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Drug Evaluation

Caspofungin: first approved agent in a new class of antifungals

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Pages 807-823 | Published online: 02 Mar 2005

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Siang Fei Yeoh, Tae Jin Lee, Ka Lip Chew, Stephen Lin, Dennis Yeo & Sajita Setia. (2018) Echinocandins for management of invasive candidiasis in patients with liver disease and liver transplantation. Infection and Drug Resistance 11, pages 805-819.
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Mario Cruciani & Giovanni Serpelloni. (2008) Management of Candida infections in the adult intensive care unit. Expert Opinion on Pharmacotherapy 9:2, pages 175-191.
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Laura Waters & Mark Nelson. (2007) The use of caspofungin in HIV-infected individuals. Expert Opinion on Investigational Drugs 16:6, pages 899-908.
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Michael A Pfaller. (2004) Anidulafungin: an echinocandin antifungal. Expert Opinion on Investigational Drugs 13:9, pages 1183-1197.
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Maria Antonia De Francesco. (2023) Drug-Resistant Aspergillus spp.: A Literature Review of Its Resistance Mechanisms and Its Prevalence in Europe. Pathogens 12:11, pages 1305.
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Thaila Fernanda dos Reis, Patrícia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro F. N. Souza, Suzanne Ackloo, Mohammad Anwar Hossain, David Harold Drewry, Sondus Alkhazraji, Ashraf S. Ibrahim, Hyunil Jo, Jorge D. Lightfoot, Emily M. Adams, Kevin K. Fuller, William F. deGrado & Gustavo H. Goldman. (2023) A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi. Nature Communications 14:1.
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Murat C. Kalem, Harini Subbiah, Jay Leipheimer, Virginia E. Glazier & John C. Panepinto. (2021) Puf4 Mediates Post-transcriptional Regulation of Cell Wall Biosynthesis and Caspofungin Resistance in Cryptococcus neoformans. mBio 12:1.
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Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W. Denning, Olaf Kniemeyer, Axel A. Brakhage & David S. Perlin. (2019) Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)- d -Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus . mBio 10:3.
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Harshad Devarbhavi, Herbert L. Bonkovsky, Mark Russo & Naga Chalasani. 2018. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 844 890.e17 .
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Curtis D. Holt & Drew J. Winston. 2015. Transplantation of the Liver. Transplantation of the Liver 1006 1039 .
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Elvira Román, Fabien Cottier, Joachim F. Ernst & Jesús Pla. (2009) Msb2 Signaling Mucin Controls Activation of Cek1 Mitogen-Activated Protein Kinase in Candida albicans . Eukaryotic Cell 8:8, pages 1235-1249.
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Guillermo Garcia-Effron, Steven Park & David S. Perlin. (2009) Correlating Echinocandin MIC and Kinetic Inhibition of fks1 Mutant Glucan Synthases for Candida albicans : Implications for Interpretive Breakpoints . Antimicrobial Agents and Chemotherapy 53:1, pages 112-122.
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Kain Regena Juliana & Chen Zhengxing. (2008) Effects of Processing Methods on the Physico-Functional Properties of Peanut Flour (Arachis hypogaea L.). Biotechnology(Faisalabad) 7:2, pages 168-174.
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Benjamin D. Brielmaier, Ed Casabar, Christine M. Kurtzeborn, Peggy S. McKinnon & David J. Ritchie. (2012) Early Clinical Experience with Anidulafungin at a Large Tertiary Care Medical Center. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 28:1, pages 64-73.
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Seema Parveen, Ashish D. Gupta & Ramasare Prasad. (2007) Arabinogalactan protein from Arachis hypogaea: Role as carrier in drug-formulations. International Journal of Pharmaceutics 333:1-2, pages 79-86.
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Matthew E. Falagas, Fotinie Ntziora, Gregoria I. Betsi & George Samonis. (2007) Caspofungin for the treatment of fungal infections: a systematic review of randomized controlled trials. International Journal of Antimicrobial Agents 29:2, pages 136-143.
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John E. Bennett. (2006) Echinocandins for Candidemia in Adults without Neutropenia. New England Journal of Medicine 355:11, pages 1154-1159.
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Andreja Hasenoehrl, Tatjana Galić, Gabrijela Ergović, Nataša Maršić, Mihael Skerlev, Joachim Mittendorf, Ulrich Geschke, Axel Schmidt & Wolfgang Schoenfeld. (2006) In Vitro Activity and In Vivo Efficacy of Icofungipen (PLD-118), a Novel Oral Antifungal Agent, against the Pathogenic Yeast Candida albicans . Antimicrobial Agents and Chemotherapy 50:9, pages 3011-3018.
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M. A. Pfaller, L. Boyken, R. J. Hollis, S. A. Messer, S. Tendolkar & D. J. Diekema. (2006) In Vitro Susceptibilities of Candida spp. to Caspofungin: Four Years of Global Surveillance . Journal of Clinical Microbiology 44:3, pages 760-763.
