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Expert Opinion on Pharmacotherapy Volume 5, 2004 - Issue 4
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Review

Antiepileptic drugs in neuroprotection

Asla Pitkänen A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland. [email protected]
&
Hana Kubova A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland. [email protected]
Pages 777-798 | Published online: 02 Mar 2005

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Pasquale Striano & Salvatore Striano. (2009) New and investigational antiepileptic drugs. Expert Opinion on Investigational Drugs 18:12, pages 1875-1884.
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Asla Pitkänen. (2004) On the way to cure epilepsy. Expert Review of Neurotherapeutics 4:6, pages 917-920.
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Articles from other publishers (51)

Oumarou Ouédraogo, Renaud Balthazard, Victoria Hannah Mamane, Hélène Jamann, Florence Millette, Audrey Daigneault, Nathalie Arbour & Catherine Larochelle. (2023) Investigating anti-inflammatory and immunomodulatory properties of brivaracetam and lacosamide in experimental autoimmune encephalomyelitis (EAE). Epilepsy Research 192, pages 107125.
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Raili Riikonen. (2023) Biochemical mechanisms in pathogenesis of infantile epileptic spasm syndrome. Seizure 105, pages 1-9.
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Mirosław Zagaja, Anna Zagaja, Joanna Szala-Rycaj, Aleksandra Szewczyk, Marta Kinga Lemieszek, Grzegorz Raszewski & Marta Andres-Mach. (2022) Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study. International Journal of Molecular Sciences 23:7, pages 3492.
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Wolfgang Löscher & Pavel Klein. (2022) New approaches for developing multi-targeted drug combinations for disease modification of complex brain disorders. Does epilepsy prevention become a realistic goal?. Pharmacology & Therapeutics 229, pages 107934.
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Elva Martin-Batista, Laura E. Maglio, Natalia Armas-Capote, Guadalberto Hernández, Diego Alvarez de la Rosa & Teresa Giraldez. (2021) SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms. Neurobiology of Disease 153, pages 105317.
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Mirosław Zagaja, Aleksandra Szewczyk, Joanna Szala-Rycaj, Grzegorz Raszewski, Magdalena Chrościńska-Krawczyk, Michał Abram, Krzysztof Kamiński & Marta Andres-Mach. (2021) C-11, a New Antiepileptic Drug Candidate: Evaluation of the Physicochemical Properties and Impact on the Protective Action of Selected Antiepileptic Drugs in the Mouse Maximal Electroshock-Induced Seizure Model. Molecules 26:11, pages 3144.
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Michał Wiciński, Oskar Puk & Bartosz Malinowski. (2020) Cenobamate: Neuroprotective Potential of a New Antiepileptic Drug. Neurochemical Research 46:3, pages 439-446.
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Yam Nath Paudel, Efthalia Angelopoulou, Enes Akyuz, Christina Piperi, Iekhsan Othman & Mohd. Farooq Shaikh. (2020) Role of Innate Immune Receptor TLR4 and its endogenous ligands in epileptogenesis. Pharmacological Research 160, pages 105172.
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Glória Maria Almeida Souza Tedrus, Maria Lina Giacomino Almeida Passos, Letícia Muniz Vargas & Larissa Estela Ferreira Jacó Menezes. (2020) Cognition and epilepsy: Cognitive screening test. Dementia & Neuropsychologia 14:2, pages 186-193.
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David M. Kern, M. Soledad Cepeda, Simon Lovestone & Guy R. Seabrook. (2019) Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications. Alzheimer's & Dementia: Translational Research & Clinical Interventions 5:1, pages 862-870.
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Christoph Helmstaedter, Ettore Beghi, Christian E. Elger, Reetta Kälviäinen, Kristina Malmgren, Theodor W. May, Emilio Perucca, Eugen Trinka & Juri-Alexander Witt. (2018) No Evidence of a Causal Role of Antiepileptic Drug Treatment with Regard to the Development of Dementia. Journal of the American Geriatrics Society 66:9, pages 1850-1852.
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Christoph Helmstaedter, Ettore Beghi, Christian E. Elger, Reetta Kälviäinen, Kristina Malmgren, Theodor W. May, Emilio Perucca, Eugen Trinka & Juri-Alexander Witt. (2018) No proof of a causal relationship between antiepileptic drug treatment and incidence of dementia. Comment on: Use of antiepileptic drugs and dementia risk-An analysis of Finnish health register and German health insurance data. Epilepsia 59:7, pages 1303-1306.
