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Drug Evaluations

Injectable testosterone undecanoate for the treatment of hypogonadism

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Giovanni Corona, Giulia Rastrelli, Paolo Comeglio, Federica Guaraldi, Diego Mazzatenta, Alessandra Sforza, Linda Vignozzi & Mario Maggi. (2022) The metabolic role of prolactin: systematic review, meta-analysis and preclinical considerations. Expert Review of Endocrinology & Metabolism 17:6, pages 533-545.
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Giovanni Corona, Giulia Rastrelli, Linda Vignozzi, Arcangelo Barbonetti, Alessandra Sforza, Edoardo Mannucci & Mario Maggi. (2021) The Role of testosterone treatment in patients with metabolic disorders. Expert Review of Clinical Pharmacology 14:9, pages 1091-1103.
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G Corona, G Rastrelli, F Guaraldi, G Tortorici, Y Reismann, A Sforza & M Maggi. (2019) An update on heart disease risk associated with testosterone boosting medications. Expert Opinion on Drug Safety 18:4, pages 321-332.
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Giulia Rastrelli, Mauro Dicuio, Yacov Reismann, Alessandra Sforza, Mario Maggi & Giovanni Corona. (2018) Cardiovascular impact of testosterone therapy for hypogonadism. Expert Review of Cardiovascular Therapy 16:9, pages 617-625.
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Giulia Rastrelli, Mario Maggi & Giovanni Corona. (2018) Pharmacological management of late-onset hypogonadism. Expert Review of Clinical Pharmacology 11:4, pages 439-458.
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G. Corona, G. Rastrelli, Y. Reisman, A. Sforza & M. Maggi. (2018) The safety of available treatments of male hypogonadism in organic and functional hypogonadism. Expert Opinion on Drug Safety 17:3, pages 277-292.
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Jan Wolf, Dieter Keipert, Heiko Motazedi, Michael Ernst, Joanne Nettleship & Louis Gooren. (2017) Effectiveness and tolerability of parenteral testosterone undecanoate: a post-marketing surveillance study. The Aging Male 20:4, pages 225-234.
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Mahmoud Salman, Dany-Jan Yassin, Huda Shoukfeh, Joanne Elisabeth Nettleship & Aksam Yassin. (2017) Early weight loss predicts the reduction of obesity in men with erectile dysfunction and hypogonadism undergoing long-term testosterone replacement therapy. The Aging Male 20:1, pages 45-48.
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Antonio Aversa, Davide Francomano & Andrea Lenzi. (2015) Does testosterone supplementation increase PDE5-inhibitor responses in difficult-to-treat erectile dysfunction patients?. Expert Opinion on Pharmacotherapy 16:5, pages 625-628.
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Giovanni Corona, Giulia Ratrelli & Mario Maggi. (2015) The pharmacotherapy of male hypogonadism besides androgens. Expert Opinion on Pharmacotherapy 16:3, pages 369-387.
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Da Woon Kim & Sang Heon Song. (2023) Sarcopenia in chronic kidney disease: from bench to bedside. The Korean Journal of Internal Medicine 38:3, pages 303-321.
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Giovanni Corona, Walter Vena, Alessandro Pizzocaro, Linda Vignozzi, Alessandra Sforza & Mario Maggi. (2022) Testosterone therapy in diabetes and pre‐diabetes. Andrology 11:2, pages 204-214.
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Kenneth W.K. Ho. 2023. Testosterone - Functions, Uses, Deficiencies, and Substitution [Working Title]. Testosterone - Functions, Uses, Deficiencies, and Substitution [Working Title].
Aksam Yassin. 2023. Testosterone. Testosterone 315 330 .
A. M. Isidori, A. Aversa, A. Calogero, A. Ferlin, S. Francavilla, F. Lanfranco, R. Pivonello, V. Rochira, G. Corona & M. Maggi. (2022) Adult- and late-onset male hypogonadism: the clinical practice guidelines of the Italian Society of Andrology and Sexual Medicine (SIAMS) and the Italian Society of Endocrinology (SIE). Journal of Endocrinological Investigation 45:12, pages 2385-2403.
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Katarzyna Romejko, Aleksandra Rymarz, Hanna Sadownik & Stanisław Niemczyk. (2022) Testosterone Deficiency as One of the Major Endocrine Disorders in Chronic Kidney Disease. Nutrients 14:16, pages 3438.
