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An update on the pharmacological management of adenomyosis

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Keep up to date with the latest research on this topic with citation updates for this article.

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Yu Fu Huang, Jia Deng, Xue Li Wei, Xin Sun, Min Xue, Xiao Gang Zhu & Xin Liang Deng. (2020) A comparison of reproductive outcomes of patients with adenomyosis and infertility treated with High-Intensity focused ultrasound and laparoscopic excision. International Journal of Hyperthermia 37:1, pages 301-307.
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Song Guo, Zhichao Li, Li Yan, Yijuan Sun & Yun Feng. (2018) GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity. Drug Design, Development and Therapy 12, pages 1621-1631.
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Jian Fa Jiang, Song Shu Xiao & Min Xue. (2018) Decreased expression of interleukin-37 in the ectopic and eutopic endometria of patients with adenomyosis. Gynecological Endocrinology 34:1, pages 83-86.
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Jianfa Jiang, Aijun Sun, Yanfang Wang & Yan Deng. (2016) Increased expression of Talin1 in the eutopic and ectopic endometria of women with adenomyosis. Gynecological Endocrinology 32:6, pages 469-472.
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Articles from other publishers (47)

Andrea Etrusco, Fabio Barra, Vito Chiantera, Simone Ferrero, Stefano Bogliolo, Giulio Evangelisti, Engin Oral, Mariana Pastore, Alberto Izzotti, Renato Venezia, Marcello Ceccaroni & Antonio Simone Laganà. (2023) Current Medical Therapy for Adenomyosis: From Bench to Bedside. Drugs 83:17, pages 1595-1611.
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Wenwen Wang, Xiangyi Ma, Minli Zhang, Zhangying Wu, Tao Xiang & Shixuan Wang. (2022) Comparison of recurrence rate and risk factors in patients with focal adenomyosis with and without medical treatment after conservative surgery. International Journal of Gynecology & Obstetrics 161:2, pages 594-600.
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Lei Han, Yanni Liu, Kaixue Lao, Jianxi Jiang, Caiying Zhang & Yanlin Wang. (2023) Individualized conservative therapeutic strategies for adenomyosis with the aim of preserving fertility. Frontiers in Medicine 10.
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J. Estadella Tarriel, J. Perelló Capó & R. Muñoz Sánchez. (2023) Actualización sobre las posibilidades de tratamiento médico hormonal para el sangrado menstrual abundante. Clínica e Investigación en Ginecología y Obstetricia 50:1, pages 100819.
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Yingchen Wu, Hao Wang, Yi Li, Yangzhi Li, Yihua Liang, Guangzheng Zhong & Qingxue Zhang. (2022) Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2. Reproductive Sciences 29:10, pages 3026-3038.
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Ling-Hui Chu, Chi-Chun Liao, Phui-Ly Liew, Chien-Wen Chen, Po-Hsuan Su, Kuo-Chang Wen, Hung-Cheng Lai, Rui-Lan Huang & Lin-Yu Chen. (2022) Epigenomic Analysis Reveals the KCNK9 Potassium Channel as a Potential Therapeutic Target for Adenomyosis. International Journal of Molecular Sciences 23:11, pages 5973.
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Wei Song, Zhibo Zhang, Ying Jiang, Yang Cao, Bo Zhang, Yujie Wang, Honghui Shi & Lan Zhu. (2022) Integrative metabolomic profiling reveals aberrations in myometrium associated with adenomyosis: a pilot study. Reproductive Biology and Endocrinology 20:1.
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Rong Huang, Xiaohan Li, Hui Jiang & Quanlei Li. (2021) Barriers to self‐management of patients with adenomyosis: A qualitative study. Nursing Open 9:2, pages 1086-1095.
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M. Bourdon, P. Santulli, L. Marcellin, C. Maignien, L. Maitrot-Mantelet & C. Chapron. (2022) Physiopathologie de l’adénomyose : une énigme non résolue. Gynécologie Obstétrique Fertilité & Sénologie  50:2, pages 182-188.
