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Pharmacotherapy for tonic–clonic seizures

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Deborah Guery & Sylvain Rheims. (2021) Clinical Management of Drug Resistant Epilepsy: A Review on Current Strategies. Neuropsychiatric Disease and Treatment 17, pages 2229-2242.
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Max Christian Pensel, Robert Daniel Nass, Erik Taubøll, Dag Aurlien & Rainer Surges. (2020) Prevention of sudden unexpected death in epilepsy: current status and future perspectives. Expert Review of Neurotherapeutics 20:5, pages 497-508.
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Michele A Faulkner. (2017) Spotlight on perampanel in the management of seizures: design, development and an update on place in therapy. Drug Design, Development and Therapy 11, pages 2921-2930.
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Alexandra Rohracher, Francesco Brigo, Julia Höfler, Gudrun Kalss, Caroline Neuray, Judith Dobesberger, Giorgi Kuchukhidze, Markus Leitinger & Eugen Trinka. (2016) Perampanel for the treatment of primary generalized tonic-clonic seizures in idiopathic generalized epilepsy. Expert Opinion on Pharmacotherapy 17:10, pages 1403-1411.
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Articles from other publishers (27)

Chih-Sheng Yang, Man-Chun Wu, Ming-Chi Lai, Sheng-Nan Wu & Chin-Wei Huang. (2023) Identification of New Antiseizure Medication Candidates in Preclinical Animal Studies. International Journal of Molecular Sciences 24:17, pages 13143.
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Déborah Guéry & Sylvain Rheims. (2022) Médicaments antiépileptiques : quoi de neuf récemment ?. Pratique Neurologique - FMC 13:3, pages 179-187.
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Jacqueline A. French, Robert T. Wechsler, Eugen Trinka, Christian Brandt, Terence J. O'Brien, Anna Patten, Alejandro Salah & Manoj Malhotra. (2022) Long‐term open‐label perampanel: Generalized tonic–clonic seizures in idiopathic generalized epilepsy. Epilepsia Open 7:3, pages 393-405.
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Yun-Fei Bai, Chang Zeng, Miaomiao Jia & Bo Xiao. (2022) Molecular mechanisms of topiramate and its clinical value in epilepsy. Seizure 98, pages 51-56.
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Trevor Resnick, Anna Patten, Leock Y. Ngo & Manoj Malhotra. (2022) Sustained seizure freedom with adjunctive perampanel in patients with convulsive seizures: Post hoc analysis of open-label extension studies 307 and 332. Epilepsy & Behavior 128, pages 108528.
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Yanzi Jin, Yujiao Liu, Xianrui Xu, Xu Wang & Qing Zhang. (2022) Mortality and causes of death among people with convulsive epilepsy in northwestern China. Epilepsy & Behavior 127, pages 108492.
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Johann de Jong, Ioana Cutcutache, Matthew Page, Sami Elmoufti, Cynthia Dilley, Holger Fröhlich & Martin Armstrong. (2021) Towards realizing the vision of precision medicine: AI based prediction of clinical drug response. Brain 144:6, pages 1738-1750.
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Ronald C. Reed, William E. Rosenfeld, Susan M. Lippmann, Rene M. J. C. Eijkemans & Dorothee G. A. Kasteleijn-Nolst Trenité. (2020) Rapidity of CNS Effect on Photoparoxysmal Response for Brivaracetam vs. Levetiracetam: A Randomized, Double-blind, Crossover Trial in Photosensitive Epilepsy Patients. CNS Drugs 34:10, pages 1075-1086.
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Christian Brandt, Robert T. Wechsler, Terence J. O’Brien, Anna Patten, Manoj Malhotra, Leock Y. Ngo & Bernhard J. Steinhoff. (2020) Adjunctive perampanel and myoclonic and absence seizures: Post hoc analysis of data from study 332 in patients with idiopathic generalized epilepsy. Seizure 80, pages 115-123.
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Ivan Rektor, Gregory L. Krauss, Yushi Inoue, Sunao Kaneko, Betsy Williams, Anna Patten, Manoj Malhotra, Antonio Laurenza & Robert T. Wechsler. (2020) Assessment of the long‐term efficacy and safety of adjunctive perampanel in tonic‐clonic seizures: Analysis of four open‐label extension studies. Epilepsia 61:7, pages 1491-1502.
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B. A. Neubauer & A. Hahn. (2019) Neue Systematik der Epilepsien und aktuelle TherapieempfehlungenNew classification of epilepsy and current treatment recommendations. Monatsschrift Kinderheilkunde 167:4, pages 299-307.
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Xavier Salas-Puig, Marc Iniesta, Laura Abraira & Josep Puig. (2019) Accidental injuries in patients with generalized tonic–clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study). Epilepsy & Behavior 92, pages 135-139.