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Faizan Mazhar, Saima M. Malhi & Shabana U. Simjee. (2017) Comparative studies on the effects of clinically used anticonvulsants on the oxidative stress biomarkers in pentylenetetrazole-induced kindling model of epileptogenesis in mice. Journal of Basic and Clinical Physiology and Pharmacology 28:1, pages 31-42.
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Georgia Zafeiridou, Martha Spilioti, Alexia Kagiava, Konstantinos Krikonis, Efstratios K. Kosmidis, Anna Karlovasitou & Vasilios K. Kimiskidis. (2016) Differential effects of lacosamide, phenytoin and topiramate on peripheral nerve excitability: An ex vivo electrophysiological study. NeuroToxicology 52, pages 57-63.
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Asla Pitkänen, Noora Huusko, Xavier Ekolle Ndode-Ekane, Jenni Kyyriäinen, Anssi Lipponen, Anu Lipsanen, Alejandra Sierra & Tamuna Bolkvadze. (2014) Gender issues in antiepileptogenic treatments. Neurobiology of Disease 72, pages 224-232.
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A. Pitkänen, R. Immonen, X. Ndode-Ekane, O. Gröhn, T. Stöhr & J. Nissinen. (2014) Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats. Epilepsy Research 108:4, pages 653-665.
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Bogdan Popescu, Maria Ţuineag & Radu Stoica. (2013) Gabapentin is neuroprotective through glutamate receptor-independent mechanisms in staurosporine-induced apoptosis of cultured rat cerebellar neurons. Translational Neuroscience 4:4, pages 429-436.
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N. Dericioglu, F. Soylemezoglu, Y. Gursoy-Ozdemir, N. Akalan, S. Saygi & T. Dalkara. (2013) Cell death and survival mechanisms are concomitantly active in the hippocampus of patients with mesial temporal sclerosis. Neuroscience 237, pages 56-65.
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Tomonori Ono & Aristea S. Galanopoulou. 2012. Neurodegenerative Diseases. Neurodegenerative Diseases 99 113 .
Robert S. Sloviter. (2011) Progress on the issue of excitotoxic injury modification vs. real neuroprotection; implications for post-traumatic epilepsy. Neuropharmacology 61:5-6, pages 1048-1050.
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Jennifer François, Katuschia Germe, Arielle Ferrandon, Estelle Koning & Astrid Nehlig. (2011) Carisbamate has powerful disease-modifying effects in the lithium-pilocarpine model of temporal lobe epilepsy. Neuropharmacology 61:1-2, pages 313-328.
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K. Kouzounias, V.K. Kimiskidis, T. Siozos, K. Violaris, N. Kostomitsopoulos, P.E. Karayannakos, K. Sotirakoglou & K. Nanassis. (2011) Topiramate promotes neurological recovery in a new model of traumatic brain injury in rats. Neuroscience 183, pages 171-177.
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Marta Rattka, Claudia Brandt, Marion Bankstahl, Sonja Bröer & Wolfgang Löscher. (2011) Enhanced susceptibility to the GABA antagonist pentylenetetrazole during the latent period following a pilocarpine-induced status epilepticus in rats. Neuropharmacology 60:2-3, pages 505-512.
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Asla Pitkänen & Katarzyna Lukasiuk. (2011) Mechanisms of epileptogenesis and potential treatment targets. The Lancet Neurology 10:2, pages 173-186.
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Michele Simonato & Silvia Zucchini. (2010) Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?. Epilepsia 51, pages 48-51.
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Asla Pitkänen. (2010) Therapeutic approaches to epileptogenesis-Hope on the horizon. Epilepsia 51, pages 2-17.
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Nadine Polascheck, Marion Bankstahl & Wolfgang Löscher. (2010) The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. Experimental Neurology 224:1, pages 219-233.
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SHERIFA A. HAMED. (2010) THE RATIONALE FOR NEUROPROTECTION IN EPILEPSY: STEPS FORWARD FOR NEW THERAPEUTIC AND PREVENTIVE STRATEGIES. Journal of Integrative Neuroscience 09:01, pages 65-102.
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Robert L. Hendren, Kiah Bertoglio, Paul Ashwood & Frank Sharp. (2009) Mechanistic biomarkers for autism treatment. Medical Hypotheses 73:6, pages 950-954.
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Muhammad U. Farooq, Archit Bhatt, Arshad Majid, Rishi Gupta, Atul Khasnis & Mounzer Y. Kassab. (2009) Levetiracetam for managing neurologic and psychiatric disorders. American Journal of Health-System Pharmacy 66:6, pages 541-561.