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Milou Cecilia Madsen, Martin den Heijer, Claudia Pees, Nienke R Biermasz & Leontine E H Bakker. (2022) Testosterone in men with hypogonadism and transgender males: a systematic review comparing three different preparations. Endocrine Connections 11:8.
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Abraham Morgentaler, Kunal LodayaSantosh TelangDavid K. HayashidaYiqun Hu. (2022) Comparison of Patterns of Use and Clinical Outcomes Between Injections of Testosterone Undecanoate and Testosterone Cypionate: An Electronic Health Record Cohort Study. Androgens: Clinical Research and Therapeutics 3:1, pages 31-40.
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Giovanni Corona, Giulia Rastrelli, Sara Marchiani, Sandra Filippi, Annamaria Morelli, Erica Sarchielli, Alessandra SforzaLinda Vignozzi & Mario Maggi. (2022) Consequences of Anabolic-Androgenic Steroid Abuse in Males; Sexual and Reproductive Perspective. The World Journal of Men's Health 40:2, pages 165.
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Aurelia S. Elz, Natalie L. Trevaskis, Christopher J.H. Porter, Joanne M. Bowen & Clive A. Prestidge. (2022) Smart design approaches for orally administered lipophilic prodrugs to promote lymphatic transport. Journal of Controlled Release 341, pages 676-701.
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Si Hyun Kim, Jae Joon Park, Ki Hong Kim, Hee Jo Yang, Doo Sang Kim, Chang Ho Lee, Youn Soo Jeon, Sung Ryul Shim & Jae Heon Kim. (2021) Efficacy of testosterone replacement therapy for treating metabolic disturbances in late-onset hypogonadism: a systematic review and meta-analysis. International Urology and Nephrology 53:9, pages 1733-1746.
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Adam J.S. McCartan, David W. Curran & Randall J. Mrsny. (2021) Evaluating parameters affecting drug fate at the intramuscular injection site. Journal of Controlled Release 336, pages 322-335.
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Giovanni Corona, Sandra Filippi, Nicola BianchiMauro DicuioGiulia Rastrelli, Sergio ConcettiAlessandra SforzaMario Maggi. (2021) Cardiovascular Risks of Androgen Deprivation Therapy for Prostate Cancer. The World Journal of Men's Health 39:3, pages 429.
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A. Pizzocaro, W. Vena, R. Condorelli, A. Radicioni, G. Rastrelli, D. Pasquali, R. Selice, A. Ferlin, C. Foresta, E. A. Jannini, M. Maggi, A. Lenzi, R. Pivonello, A. M. Isidori, A. Garolla, S. Francavilla & G. Corona. (2020) Testosterone treatment in male patients with Klinefelter syndrome: a systematic review and meta-analysis. Journal of Endocrinological Investigation 43:12, pages 1675-1687.
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Arcangelo Barbonetti, Settimio D’Andrea & Sandro Francavilla. (2020) Testosterone replacement therapy. Andrology 8:6, pages 1551-1566.
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Giovanni Corona, Luiz Otavio Torres & Mario Maggi. (2020) Testosterone Therapy: What We Have Learned From Trials. The Journal of Sexual Medicine 17:3, pages 447-460.
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Giovanni Corona, Giulia Rastrelli, Annamaria Morelli, Erica Sarchielli, Sarah Cipriani, Linda Vignozzi & Mario Maggi. (2020) Treatment of Functional Hypogonadism Besides Pharmacological Substitution. The World Journal of Men's Health 38:3, pages 256.
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Giulia Rastrelli, Federica Guaraldi, Yacov Reismann, Alessandra Sforza, Andrea M. Isidori, Mario Maggi & Giovanni Corona. (2019) Testosterone Replacement Therapy for Sexual Symptoms. Sexual Medicine Reviews 7:3, pages 464-475.
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G. Rastrelli, Y. Reisman, S. Ferri, O. Prontera, A. Sforza, M. Maggi & G. Corona. 2019. Sexual Medicine. Sexual Medicine 79 93 .
F. Coluzzi, D. Billeci, M. Maggi & G. Corona. (2018) Testosterone deficiency in non-cancer opioid-treated patients. Journal of Endocrinological Investigation 41:12, pages 1377-1388.