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Liwen Wu, Kazuichi Yagi, Zhen Hong, Weiping Liao, Xuefeng Wang, Dong Zhou, Yushi Inoue, Yoko Ohtsuka, Mutsuo Sasagawa, Kiyohito Terada, Xinlu Du, Yoshihiro Muramoto & Tomonobu Sano. (2018) Adjunctive levetiracetam in the treatment of Chinese and Japanese adults with generalized tonic–clonic seizures: A double‐blind, randomized, placebo‐controlled trial. Epilepsia Open 3:4, pages 474-484.
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Vicente Villanueva, Javier Montoya, Ascension Castillo, José Á. Mauri‐Llerda, Pau Giner, Francisco J. López‐González, Anna Piera, Pedro Villanueva‐Hernández, Vicente Bertol, Alejandro Garcia‐Escrivá, Juan J. Garcia‐Peñas, Iñigo Garamendi, Patricia Esteve‐Belloch, Juan J. Baiges‐Octavio, Júlia Miró, Mercè Falip, Mercedes Garcés, Asier Gómez, Francisco J. Gil‐López, Mar Carreño, Juan J. Rodriguez‐Uranga, Dulce Campos, Macarena Bonet, Rosa Querol, Albert Molins, Diego Tortosa & Javier Salas‐Puig. (2018) Perampanel in routine clinical use in idiopathic generalized epilepsy: The 12‐month GENERAL study. Epilepsia 59:9, pages 1740-1752.
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Marine Loizon & Sylvain Rheims. (2018) Prise en charge d’une épilepsie pharmacorésistante. La Presse Médicale 47:3, pages 234-242.
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Louis Wei-Hsi Chen, Melody Yun-Si Chen, Kuo-Yen Chen, Hung-Sheng Lin, Chia-Chang Chien & Hsin-Ling Yin. (2017) Topiramate-associated sexual dysfunction: A systematic review. Epilepsy & Behavior 73, pages 10-17.
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Ali A. Asadi-Pooya, Michael R. Sperling, Steve Chung, Pavel Klein, Anyzeila Diaz, Sami Elmoufti, Jimmy Schiemann & John Whitesides. (2017) Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study. Epilepsy Research 131, pages 70-75.
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Robert T. Wechsler, Stephen L. Yates, John Messenheimer, Robert Leroy, Cynthia Beller & Pamela Doty. (2017) Lacosamide for uncontrolled primary generalized tonic-clonic seizures: An open-label pilot study with 59-week extension. Epilepsy Research 130, pages 13-20.
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Lia Santulli, Antonietta Coppola, Simona Balestrini & Salvatore Striano. (2016) The challenges of treating epilepsy with 25 antiepileptic drugs. Pharmacological Research 107, pages 211-219.
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Alison M. Pack. (2016) Perampanel: Another Choice for Patients with Idiopathic Generalized Epilepsy who Have Tonic–Clonic Seizures. Epilepsy Currents 16:1, pages 27-28.
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Lorenz Breuer, Burkhard S. Kasper, Bernd Schwarze, Juergen M. Gschossmann, Johannes Kornhuber & Helge H. Müller. (2015) “Herbal seizures” – atypical symptoms after ibogaine intoxication: a case report. Journal of Medical Case Reports 9:1.
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Jacqueline A. FrenchGregory L. KraussRobert T. WechslerXue-Feng WangBree DiVenturaChristian BrandtEugen TrinkaTerence J. O'BrienAntonio LaurenzaAnna PattenFrancesco Bibbiani. (2015) Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy. Neurology 85:11, pages 950-957.
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James E. Frampton. (2015) Perampanel: A Review in Drug-Resistant Epilepsy. Drugs 75:14, pages 1657-1668.
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Zahra Tolou-Ghamari & Abbas Ali Palizban. (2015) Review of Sodium Valproate Clinical and Biochemical Properties. Zahedan Journal of Research in Medical Sciences 17:8.
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María M. Adeva-Andany, Carlos Fernández-Fernández, Rocío Sánchez-Bello, Cristóbal Donapetry-García & Julia Martínez-Rodríguez. (2015) The role of carbonic anhydrase in the pathogenesis of vascular calcification in humans. Atherosclerosis 241:1, pages 183-191.
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S. G. Burd, Yu. V. Rubleva & S. E. Serdyuk. (2015) Current possibilities of treatment of generalized convulsive seizures. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 115:10, pages 29.
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Claire Hemery, Philippe Ryvlin & Sylvain Rheims. (2014) Prevention of generalized tonic-clonic seizures in refractory focal epilepsy: A meta-analysis. Epilepsia 55:11, pages 1789-1799.
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