18, pages 2673-2680.
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Manfredi Rizzo, Giuseppe Montalto & Khalid Al-Rasadi. (2014) Treatment options for managing atherogenic dyslipidemia and fatty liver disease. Expert Opinion on Pharmacotherapy 15:8, pages 1065-1068.
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Articles from other publishers (133)

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J.W. Olivier van Till, Hiroyuki Nojima, Chisato Kameoka, Chieri Hayashi, Taishi Sakatani, T. Benton Washburn, Bruce A. Molitoris, Andrew D. Shaw, Daniel T. Engelman & John A. Kellum. (2023) The Effects of Peroxisome Proliferator-Activated Receptor-Delta Modulator ASP1128 in Patients at Risk for Acute Kidney Injury Following Cardiac Surgery. Kidney International Reports 8:7, pages 1407-1416.
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D. V. Minin, S. V. Popkov, K. V. Pesochinskaya & D. R. Aleksanov. (2023) Synthesis of [4-(3-aryl-1,2,4-oxadiazol-5-ylmethylthio)-2-methylphenoxy]acetic acids as new potential PPAR agonists. Russian Chemical Bulletin 72:7, pages 1648-1653.
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Yutaro Tobita, Takeshi Arima, Yuji Nakano, Masaaki Uchiyama, Akira Shimizu & Hiroshi Takahashi. (2020) Peroxisome Proliferator-Activated Receptor Beta/Delta Agonist Suppresses Inflammation and Promotes Neovascularization. International Journal of Molecular Sciences 21:15, pages 5296.
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Yu Yang, Yu Zhao, Wenzhen Li, Yuyao Wu, Xin Wang, Yijie Wang, Tingmei Liu, Tinghong Ye, Yongmei Xie, Zhiqiang Cheng, Jun He, Peng Bai, Yiwen Zhang & Liang Ouyang. (2020) Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment. European Journal of Medicinal Chemistry 197, pages 112311.
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Cheng, Tan, Low, Marvalim, Lee & Tan. (2019) Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence. International Journal of Molecular Sciences 20:20, pages 5055.
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Eric L. Bell, Robert W. Shine, Peter Dwyer, Lyndsay Olson, Jennifer Truong, Ross Fredenburg, Matthew Goddeeris, Dominique Stickens & Effie Tozzo. (2019) PPARδ modulation rescues mitochondrial fatty acid oxidation defects in the mdx model of muscular dystrophy. Mitochondrion 46, pages 51-58.
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Amir Abbas Momtazi-Borojeni, Seyed Hasan Ayati, Mahmoud Reza Jaafari & Amirhossein Sahebkar. (2019) A simple and rapid-acting approach for the reduction of C-reactive protein. Biomedicine & Pharmacotherapy 109, pages 2305-2308.
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Akshay Shetty, Jennifer W. Hsu, Paul P. Manka & Wing-Kin Syn. (2018) Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease. Digestive Diseases and Sciences 63:12, pages 3187-3206.
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Shiva Ganjali, Antonio M. GottoJr.Jr., Massimiliano Ruscica, Stephen L. Atkin, Alexandra E. Butler, Maciej Banach & Amirhossein Sahebkar. (2018) Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases. Journal of Cellular Physiology 233:12, pages 9237-9246.
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Yi Liu, Jennifer Colby, Xiangsheng Zuo, Jonathan Jaoude, Daoyan Wei & Imad Shureiqi. (2018) The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor. International Journal of Molecular Sciences 19:11, pages 3339.
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Nadia Bougarne, Basiel Weyers, Sofie J Desmet, Julie Deckers, David W Ray, Bart Staels & Karolien De Bosscher. (2018) Molecular Actions of PPARα in Lipid Metabolism and Inflammation. Endocrine Reviews 39:5, pages 760-802.
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Habib Yaribeygi, Mohammad T. Mohammadi, Ramin Rezaee & Amirhossein Sahebkar. (2018) Fenofibrate improves renal function by amelioration of NOX‐4, IL‐18, and p53 expression in an experimental model of diabetic nephropathy. Journal of Cellular Biochemistry 119:9, pages 7458-7469.
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Yu Yuan Li, Dan Tang, Yan Lei Du, Chuang Yu Cao, Yu Qiang Nie, Jie Cao & Yong Jian Zhou. (2018) Fatty liver mediated by peroxisome proliferator-activated receptor-α DNA methylation can be reversed by a methylation inhibitor and curcumin. Journal of Digestive Diseases 19:7, pages 421-430.
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Amir Hooshang Mohammadpour, Zakieh Salehinejad, Sepideh Elyasi, Mohsen Mouhebati, Seyed Reza Mirhafez, Sara Samadi, Majid Ghayour-Mobarhan, Gordon Ferns & Amirhossein Sahebkar. (2018) Evaluation of serum cathepsin D concentrations in coronary artery disease. Indian Heart Journal 70:4, pages 471-475.
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Clifford J Bailey & Caroline Day. (2018) Treatment of type 2 diabetes: future approaches. British Medical Bulletin 126:1, pages 123-137.
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Margherita Botta, Matteo Audano, Amirhossein Sahebkar, Cesare Sirtori, Nico Mitro & Massimiliano Ruscica. (2018) PPAR Agonists and Metabolic Syndrome: An Established Role?. International Journal of Molecular Sciences 19:4, pages 1197.