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Manuel Gonçalves-Henriques, António de Pinho, Marília Freixo, Maria Liz-Coelho, Fabiana Castro, Nathan Ceschin & Pedro Brandão. (2022) Ulipristal acetate in adenomyosis. Gynecology and Minimally Invasive Therapy 0:0, pages 0.
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欣欣 席. (2022) Clinical Research Progress of Adenomyosis. Advances in Clinical Medicine 12:12, pages 11852-11857.
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Mathilde Bourdon, Pietro Santulli, Fatiha Kateb, Khaled Pocate-Cheriet, Frederic Batteux, Chloé Maignien, Sandrine Chouzenoux, Corinne Bordonne, Louis Marcellin, Gildas Bertho & Charles Chapron. (2021) Adenomyosis is associated with specific proton nuclear magnetic resonance (1H-NMR) serum metabolic profiles. Fertility and Sterility 116:1, pages 243-254.
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Xiaopei Chao, Xiaochen Song, Huanwen Wu, Yan You, Lei Li & Jinghe Lang. (2021) Adjuvant therapy in conservative surgery for adenomyosis. International Journal of Gynecology & Obstetrics 154:1, pages 119-126.
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Zhiyong Liu, Zhonghua Sun, Hongyun Liu, Weipin Niu, Xin Wang, Na Liang, Xin Wang, Yanfei Wang, Yaxin Shi, Li Xu & Wei Shi. (2021) Single-cell transcriptomic analysis of eutopic endometrium and ectopic lesions of adenomyosis. Cell & Bioscience 11:1.
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Xiaoxue Li, Ningning Pan, Wen Zhang, Yang Wang, Yimeng Ge, Hongyi Wei, Yihua Lin & Caihong Ma. (2021) Association between uterine volume and pregnancy outcomes in adenomyosis patients undergoing frozen-thawed embryo transfer. Reproductive BioMedicine Online 42:2, pages 384-389.
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M Bourdon, J Oliveira, L Marcellin, P Santulli, C Bordonne, L Maitrot Mantelet, A E Millischer, G Plu Bureau & C Chapron. (2021) Adenomyosis of the inner and outer myometrium are associated with different clinical profiles. Human Reproduction 36:2, pages 349-357.
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Popov Alexander, Koval Alexey, Fedorov Anton, Tyurina Svetlana, Fedotova Irina & Khabibullakh Tamana. 2021. Endometriosis. Endometriosis.
A.A. Koval’, A.A. Popov, A.A. Fedorov, S.S. Tyurina, D.V. Ovcharenko & T. Khabibullah. (2021) Adenomyosis and infertility. Rossiiskii vestnik akushera-ginekologa 21:4, pages 35.
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Wenwen Wang, Xiangyi Ma, Wei Zhang, Zhiying Li, Yan Wang, Zhiying Yu, Chunlian Zhang, Li Hong, Ruoyu Luo, Hui Xing, Wuliang Wang, Qingfen Yue, Jia Wei, Minli Zhang & Shixuan Wang. (2020) Relapse after conservative surgery combined with triptorelin acetate versus conservative surgery only in women with focal adenomyosis: study protocol for a multicenter, prospective, randomized controlled trial. Trials 21:1.
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Cem Yalaza, Necmiye Canacankatan, İclal Gürses, Hakan Aytan & Bahar Taşdelen. (2020) Altered VEGF, Bcl-2 and IDH1 expression in patients with adenomyosis. Archives of Gynecology and Obstetrics 302:5, pages 1221-1227.
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Qiuju Li, Ming Yuan, Ni Li, Qianwei Zhen, Chang Chen & Guoyun Wang. (2020) The efficacy of medical treatment for adenomyosis after adenomyomectomy. Journal of Obstetrics and Gynaecology Research 46:10, pages 2092-2099.
