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Review

Abuse-deterrent formulations: Part 2: commercial products and proprietary technologies

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Keep up to date with the latest research on this topic with citation updates for this article.

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Rand Ahmad, Samaneh Alaei & Hamid Omidian. (2018) Safety and performance of current abuse-deterrent formulations. Expert Opinion on Drug Metabolism & Toxicology 14:12, pages 1255-1271.
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Joseph V. Pergolizzi$suffix/text()$suffix/text(), Flaminia Coluzzi & Robert Taylor$suffix/text()$suffix/text(). (2018) Transdermal buprenorphine for moderate chronic noncancer pain syndromes. Expert Review of Neurotherapeutics 18:5, pages 359-369.
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Mohammad Hadi Foroughi, Maryam Akhgari, Farzaneh Jokar & Zahra Mousavi. (2017) Identification of undeclared active pharmaceutical ingredients in counterfeit herbal medicines used as opioid substitution therapy. Australian Journal of Forensic Sciences 49:6, pages 720-729.
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David J. Mastropietro, Srinath Muppalaneni & Hossein Omidian. (2016) Deterred drug abuse using superabsorbent polymers. Expert Opinion on Drug Delivery 13:11, pages 1523-1531.
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Maciej Gasior, Mary Bond & Richard Malamut. (2016) Routes of abuse of prescription opioid analgesics: a review and assessment of the potential impact of abuse-deterrent formulations. Postgraduate Medicine 128:1, pages 85-96.
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Articles from other publishers (30)

