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An update on male hypogonadism therapy

, MD, , MD & , MD

Keep up to date with the latest research on this topic with citation updates for this article.

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Magdalena Celichowska, Miłosz Miedziaszczyk & Katarzyna Lacka. (2022) Pharmacotherapy in Cachexia: A Review of Endocrine Abnormalities and Steroid Pharmacotherapy. Journal of Pain & Palliative Care Pharmacotherapy 36:2, pages 117-131.
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Sandy Yeo, Katsiaryna Holl, Nicolás Peñaherrera, Ulrike Wissinger, Kate Anstee & Robin Wyn. (2021) Burden of Male Hypogonadism and Major Comorbidities, and the Clinical, Economic, and Humanistic Benefits of Testosterone Therapy: A Narrative Review. ClinicoEconomics and Outcomes Research 13, pages 31-38.
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Heitor O. Santos & Filipe J. Teixeira. (2020) Use of medicinal doses of zinc as a safe and efficient coadjutant in the treatment of male hypogonadism. The Aging Male 23:5, pages 669-678.
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Katherine M. Rodriguez, Alexander W. Pastuszak & Larry I. Lipshultz. (2016) Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opinion on Pharmacotherapy 17:11, pages 1561-1567.
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Articles from other publishers (33)

A. Faix, C. Methorst, V. Hupertan & E. Huyghe. (2023) Contraception masculine. Progrès en Urologie 33:13, pages 718-732.
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Sabah Hammoud, Bart J.F. van den Bemt, Ayman Jaber & Mazen Kurdi. (2023) Impaired cardiac structure and systolic function in athletes using supra-physiological doses of anabolic androgenic steroids. Journal of Science and Medicine in Sport 26:10, pages 514-521.
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Manou Huijben, Roel L. N. Huijsmans, M. Tycho W. T. Lock, Vincent F. de Kemp, Laetitia M. O. de Kort & Jetske H. M. K. van Breda. (2023) Clomiphene citrate for male infertility: A systematic review and meta‐analysis. Andrology 11:6, pages 987-996.
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M. Huijben, M. T. W. T. Lock, V. F. de Kemp, J. J. H. Beck, L. M. O. De Kort & H. M. K. van Breda. (2023) Clomiphene citrate: A potential alternative for testosterone therapy in hypogonadal males. Endocrinology, Diabetes & Metabolism 6:3.
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Geoffrey Hackett, Michael KirbyRowland W. Rees, T. Hugh Jones, Asif Muneer, Mark Livingston, Nick Ossei-Gerning, Janine David, Jeff Foster, Philip A. Kalra & Sudarshan Ramachandran. (2023) The British Society for Sexual Medicine Guidelines on Male Adult Testosterone Deficiency, with Statements for Practice. The World Journal of Men's Health 41:3, pages 508.
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N. I. Volkova, A. V. Safronenko, E. V. Gantsgorn & Yu. S. Degtyareva. (2022) Clinical and pharmacological basis of the use of testosterone drugs for hormonal replacement therapy for hypogonadism in men. Obesity and metabolism 19:2, pages 233-241.
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Heitor O. Santos, Flávio A. Cadegiani & Scott C. Forbes. (2022) Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review. Clinical Therapeutics 44:8, pages 1129-1149.
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Raj Vikesh Tiwari, Maria Di Jiang, Keith Jarvi & Robert Hamilton. (2022) Elevated HCG and retroperitoneal adenopathy after clomiphene therapy for infertility. BMJ Case Reports 15:4, pages e249766.
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Manou Huijben, M. Tycho W.T. Lock, Vincent F. de Kemp, Laetitia M.O. de Kort & H.M.K van Breda. (2022) Clomiphene citrate for men with hypogonadism: a systematic review and meta‐analysis. Andrology 10:3, pages 451-469.
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Manou Huijben & M. W. T. Tycho Lock. (2022) Clomifeencitraat voor hypogonadale klachten: bijna 10 jaar ervaringClomiphene citrate in hypogonadism: almost 10 years of experience. Tijdschrift voor Urologie 12:2-3, pages 29-41.
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Jordan Cohen, Andrew Rezk & Ranjith Ramasamy. 2022. Female and Male Fertility Preservation. Female and Male Fertility Preservation 497 515 .
Lu Li & Vassilios Papadopoulos. (2021) Advances in stem cell research for the treatment of primary hypogonadism. Nature Reviews Urology 18:8, pages 487-507.
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Rastafa I. Geddes, Amita Kapoor, Kentaro Hayashi, Ryan Rauh, Marlyse Wehber, Quinn Bongers, Alex D. Jansen, Icelle M. Anderson, Gabrielle Farquhar, Sivan Vadakkadath‐Meethal, Toni E. Ziegler & Craig S. Atwood. (2021) Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI‐induced hypogonadism?. Endocrinology, Diabetes & Metabolism 4:3.