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Christina Dimopoulou, Dimitrios G. Goulis, Giovanni Corona & Mario Maggi. (2018) The complex association between metabolic syndrome and male hypogonadism. Metabolism 86, pages 61-68.
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Giovanni Corona, Giulia Rastrelli, Giuseppe Di Pasquale, Alessandra Sforza, Edoardo Mannucci & Mario Maggi. (2018) Endogenous Testosterone Levels and Cardiovascular Risk: Meta-Analysis of Observational Studies. The Journal of Sexual Medicine 15:9, pages 1260-1271.
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Giovanni Corona & Mario Maggi. (2018) Deciding Which Testosterone Therapy to Prescribe. The Journal of Sexual Medicine 15:5, pages 619-621.
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Rune Rasmussen, Mette Midttun, Tine Kolenda, Anne-Mette Ragle, Thea Winther Sørensen, Anders Vinther, Bo Zerahn, Maria Pedersen & Karsten Overgaard. (2018) Therapist-Assisted Progressive Resistance Training, Protein Supplements, and Testosterone Injections in Frail Older Men with Testosterone Deficiency: Protocol for a Randomized Placebo-Controlled Trial. JMIR Research Protocols 7:3, pages e71.
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N. Regouat, A. Cheboub, M. Benahmed, A. Belarbi & F. Hadj-Bekkouche. (2018) Effect of testosterone supplementation on nitroso-redox imbalance, cardiac metabolism markers, and S100 proteins expression in the heart of castrated male rats. Andrology 6:1, pages 74-85.
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Giovanni Corona, Giulia Rastrelli, Abraham Morgentaler, Alessandra Sforza, Edoardo Mannucci & Mario Maggi. (2017) Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores. European Urology 72:6, pages 1000-1011.
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Giovanni Corona, Giulia Rastrelli, Mauro Dicuio, Alessandra Sforza & Mario Maggi. (2017) Testosterone and Cardiovascular Diseases: Causes or Consequences: The Lesson from the Last 5 Years. Current Sexual Health Reports 9:4, pages 277-289.
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Yonah Krakowsky, William Conners, Emily Davidson, Alex Rawji & Abraham Morgentaler. (2017) Initial Clinical Experience With Testosterone Undecanoate Therapy (AVEED) in Men With Testosterone Deficiency in the United States. Urology 109, pages 27-31.
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Faysal A. Yafi, Nora M. Haney, James Anaissie, Kenneth J. DeLay, Landon Trost, Mohit Khera & Wayne J.G. Hellstrom. (2017) Practice Patterns in the Diagnosis and Management of Hypogonadism: A Survey of Sexual Medicine Society of North America Members. Urology 106, pages 87-95.
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Geoffrey Hackett, Michael Kirby, David Edwards, T. Hugh Jones, Jonathan Rees & Asif Muneer. (2017) UK policy statements on testosterone deficiency. International Journal of Clinical Practice 71:3-4, pages e12901.
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Giovanni CoronaAlessandra SforzaMario Maggi. (2017) Testosterone Replacement Therapy: Long-Term Safety and Efficacy. The World Journal of Men's Health 35:2, pages 65.
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Aksam A. Yassin. 2017. Testosterone. Testosterone 237 251 .
Daniele Santi & Giovanni Corona. 2017. Endocrinology of the Testis and Male Reproduction. Endocrinology of the Testis and Male Reproduction 687 747 .
Daniele Santi & Giovanni Corona. 2017. Thyroid Diseases. Thyroid Diseases 1 62 .
Abraham Morgentaler, M. Zitzmann, A. M. Traish, A. W. Fox, T. H. Jones, M. Maggi, S. Arver, A. Aversa, J.C.N. Chan, A. S. Dobs, G. I. Hackett, W. J. Hellstrom, P. Lim, B. Lunenfeld, G. Mskhalaya, C. C. Schulman & L. O. Torres. (2016) The consensus recommendations of a group of international experts on the fundamental concepts related to the issues of testosterone deficiency and its treatment.. Obesity and metabolism 13:3, pages 15-31.
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G. Corona, G. Rastrelli, A. Burri, E. Serra, D. Gianfrilli, E. Mannucci, E. A. Jannini & M. Maggi. (2016) First-generation phosphodiesterase type 5 inhibitors dropout: a comprehensive review and meta-analysis. Andrology 4:6, pages 1002-1009.