Haiou Qu, William C. Smith, Xin Feng, Jiang Wang, Julia Pinto, Xiaoming Xu & Patrick J. Faustino. (2023) Asymmetrical Flow Field Flow Fractionation for Molar Mass Characterization of Polyethylene Oxide in Abuse-Deterrent Formulations. Journal of Chromatography A 1705, pages 464186.
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Jeong Sun Sohn & Jin-Seok Choi. (2023) Design of Abuse-Deterrent Formulations Using Various Types of Thermal Deformed Starch (TDS). Journal of Pharmaceutical Innovation.
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Aljoscha JanssenXuan Zhang. (2023) Retail Pharmacies and Drug Diversion during the Opioid Epidemic. American Economic Review 113:1, pages 1-33.
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Golam Kibria, Bandaranayake Bandaranayake, Jiwen Zheng, Sau Lee & Celia Cruz. (2023) Stability of Abuse-deterrent properties of PEO-based Abuse-deterrent formulation. International Journal of Pharmaceutics 631, pages 122430.
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Dhwani Rana, Sagar Salave & Derajram Benival. (2022) Emerging Trends in Abuse-Deterrent Formulations: Technological Insights and Regulatory Considerations. Current Drug Delivery 19:8, pages 846-859.
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Leyla Rezaei, Saikishore Meruva & Maureen D. Donovan. (2021) Effect of Manufacturing Process on the Retention of Abuse-Deterrent Properties of PEO-Matrix Tablets. AAPS PharmSciTech 23:1.
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Jeong Sun Sohn & Jin-Seok Choi. (2021) Development and evaluation of pseudoephedrine hydrochloride abuse-deterrent formulations using thermal modified rice starch. International Journal of Biological Macromolecules 182, pages 1248-1258.
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Kanishka Rajput & Nalini Vadivelu. (2021) Acute Pain Management of Chronic Pain Patients in Ambulatory Surgery Centers. Current Pain and Headache Reports 25:1.
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Siddhant Palekar, Pavan Kumar Nukala, Richa Vartak & Ketan Patel. (2020) Abuse deterrent immediate release film technology (ADRIFT): A novel bilayer film technology for limiting intentional drug abuse. International Journal of Pharmaceutics 590, pages 119944.
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Saikishore Meruva, Leyla Rezaei, Prajwal Thool & Maureen D. Donovan. (2020) Use of Drug Release Testing to Evaluate the Retention of Abuse-Deterrent Properties of Polyethylene Oxide Matrix Tablets. AAPS PharmSciTech 21:7.
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C. Austin Zamarripa, Jennifer E. Naylor, Sally L. Huskinson, E. Andrew Townsend, Thomas E. Prisinzano & Kevin B. Freeman. (2020) Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys. Psychopharmacology 237:5, pages 1471-1480.
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Jun Jie Ong, Atheer Awad, Annalisa Martorana, Simon Gaisford, Edmont Stoyanov, Abdul W. Basit & Alvaro Goyanes. (2020) 3D printed opioid medicines with alcohol-resistant and abuse-deterrent properties. International Journal of Pharmaceutics 579, pages 119169.
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Xin Feng, Ahmed Zidan, Nahid S. Kamal, Xiaoming Xu, Dajun Sun, Ross Walenga, Heather Boyce, Celia N. Cruz & Muhammad Ashraf. (2020) Assessing Drug Release from Manipulated Abuse Deterrent Formulations. AAPS PharmSciTech 21:2.
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Saikishore Meruva & Maureen D. Donovan. (2019) Polyethylene Oxide (PEO) Molecular Weight Effects on Abuse-Deterrent Properties of Matrix Tablets. AAPS PharmSciTech 21:1.
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Saikishore Meruva & Maureen D. Donovan. (2019) Effects of Drug-Polymer Interactions on Tablet Properties During the Development of Abuse-Deterrent Dosage Forms. AAPS PharmSciTech 20:3.
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Nora VolkowHelene BenvenisteA. Thomas McLellan. (2018) Use and Misuse of Opioids in Chronic Pain. Annual Review of Medicine 69:1, pages 451-465.
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Britni L. Lookabaugh & Charles F. Von Gunten. 2018. Essentials of Pain Medicine. Essentials of Pain Medicine 299 308.e1 .
J. Rick Turner. (2017) Commissioner Gottlieb and the Crusade Against Opioid Abuse: Baptism by Fire. Therapeutic Innovation & Regulatory Science 51:4, pages 400-403.
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Nalini Vadivelu, Daniel Chang, Leandro Lumermann, Thomas Suchy, Matthew M. Burg & Manuel L. Fontes. (2017) Management of Patients on Abuse-Deterrent Opioids in the Ambulatory Surgery Setting. Current Pain and Headache Reports 21:2.
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J. David Haddox & Richard O. Mannion. (2016) A tale of 2 ADFs—with 2 different abuse-deterrent formulations. Pain 157:12, pages 2875-2875.
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Yvette N. Lamb, Karly P. Garnock-Jones & Susan J. Keam. (2016) Oxycodone DETERx® ER Capsules: A Review in Severe, Chronic Pain. Drugs 76:18, pages 1759-1769.
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Martin E Hale, Derek Moe, Mary Bond, Maciej Gasior & Richard Malamut. (2016) Abuse-deterrent formulations of prescription opioid analgesics in the management of chronic noncancer pain. Pain Management 6:5, pages 497-508.
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PM Coplan, HD Chilcoat, SF Butler, EM Sellers, A Kadakia, V Harikrishnan, JD Haddox & RC Dart. (2016) The effect of an abuse‐deterrent opioid formulation (OxyContin) on opioid abuse‐related outcomes in the postmarketing setting. Clinical Pharmacology & Therapeutics 100:3, pages 275-286.
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Carmen Walter, Claudia Knothe & Jörn Lötsch. (2015) Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations. Clinical Pharmacokinetics 55:7, pages 751-767.
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Theodore J. Cicero, Matthew S. Ellis & Zachary A. Kasper. (2016) A tale of 2 ADFs. Pain 157:6, pages 1232-1238.
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Nora D. Volkow & A. Thomas McLellan. (2016) Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies. New England Journal of Medicine 374:13, pages 1253-1263.
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Xiaoming Xu, Abhay Gupta, Manar Al-Ghabeish, Silvia N. Calderon & Mansoor A. Khan. (2016) Risk based in vitro performance assessment of extended release abuse deterrent formulations. International Journal of Pharmaceutics 500:1-2, pages 255-267.
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Nathaniel Katz, Ernest A. Kopecky, Melinda O'Connor, Robert H. Brown & Alison B. Fleming. (2015) A phase 3, multicenter, randomized, double-blind, placebo-controlled, safety, tolerability, and efficacy study of Xtampza ER in patients with moderate-to-severe chronic low back pain. Pain 156:12, pages 2458-2467.
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Kaoru Toyama, Naoki Uchida, Hitoshi Ishizuka, Takehiko Sambe & Shinichi Kobayashi. (2015) Single-dose evaluation of safety, tolerability and pharmacokinetics of newly formulated hydromorphone immediate-release and hydrophilic matrix extended-release tablets in healthy Japanese subjects without co-administration of an opioid antagonist. The Journal of Clinical Pharmacology 55:9, pages 975-984.
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Aljoscha Janssen & Xuan Zhang. (2020) Retail Pharmacies and Drug Diversion during the Opioid Epidemic. SSRN Electronic Journal.
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