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V. A. Kudinov, T. S. Zakharova, T. I. Torkhovskaya, O. M. Ipatova & A. I. Archakov. (2018) Pharmacological Targets for Correction of Dyslipidemias. Opportunities and Prospects of Therapeutic Use. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 12:2, pages 96-113.
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Farshad Amirkhizi, Soudabeh Hamedi-Shahraki, Sonya Hosseinpour-Arjmand & Mehrangiz Ebrahimi-Mameghani. (2018) The Effect of Alpha-Lipoic Acid on Liver Function and Metabolic Markers in Obese Patients with Non-Alcoholic Fatty Liver Disease: A Double - Blind Randomized Controlled Trial. Iranian Red Crescent Medical Journal 20:3.
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Myong-Min Lee, Hyeong-Geug Kim, Sung-Bae Lee, Jin-Seok Lee, Won-Yong Kim, Seung-Hoon Choi, Sam-Keun Lee, Chang-Kyu Byun, Pung-Mi Hyun & Chang-Gue Son. (2018) CGplus, a standardized herbal composition ameliorates non-alcoholic steatohepatitis in a tunicamycin-induced mouse model. Phytomedicine 41, pages 24-32.
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Martin Weihrauch & Christoph Handschin. (2018) Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochemical Pharmacology 147, pages 211-220.
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Amirhossein Sahebkar, Luis E. Simental-Mendía, Gerald F. Watts, Maria-Corina Serban & Maciej Banach. (2017) Comparison of the effects of fibrates versus statins on plasma lipoprotein(a) concentrations: a systematic review and meta-analysis of head-to-head randomized controlled trials. BMC Medicine 15:1.
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Xiao-Feng Li, Ying-Yin Sun, Jing Bao, Xin Chen, Yu-Huan Li, Yang Yang, Lei Zhang, Cheng Huang, Bao-Ming Wu, Xiao-Ming Meng & Jun Li. (2017) Functional role of PPAR-γ on the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. Scientific Reports 7:1.
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Fahrettin Haczeyni, Hans Wang, Vanessa Barn, Auvro R. Mridha, Matthew M. Yeh, W. Geoffrey Haigh, George N. Ioannou, Yun‐Jung Choi, Charles A. McWherter, Narcissus C.‐H. Teoh & Geoffrey C. Farrell. (2017) The selective peroxisome proliferator–activated receptor‐delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. Hepatology Communications 1:7, pages 663-674.
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Lulu Wang, Susu Wu, Minxuan Cai, Ji Ma, Shengcun Li, Maoru Li, Yan Xu, Lixin Wei & Jing Shang. (2017) Comprehensive Study of Multiple Stages Progressing to Nonalcoholic Steatohepatitis with Subsequent Fibrosis in SD Rats. International Journal of Molecular Sciences 18:8, pages 1681.
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Ajit Magadum, Yishu Ding, Lan He, Teayoun Kim, Mohankrishna Dalvoy Vasudevarao, Qinqiang Long, Kevin Yang, Nadeera Wickramasinghe, Harsha V Renikunta, Nicole Dubois, Gilbert Weidinger, Qinglin Yang & Felix B Engel. (2017) Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair. Cell Research 27:8, pages 1002-1019.
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Amirhossein Sahebkar, Luis E. Simental-Mendía, Željko Reiner, Petri T. Kovanen, Mario Simental-Mendía, Vanessa Bianconi & Matteo Pirro. (2017) Effect of orlistat on plasma lipids and body weight: A systematic review and meta-analysis of 33 randomized controlled trials. Pharmacological Research 122, pages 53-65.
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Chang Feng, Dandan Li, Liping Jiang, Xiaofang Liu, Qiujuan Li, Chengyan Geng, Xiance Sun, Guang Yang, Xiaofeng Yao & Min Chen. (2017) Citreoviridin induces triglyceride accumulation in hepatocytes through inhibiting PPAR-α in vivo and in vitro. Chemico-Biological Interactions 273, pages 212-218.
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Vasilios G. Athyros, Theodore K. Alexandrides, Helen Bilianou, Evangelos Cholongitas, Michael Doumas, Emmanuel S. Ganotakis, John Goudevenos, Moses S. Elisaf, Georgios Germanidis, Olga Giouleme, Asterios Karagiannis, Charalambos Karvounis, Niki Katsiki, Vasilios Kotsis, Jannis Kountouras, Evangelos Liberopoulos, Christos Pitsavos, Stergios Polyzos, Loukianos S. Rallidis, Dimitrios Richter, Apostolos G. Tsapas, Alexandros D. Tselepis, Konstantinos Tsioufis, Konstantinos Tziomalos, Themistoklis Tzotzas, Themistoklis G. Vasiliadis, Charalambos Vlachopoulos, Dimitri P. Mikhailidis & Christos Mantzoros. (2017) The use of statins alone, or in combination with pioglitazone and other drugs, for the treatment of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and related cardiovascular risk. An Expert Panel Statement. Metabolism 71, pages 17-32.
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Lu Han, Wen-Jun Shen, Stefanie Bittner, Fredric B Kraemer & Salman Azhar. (2017) PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-β/δ and PPAR-γ. Future Cardiology 13:3, pages 279-296.
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Na-Na Duan, Xue-Jing Liu & Jian Wu. (2017) Palmitic acid elicits hepatic stellate cell activation through inflammasomes and hedgehog signaling. Life Sciences 176, pages 42-53.
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Bret H. Goodpaster & Lauren M. Sparks. (2017) Metabolic Flexibility in Health and Disease. Cell Metabolism 25:5, pages 1027-1036.
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