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Harald Krentel & Rudy Leon De Wilde. (2020) Adenomyosis: diagnostics and treatmentAdenomyose: Diagnostik und Therapie. Der Gynäkologe 53:10, pages 683-688.
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Yuqian Xiang, Yabing Sun, Bingxin Yang, Yeping Yang, Ying Zhang, Tiantian Yu, Hefeng Huang, Junyu Zhang & Hong Xu. (2019) Transcriptome sequencing of adenomyosis eutopic endometrium: A new insight into its pathophysiology. Journal of Cellular and Molecular Medicine 23:12, pages 8381-8391.
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Marissa J Harmsen, Caroline F C Wong, Velja Mijatovic, Arjan W Griffioen, Freek Groenman, Wouter J K Hehenkamp & Judith A F Huirne. (2019) Role of angiogenesis in adenomyosis-associated abnormal uterine bleeding and subfertility: a systematic review. Human Reproduction Update 25:5, pages 646-670.
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Kateryna Ostrovska. (2019) Menstrual Pain: A Review of Foreign Literature. Pain medicine 4:2, pages 53-64.
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Khaleque N Khan, Akira Fujishita, Akemi Koshiba, Taisuke Mori, Haruo Kuroboshi, Hiroshi Ogi, Kyoko Itoh, Masahiro Nakashima & Jo Kitawaki. (2019) Biological differences between focal and diffuse adenomyosis and response to hormonal treatment. Reproductive BioMedicine Online 38:4, pages 634-646.
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Mathilde Bourdon, Pietro Santulli, Sandrine Chouzenoux, Chloé Maignien, Karine Bailly, Muriel Andrieu, Anne-Elodie Millischer, Ludivine Doridot, Louis Marcellin, Fréderic Batteux & Charles Chapron. (2019) The Disease Phenotype of Adenomyosis-Affected Women Correlates With Specific Serum Cytokine Profiles. Reproductive Sciences 26:2, pages 198-206.
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Beibei Shi, Hongxiang Tu, Lixiao Sha, Xishao Luo, Wenlie Wu, Ying Su, Simeng Yang & Hanchu Wang. (2019) Upregulation of long noncoding RNA TUG1 by EGR1 promotes adenomyotic epithelial cell migration and invasion through recruiting EZH2 and suppressing TIMP2. Molecular Reproduction and Development 86:2, pages 239-247.
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Sun-Wei Guo & Patrick G Groothuis. (2018) Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?. Human Reproduction Update 24:5, pages 577-598.
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Qing Li, Yan Ding, Xu-Yin Zhang, Wei-Wei Feng & Ke-Qin Hua. (2018) Drug therapy for adenomyosis: a prospective, nonrandomized, parallel-controlled study. Journal of International Medical Research 46:5, pages 1855-1865.
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Tainá Pezzin Rocha, Marina Paula Andres, Giuliano Moysés Borrelli & Mauricio Simões Abrão. (2018) Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options. Reproductive Sciences 25:4, pages 480-486.
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Folabomi A. Oladosu, Frank F. Tu & Kevin M. Hellman. (2018) Nonsteroidal antiinflammatory drug resistance in dysmenorrhea: epidemiology, causes, and treatment. American Journal of Obstetrics and Gynecology 218:4, pages 390-400.
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Silvia Vannuccini, Stefano Luisi, Claudia Tosti, Flavia Sorbi & Felice Petraglia. (2018) Role of medical therapy in the management of uterine adenomyosis. Fertility and Sterility 109:3, pages 398-405.
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Javier García-Solares, Jacques Donnez, Olivier Donnez & Marie-Madeleine Dolmans. (2018) Pathogenesis of uterine adenomyosis: invagination or metaplasia?. Fertility and Sterility 109:3, pages 371-379.
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Marco Aurelio Pinho Oliveira, Claudio Peixoto CrispiJr.Jr., Leila Cristina Brollo, Claudio Peixoto Crispi & Rudy Leon De Wilde. (2017) Surgery in adenomyosis. Archives of Gynecology and Obstetrics 297:3, pages 581-589.
