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Expert Opinion on Pharmacotherapy Volume 16, 2015 - Issue 3
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Drug Evaluation

Naloxegol, a new drug for the treatment of opioid-induced constipation

Maura CorsettiTranslational Research Center for Gastrointestinal disorders (TARGID), Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium
, MD PhD &
Jan TackUniversity of Leuven, TARGID, Department of Pathophysiology, Herestraat 49, 0&N 1, bus 701, B-3000 Leuven, Belgium+32 16344225; +32 16344419; [email protected]
, MD PhD
Pages 399-406 | Published online: 13 Dec 2014

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Shilan Mozaffari, Shekoufeh Nikfar & Mohammad Abdollahi. (2018) Investigational opioid antagonists for treating opioid-induced bowel dysfunction. Expert Opinion on Investigational Drugs 27:3, pages 235-242.
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Blanca Serrano-Falcón & Enrique Rey. (2017) The safety of available treatments for chronic constipation. Expert Opinion on Drug Safety 16:11, pages 1243-1253.
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Amir Rumman, Zane R. Gallinger & Louis W. C. Liu. (2016) Opioid induced constipation in cancer patients: pathophysiology, diagnosis and treatment. Expert Review of Quality of Life in Cancer Care 1:1, pages 25-35.
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Articles from other publishers (20)

Siva Rama Kasibabu Velugula, Nimesh Chandra Misra, Suresh Chapala, Sunil Kumar Reddy Aaramadaka, Ramadas Chavakula & Paul Douglas Sanasi. (2023) Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist. ACS Omega.
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Efterpi Bouroutzika, Stavros Proikakis, Athanasios K. Anagnostopoulos, Angeliki I. Katsafadou, George C. Fthenakis & George Th. Tsangaris. (2021) Proteomics Analysis in Dairy Products: Cheese, a Review. Applied Sciences 11:16, pages 7622.
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Hideki Mori, Jan Tack & Hidekazu Suzuki. (2021) Magnesium Oxide in Constipation. Nutrients 13:2, pages 421.
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Laura Micheli, Lorenzo Di Cesare Mannelli, Elena Lucarini, Carmen Parisio, Alessandra Toti, Bruno Fiorentino, Maria Adele Rigamonti, Laura Calosi & Carla Ghelardini. (2020) Intranasal Low-Dose Naltrexone Against Opioid Side Effects: A Preclinical Study. Frontiers in Pharmacology 11.
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Gian Tenore, Ester Pagano, Stefania Lama, Daniela Vanacore, Salvatore Di Maro, Maria Maisto, Raffaele Capasso, Francesco Merlino, Francesca Borrelli, Paola Stiuso & Ettore Novellino. (2019) Intestinal Anti-Inflammatory Effect of a Peptide Derived from Gastrointestinal Digestion of Buffalo (Bubalus bubalis) Mozzarella Cheese. Nutrients 11:3, pages 610.
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Maura Corsetti, Jasper Pannemans & Peter Whorwell. (2019) Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?. F1000Research 8, pages 257.
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J Pannemans & M Corsetti. (2018) Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?. Current Opinion in Pharmacology 43, pages 53-58.
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Joseph S. Redman, J. Nicholas Francis, Robert Marquardt, Damon Papac, Alan L. Mueller, Debra M. Eckert, Brett D. Welch & Michael S. Kay. (2018) Pharmacokinetic and Chemical Synthesis Optimization of a Potent d -Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery . Molecular Pharmaceutics 15:3, pages 1169-1179.
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Hong Yang & Tonghui Ma. (2017) Luminally Acting Agents for Constipation Treatment: A Review Based on Literatures and Patents. Frontiers in Pharmacology 8.
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Robert S. Bresalier, H. Franklin Herlong & Boris Blechacz. 2016. Holland-Frei Cancer Medicine. Holland-Frei Cancer Medicine 1 16 .
Ester Pagano, Raffaele Capasso, Fabiana Piscitelli, Barbara Romano, Olga A. Parisi, Stefania Finizio, Anna Lauritano, Vincenzo Di Marzo, Angelo A. Izzo & Francesca Borrelli. (2016) An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse. Frontiers in Pharmacology 7.
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Satish S. C. Rao, Kulthep Rattanakovit & Tanisa Patcharatrakul. (2016) Diagnosis and management of chronic constipation in adults. Nature Reviews Gastroenterology & Hepatology 13:5, pages 295-305.
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Andrew C. Flick, Hong X. Ding, Carolyn A. Leverett, Robert E. KyneJr.Jr., Kevin K.-C. Liu, Sarah J. Fink & Christopher J. O’Donnell. (2016) Synthetic approaches to the 2014 new drugs. Bioorganic & Medicinal Chemistry 24:9, pages 1937-1980.
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Paula Mosińska, Marta Zielińska & Jakub Fichna. (2016) Expression and physiology of opioid receptors in the gastrointestinal tract. Current Opinion in Endocrinology, Diabetes & Obesity 23:1, pages 3-10.
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Anupam Aich, Pankaj Gupta & Kalpna Gupta. (2016) Could Perioperative Opioid Use Increase the Risk of Cancer Progression and Metastases?. International Anesthesiology Clinics 54:4, pages e1-e16.
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. (2015) ▼Naloxegol for opioid-induced constipation. Drug and Therapeutics Bulletin 53:12, pages 138-140.
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Mellar Davis & Pamela Gamier. (2015) New Options in Constipation Management. Current Oncology Reports 17:12.
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Hani Sbahi & Brooks D. Cash. (2015) Chronic Constipation: a Review of Current Literature. Current Gastroenterology Reports 17:12.
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Jakob Lykke Poulsen, Christina Brock, Anne Estrup Olesen, Matias Nilsson & Asbjørn Mohr Drewes. (2015) Evolving paradigms in the treatment of opioid-induced bowel dysfunction. Therapeutic Advances in Gastroenterology 8:6, pages 360-372.
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Lynn R. Webster. (2015) Opioid-Induced Constipation. Pain Medicine 16:suppl 1, pages S16-S21.
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