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Drug Evaluation

Donepezil: a clinical review of current and emerging indications

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Pages 161-180 | Published online: 02 Mar 2005

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Sirasa Ruangritchankul, Prawat Chantharit, Sahaphume Srisuma & Leonard C Gray. (2021) Adverse Drug Reactions of Acetylcholinesterase Inhibitors in Older People Living with Dementia: A Comprehensive Literature Review. Therapeutics and Clinical Risk Management 17, pages 927-949.
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Parisa Hasanein, Rosa Seifi, Mohammad Reza Hajinezhad & Abbasali Emamjomeh. (2017) Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats. Nutritional Neuroscience 20:9, pages 547-554.
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Alberto Halabe Bucay. (2009) Donepezil (aricept) as a treatment for anorexia nervosa: a very feasible therapeutic possibility. Expert Opinion on Investigational Drugs 18:5, pages 569-571.
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Ben Seltzer. (2007) Donepezil: an update. Expert Opinion on Pharmacotherapy 8:7, pages 1011-1023.
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Maria Laura Bolognesi, Anna Minarini, Vincenzo Tumiatti & Carlo Melchiorre. (2006) Progress in acetylcholinesterase inhibitors for Alzheimer’s disease. Expert Opinion on Therapeutic Patents 16:6, pages 811-823.
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Articles from other publishers (31)

