1,082
Views
72
CrossRef citations to date
0
Altmetric
Drug Evaluation

Apatinib for the treatment of gastric cancer

, MD & , MD PhD (Professor and Dean)

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Shao-Liang Jiang, Li Li, Song-Bo Kou, Lu Hu & Jie-Hua Shi. (2023) Insight into intermolecular binding mechanism of apatinib mesylate and human alpha-1-acid glycoprotein: combined multi-spectroscopic approaches with in silico. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
Read now
Xiaomin Cai, Bin Wei, Lele Li, Xiaofeng Chen, Jing Yang, Xiaofei Li, Xiaozheng Jiang, Mu Lv, Mingyang Li, Yumeng Lin, Qiang Xu, Wenjie Guo & Yanhong Gu. (2020) Therapeutic Potential of Apatinib Against Colorectal Cancer by Inhibiting VEGFR2-Mediated Angiogenesis and β-Catenin Signaling. OncoTargets and Therapy 13, pages 11031-11044.
Read now
Yun-Ting Zhu, Zan Teng, Yi-Fan Zhang, Wei Li, Li-Xia Guo, Yun-Peng Liu, Xiu-Juan Qu, Quan-Ren Wang, Si-Yuan Mao, Xiao-Yan Chen & Da-Fang Zhong. (2020) Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors. Drug Design, Development and Therapy 14, pages 1963-1970.
Read now
Xiaoqing Zhang, Xiaomei Ren, Jiayin Tang, Jiangtao Wang, Xiang Zhang, Peng He, Chang Yao, Weihe Bian & Lizhu Sun. (2020) Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance. Drug Delivery 27:1, pages 825-835.
Read now
Zhandong Zhang, Wei Yang, Fei Ma, Qi Ma, Bin Zhang, Yonglei Zhang, Yingqiang Liu, Hongxing Liu & Yawei Hua. (2020) Enhancing the chemotherapy effect of Apatinib on gastric cancer by co-treating with salidroside to reprogram the tumor hypoxia micro-environment and induce cell apoptosis. Drug Delivery 27:1, pages 691-702.
Read now
Meng Su, Ya Gao, XuXue Ye, QingYu Zhou, LiHao Zhao, Xiaona Cai, Didi Chen, Huafang Su, Xiaohua Zhang & Congying Xie. (2019) Clinical Value Of Apatinib As A Salvage Treatment In Patients With Chemo-Refractory Advanced Cervical Cancer. OncoTargets and Therapy 12, pages 9707-9713.
Read now
Di Zhang, Jiaqi Huang, Yulan Sun & Qisen Guo. (2019) Long-term progression-free survival of apatinib monotherapy for relapsed ovarian cancer: a case report and literature review. OncoTargets and Therapy 12, pages 3635-3644.
Read now
Dongdong Yu, Guang Han, Huali Liu, Likun Gao & Vivek Verma. (2019) Treatment of adult brainstem glioma with combined antiangiogenic therapy: a case report and literature review. OncoTargets and Therapy 12, pages 1333-1339.
Read now
Deze Zhao, Helei Hou & Xiaochun Zhang. (2018) Progress in the treatment of solid tumors with apatinib: a systematic review. OncoTargets and Therapy 11, pages 4137-4147.
Read now
Xiaofen Li, Xia Li, Xuefeng Fang & Ying Yuan. (2018) Long-term progression-free survival of third-line apatinib in lung squamous cell carcinoma. OncoTargets and Therapy 11, pages 4047-4050.
Read now
Minghong Bi, Jingru Yang, Yaping Wang, Haoran Zhang, Zhenyuan Gao, Hairong Zhou & Mohan Shi. (2018) Successful treatment of metastatic colorectal cancer with apatinib: report of two cases and literature review. OncoTargets and Therapy 11, pages 883-890.
Read now
Haijun Zhang. (2015) Apatinib for molecular targeted therapy in tumor. Drug Design, Development and Therapy 9, pages 6075-6081.
Read now

Articles from other publishers (60)

Su-su Bao, Peng-fei Tang, Nan-yong Gao, Zhong-xiang Xiao, Jian-chang Qian, Long Zheng, Guo-xin Hu & Huan-hai Xu. (2023) Effect of apatinib on the pharmacokinetics of tramadol and O-desmethyltramadol in rats. PeerJ 11, pages e16051.
Crossref
Huanle Pan, Xiaobo Zhou, Lanxiao Shen, Yida Li, Wenjun Dong, Saijun Wang, Yuyue Zhang, Wenkai Pan, Congying Xie & Xiaona Cai. (2023) Efficacy of apatinib+radiotherapy vs radiotherapy alone in patients with advanced multiline therapy failure for non small cell lung cancer with brain metastasis . The British Journal of Radiology 96:1149.
