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Editorial

Proton pump inhibitors may reduce tumour resistance

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Pages 1049-1054 | Published online: 15 Jun 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Luana Lugini, Cristina Federici, Martina Borghi, Tommaso Azzarito, Maria Lucia Marino, Albino Cesolini, Enrico Pierluigi Spugnini & Stefano Fais. (2016) Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect. Journal of Enzyme Inhibition and Medicinal Chemistry 31:4, pages 538-545.
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Paola Pellegrini, Angela Strambi, Chiara Zipoli, Maria Hägg-Olofsson, Maria Buoncervello, Stig Linder & Angelo De Milito. (2014) Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine. Autophagy 10:4, pages 562-571.
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Fang Zhou, Jingwei Zhang, Peng Li, Fang Niu, Xiaolan Wu, Guangji Wang & Michael S. Roberts. (2011) Toward a new age of cellular pharmacokinetics in drug discovery. Drug Metabolism Reviews 43:3, pages 335-345.
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Antonio Pirodda, Cristina Brandolini, Maria Chiara Raimondi, Giovanni Carlo Modugno & Claudio Borghi. (2008) Gastric type proton pump of the inner ear: Its possible involvement in labyrinthine disorders. Audiological Medicine 6:4, pages 249-250.
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Fabio Pace, Stefano Pallotta, Stefania Casalini & Gabriele Bianchi Porro. (2007) A review of rabeprazole in the treatment of acid-related diseases. Therapeutics and Clinical Risk Management 3:3, pages 363-379.
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Tiago M. A. Carvalho, Daria Di Molfetta, Maria Raffaella Greco, Tomas Koltai, Khalid O. Alfarouk, Stephan J. Reshkin & Rosa A. Cardone. (2021) Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches. Cancers 13:23, pages 6135.
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Venkateshwar Madka, Gaurav Kumar, Gopal Pathuri, Janani Panneerselvam, Yuting Zhang, Vishal Ganta, Stanley Lightfoot, Ronald Lubet, Chen S. Suen, Vernon E. Steele, Naveena B. Janakiram, Altaf Mohammed & Chinthalapally V. Rao. (2021) Proton Pump Inhibitor Omeprazole Suppresses Carcinogen-induced Colonic Adenoma Progression to Adenocarcinoma in F344 Rat. Cancer Prevention Research 14:11, pages 1009-1020.
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Noor A. Hussein, Saloni Malla, Mariah A. Pasternak, David Terrero, Noah G. Brown, Charles R. AshbyJr.Jr., Yehuda G. Assaraf, Zhe-Sheng Chen & Amit K. Tiwari. (2021) The role of endolysosomal trafficking in anticancer drug resistance. Drug Resistance Updates 57, pages 100769.
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Yanyan Tang, Gang Xiao, Zhiwei Shen, Caiyu Zhuang, Yudan Xie, Xiaolei Zhang, Zhongxian Yang, Jitian Guan, Yuanyu Shen, Yanzi Chen, Lihua Lai, Yuanfeng Chen, Shuo Chen, Zhuozhi Dai, Runrun Wang & Renhua Wu. (2020) Noninvasive Detection of Extracellular pH in Human Benign and Malignant Liver Tumors Using CEST MRI. Frontiers in Oncology 10.
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Raed S. Ismail, Mohammed S. El-Awady & Memy H. Hassan. (2020) Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress. Naunyn-Schmiedeberg's Archives of Pharmacology 393:7, pages 1161-1171.
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Chenxu Zhang, Shihui Li, Ao Yu & Yongjian Wang. (2019) Nano CaCO 3 “Lysosomal Bombs” Enhance Chemotherapy Drug Efficacy via Rebalancing Tumor Intracellular pH . ACS Biomaterials Science & Engineering 5:7, pages 3398-3408.
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Moon Kyung Joo, Jong-Jae Park & Hoon Jai Chun. (2019) Proton pump inhibitor: The dual role in gastric cancer. World Journal of Gastroenterology 25:17, pages 2058-2070.
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Jiriporn Nantavishit, Varanuj Chatsudthipong & Sunhapas Soodvilai. (2018) Lansoprazole reduces renal cyst in polycystic kidney disease via inhibition of cell proliferation and fluid secretion. Biochemical Pharmacology 154, pages 175-182.
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Elisabetta Iessi, Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Claudiu Supuran & Stefano Fais. (2017) Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy. Metabolites 8:1, pages 2.
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Kenji Ikemura, Shunichi Hiramatsu & Masahiro Okuda. (2017) Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy. Frontiers in Pharmacology 8.
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Kun Zhuang, Lingxia Zhang, Xin Zhang, Hailing Tang, Jun Zhang, Yuan Yan, Kun Han & Hanqing Guo. (2017) Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901. International Journal of Oncology 50:6, pages 2091-2100.
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Sara Granja, Diana Tavares-Valente, Odília Queirós & Fátima Baltazar. (2017) Value of pH regulators in the diagnosis, prognosis and treatment of cancer. Seminars in Cancer Biology 43, pages 17-34.
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Jin-Liang Zhang, Min Liu, Qing Yang, Shi-Yong Lin, Hong-Bo Shan, Hui-Yun Wang & Guo-Liang Xu. (2017) Effects of omeprazole in improving concurrent chemoradiotherapy efficacy in rectal cancer. World Journal of Gastroenterology 23:14, pages 2575.
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