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Expert Opinion on Pharmacotherapy Volume 15, 2014 - Issue 4
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Drug Evaluations

Regorafenib for treatment of advanced gastrointestinal stromal tumors

Lindsay C OvertonPortland VA Medical Center, Oregon Helath & Science University and OHSU Knight Cancer Institute, 3710 SW US Veterans Hospital Rd., Building 103 Lab E223, R&D 19, Portland OR 97239-2999, USA+1 503 220 3405; +1 503 273 5158; [email protected]
, MD &
Michael C HeinrichPortland VA Medical Center, Oregon Helath & Science University and OHSU Knight Cancer Institute, 3710 SW US Veterans Hospital Rd., Building 103 Lab E223, R&D 19, Portland OR 97239-2999, USA+1 503 220 3405; +1 503 273 5158; [email protected]
, MD
Pages 549-558 | Published online: 10 Jan 2014

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Piotr Rutkowski & Joanna Stępniak. (2016) The safety of regorafenib for the treatment of gastrointestinal stromal tumors. Expert Opinion on Drug Safety 15:1, pages 105-116.
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Rania S. M. Ismail, Ahmed M. El Kerdawy, Dalia H. Soliman, Hanan H. Georgey, Nagwa M. Abdel Gawad, Andrea Angeli & Claudiu T. Supuran. (2023) Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents. BMC Chemistry 17:1.
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Homma M. Khosroyani, Lillian R. Klug & Michael C. Heinrich. (2023) TKI Treatment Sequencing in Advanced Gastrointestinal Stromal Tumors. Drugs 83:1, pages 55-73.
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Mingjia ZhangXuechun LiWenjing WuJingxi GaoQin HanZhao SunRobert Chunhua Zhao. (2022) Regorafenib Induces the Apoptosis of Gastrointestinal Cancer-Associated Fibroblasts by Inhibiting AKT Phosphorylation. Stem Cells and Development 31:13-14, pages 383-394.
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Flavia Fondevila, Carolina Méndez-Blanco, Paula Fernández-Palanca, Javier González-Gallego & José L. Mauriz. (2019) Anti-tumoral activity of single and combined regorafenib treatments in preclinical models of liver and gastrointestinal cancers. Experimental & Molecular Medicine 51:9, pages 1-15.
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Mekala Gunaratnam, Gavin W. Collie, Anthony P. Reszka, Alan K. Todd, Gary N. Parkinson & Stephen Neidle. (2018) A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line. Bioorganic & Medicinal Chemistry 26:11, pages 2958-2964.
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Martin Prause, Sabrina Niedermoser, Carmen Wängler, Clemens Decristoforo, Uwe Seibold, Stephanie Riester, Takahiro Taguchi, Ralf Schirrmacher, Gert Fricker & Björn Wängler. (2018) Synthesis, in vitro and in vivo evaluation of 18F-fluoronorimatinib as radiotracer for Imatinib-sensitive gastrointestinal stromal tumors. Nuclear Medicine and Biology 57, pages 1-11.
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Alison C. Macleod, Lillian R. Klug & Michael C. Heinrich. 2017. Cancer Therapeutic Targets. Cancer Therapeutic Targets 683 692 .
Li-Mei Wang, Bao-Quan Du, Da-Zhuang Zuo, Ming-Ke Cheng, Meng Zhao, Si-Jia Zhao, Xin Zhai & Ping Gong. (2015) An efficient and high-yielding protocol for the production of Regorafenib via a new synthetic strategy. Research on Chemical Intermediates 42:4, pages 3209-3218.
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Chaochao Xu, Wulan Li, Peihong Qiu, Yiqun Xia, Xiaojing Du, Fen Wang, Lailai Shen, Qiuxiang Chen, Yunjie Zhao, Rong Jin, Jianzhang Wu, Guang Liang & Xiaokun Li. (2015) The therapeutic potential of a novel non-ATP-competitive fibroblast growth factor receptor 1 inhibitor on gastric cancer. Anti-Cancer Drugs 26:4, pages 379-387.
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Ni Zhu, Haowen Xiao, Li-Mengmeng Wang, Shan Fu, Chan Zhao & He Huang. (2015) Mutations in tyrosine kinase and tyrosine phosphatase and their relevance to the target therapy in hematologic malignancies. Future Oncology 11:4, pages 659-673.
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Jia-Qing Zhu. (2015) Therapeutic targets in gastrointestinal stromal tumors. World Journal of Translational Medicine 4:1, pages 25.
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Alison C. Macleod, Lillian R. Klug & Michael C. Heinrich. 2016. Cancer Therapeutic Targets. Cancer Therapeutic Targets 1 9 .
Jie Shao, John S. Markowitz, Di Bei & Guohua An. (2014) Enzyme-Transporter-Mediated Drug Interactions with Small Molecule Tyrosine Kinase Inhibitors. Journal of Pharmaceutical Sciences 103:12, pages 3810-3833.
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