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Expert Opinion on Pharmacotherapy Volume 6, 2005 - Issue 5
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Editorial

Microtubule-stabilising drugs for therapy of Alzheimer’s disease and other neurodegenerative disorders with axonal transport impairments

John Q TrojanowskiThe Marian S Ware Alzheimer Program Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Ageing, University of Pennsylvania School of Medicine, University of Pennsylvania School of Arts and Sciences, Philadelphia, PA 19104USAE-mail: [email protected]
,
Amos B SmithDepartment of Chemistry University of Pennsylvania School of Arts and Sciences, Philadelphia, PA 19104USA
,
Donna HurynThe Marian S Ware Alzheimer Program Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Ageing, University of Pennsylvania School of Medicine, University of Pennsylvania School of Arts and Sciences, Philadelphia, PA 19104USAE-mail: [email protected]
&
Virginia M-Y LeeDepartment of Chemistry University of Pennsylvania School of Arts and Sciences, Philadelphia, PA 19104USA
Pages 683-686 | Published online: 10 May 2005

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Sharon M Rymut & Thomas J Kelley. (2015) Broader implications: biological and clinical significance of microtubule acetylation. Cell Health and Cytoskeleton 7, pages 71-82.
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Wei-Shuo Fang & Shao-Rong Wang. (2008) Structural studies of taxol analogues for drug discovery. Expert Opinion on Drug Discovery 3:9, pages 1109-1122.
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Hanno M Roder & Michael L Hutton. (2007) Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease. Expert Opinion on Therapeutic Targets 11:4, pages 435-442.
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Ritesh P. Bhole, Rupesh V. Chikhale & Karishma M. Rathi. (2023) Current Biomarkers and Treatment Strategies in Alzheimer Disease: An Overview and Future Perspectives. IBRO Neuroscience Reports.
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Christopher Nishioka, Hsiao-Fang Liang, Stephen Ong & Shu-Wei Sun. (2022) Axonal Transport Impairment and its Relationship with Diffusion Tensor Imaging Metrics of a Murine Model of p301L Tau Induced Tauopathy. Neuroscience 498, pages 144-154.
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Yi-Wei Wang, Liang Wang, Sheng-Jie Yuan, Yuan Zhang, Xin Zhang & Le-Ting Zhou. (2022) Postoperative Cognitive Dysfunction and Alzheimer’s Disease: A Transcriptome-Based Comparison of Animal Models. Frontiers in Aging Neuroscience 14.
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Shibi Muralidar, Senthil Visaga Ambi, Saravanan Sekaran, Diraviyam Thirumalai & Balamurugan Palaniappan. (2020) Role of tau protein in Alzheimer's disease: The prime pathological player. International Journal of Biological Macromolecules 163, pages 1599-1617.
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Chinthalapally V. Rao, Adam S. Asch, Daniel J. J. Carr & Hiroshi Y. Yamada. (2020) “Amyloid‐beta accumulation cycle” as a prevention and/or therapy target for Alzheimer's disease. Aging Cell 19:3.
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Vidur Sabharwal & Sandhya P. Koushika. (2019) Crowd Control: Effects of Physical Crowding on Cargo Movement in Healthy and Diseased Neurons. Frontiers in Cellular Neuroscience 13.
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Prasenjit Mondal, Gaurav Das, Juhee Khan, Krishnangsu Pradhan & Surajit Ghosh. (2017) Crafting of Neuroprotective Octapeptide from Taxol-Binding Pocket of β-Tubulin. ACS Chemical Neuroscience 9:3, pages 615-625.
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Yung-Chih Kuo & Rajendiran Rajesh. (2017) A critical overview of therapeutic strategy and advancement for Alzheimer's disease treatment. Journal of the Taiwan Institute of Chemical Engineers 77, pages 92-105.
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Hena Khanam, Abad Ali, Mohd Asif & Shamsuzzaman. (2016) Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review. European Journal of Medicinal Chemistry 124, pages 1121-1141.
