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Expert Opinion on Pharmacotherapy Volume 16, 2015 - Issue 5
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Editorial

Does testosterone supplementation increase PDE5-inhibitor responses in difficult-to-treat erectile dysfunction patients?

Antonio AversaDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section,“Sapienza” University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy+39 06 49970721; +39 06 4461450; [email protected]
, MD PhD,
Davide FrancomanoDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section,“Sapienza” University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy+39 06 49970721; +39 06 4461450; [email protected]
&
Andrea LenziDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section,“Sapienza” University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy+39 06 49970721; +39 06 4461450; [email protected]
Pages 625-628 | Published online: 03 Feb 2015

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Mattia Longoni, Alessandro Bertini, Nicolò Schifano, Emanuele Zaffuto, Paolo Maggio, Rossi Piercarlo, Sara Baldini, Giulio Carcano, Gabriele Antonini, Andrea Salonia, Francesco Montorsi, Federico Dehò & Paolo Capogrosso. (2023) A review on pharmacological options for the treatment of erectile dysfunction: state of the art and new strategies. Expert Opinion on Pharmacotherapy 24:12, pages 1375-1386.
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Rosita A. Condorelli, Aldo E. Calogero, Maurizio Di Mauro, Laura M. Mongioì, Giorgio I. Russo, Giuseppe Morgia & Sandro La Vignera. (2016) Effects of tadalafil treatment combined with physical activity in patients with low onset hypogonadism: results from a not-randomized single arm phase 2 study. The Aging Male 19:3, pages 155-160.
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Articles from other publishers (31)

Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella & Antonio Aversa. (2023) Sexual and Reproductive Outcomes in Obese Fertile Men with Functional Hypogonadism after Treatment with Liraglutide: Preliminary Results. Journal of Clinical Medicine 12:2, pages 672.
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Ria Margiana, Muhammad Fadhli Abdullah, Cennikon Pakpahan, Reny I'tishom, Supardi Supardi, Huriyah Adani Saoemi & Nguyen Hoai Bac. (2023) Analyzing the Current Umbilical Cord-derived Mesenchymal Stem Cell Secretome Evidence for Erectile Dysfunction Management. Biomolecular and Health Science Journal 6:2, pages 141-146.
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Giovanni Corona, Giulia Rastrelli, Simona Ferri, Alessandra Sforza & Mario Maggi. 2023. Testosterone. Testosterone 349 362 .
Linda My Huynh, Rafael GevorkyanThomas E. Ahlering. (2022) The Role of Post-Radical Prostatectomy Testosterone Therapy in Erectile Function Recovery. Androgens: Clinical Research and Therapeutics 3:1, pages 138-148.
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Farnoosh Nik-Ahd & Alan W. Shindel. (2022) Pharmacotherapy for Erectile Dysfunction in 2021 and Beyond. Urologic Clinics of North America 49:2, pages 209-217.
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Pablo Garrido-Abad, Isabel Senra-Bravo, Celeste Manfredi, Esaú Fernández-Pascual, Estefanía Linares-Espinós, Manuel Fernández-Arjona, David Varillas-Delgado & Juan Ignacio Martínez-Salamanca. (2021) Combination therapy with topical alprostadil and phosphodiesterase-5 inhibitors after failure of oral therapy in patients with erectile dysfunction: a prospective, two-arm, open-label, non-randomized study. International Journal of Impotence Research 34:2, pages 164-171.
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Giuseppe Defeudis, Rossella Mazzilli, Marta Tenuta, Giovanni Rossini, Virginia Zamponi, Soraya Olana, Antongiulio Faggiano, Paolo Pozzilli, Andrea M. Isidori & Daniele Gianfrilli. (2021) Erectile dysfunction and diabetes: A melting pot of circumstances and treatments. Diabetes/Metabolism Research and Reviews 38:2.
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Angelo Cignarelli, Valentina Annamaria Genchi, Rossella D’Oria, Fiorella Giordano, Irene Caruso, Sebastio Perrini, Annalisa Natalicchio, Luigi Laviola & Francesco Giorgino. (2021) Role of Glucose-Lowering Medications in Erectile Dysfunction. Journal of Clinical Medicine 10:11, pages 2501.
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Andrea M. Isidori, Elisa Giannetta, Riccardo Pofi, Mary A. Venneri, Daniele Gianfrilli, Federica Campolo, Claudio M. Mastroianni, Andrea Lenzi & Gabriella d’Ettorre. (2020) Targeting the NO‐cGMP‐PDE5 pathway in COVID‐19 infection. The DEDALO project. Andrology 9:1, pages 33-38.
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Ruocong Yang, Chao Liu, Qianqian Li, Weilu Wang, Bingbing Wu, Aiping Chen, Bin Wang, Wei Li & Jianxin Chen. (2021) Artificial intelligence based identification of the functional role of hirudin in diabetic erectile dysfunction treatment. Pharmacological Research 163, pages 105244.
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Zhonglin Cai, Xiaoqing Song, Jianzhong Zhang, Bin Yang & Hongjun Li. (2020) Practical Approaches to Treat ED in PDE5i Nonresponders. Aging and disease 11:5, pages 1202.
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Ylenia Duca, Aldo E. Calogero, Rossella Cannarella, Filippo Giacone, Laura M. Mongioi, Rosita A. Condorelli & Sandro La Vignera. (2019) Erectile dysfunction, physical activity and physical exercise: Recommendations for clinical practice. Andrologia 51:5, pages e13264.
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Erik Wibowo, Richard J. Wassersug, John W. Robinson, Andrew Matthew, Deborah McLeod & Lauren M. Walker. (2019) How Are Patients With Prostate Cancer Managing Androgen Deprivation Therapy Side Effects?. Clinical Genitourinary Cancer 17:3, pages e408-e419.
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Antonio Aversa, Ylenia Duca, Rosita Angela Condorelli, Aldo Eugenio Calogero & Sandro La Vignera. (2019) Androgen Deficiency and Phosphodiesterase Type 5 Expression Changes in Aging Male: Therapeutic Implications. Frontiers in Endocrinology 10.
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Xu Li, Jun Jiang, Jiyi Xia & Rui Jiang. (2019) Effect of low androgen levels on the sulphur dioxide signalling pathway in rat penile corpus cavernosum. Andrologia 51:1, pages e13167.
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Jie Jin, Hui Wang, Xiaoying Hua, Dongjian Chen, Chao Huang & Zhuo Chen. (2019) An outline for the pharmacological effect of icariin in the nervous system. European Journal of Pharmacology 842, pages 20-32.
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Shiao-Jin Guu, Jiun-Hung Geng, I-Ting Chao, Hui-Tzu Lin, Yung-Chin Lee, Yung-Shun Juan, Chia-Chu Liu, Chii-Jye Wang & Chia-Chun Tsai. (2017) Efficacy of Low-Intensity Extracorporeal Shock Wave Therapy on Men With Chronic Pelvic Pain Syndrome Refractory to 3-As Therapy. American Journal of Men's Health 12:2, pages 441-452.
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Mary Lee & Roohollah Sharifi. (2018) Non-invasive Management Options for Erectile Dysfunction When a Phosphodiesterase Type 5 Inhibitor Fails. Drugs & Aging 35:3, pages 175-187.
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M.H. Colson, B. Cuzin, A. Faix, L. Grellet & E. Huyghes. (2018) Les traitements oraux de la dysfonction érectile aujourd’hui, pour quel patient ?. Sexologies 27:1, pages 37-46.
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Alessandro Ilacqua, Davide Francomano & Antonio Aversa. 2018. Principles of Endocrinology and Hormone Action. Principles of Endocrinology and Hormone Action 455 491 .
Ivan I. Dedov, Galina A. Mel'nichenko, Marina V. Shestakova, Roman V. Rozhivanov, Anna L. Terehova, Alexey V. Zilov, Daria O. Ladygina & Dmitriy G. Kurbatov. (2017) Guidelines for the Diagnosis and Treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus. Obesity and metabolism 14:4, pages 83-92.
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Chia-Chun Tsai, Chii-Jye Wang, Yung-Chin Lee, Yen-Ting Kuo, Hsiao-Hua Lin, Ching-Chia Li, Wen-Jeng Wu & Chia-Chu Liu. (2017) Low-Intensity Extracorporeal Shockwave Therapy Can Improve Erectile Function in Patients Who Failed to Respond to Phosphodiesterase Type 5 Inhibitors. American Journal of Men's Health 11:6, pages 1781-1790.
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Vincenzo Mirone, Frans Debruyne, Gert Dohle, Andrea Salonia, Nikolaos Sofikitis, Paolo Verze, Mikkel Fode & Christopher Chapple. (2017) European Association of Urology Position Statement on the Role of the Urologist in the Management of Male Hypogonadism and Testosterone Therapy. European Urology 72:2, pages 164-167.
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Galina Afanas'evna Melnichenko, Marina Vladimirovna Shestakova, Roman Viktorovich Rozhivanov, Anna Leont'evna Terehova, Alexey Vadimovich Zilov, Daria Olegovna Ladygina & Dmitriy Gennad'evich Kurbatov. (2017) Guidelines for the diagnosis and treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus (Draft). Diabetes mellitus 20:2, pages 151-160.
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Giovanni Corona, Giulia Rastrelli, Simona Ferri, Alessandra Sforza & Mario Maggi. 2017. Testosterone. Testosterone 271 284 .
Ângela Castela & Carla Costa. (2016) Molecular mechanisms associated with diabetic endothelial–erectile dysfunction. Nature Reviews Urology 13:5, pages 266-274.
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Yigit O. Tiftikcioglu, Cagil M. Erenoglu, William C. Lineaweaver & Feng Zhang. (2016) Perioperative management of penile transplantation. Microsurgery 36:4, pages 271-275.
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Antonio Aversa, Mariano Galdiero, Laura Cucinella & Rossella E. Nappi. (2016) La sessualità nell’anziano. L'Endocrinologo 17:2, pages 97-106.
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Giacomo Ciocca, Erika Limoncin, Eleonora Carosa, Stefania Di Sante, Giovanni L. Gravina, Daniele Mollaioli, Daniele Gianfrilli, Andrea Lenzi & Emmanuele A. Jannini. (2016) Is Testosterone a Food for the Brain?. Sexual Medicine Reviews 4:1, pages 15-25.
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Alessandro Ilacqua, Davide Francomano & Antonio Aversa. 2016. Principles of Endocrinology and Hormone Action. Principles of Endocrinology and Hormone Action 1 38 .
Giuseppe Defeudis, Daniele Gianfrilli, Chiara Di Emidio, Riccardo Pofi, Dario Tuccinardi, Andrea Palermo, Andrea Lenzi & Paolo Pozzilli. (2015) Erectile dysfunction and its management in patients with diabetes mellitus. Reviews in Endocrine and Metabolic Disorders 16:3, pages 213-231.
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