Weilin Liu, Jianhong Li, Minguang Yang, Xiaohua Ke, Yaling Dai, Huawei Lin, Sinuo Wang, Lidian Chen & Jing Tao. (2022) Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease. Alzheimer's Research & Therapy 14:1.
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Robert R. Redman, Harry Mackenzie, Kosala N. Dissanayake, Michael Eddleston & Richard R. Ribchester. (2022) Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle. British Journal of Pharmacology 179:24, pages 5273-5289.
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Tarek Zieneldien, Janice Kim, Darrell Sawmiller & Chuanhai Cao. (2022) The Immune System as a Therapeutic Target for Alzheimer’s Disease. Life 12:9, pages 1440.
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Zafer Sahin, Sevde Nur Biltekin, Leyla Yurttaş, Barkin Berk, Tuba Tüylü Küçükkılınç & Şeref Demirayak. (2022) Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors. Journal of Molecular Structure 1264, pages 133193.
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Jee Hyun Yi, Somin Moon, Eunbi Cho, Huiyoung Kwon, Seungjin Lee, Jieun Jeon, A Young Park, Ye Hee Lee, Kyoung Ja Kwon, Jong Hoon Ryu, Se Jin Jeon, Chan Young Shin, Sang Hee Shim & Dong Hyun Kim. (2022) Hyperoside improves learning and memory deficits by amyloid β1-42 in mice through regulating synaptic calcium-permeable AMPA receptors. European Journal of Pharmacology 931, pages 175188.
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Lucía Torres-Simón, Sandra Doval, Alberto Nebreda, Sophia J. Llinas, Elisabeth B. Marsh & Fernando Maestú. (2022) Understanding brain function in vascular cognitive impairment and dementia with EEG and MEG: A systematic review. NeuroImage: Clinical 35, pages 103040.
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Elham Zarean, Morteza Sedehi & Yalda Heshmati. (2021) Efficacy of Donepezil in Improving Cognitive Impairment Induced by Electroconvulsive Therapy in Patients with Mood Disorders: A Randomized, Double-blind, Placebo-Controlled Trial. Iranian Journal of Psychiatry and Behavioral Sciences 15:3.
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Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova & Jana Zdarova Karasova. (2021) The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs. Molecules 26:8, pages 2160.
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Song Yi Lee, Ju-Hwan Park, Mingyu Yang, Min-Jun Baek, Min-Hwan Kim, Junmin Lee, Ali Khademhosseini, Dae-Duk Kim & Hyun-Jong Cho. (2020) Ferrous sulfate-directed dual-cross-linked hyaluronic acid hydrogels with long-term delivery of donepezil. International Journal of Pharmaceutics 582, pages 119309.
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Narges Shams-Alizadeh, Azad Maroufi, Akbar Qanbarzadeh Chelan Sofla, Ebrahim Ghaderi & Kambiz Hassanzadeh. (2019) Effect of Donepezil on Cognitive Deficits Associated With Electroconvulsive Therapy: A Randomized Triple-blind Clinical Trial. Clinical Neuropharmacology 42:2, pages 27-31.
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Jonathan L. Melamed, Fernando M. de Jesus, Rafael S. Maior & Marilia Barros. (2017) Scopolamine Induces Deficits in Spontaneous Object-Location Recognition and Fear-Learning in Marmoset Monkeys. Frontiers in Pharmacology 8.
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Jun Yan, Jinhui Hu, Anqiu Liu, Lin He, Xingshu Li & Hui Wei. (2017) Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer’s disease based on the fusion of donepezil and curcumin. Bioorganic & Medicinal Chemistry 25:12, pages 2946-2955.
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Sang-Ho Kim, Dae-Kyoo Chung, Young Joon Lee, Chang-Hyun Song & Sae-Kwang Ku. (2016) Neuroprotective effects of Danggui-Jakyak-San on rat stroke model through antioxidant/antiapoptotic pathway. Journal of Ethnopharmacology 188, pages 123-133.
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Kyung-Seok Lee & Dae-Kyoo Chung. (2015) Sungshim-san-mediated Recovery of Cognition and Motor Function in the Severe Rat Stroke, Permanent Middle Cerebral Artery Occlusion Model. Journal of Oriental Neuropsychiatry 26:3, pages 319-336.
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Parisa Hasanein & Azam Kazemian Mahtaj. (2015) Ameliorative effect of rosmarinic acid on scopolamine-induced memory impairment in rats. Neuroscience Letters 585, pages 23-27.
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Paul A. Howard-Jones & Kate D. Fenton. (2011) The Need for Interdisciplinary Dialogue in Developing Ethical Approaches to Neuroeducational Research. Neuroethics 5:2, pages 119-134.
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Ümide Demir Özkay, Özgür Devrim Can, Yusuf Özkay & Yusuf Öztürk. (2012) Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits. Pharmacological Reports 64:4, pages 834-847.
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Cesare Mancuso, Raffaella Siciliano, Eugenio Barone & Paolo Preziosi. (2012) Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822:5, pages 616-624.
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William Cho, Paul Maruff, John Connell, Cindy Gargano, Nicole Calder, Scott Doran, Sabrina Fox-Bosetti, Aizza Hassan, John Renger, Gary Herman, Christopher Lines & Ajay Verma. (2011) Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans. Psychopharmacology 218:3, pages 513-524.
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Shahin Akhondzadeh, Maryam Gerami, Maryam Noroozian, Narges Karamghadiri, Aboulfazl Ghoreishi, Seyed-Hesameddin Abbasi & Sams-Ali Rezazadeh. (2008) A 12-week, double-blind, placebo-controlled trial of donepezil adjunctive treatment to risperidone in chronic and stable schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 32:8, pages 1810-1815.
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Jerry J. Buccafusco, Alvin V. TerryJrJr, Scott J. Webster, Daniel Martin, Elizabeth J. Hohnadel, Kristy A. Bouchard & Samantha E. Warner. (2007) The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant-conditioning memory tasks for screening drug candidates. Psychopharmacology 199:3, pages 481-494.
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A. Marighetto, S. Valerio, A. Desmedt, J. N. Philippin, C. Trocmé-Thibierge & P. Morain. (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology 197:3, pages 499-508.
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Gustavo C. Román. 2008. Dementias. Dementias 639 658 .
AiLin Liu, HongMei Guang, LiYa Zhu, GuanHua Du, Simon M. Y. Lee & YiTao Wang. (2007) 3D-QSAR analysis of a new type of acetylcholinesterase inhibitors. Science in China Series C: Life Sciences 50:6, pages 726-730.
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Helen Hudson. (2007) Revised NICE guidance on drugs for Alzheimer's disease and its impact on patients and carers. British Journal of Neuroscience Nursing 3:3, pages 87-91.
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William L. Klein. (2006) Synaptic targeting by Aβ oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease. Alzheimer's & Dementia 2:1, pages 43-55.
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David S. Janowsky, John M. Davis & David H. Overstreet. (2005) Anticholinesterase (DFP) toxicity antagonism by chronic donepezil: A potential nerve agent treatment. Pharmacology Biochemistry and Behavior 81:4, pages 917-922.
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Gustavo C. Román. (2005) Cholinergic dysfunction in vascular dementia. Current Psychiatry Reports 7:1, pages 18-26.
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Cristina Paci, Rocco Di Mascio, Roberto Gobbato, Terenzio Carboni, Sandro Sanguigni, Stefania Sobrini, Vittoria Urbano, Federico Olivieri & Luigi Curatola. (2005) Donepezil in Vascular Dementia. Clinical Drug Investigation 25:4, pages 271-276.
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Timo ErkinjunttiGustavo RománSerge GauthierHoward FeldmanKenneth Rockwood. (2004) Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment. Stroke 35:4, pages 1010-1017.
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Cl??ment Fran??ois, Harri Sintonen, Raimo Sulkava & Beno??t Rive. (2004) Cost Effectiveness of Memantine in???Moderately Severe to Severe Alzheimer???s Disease. Clinical Drug Investigation 24:7, pages 373-384.
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