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Jerome Bouaziz & David Soriano. 2018. Hysteroscopy. Hysteroscopy 471 478 .
Mohamed Gamal Ibrahim, Martin Sillem, Johanna Plendl, Vito Chiantera, Jalid Sehouli & Sylvia Mechsner. (2017) Myofibroblasts Are Evidence of Chronic Tissue Microtrauma at the Endometrial-Myometrial Junctional Zone in Uteri With Adenomyosis. Reproductive Sciences 24:10, pages 1410-1418.
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Claudia Tosti, Silvia Vannuccini, Libera Troìa, Stefano Luisi, Gabriele Centini, Lucia Lazzeri & Felice Petraglia. (2017) Long-Term Vaginal Danazol Treatment in Fertile Age Women with Adenomyosis. Journal of Endometriosis and Pelvic Pain Disorders 9:1, pages 39-43.
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Yu-yan Zeng & Kun-yin Li. (2017) Effects of Jiawei Shaoyao-Gancao Decoction and Its Drug-Containing Serum on Proliferation, Apoptosis, and Ultrastructure of Human Adenomyosis Foci Cells. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-8.
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Jing Zhou, Li He, Ping Liu, Hui Duan, Hanze Zhang, Weili Li, Shipeng Gong, Guidong Su & Chunlin Chen. (2016) Outcomes in Adenomyosis Treated with Uterine Artery Embolization Are Associated with Lesion Vascularity: A Long-Term Follow-Up Study of 252 Cases. PLOS ONE 11:11, pages e0165610.
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Claudia Tosti, Libera Troìa, Silvia Vannuccini, Lucia Lazzeri, Stefano Luisi & Felice Petraglia. (2016) Current and Future Medical Treatment of Adenomyosis. Journal of Endometriosis and Pelvic Pain Disorders 8:4, pages 127-135.
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Jennifer Struble, Shannon Reid & Mohamed A. Bedaiwy. (2016) Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition. Journal of Minimally Invasive Gynecology 23:2, pages 164-185.
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Ludovico Muzii, Chiara Di Tucci, Chiara Achilli, Violante Di Donato, Angela Musella, Innocenza Palaia & Pierluigi Benedetti Panici. (2016) Continuous versus cyclic oral contraceptives after laparoscopic excision of ovarian endometriomas: a systematic review and metaanalysis. American Journal of Obstetrics and Gynecology 214:2, pages 203-211.
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Hana ParkSung-Hoon Kim, Yoo Mi ChoHyo Jin IhmYoung Sang OhSeung Hwa HongHee Dong ChaeChung-Hoon KimByung Moon Kang. (2016) Increased expression of nuclear factor kappa-B p65 subunit in adenomyosis. Obstetrics & Gynecology Science 59:2, pages 123.
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Isabelle Streuli, Pietro Santulli, Sandrine Chouzenoux, Charles Chapron & Frédéric Batteux. (2015) Activation of the MAPK/ERK Cell-Signaling Pathway in Uterine Smooth Muscle Cells of Women With Adenomyosis. Reproductive Sciences 22:12, pages 1549-1560.
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Omar M. Shaaban, Mohammed K. Ali, Ali Mohamed A. Sabra & Diaa Eldeen M. Abd El Aal. (2015) Levonorgestrel-releasing intrauterine system versus a low-dose combined oral contraceptive for treatment of adenomyotic uteri: a randomized clinical trial. Contraception 92:4, pages 301-307.
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A. A. Shklyar, L. V. Adamian, E. A. Kogan, N. B. Paramonova, I. F. Kozachenko, T. Yu. Gavrilova & S. N. Kononov. (2015) Receptor status of endometrioid heterotopias as the indication for hormonal therapy of nodular and diffuse forms of adenomyosis. Problemy reproduktsii 21:2, pages 88.
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