Crossref
Rui Liu & Lijun Liu. (2023) Use of Apatinib as a Bait to Fish its Unexpected Kinase Targets from the Hepatocellular Carcinoma Druggable Kinome. Journal of Computational Biophysics and Chemistry 22:04, pages 439-451.
Crossref
Yi Jin & Daqing Jiang. (2023) GATA6-AS1 via Sponging miR-543 to Regulate PTEN/AKT Signaling Axis Suppresses Cell Proliferation and Migration in Gastric Cancer. Mediators of Inflammation 2023, pages 1-19.
Crossref
Longbo Yu, Yuanyuan Wang, Yingxue He, Haiqing Zhong, Shushan Ge, Yi Zou, Yisheng Lai, Qiang Xu, Jian Gao, Wen Liu & Wenjie Guo. (2022) Combination of apatinib with apo-IDO1 inhibitor for the treatment of colorectal cancer. International Immunopharmacology 112, pages 109233.
Crossref
Qi Feng, Donglai Wang, Peng Guo, Zibo Zhang & Jiangang Feng. (2022) Apatinib Functioned as Tumor Suppressor of Synovial Sarcoma through Regulating miR-34a-5p/HOXA13 Axis. Computational and Mathematical Methods in Medicine 2022, pages 1-15.
Crossref
Shi-Qi Dong, Fan Yang, Dong-Xu Zhang, Ling-Mei Wang, Jian-Feng Liu, Ai-Jie Zhang & Hui-Rong Fan. (2022) Effect of X-ray radiation on the pharmacokinetics of apatinib in vivo in rats. Frontiers in Pharmacology 13.
Crossref
Shumin Yuan, Qiang Fu, Lingdi Zhao, Xiaomin Fu, Tiepeng Li, Lu Han, Peng Qin, Yingkun Ren, Mingke Huo, Zhimeng Li, Chaomin Lu, Long Yuan, Quanli Gao & Zibing Wang. (2022) Efficacy and Safety of Apatinib in Patients with Recurrent or Refractory Melanoma. The Oncologist 27:6, pages e463-e470.
Crossref
Fei Teng, Puyuan Xing, Ke Yang, Lizhen Gao, Zhongqiu Tian & Junling Li. (2022) Apatinib as maintenance therapy following standard first‐line chemotherapy in extensive disease small cell lung cancer: A phase II single‐arm trial . Thoracic Cancer 13:4, pages 557-562.
Crossref
Poupak Fallahi, Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Armando Patrizio, Sabrina Rosaria Paparo, Gianni Marone, Maria Rosaria Galdiero, Giovanni Guglielmi, Rudy Foddis, Alfonso Cristaudo & Alessandro Antonelli. (2022) Primary cell cultures for the personalized therapy in aggressive thyroid cancer of follicular origin. Seminars in Cancer Biology 79, pages 203-216.
Crossref
Chengfei Xu, Ziling Liu & Jiangwei Xiao. (2021) Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease. International Journal of Molecular Sciences 22:22, pages 12403.
Crossref
Zhe Li, Zhibao Liu, Yuanyuan Wu, Huarui Li, Zhen Sun, Chenggang Han, Xiaoling Zhang & Jinghua Zhang. (2021) Efficacy and safety of apatinib alone or apatinib plus paclitaxel/docetaxel versus paclitaxel/docetaxel in the treatment of advanced non‐small cell lung cancer: A meta‐analysis. Thoracic Cancer 12:21, pages 2838-2848.
Crossref
Hui Yao, Jiangang Liu, Chi Zhang, Yunxiang Shao, Xuetao Li, Zhengquan Yu & Yulun Huang. (2021) Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis. Cell Death & Disease 12:10.
Crossref
Zhichao Tian, Xiaohui Niu & Weitao Yao. (2021) Efficacy and Response Biomarkers of Apatinib in the Treatment of Malignancies in China: A Review. Frontiers in Oncology 11.
Crossref
Yi Chen, Nan Chen, Jin Xu, Xindong Wang, Xiaowei Wei, Cuiju Tang, Zhong Duanmu & Junfeng Shi. (2021) Apatinib inhibits the proliferation of gastric cancer cells via the AKT/GSK signaling pathway in vivo. Aging 13:16, pages 20738-20747.