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G. H. Talbot, J. Bradley, J. E. Edwards, D. Gilbert, M. Scheld & J. G. Bartlett. (2006) Bad Bugs Need Drugs: An Update on the Development Pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clinical Infectious Diseases 42:5, pages 657-668.
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Ekatherina Charvalos, Manolis N. Tzatzarakis, Françoise Van Bambeke, Paul M. Tulkens, Aristidis M. Tsatsakis, George N. Tzanakakis & Marie-Paule Mingeot-Leclercq. (2006) Water-soluble amphotericin B–polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects. Journal of Antimicrobial Chemotherapy 57:2, pages 236-244.
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Kenji Tabata, Masataka Katashima, Akio Kawamura, Atsunori Kaibara & Yusuke Tanigawara. (2006) Population Pharmacokinetic Analysis of Micafungin in Japanese Patients with Fungal Infections. Drug Metabolism and Pharmacokinetics 21:4, pages 324-331.
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Herbert L. Bonkovsky, Dean P. Jones, Douglas R. LaBrecque & Steven I. Shedlofsky. 2006. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 503 550 .
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Patrick Vandeputte, Gérald Larcher, Thierry Bergès, Gilles Renier, Dominique Chabasse & Jean-Philippe Bouchara. (2005) Mechanisms of Azole Resistance in a Clinical Isolate of Candida tropicalis . Antimicrobial Agents and Chemotherapy 49:11, pages 4608-4615.
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Oksana Anatolia Shlobin, Lesia K. Dropulic, Jonathan B. Orens, John F. Mcdyer, John V. Conte, Stephen Y. Yang & Reda Girgis. (2005) Mediastinal Mass Due to Aspergillus fumigatus After Lung Transplantation: A Case Report. The Journal of Heart and Lung Transplantation 24:11, pages 1991-1994.
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Donna M. MacCallum, Julie A. Whyte & Frank C. Odds. (2005) Efficacy of Caspofungin and Voriconazole Combinations in Experimental Aspergillosis. Antimicrobial Agents and Chemotherapy 49:9, pages 3697-3701.
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Ruta Petraitiene, Vidmantas Petraitis, Amy M. Kelaher, Alia A. Sarafandi, Diana Mickiene, Andreas H. Groll, Tin Sein, John Bacher & Thomas J. Walsh. (2005) Efficacy, Plasma Pharmacokinetics, and Safety of Icofungipen, an Inhibitor of Candida Isoleucyl-tRNA Synthetase, in Treatment of Experimental Disseminated Candidiasis in Persistently Neutropenic Rabbits . Antimicrobial Agents and Chemotherapy 49:5, pages 2084-2092.
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Quanbo Xiong, Saad A. Hassan, William K. Wilson, Xiang Y. Han, Gregory S. May, Jeffrey J. Tarrand & Seiichi P. T. Matsuda. (2005) Cholesterol Import by Aspergillus fumigatus and Its Influence on Antifungal Potency of Sterol Biosynthesis Inhibitors . Antimicrobial Agents and Chemotherapy 49:2, pages 518-524.
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Anant Mohan, Randeep Guleria, Chinmoyee Das, Surendra Kumar Sharma, Seema Mukhopadhyaya & Anupma Nayak. (2005) Invasive Tracheobronchial Aspergillosis in an Immunocompetent Person. The American Journal of the Medical Sciences 329:2, pages 107-109.
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CURTIS D. HOLT & DREW J. WINSTON. 2005. Transplantation of the Liver. Transplantation of the Liver 963 994 .
Jill P. Adler-Moore, Jon A. Olson & Richard T. Proffitt. (2004) Alternative dosing regimens of liposomal amphotericin B (AmBisome) effective in treating murine systemic candidiasis. Journal of Antimicrobial Chemotherapy 54:6, pages 1096-1102.
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Axel Glasmacher. (2004) Invasive Fungal Infections in Patients with Hematologic Malignancies: The Next Steps. Supportive Cancer Therapy 2:1, pages 31-33.
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Angela Rösen-Wolff, Anne Koch, Wilhelm Friedrich, Gabriele Hahn, Manfred Gahr & Joachim Roesler. (2004) Successful Elimination of an Invasive Aspergillus nidulans Lung Infection by Voriconazole After Failure of a Combination of Caspofungin and Liposomal Amphotericin B in a Boy With Chronic Granulomatous Disease. The Pediatric Infectious Disease Journal 23:6, pages 584-586.
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K. Hübel, J. Chemnitz, H.-G. Brochhagen & O. A. Cornelya. (2004) Successful Treatment of Chronic Disseminated Candidiasis with Caspofungin and Itraconazole in a Patient with Progressive Acute Leukemia and Prolonged Neutropenia. International Journal of Hematology 79:3, pages 289-292.
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Punam Sandhu, Xin Xu, Peter J. Bondiskey, Suresh K. Balani, Michael L. Morris, Yui S. Tang, Alisha R. Miller & Paul G. Pearson. (2004) Disposition of Caspofungin, a Novel Antifungal Agent, in Mice, Rats, Rabbits, and Monkeys. Antimicrobial Agents and Chemotherapy 48:4, pages 1272-1280.
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Arnab Pain, John Woodward, Michael A Quail, Michael J Anderson, Richard Clark, Matthew Collins, Nigel Fosker, Audrey Fraser, David Harris, Natasha Larke, Lee Murphy, Sean Humphray, Susan O’Neil, Mihaela Pertea, Claire Price, Ester Rabbinowitsch, Marie-Adele Rajandream, Steven Salzberg, David Saunders, Kathy Seeger, Sarah Sharp, Tim Warren, David W Denning, Bart Barrell & Neil Hall. (2004) Insight into the genome of Aspergillus fumigatus: analysis of a 922kb region encompassing the nitrate assimilation gene cluster. Fungal Genetics and Biology 41:4, pages 443-453.
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