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Asla Pitkänen & Katarzyna Lukasiuk. (2009) Molecular and cellular basis of epileptogenesis in symptomatic epilepsy. Epilepsy & Behavior 14:1, pages 16-25.
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S.J. Czuczwar. 2009. Encyclopedia of Basic Epilepsy Research. Encyclopedia of Basic Epilepsy Research 600 604 .
A. Pitkänen & K. Lukasiuk. 2009. Encyclopedia of Neuroscience. Encyclopedia of Neuroscience 1159 1166 .
Joost Nicolai, Johan S.H. Vles & Albert P. Aldenkamp. (2008) Neurodevelopmental delay in children exposed to antiepileptic drugs in utero: A critical review directed at structural study-bias. Journal of the Neurological Sciences 271:1-2, pages 1-14.
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Elinor Ben-Menachem, Josemir W. Sander, Hermann Stefan, Susanne Schwalen & Barbara Schäuble. (2008) Topiramate monotherapy in the treatment of newly or recently diagnosed epilepsy. Clinical Therapeutics 30:7, pages 1180-1195.
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Wolfgang Löscher, Manuela Gernert & Uwe Heinemann. (2008) Cell and gene therapies in epilepsy – promising avenues or blind alleys?. Trends in Neurosciences 31:2, pages 62-73.
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Astrid Nehlig. (2007) What is animal experimentation telling us about new drug treatments of status epilepticus?. Epilepsia 48:s8, pages 78-81.
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Frank J.E. Vajda. (2007) Pharmacotherapy of epilepsy: New armamentarium, new issues. Journal of Clinical Neuroscience 14:9, pages 813-823.
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Alexandra Olimpio Siqueira Cunha, Márcia Renata Mortari, Ruither Oliveira Gomes Carolino, Joaquim Coutinho-Netto & Wagner Ferreira dos Santos. (2007) Glutamate binding is altered in hippocampus and cortex of Wistar rats after pilocarpine-induced Status Epilepticus. Neuroscience Letters 424:1, pages 51-54.
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Christian Frisch, Alexei P. Kudin, Christian E. Elger, Wolfram S. Kunz & Christoph Helmstaedter. (2007) Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. Epilepsy Research 73:2, pages 173-180.
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Steven Karceski. 2007. Operative Neuromodulation. Operative Neuromodulation 247 259 .
Jennifer François, Estelle Koning, Arielle Ferrandon & Astrid Nehlig. (2006) The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. Epilepsy Research 72:2-3, pages 147-163.
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Claudia Brandt, Anna Heile, Heidrun Potschka, Thomas Stoehr & Wolfgang Löscher. (2006) Effects of the Novel Antiepileptic Drug Lacosamide on the Development of Amygdala Kindling in Rats. Epilepsia 47:11, pages 1803-1809.
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Asla Pitkänen. (2006) New Data Suggest that Discontinuation of Status Epilepticus is Not Necessary for Antiepileptogenic Effect in Immature Brain. Epilepsy Currents 6:5, pages 170-172.
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James WY Chen & Claude G Wasterlain. (2006) Status epilepticus: pathophysiology and management in adults. The Lancet Neurology 5:3, pages 246-256.
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Marc A. Dichter. (2006) Models of epileptogenesis in adult animals available for antiepileptogenesis drug screening. Epilepsy Research 68:1, pages 31-35.
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ANDREY M. MAZARATI, KERRY W. THOMPSON, LUCIE SUCHOMELOVA, RAMAN SANKAR, YUKIYOSHI SHIRASAKA, JARI NISSINEN, ASLA PITKÄNEN, EDWARD BERTRAM & CLAUDE G. WASTERLAIN. 2006. Models of Seizures and Epilepsy. Models of Seizures and Epilepsy 449 464 .
Claudia Brandt, Holger A. Volk & Wolfgang Loscher. (2004) Striking Differences in Individual Anticonvulsant Response to Phenobarbital in Rats with Spontaneous Seizures after Status Epilepticus. Epilepsia 45:12, pages 1488-1497.
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Andrey M. Mazarati. (2004) Galanin and galanin receptors in epilepsy. Neuropeptides 38:6, pages 331-343.
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Christian E Elger, Christoph Helmstaedter & Martin Kurthen. (2004) Chronic epilepsy and cognition. The Lancet Neurology 3:11, pages 663-672.
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Roberto Tuchman. (2004) AEDs and psychotropic drugs in children with autism and epilepsy. Mental Retardation and Developmental Disabilities Research Reviews 10:2, pages 135-138.
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