1,627
Views
62
CrossRef citations to date
0
Altmetric
Review

Current status of antiretroviral therapy

, &
Pages 1541-1554 | Published online: 28 Jul 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Punna Rao Ravi, Rahul Vats, Vikas Dalal, Nitin Gadekar & Aditya N. (2015) Design, optimization and evaluation of poly-ɛ-caprolactone (PCL) based polymeric nanoparticles for oral delivery of lopinavir. Drug Development and Industrial Pharmacy 41:1, pages 131-140.
Read now
WIW Ismail, JA King & TS Pillay. (2009) Insulin resistance induced by antiretroviral drugs: Current understanding of molecular mechanisms. Journal of Endocrinology, Metabolism and Diabetes of South Africa 14:3, pages 129-132.
Read now
Catherine S Adamson, Karl Salzwedel & Eric O Freed. (2009) Virus maturation as a new HIV-1 therapeutic target. Expert Opinion on Therapeutic Targets 13:8, pages 895-908.
Read now
Jan ter Meulen. (2007) Monoclonal antibodies for prophylaxis and therapy of infectious diseases. Expert Opinion on Emerging Drugs 12:4, pages 525-540.
Read now
Rino Ragno, Antonia Coluccia, Giuseppe La Regina & Romano Silvestri. (2007) Indolyl aryl sulphones as HIV-1 reverse transcriptase inhibitors: docking and 3D QSAR studies. Expert Opinion on Drug Discovery 2:1, pages 87-114.
Read now
Kai Hilpert, Dirk FH Winkler & Robert EW Hancock. (2007) Cellulose-bound Peptide Arrays: Preparation and Applications. Biotechnology and Genetic Engineering Reviews 24:1, pages 31-106.
Read now

Articles from other publishers (56)

Mbasakazi Saki, Helena De Villiers, Claudia Ntsapi & Charlette Tiloke. (2023) The Hepatoprotective Effects of Moringa oleifera against Antiretroviral-Induced Cytotoxicity in HepG2 Cells: A Review. Plants 12:18, pages 3235.
Crossref
Xiong Xie, Yu-Gui Zheng, Huan Chen, Jian Li, Rong-Hua Luo, Liang Chen, Chang-Bo Zheng, Shurui Zhang, Panfeng Peng, Dakota Ma, Liu-Meng Yang, Yong-Tang Zheng, Hong Liu & Jiang Wang. (2022) Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability. Journal of Medicinal Chemistry 65:24, pages 16526-16540.
Crossref
Irin Tanaudommongkon, Asama Tanaudommongkon & Xiaowei Dong. (2021) Development of In Situ Self-Assembly Nanoparticles to Encapsulate Lopinavir and Ritonavir for Long-Acting Subcutaneous Injection. Pharmaceutics 13:6, pages 904.
Crossref
Haibin Shi, Colin M. Tice, Lori Emert-Sedlak, Li Chen, Wing Fai Li, Marianne Carlsen, Jay E. Wrobel, Allen B. Reitz & Thomas E. Smithgall. (2019) Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation. ACS Infectious Diseases 6:2, pages 302-312.
Crossref
Ya Zhu, Yan-long Zhao, Jian Li, Hong Liu, Qiang Zhao, Bei-li Wu & Zhen-lin Yang. (2018) Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5. Acta Pharmacologica Sinica 40:4, pages 563-568.
Crossref
Huda Ansari & Prabha Singh. (2019) Formulation and in-vivo Evaluation of Novel Topical Gel of Lopinavir for Targeting HIV. Current HIV Research 16:4, pages 270-279.
Crossref
Somandla Ncube, Lawrence M. Madikizela, Luke Chimuka & Mathew M. Nindi. (2018) Environmental fate and ecotoxicological effects of antiretrovirals: A current global status and future perspectives. Water Research 145, pages 231-247.
Crossref
Lori A. Emert-Sedlak, H. Marie Loughran, Haibin Shi, John L. KulpIIIIII, Sherry T. Shu, Jielu Zhao, Billy W. Day, Jay E. Wrobel, Allen B. Reitz & Thomas E. Smithgall. (2016) Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists. Bioorganic & Medicinal Chemistry Letters 26:5, pages 1480-1484.