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S. Roy, D.J. Irwin, V.M.-Y. Lee & J.Q. Trojanowski. 2015. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
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Sara Anna Bonini, Giulia Ferrari-Toninelli, Giuseppina Maccarinelli, Paola Bettinsoli, Mery Montinaro & Maurizio Memo. (2014) Cytoskeletal Protection: Acting on Notch to Prevent Neuronal Dysfunction. Neurodegenerative Diseases 13:2-3, pages 93-95.
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Ramón Cacabelos, Pablo Cacabelos & Clara Torrellas. 2014. Handbook of Pharmacogenomics and Stratified Medicine. Handbook of Pharmacogenomics and Stratified Medicine 563 615 .
Ramón Cacabelos, Pablo Cacabelos, Clara Torrellas, Iván Tellado & Juan C. Carril. 2014. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 323 556 .
Sara Anna Bonini, Giulia Ferrari-Toninelli, Mery Montinaro & Maurizio Memo. (2013) Notch signalling in adult neurons: a potential target for microtubule stabilization. Therapeutic Advances in Neurological Disorders 6:6, pages 375-385.
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Kurt R. Brunden, Nicola M. GardnerMichael J. James, Yuemang Yao, John Q. Trojanowski, Virginia M.-Y. Lee, Ian PatersonCarlo Ballatore & Amos B. SmithIIIIII. (2013) MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. ACS Medicinal Chemistry Letters 4:9, pages 886-889.
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S Quraishe, C M Cowan & A Mudher. (2013) NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Molecular Psychiatry 18:7, pages 834-842.
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Oveis Karima, Gholamhossein Riazi, Sirus Khodadadi, Reza Yousefi, Karim Mahnam, Farzad Mokhtari, Tayebe Cheraghi, Elham Hoveizi & Ali Akbar Moosavi-Movahedi. (2012) An in vitro study of the role of β‐boswellic acid in the microtubule assembly dynamics. FEBS Letters 586:23, pages 4132-4138.
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Carlo Ballatore, Kurt R. Brunden, Donna M. Huryn, John Q. Trojanowski, Virginia M.-Y. Lee & Amos B. SmithIIIIII. (2012) Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies. Journal of Medicinal Chemistry 55:21, pages 8979-8996.
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Peter W. Baas & Olga I. Mozgova. (2012) A novel role for retrograde transport of microtubules in the axon. Cytoskeleton 69:7, pages 416-425.
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Gustavo Pigino, Yuyu Song, Laura L. Kirkpatrick & Scott T. Brady. 2012. Basic Neurochemistry. Basic Neurochemistry 101 118 .
Michael VoronkovSteven P BraithwaiteJeffry B Stock. (2011) Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer’s disease. Future Medicinal Chemistry 3:7, pages 821-833.
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Kurt R. Brunden, Yuemang Yao, Justin S. Potuzak, Nuria Ibarz Ferrer, Carlo Ballatore, Michael J. James, Anne-Marie L. Hogan, John Q. Trojanowski, Amos B. SmithIIIIII & Virginia M.-Y. Lee. (2011) The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacological Research 63:4, pages 341-351.
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Rakez KayedGeorge R. JacksonD. Mark EstesAlan D.T. Barrett. (2011) Alzheimers Disease: Review of Emerging Treatment Role for Intravenous Immunoglobulins. Journal of Central Nervous System Disease 3, pages JCNSD.S5018.
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Christopher P. Corbo & Alejandra del C. Alonso. 2011. The Brain as a Drug Target. The Brain as a Drug Target 47 83 .
Young-Jung Lee, Sang Bae Han, Sang-Yoon Nam, Ki-Wan Oh & Jin Tae Hong. (2010) Inflammation and Alzheimer’s disease. Archives of Pharmacal Research 33:10, pages 1539-1556.
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Donald J. AbrahamLone Veng, Mary J. Savage, James C. Barrow & Celina V. Zerbinatti. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 405 446 .