Crossref
Jinglin Gao, Zhangying Feng, Huan Ren, Mengdi Yu, Haidong Wang & Mingxia Wang. (2021) A Rapid and Selective UPLC-MS/MS Assay for Accurate Analysis of Apatinib in Rat Plasma and its Application to a Pharmacokinetic Study. Current Pharmaceutical Analysis 17:5, pages 594-602.
Crossref
Kang Cheng, Chen-Fu Liu & Guo-Wu Rao. (2021) Anti-angiogenic Agents: A Review on Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors. Current Medicinal Chemistry 28:13, pages 2540-2564.
Crossref
Man-Ping Huang, Shan-Zhi Gu, Bin Huang, Guo-Wen Li, Zheng-Ping Xiong, Tian Tang & Sai-Nan Zeng. (2021) Apatinib Inhibits Angiogenesis in Intrahepatic Cholangiocarcinoma by Regulating the Vascular Endothelial Growth Factor Receptor-2/Signal Transducer and Activator of Transcription Factor 3/Hypoxia Inducible Factor 1 Subunit Alpha Signaling Axis. Pharmacology 106:9-10, pages 509-519.
Crossref
Wenchao Shao, Xiaoguang Li, Jiangtong Peng, Siyuan Fan, Minglu Liang & Kai Huang. (2020) Apatinib attenuates phenotypic switching of arterial smooth muscle cells in vascular remodelling by targeting the PDGF Receptor‐β. Journal of Cellular and Molecular Medicine 24:17, pages 10128-10139.
Crossref
Sheng-Quan Fang, Jian Huang, Feng Zhang, Hong-Mei Ni, Qi-Long Chen, Jun-Ran Zhu, Zhi-Chao Fu, Liang Zhu, Wei-Wei Hao & Guang-Bo Ge. (2020) Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo . Journal of Pharmacy and Pharmacology 72:7, pages 979-989.
Crossref
Zhi C. Tian, Jia Q. Wang & Hong Ge. (2020) Apatinib ameliorates doxorubicin-induced migration and cancer stemness of osteosarcoma cells by inhibiting Sox2 via STAT3 signalling. Journal of Orthopaedic Translation 22, pages 132-141.
Crossref
Jing Qi, Sheng Liu, Weihang Liu, Gaoqiang Cai & Guoqing Liao. (2020) Identification of UAP1L1 as tumor promotor in gastric cancer through regulation of CDK6. Aging 12:8, pages 6904-6927.
Crossref
Chaofeng Li, Tao Tang & Wenyue Wang. (2020) Combination Use of Tegafur and Apatinib as First-Line Therapy in Treatment of Advanced Gastric Cancer: A Single-Blinded Randomized Study. Gastroenterology Research and Practice 2020, pages 1-6.
Crossref
Yanxiong Gan, Xue Zhang, Dengqiu Xu, Hongjuan Zhang, Jan P. Baak, Lin Luo, Yulong Xia, Jie Wang, Xue Ke & Piaoyang Sun. (2020) Evaluating supersaturation in vitro and predicting its performance in vivo with Biphasic gastrointestinal Simulator: A case study of a BCS IIB drug. International Journal of Pharmaceutics 578, pages 119043.
Crossref
Zongru Jiang, Li Wang, Xuesong Liu, Cheng Chen, Beilei Wang, Wenliang Wang, Chen Hu, Kailin Yu, Ziping Qi, Qingwang Liu, Aoli Wang, Jing Liu, Guangchen Hong, Wenchao Wang & Qingsong Liu. (2020) Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent. Acta Pharmaceutica Sinica B 10:3, pages 488-497.
Crossref
Hongxia Yan, Xiaolu Li, Yi Peng, Pingping Zhang, Ning Zou & Xiyou Liu. (2020) Apatinib and fractionated stereotactic radiotherapy for the treatment of limited brain metastases from primary lung mucoepidermoid carcinoma. Medicine 99:43, pages e22925.
Crossref
Julie H. Selim, Shagufta Shaheen, Wei-Chun Sheu & Chung-Tsen Hsueh. (2019) Targeted and novel therapy in advanced gastric cancer. Experimental Hematology & Oncology 8:1.
Crossref
Jieshan Guan, Zhijie Luo, Zhiwei Xiao, Yubin Xie & Lizhu Lin. (2019) Treatment of consistent BRAF/HRAS gene mutation and MYC amplification radiation-induced abdominal wall angiosarcoma with low-dose apatinib: a case report. BMC Cancer 19:1.