Crossref
Punna Rao Ravi, Rahul Vats, Jagadeesh Balija, Sathya Prabhu Naidu Adapa & N. Aditya. (2014) Modified pullulan nanoparticles for oral delivery of lopinavir: Formulation and pharmacokinetic evaluation. Carbohydrate Polymers 110, pages 320-328.
Crossref
Patcharawee Nunthanavanit & Jiraporn Ungwitayatorn. (2014) Molecular docking studies of chromone derivatives against wild type and mutant strains of HIV-1 protease. Medicinal Chemistry Research 23:9, pages 4198-4208.
Crossref
Punna Rao Ravi, Rahul Vats, Vikas Dalal & Aditya Narasimha Murthy. (2014) A hybrid design to optimize preparation of lopinavir loaded solid lipid nanoparticles and comparative pharmacokinetic evaluation with marketed lopinavir/ritonavir coformulation. Journal of Pharmacy and Pharmacology 66:7, pages 912-926.
Crossref
Kelechi N. Eguzo, Adegboyega K. Lawal, Cynthia E. Eseigbe & Chisara C. Umezurike. (2014) Determinants of Mortality among Adult HIV-Infected Patients on Antiretroviral Therapy in a Rural Hospital in Southeastern Nigeria: A 5-Year Cohort Study. AIDS Research and Treatment 2014, pages 1-6.
Crossref
Ronald P Trible, Purushottam Narute, Lori A Emert-Sedlak, John Jeff Alvarado, Katelyn Atkins, Laurel Thomas, Toshiaki Kodama, Naveena Yanamala, Vasiliy Korotchenko, Billy W Day, Gary Thomas & Thomas E Smithgall. (2013) Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen. Retrovirology 10:1.
Crossref
Thomas E. Smithgall & Gary Thomas. (2013) Small molecule inhibitors of the HIV-1 virulence factor, Nef. Drug Discovery Today: Technologies 10:4, pages e523-e529.
Crossref
Erik Serrao, Zhong-Liang Xu, Bikash Debnath, Frauke Christ, Zeger Debyser, Ya-Qiu Long & Nouri Neamati. (2013) Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase–LEDGF/p75 interaction. Bioorganic & Medicinal Chemistry 21:19, pages 5963-5972.
Crossref
Brian M. Capogna, Andrew Lovy, Yossef Blum, Sun Jin Kim, Uriel R. Felsen & David S. Geller. (2013) Infection Rate Following Total Joint Arthroplasty in the HIV Population. The Journal of Arthroplasty 28:8, pages 1254-1258.
Crossref
Liyu Chen, Zhujun Ao, Kallesh Danappa Jayappa, Gary Kobinger, ShuiPing Liu, Guojun Wu, Mark A. Wainberg & Xiaojian Yao. (2013) Characterization of Antiviral Activity of Benzamide Derivative AH0109 against HIV-1 Infection. Antimicrobial Agents and Chemotherapy 57:8, pages 3547-3554.
Crossref
Shegokar Ranjita. (2013) Nanosuspensions: a new approach for organ and cellular targeting in infectious diseases. Journal of Pharmaceutical Investigation 43:1, pages 1-26.
Crossref
Lori A. Emert-Sedlak, Purushottam Narute, Sherry T. Shu, Jerrod A. Poe, Haibin Shi, Naveena Yanamala, John Jeff Alvarado, John S. Lazo, Joanne I. Yeh, Paul A. Johnston & Thomas E. Smithgall. (2013) Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity. Chemistry & Biology 20:1, pages 82-91.
Crossref
Ndeke Musee, Lucky Sikhwivhilu & Mary Gulumian. 2013. Chemistry for Sustainable Development in Africa. Chemistry for Sustainable Development in Africa 123 158 .
P. R. Ravi, R. Vats, R. Thakur, S. Srivani & N. Aditya. (2012) Effect of Grapefruit Juice and Ritonavir on Pharmacokinetics of Lopinavir in Wistar Rats. Phytotherapy Research 26:10, pages 1490-1495.