Shaohua Xu, Kurt R. Brunden, John Q. Trojanowski & Virginia M.‐Y. Lee. (2010) Characterization of tau fibrillization in vitro. Alzheimer's & Dementia 6:2, pages 110-117.
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Alex Crowe, Wenwei Huang, Carlo Ballatore, Ronald L. Johnson, Anne-Marie L. Hogan, Ruili Huang, Jennifer Wichterman, Joshua McCoy, Donna Huryn, Douglas S. Auld, Amos B. SmithIIIIII, James Inglese, John Q. Trojanowski, Christopher P. Austin, Kurt R. Brunden & Virginia M.-Y. Lee. (2009) Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-Throughput Screening. Biochemistry 48:32, pages 7732-7745.
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Mary J. Savage & Diane E. Gingrich. (2009) Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease. Drug Development Research 70:2, pages 125-144.
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S. Roy, V.M.-Y. Lee & J.Q. Trojanowski. 2009. Encyclopedia of Neuroscience. Encyclopedia of Neuroscience 1199 1203 .
Carlo Ballatore, Bin Zhang, John Q. Trojanowski, Virginia M.-Y. Lee & Amos B. SmithIIIIII. (2008) In situ blood–brain barrier permeability of a C-10 paclitaxel carbamate. Bioorganic & Medicinal Chemistry Letters 18:23, pages 6119-6121.
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G. Ferrari-Toninelli, S.A. Bonini, P. Bettinsoli, D. Uberti & M. Memo. (2008) Microtubule stabilizing effect of notch activation in primary cortical neurons. Neuroscience 154:3, pages 946-952.
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Donna M. Barten & Charles F. Albright. (2008) Therapeutic Strategies for Alzheimer’s Disease. Molecular Neurobiology 37:2-3, pages 171-186.
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Stephan Frank, Florence Clavaguera & Markus Tolnay. (2007) Tauopathy models and human neuropathology: similarities and differences. Acta Neuropathologica 115:1, pages 39-53.
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Carlo Ballatore, Virginia M.-Y. Lee & John Q. Trojanowski. (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nature Reviews Neuroscience 8:9, pages 663-672.
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Carlo Ballatore, Edward Hyde, Robert F. Deiches, Virginia M.-Y. Lee, John Q. Trojanowski, Donna Huryn & Amos B. SmithIIIIII. (2007) Paclitaxel C-10 carbamates: Potential candidates for the treatment of neurodegenerative tauopathies. Bioorganic & Medicinal Chemistry Letters 17:13, pages 3642-3646.
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Alex Crowe, Carlo Ballatore, Edward Hyde, John Q. Trojanowski & Virginia M.-Y. Lee. (2007) High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation. Biochemical and Biophysical Research Communications 358:1, pages 1-6.
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Vikas Dhikav & Kuljeet Singh Anand. (2007) Glucocorticoids may initiate Alzheimer’s disease: A Potential therapeutic role for mifepristone (RU-486). Medical Hypotheses 68:5, pages 1088-1092.
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Dale Schenk, Maria C. Carrillo & John Q. Trojanowski. (2006) Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery. Alzheimer's & Dementia 2:4, pages 275-281.
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Paul A. Wender, Michael K. Hilinski, Philip R. Skaanderup, Nicolas G. Soldermann & Susan L. Mooberry. (2006) Pharmacophore Mapping in the Laulimalide Series:  Total Synthesis of a Vinylogue for a Late-Stage Metathesis Diversification Strategy. Organic Letters 8:18, pages 4105-4108.
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Gorazd B. StokinLawrence S.B. Goldstein. (2006) Axonal Transport and Alzheimer's Disease. Annual Review of Biochemistry 75:1, pages 607-627.
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John Q. Trojanowski & Virginia M.-Y. Lee. (2005) The Alzheimer's Brain. The American Journal of Pathology 167:5, pages 1183-1188.
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