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Targeting the androgen receptor in prostate cancer

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Abdul Majeed, Muhammad Tahir ul Qamar, Arooma Maryam, Muhammad Usman Mirza, Laila Alhussain, Seham Obaid Al Otaibi, Ahmad Almatroudi, Khaled S. Allemailem, Faris Alrumaihi, Abdulaziz A. Aloliqi & Faez Falah Alshehri. (2023) Structural insights into the mechanism of resistance to bicalutamide by the clinical mutations in androgen receptor in chemo-treatment resistant prostate cancer. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-10.
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Divakar Selvaraj, Santhoshkumar Muthu, Satvik Kotha, Ramachandra Setty Siddamsetty, Sasikumar Andavar & Saravanan Jayaraman. (2021) Syringaresinol as a novel androgen receptor antagonist against wild and mutant androgen receptors for the treatment of castration-resistant prostate cancer: molecular docking, in-vitro and molecular dynamics study. Journal of Biomolecular Structure and Dynamics 39:2, pages 621-634.
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Stefano Pierini, Renzo Perales-Linares, Mireia Uribe-Herranz, Jonathan G. Pol, Laurence Zitvogel, Guido Kroemer, Andrea Facciabene & Lorenzo Galluzzi. (2017) Trial watch: DNA-based vaccines for oncological indications. OncoImmunology 6:12.
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Giuseppe Lucarelli, Monica Rutigliano, Vanessa Galleggiante, Andrea Giglio, Silvano Palazzo, Matteo Ferro, Cristiano Simone, Carlo Bettocchi, Michele Battaglia & Pasquale Ditonno. (2015) Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer. Expert Review of Molecular Diagnostics 15:9, pages 1211-1224.
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Mangala Hegde, Sosmitha Girisa, Nikunj Naliyadhara, Aviral Kumar, Mohammed S. Alqahtani, Mohamed Abbas, Chakrabhavi Dhananjaya Mohan, Sudha Warrier, Kam Man Hui, Kanchugarakoppal S. Rangappa, Gautam Sethi & Ajaikumar B. Kunnumakkara. (2022) Natural compounds targeting nuclear receptors for effective cancer therapy. Cancer and Metastasis Reviews 42:3, pages 765-822.
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Bharathi M. Rajamani, Raveen Stephen Stallon Illangeswaran, Esther Sathya Bama Benjamin, Balaji Balakrishnan, Daniel Zechariah Paul Jebanesan, Saswati Das, Aswin Anand Pai, Rakhi Thalayattu Vidhyadharan, Ajith Mohan, Sreeja Karathedath, Aby Abraham, Vikram Mathews, Shaji R. Velayudhan & Poonkuzhali Balasubramanian. (2023) Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo. Frontiers in Pharmacology 14.
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Abbas Khan, Yuanshen Mao, Sana Tahreem, Dong-Qing Wei & Yanjing Wang. (2022) Structural and molecular insights into the mechanism of resistance to enzalutamide by the clinical mutants in androgen receptor (AR) in castration-resistant prostate cancer (CRPC) patients. International Journal of Biological Macromolecules 218, pages 856-865.
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Shailendra Kumar Gangwar, Aviral Kumar, Kenneth Chun-Hong Yap, Sandra Jose, Dey Parama, Gautam Sethi, Alan Prem Kumar & Ajaikumar B. Kunnumakkara. (2022) Targeting Nuclear Receptors in Lung Cancer—Novel Therapeutic Prospects. Pharmaceuticals 15:5, pages 624.
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Namita Mahadik, Dwaipayan Bhattacharya, Akshaya Padmanabhan, Kalyani Sakhare, Kumar Pranav Narayan & Rajkumar Banerjee. (2021) Targeting steroid hormone receptors for anti‐cancer therapy—A review on small molecules and nanotherapeutic approaches. WIREs Nanomedicine and Nanobiotechnology 14:2.
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In-Sung Song, Yu Jeong Jeong, Jueun Kim, Kyoung-Hwa Seo, Nam-In Baek, Yunlim Kim, Choung-Soo Kim & Sung-Wuk Jang. (2020) Pharmacological inhibition of androgen receptor expression induces cell death in prostate cancer cells. Cellular and Molecular Life Sciences 77:22, pages 4663-4673.
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Shiv Ram Krishn, Amrita Singh, Nicholas Bowler, Alexander N. Duffy, Andrea Friedman, Carmine Fedele, Senem Kurtoglu, Sushil K. Tripathi, Kerith Wang, Adam Hawkins, Aejaz Sayeed, Chirayu P. Goswami, Madhukar L. Thakur, Renato V. Iozzo, Stephen C. Peiper, William K. Kelly & Lucia R. Languino. (2019) Prostate cancer sheds the αvβ3 integrin in vivo through exosomes. Matrix Biology 77, pages 41-57.
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Fabrizio Pertusati, Michaela Serpi & Elisa Pileggi. 2019. Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals. Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals 141 180 .