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Giovanni Corona, Sarah Cipriani, Giulia Rastrelli, Alessandra Sforza, Edoardo Mannucci & Mario Maggi. (2016) High Triglycerides Predicts Arteriogenic Erectile Dysfunction and Major Adverse Cardiovascular Events in Subjects With Sexual Dysfunction. The Journal of Sexual Medicine 13:9, pages 1347-1358.
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G. Corona, V. A. Giagulli, E. Maseroli, L. Vignozzi, A. Aversa, M. Zitzmann, F. Saad, E. Mannucci & M. Maggi. (2016) Testosterone supplementation and body composition: results from a meta-analysis of observational studies. Journal of Endocrinological Investigation 39:9, pages 967-981.
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Sompol Permpongkosol, Kalayanee Khupulsup, Supatra Leelaphiwat, Sarawan Pavavattananusorn, Supranee Thongpradit & Thanom Petchthong. (2016) Effects of 8-Year Treatment of Long-Acting Testosterone Undecanoate on Metabolic Parameters, Urinary Symptoms, Bone Mineral Density, and Sexual Function in Men With Late-Onset Hypogonadism. The Journal of Sexual Medicine 13:8, pages 1199-1211.
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Abraham Morgentaler, Michael Zitzmann, Abdulmaged M. Traish, Anthony W. Fox, T. Hugh Jones, Mario Maggi, Stefan Arver, Antonio Aversa, Juliana C.N. Chan, Adrian S. Dobs, Geoffrey I. Hackett, Wayne J. Hellstrom, Peter Lim, Bruno Lunenfeld, George Mskhalaya, Claude C. Schulman & Luiz O. Torres. (2016) Fundamental Concepts Regarding Testosterone Deficiency and Treatment. Mayo Clinic Proceedings 91:7, pages 881-896.
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D. Francomano, G. Fattorini, D. Gianfrilli, D. Paoli, P. Sgrò, A. Radicioni, F. Romanelli, L. Di Luigi, L. Gandini, A. Lenzi & A. Aversa. (2015) Acute endothelial response to testosterone gel administration in men with severe hypogonadism and its relationship to androgen receptor polymorphism: a pilot study. Journal of Endocrinological Investigation 39:3, pages 265-271.
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G. Corona, L. Vignozzi, A. Sforza, E. Mannucci & M. Maggi. (2015) Obesity and late-onset hypogonadism. Molecular and Cellular Endocrinology 418, pages 120-133.
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Antonio Aversa & Abraham Morgentaler. (2015) The practical management of testosterone deficiency in men. Nature Reviews Urology 12:11, pages 641-650.
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Joshua R. Gonzalez & Irwin Goldstein. (2015) Testosterone replacement and cardiovascular disease risk. Cardiovascular Endocrinology 4:3, pages 100-107.
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John D. Dean, Chris G. McMahon, Andre T. Guay, Abraham Morgentaler, Stanley E. Althof, Edgardo F. Becher, Trinity J. Bivalacqua, Arthur L. Burnett, Jacques Buvat, Amr El Meliegy, Wayne J.G. Hellstrom, Emmanuele A. Jannini, Mario Maggi, Andrew McCullough, Luiz Otavio Torres & Michael Zitzmann. (2015) The International Society for Sexual Medicine's Process of Care for the Assessment and Management of Testosterone Deficiency in Adult Men. The Journal of Sexual Medicine 12:8, pages 1660-1686.
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D. M. Kelly & T. H. Jones. (2015) Testosterone and obesity. Obesity Reviews 16:7, pages 581-606.
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T Middleton, L Turner, C Fennell, S Savkovic, V Jayadev, A J Conway & D J Handelsman. (2015) Complications of injectable testosterone undecanoate in routine clinical practice. European Journal of Endocrinology 172:5, pages 511-517.
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Giovanni Corona GGiulia RastrelliElisa MaseroliAlessandra SforzaMario Maggi. (2015) Testosterone Replacement Therapy and Cardiovascular Risk: A Review. The World Journal of Men's Health 33:3, pages 130.
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Rena D. Malik, Brittany Lapin, Chihsiung E. Wang, Justin C. Lakeman & Brian T. Helfand. (2015) Are We Testing Appropriately for Low Testosterone?: Characterization of Tested Men and Compliance with Current Guidelines. The Journal of Sexual Medicine 12:1, pages 66-75.
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