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Carmen Abbe, Bradley D. Anawalt & Stephanie T. Page. 2021. Female and Male Contraception. Female and Male Contraception 439 460 .
Mykola P. Lykhonosov, Alina Y. Babenko, Viktor A. Makarin & Yury  N. Fedotov. (2020) Peculiarity of recovery of the hypothalamic-pituitary-gonadal (hpg) axis, in men after using androgenic anabolic steroids. Problems of Endocrinology 66:1, pages 104-112.
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Preeyarad Charoensumran & Hiroharu Ajiro. (2020) Controlled release of testosterone by polymer-polymer interaction enriched organogel as a novel transdermal drug delivery system: Effect of limonene/PG and carbon-chain length on drug permeability. Reactive and Functional Polymers 148, pages 104461.
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Christopher Wolf-Gould & Carolyn Wolf-Gould. 2020. Comprehensive Care of the Transgender Patient. Comprehensive Care of the Transgender Patient 114 130 .
Ranjith Ramasamy & John M. Masterson. 2020. Male Infertility. Male Infertility 883 889 .
Vinayak Madhusoodanan, Premal Patel, Thiago Fernandes Negris Lima, Jabez Gondokusumo, Eric Lo, Nannan Thirumavalavan, Larry I. Lipshultz & Ranjith Ramasamy. (2019) Human Chorionic Gonadotropin monotherapy for the treatment of hypogonadal symptoms in men with total testosterone > 300 ng/dL. International braz j urol 45:5, pages 1008-1012.
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Caroline Salas-Humara, Gina M. Sequeira, Wilma Rossi & Cherie Priya Dhar. (2019) Gender affirming medical care of transgender youth. Current Problems in Pediatric and Adolescent Health Care 49:9, pages 100683.
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Omar Seyam, Jason Gandhi, Gunjan Joshi, Noel L. Smith & Sardar Ali Khan. (2019) Obesity’s role in secondary male hypogonadism: a review of pathophysiology and management issues. SN Comprehensive Clinical Medicine 1:6, pages 408-418.
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Marc J. Kaufman, Gen Kanayama, James I. Hudson & Harrison G. PopeJr.Jr.. (2019) Supraphysiologic-dose anabolic–androgenic steroid use: A risk factor for dementia?. Neuroscience & Biobehavioral Reviews 100, pages 180-207.
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Robert Carrasquillo, Kevin Chu & Ranjith Ramasamy. (2018) Novel Therapy for Male Hypogonadism. Current Urology Reports 19:8.
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Charles J Glueck, Naila Goldenberg & Ping Wang. (2023) Thromboembolism Peaking 3 Months after Starting Testosterone Therapy: Testosterone–Thrombophilia Interactions. Journal of Investigative Medicine 66:4, pages 733-738.
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Eric M. Lo, Katherine M. Rodriguez, Alexander W. Pastuszak & Mohit Khera. (2018) Alternatives to Testosterone Therapy: A Review. Sexual Medicine Reviews 6:1, pages 106-113.
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Carmita Helena Najjar Abdo. 2018. Sexual Dysfunctions in Mentally Ill Patients. Sexual Dysfunctions in Mentally Ill Patients 225 249 .
Julia Fedotova & Lucian Hritcu. (2017) RETRACTED: Testosterone promotes anxiolytic-like behavior in gonadectomized male rats via blockade of the 5-HT1A receptors. General and Comparative Endocrinology 254, pages 14-21.
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Dan Xu, Liangsheng Lu, Li Xi, Ruoqian Cheng, Zhou Pei, Yunli Bi, Shuangsui Ruan & Feihong Luo. (2017) Efficacy and safety of percutaneous administration of dihydrotestosterone in children of different genetic backgrounds with micropenis. Journal of Pediatric Endocrinology and Metabolism 30:12.
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Mohammad Saied Salehi, Sareh Pandamooz & Homayoun Khazali. (2017) Oxytocin intranasal administration as a new hope for hypogonadotropic hypogonadism patients. Medical Hypotheses 109, pages 88-89.
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Suhaib Radi & Andrew C. Karaplis. (2017) A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures. Case Reports in Endocrinology 2017, pages 1-7.
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Christina Wang, Mario P. R. Festin & Ronald S. Swerdloff. (2016) Male Hormonal Contraception: Where Are We Now?. Current Obstetrics and Gynecology Reports 5:1, pages 38-47.
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Robert A. Kloner, Culley CarsonIIIIII, Adrian Dobs, Stephen Kopecky & Emile R. MohlerIIIIII. (2016) Testosterone and Cardiovascular Disease. Journal of the American College of Cardiology 67:5, pages 545-557.
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Satya K. Vatti, Raef Madanieh, Abed Madanieh, Constantine E. Kosmas & Timothy J. Vittorio. (2015) Cardiovascular Benefits of Testosterone Replacement Therapy in the Andropausal Male. Health 07:09, pages 1206-1214.
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