Yangguang Liu, Meng Wu, Tianqi Wang, Yongli Xie, Xiangling Cui, Liujun He, Yang He, Xiaoyu Li, Mingliang Liu, Laixing Hu, Shan Cen & Jinming Zhou. (2018) Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site. Frontiers in Pharmacology 9.
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Huimin Lu, Nicholas Bowler, Larry A. Harshyne, D. Craig Hooper, Shiv Ram Krishn, Senem Kurtoglu, Carmine Fedele, Qin Liu, Hsin-Yao Tang, Andrew V. Kossenkov, William K. Kelly, Kerith Wang, Rhonda B. Kean, Paul H. Weinreb, Lei Yu, Anindita Dutta, Paolo Fortina, Adam Ertel, Maria Stanczak, Flemming Forsberg, Dmitry I. Gabrilovich, David W. Speicher, Dario C. Altieri & Lucia R. Languino. (2018) Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer. Matrix Biology 70, pages 20-35.
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Edel M. McCrea, Daniel K. Lee, Tristan M. Sissung & William D. Figg. (2018) Precision medicine applications in prostate cancer. Therapeutic Advances in Medical Oncology 10, pages 175883591877692.
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P.S. Suresh, Nuggehally R. Srinivas & Ramesh Mullangi. (2018) Review of HPLC and LC-MS/MS assays for the determination of various nonsteroidal anti-androgens used in the treatment of prostate cancer. Biomedical Chromatography 32:1, pages e4034.
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Letizia Mezzasoma, Matthew Peirce, Alba Minelli & Ilaria Bellezza. (2017) Natriuretic Peptides: The Case of Prostate Cancer. Molecules 22:10, pages 1680.
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Kyu-pyo Kim, Robert A. Parise, Julianne L. Holleran, Lionel D. Lewis, Leonard Appleman, Nielka van Erp, Michael J. Morris & Jan H. Beumer. (2017) Simultaneous quantitation of abiraterone, enzalutamide, N -desmethyl enzalutamide, and bicalutamide in human plasma by LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis 138, pages 197-205.
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M-K Siu, F Suau, W-Y Chen, Y-C Tsai, H-Y Tsai, H-L Yeh & Y-N Liu. (2016) KLF4 functions as an activator of the androgen receptor through reciprocal feedback. Oncogenesis 5:12, pages e282-e282.
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Amrita Singh, Carmine Fedele, Huimin Lu, Marja T. Nevalainen, James H. Keen & Lucia R. Languino. (2016) Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. Molecular Cancer Research 14:11, pages 1136-1146.
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Takashi Kawahara, Hiroki Ide, Eiji Kashiwagi, Kareem A. El-Shishtawy, Yi Li, Leonardo O. Reis, Yichun Zheng & Hiroshi Miyamoto. (2016) Enzalutamide inhibits androgen receptor–positive bladder cancer cell growth. Urologic Oncology: Seminars and Original Investigations 34:10, pages 432.e15-432.e23.
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Kristine M. Wadosky & Shahriar Koochekpour. (2016) Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer. Oncotarget 7:39, pages 64447-64470.
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Huimin Lu, Tao Wang, Jing Li, Carmine Fedele, Qin Liu, Jianzhong Zhang, Zhong Jiang, Dhanpat Jain, Renato V. Iozzo, Shelia M. Violette, Paul H. Weinreb, Roger J. Davis, Daniel Gioeli, Thomas J. FitzGerald, Dario C. Altieri & Lucia R. Languino. (2016) αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor. Cancer Research 76:17, pages 5163-5174.
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Ingvild Løberg Tangen, Therese Bredholt Onyango, Reidun Kopperud, Anna Berg, Mari K. Halle, Anne M. Øyan, Henrica M.J. Werner, Jone Trovik, Karl Henning Kalland, Helga B. Salvesen & Camilla Krakstad. (2016) Androgen receptor as potential therapeutic target in metastatic endometrial cancer. Oncotarget 7:31, pages 49289-49298.
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Jey Sabith Ebron & Girish C. Shukla. (2016) Molecular characterization of a novel androgen receptor transgene responsive to MicroRNA mediated post-transcriptional control exerted via 3′-untranslated region. The Prostate 76:9, pages 834-844.
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Xiaohong Tian, Yang He & Jinming Zhou. (2015) Progress in antiandrogen design targeting hormone binding pocket to circumvent mutation based resistance. Frontiers in Pharmacology 6.
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Anandita Agarwala, Peter Jones & Vijay Nambi. (2014) The Role of Antisense Oligonucleotide Therapy in Patients with Familial Hypercholesterolemia: Risks, Benefits, and Management Recommendations. Current Atherosclerosis Reports 17:1.
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Elana Godebu, Michelle Muldong, Amy Strasner, Christina N Wu, Seung Chol Park, Jason R Woo, Wenxue Ma, Michael A Liss, Takeshi Hirata, Omer Raheem, Nicholas A Cacalano, Anna A Kulidjian & Christina AM Jamieson. (2014) PCSD1, a new patient-derived model of bone metastatic prostate cancer, is castrate-resistant in the bone-niche. Journal of Translational Medicine 12:1.
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