Crossref
Shaoxing Guan, Wei Shi, Zerui Zhao, Fei Wang, Fulin Jiang, Caibin Zhang, Zhongming Jin, Yanping Guan, Dihan Liu, GuoPing Zhong, Min Huang, Hao Long & Xueding Wang. (2019) Determination of apatinib and its three active metabolites by UPLC–MS/MS in a Phase IV clinical trial in NSCLC patients. Bioanalysis 11:22, pages 2049-2060.
Crossref
Xian Wu & Shucheng Huang. (2019) HER2-specific chimeric antigen receptor-engineered natural killer cells combined with apatinib for the treatment of gastric cancer. Bulletin du Cancer 106:11, pages 946-958.
Crossref
Lihua Chen, Xi Cheng, Wenzhi Tu, Zihao Qi, Haoran Li, Fei Liu, Yufei Yang, Zhe Zhang & Ziliang Wang. (2019) Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells. Cellular Oncology 42:5, pages 679-690.
Crossref
Ran Chen, Qi‑Tian Chen & You‑Hong Dong. (2019) Clinical efficacy of apatinib in treating metastatic gastric cancer and its effect on IL‑17. Oncology Letters.
Crossref
Shan Wu, Jianjun Zhou, Jing Guo, Zhan Hua, Jianchen Li & Zai Wang. (2019) Apatinib inhibits tumor growth and angiogenesis in PNET models. Endocrine Connections, pages 8-19.
Crossref
Yuan-Peng Wu, Ji-Jin Wu, Shu-Mei Tian, Tao Jin, Chan Li & Ke Xie. (2019) Apatinib with EGFR-TKIs in advanced wild gene-type NSCLC. Medicine 98:1, pages e13924.
Crossref
Su-su Bao, Jian Wen, Qian-meng Lin, Ying-hui Li, Yang-ge Huang, Hong-yu Zhou & Guo-xin Hu. (2018) Evaluation of the Effects of Apatinib on the Pharmacokinetics of Venlafaxine and O-desmethylvenlafaxine in SD Male Rats by UPLC-MS/MS. Basic & Clinical Pharmacology & Toxicology 123:6, pages 721-726.
Crossref
Mai Adel, Rabah A.T. Serya, Deena S. Lasheen & Khaled A.M. Abouzid. (2018) Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling. Bioorganic Chemistry 81, pages 612-629.
Crossref
Zong-Jun-Lin Liu, Yu-Juan Zhou, Rui-Lin Ding, Fang Xie, Shao-Zhi Fu, Jing-Bo Wu, Ling-Lin Yang & Qing-Lian Wen. (2018) In vitro and in vivo apatinib inhibits vasculogenic mimicry in melanoma MUM-2B cells. PLOS ONE 13:7, pages e0200845.
Crossref
Muhammad Abbas, Alessia Faggian, Dahiru Nasiru Sintali, Ghulam Jilany Khan, Shagufta Naeem, Meiqi Shi & Chen Dingding. (2018) Current and future biomarkers in gastric cancer. Biomedicine & Pharmacotherapy 103, pages 1688-1700.
Crossref
Xiaojin Li, Anjian Xu, Huihui Li, Bei Zhang, Bangwei Cao & Jian Huang. (2018) Novel role of apatinib as a multi-target RTK inhibitor in the direct suppression of hepatocellular carcinoma cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:5, pages 1693-1701.
Crossref
Lesley J. Scott. (2018) Apatinib: A Review in Advanced Gastric Cancer and Other Advanced Cancers. Drugs 78:7, pages 747-758.
Crossref
Magdalena Cisło, Agata Anna Filip, George Johan Arnold Offerhaus, Bogumiła Ciseł, Karol Rawicz-Pruszyński, Małgorzata Skierucha & Wojciech Piotr Polkowski. (2018) Distinct molecular subtypes of gastric cancer: from Laurén to molecular pathology. Oncotarget 9:27, pages 19427-19442.
Crossref
Hua Zhang, Yumei Cao, Yuru Chen, Guangxi Li & Hanshu Yu. (2018) Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway. Oncology Letters.
Crossref
L. V. K. S. Bhaskar & L. Saikrishna. 2018. Role of Tyrosine Kinases in Gastrointestinal Malignancies. Role of Tyrosine Kinases in Gastrointestinal Malignancies 191 224 .
Hanguang Ruan, Junlin Dong, Xueliang Zhou, Juan Xiong, Hua Wang, Xiaoming Zhong & Xiaolong Cao. (2017) Multicenter phase II study of apatinib treatment for metastatic gastric cancer after failure of second-line chemotherapy. Oncotarget 8:61, pages 104552-104559.
Crossref
Mingzi Zhang, Zhongkai Tian & Yehong Sun. (2017) Successful treatment of ovarian cancer with apatinib combined with chemotherapy. Medicine 96:45, pages e8570.
Crossref
Youmao Tao, Songbai Yang, Yuanyu Wu, Xuedong Fang, Yannan Wang, Yan Song & Tao Han. (2017) MicroRNA-216a inhibits the metastasis of gastric cancer cells by targeting JAK2/STAT3-mediated EMT process. Oncotarget 8:51, pages 88870-88881.
Crossref
Daniela Lazar, Sorina Taban, Marioara Cornianu, Alexandra Faur, Ioan Romosan & Adrian Goldis. 2017. Gastric Cancer. Gastric Cancer.
Ying Lin, Zheng Wu, Jian Zhang, Xichun Hu, Zhonghua Wang, Biyun Wang, Jun Cao & Leiping Wang. (2017) Apatinib for metastatic breast cancer in non-clinical trial setting: Satisfying efficacy regardless of previous anti-angiogenic treatment. Tumor Biology 39:6, pages 101042831771103.
Crossref
Ming Zhang, Weiye Deng, Xiaoci Cao, Xiaoming Shi, Huanfen Zhao, Zheping Duan, Bonan Lv & Bin Liu. (2017) Concurrent apatinib and local radiation therapy for advanced gastric cancer. Medicine 96:9, pages e6241.
Crossref
Yongrui Bai, Yuejuan Xu & Bin Wu. (2017) Cost-Effectiveness and Budget Impact Analysis of Apatinib for Advanced Metastatic Gastric Cancer from the Perspective of Health Insurance System. Gastroenterology Research and Practice 2017, pages 1-7.
Crossref
Mingming Yu, Zhiwei Gao, Xiaojian Dai, Hui Gong, Lianshan Zhang, Xiaoyan Chen, Da-Fang Zhong & Sherwin K. B. Sy. (2016) Population Pharmacokinetic and Covariate Analysis of Apatinib, an Oral Tyrosine Kinase Inhibitor, in Healthy Volunteers and Patients with Solid Tumors. Clinical Pharmacokinetics 56:1, pages 65-76.
Crossref
Chen Lin, Shanshan Wang, Weiwei Xie, Rongliang Zheng, Yu Gan & Jianhua Chang. (2016) Apatinib inhibits cellular invasion and migration by fusion kinase KIF5B-RET via suppressing RET/Src signaling pathway. Oncotarget 7:37, pages 59236-59244.
Crossref
Xue-Ru Zhu, Mei-Ling Zhu, Qing Wang, Wen-Ji Xue, Yi-Wei Wang, Rui-Fen Wang, Si-Yu Chen & Lei-Zhen Zheng. (2016) A case report of targeted therapy with apatinib in a patient with advanced gastric cancer and high serum level of alpha-fetoprotein. Medicine 95:37, pages e4610.
Crossref
Wenyan Wang, Hui Wang, Yingying Ni, Zhenming Yao, Liang Ye & Jingwei Tian. (2016) DCT015, a new sorafenib derivate, inhibits tumor growth and angiogenesis in gastric cancer models. Tumor Biology 37:7, pages 9221-9232.
Crossref
Hao Huang, Yong Han, Cheng Zhang, Jian Wu, Junnan Feng, Like Qu & Chengchao Shou. (2015) HNRNPC as a candidate biomarker for chemoresistance in gastric cancer. Tumor Biology 37:3, pages 3527-3534.
Crossref
Daniela Cornelia Lazăr, Sorina Tăban, Marioara Cornianu, Alexandra Faur & Adrian Goldiş. (2016) New advances in targeted gastric cancer treatment. World Journal of Gastroenterology 22:30, pages 6776.
Crossref
Suk-young Lee. (2016) Changing strategies for target therapy in gastric cancer. World Journal of Gastroenterology 22:3, pages 1179.
Crossref
Kaichun Li & Jin Li. (2016) Current Molecular Targeted Therapy in Advanced Gastric Cancer: A Comprehensive Review of Therapeutic Mechanism, Clinical Trials, and Practical Application. Gastroenterology Research and Practice 2016, pages 1-9.
Crossref
Suneet Shukla, Atish Patel & Suresh V. Ambudkar. 2016. ABC Transporters - 40 Years on. ABC Transporters - 40 Years on 227 272 .
Xiao-Fen Li, Yi-Nuo Tan, Ying Cao, Jing-Hong Xu, Shu Zheng & Ying Yuan. (2015) A Case Report of Gastrointestinal Hemorrhage and Perforation During Apatinib Treatment of Gastric Cancer. Medicine 94:39, pages e1661.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.