Crossref
Susan C. Aitken, Aletta Kliphuis, Carole L. Wallis, Mei Ling Chu, Quirine Fillekes, Roos Barth, Wendy Stevens, Tobias F. Rinke de Wit & Rob Schuurman. (2012) Development and evaluation of an assay for HIV-1 protease and reverse transcriptase drug resistance genotyping of all major group-M subtypes. Journal of Clinical Virology 54:1, pages 21-25.
Crossref
Vincent Guiyedi, Olivier Mounoury, Soraya Boucherit, Pascale Longuet, C. Brunet-François, Eric Kendjo, J. L. Ecobichon, Madeleine Okome-Nkoumou, Catherine Leport & F. Raffi. (2012) Optimized Antiretroviral Therapy with Darunavir/Ritonavir, Etravirine and/or Raltegarvir: A Salvage Therapy Option in HIV-1 Infected Patients with Long-Term Therapeutic Failures, about 23 Cases. World Journal of AIDS 02:04, pages 300-305.
Crossref
Kyle A. Nilson & David H. Price. (2011) The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency. Genetics Research International 2011, pages 1-9.
Crossref
Jiraporn Ungwitayatorn, Chanpen Wiwat, Weerasak Samee, Patcharawee Nunthanavanit & Narumol Phosrithong. (2011) Synthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor. Journal of Molecular Structure 1001:1-3, pages 152-161.
Crossref
Paul A. Stupple, David V. Batchelor, Martin Corless, Patrick K. Dorr, David Ellis, David R. Fenwick, Sébastien R. G. Galan, Rhys M. Jones, Helen J. Mason, Donald S. Middleton, Manos Perros, Francesca Perruccio, Michelle Y. Platts, David C. Pryde, Deborah Rodrigues, Nicholas N. Smith, Peter T. Stephenson, Robert Webster, Mike Westby & Anthony Wood. (2010) An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N -{(1 S )-1-(3-Fluorophenyl)-3-[(3- endo )-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1 H -imidazo[4,5- c ]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798) . Journal of Medicinal Chemistry 54:1, pages 67-77.
Crossref
Irene T. Weber & Yuan‐Fang Wang. 2010. Aspartic Acid Proteases as Therapeutic Targets. Aspartic Acid Proteases as Therapeutic Targets 107 137 .
Tânia Regina Beraldo Battistini, Roseli Oselka Saccardo Sarni, Fabíola Isabel Suano de Souza, Tassiana Sacchi Pitta, Ana Paula Fernandes, Sonia Hix, Fernando Luiz Affonso Fonseca, Priscila Chemiotti Tardini, Valter Pinho dos Santos & Fábio Ancona Lopez. (2010) Lipodystrophy, lipid profile changes, and low serum retinol and carotenoid levels in children and adolescents with acquired immunodeficiency syndrome. Nutrition 26:6, pages 612-616.
Crossref
Ho Lun Wong, Niladri Chattopadhyay, Xiao Yu Wu & Reina Bendayan. (2010) Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Advanced Drug Delivery Reviews 62:4-5, pages 503-517.
Crossref
Shivaan Cooppan, Viness Pillay, Yahya E. Choonara, Lisa C. Du Toit & Valence M.K. Ndesendo. (2010) Rationalising fixed dose combinations for tuberculosis and acquired immunodeficiency syndrome therapy. International Journal of Biotechnology 11:3/4, pages 284.
Crossref
Lori Emert-Sedlak, Toshiaki Kodama, Edwina C. Lerner, Weixiang Dai, Caleb Foster, Billy W. Day, John S. Lazo & Thomas E. Smithgall. (2009) Chemical Library Screens Targeting an HIV-1 Accessory Factor/Host Cell Kinase Complex Identify Novel Antiretroviral Compounds. ACS Chemical Biology 4:11, pages 939-947.
Crossref
Karem L. Ortega, Daniela A. Vale & Marina H. C. G. Magalhães. (2009) Impact of PI and NNRTI HAART-based therapy on oral lesions of Brazilian HIV-infected patients. Journal of Oral Pathology & Medicine 38:6, pages 489-494.
Crossref
Catherine S. Adamson, Kayoko Waki, Sherimay D. Ablan, Karl Salzwedel & Eric O. Freed. (2009) Impact of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Evolution of Resistance to the Maturation Inhibitor Bevirimat (PA-457). Journal of Virology 83:10, pages 4884-4894.
Crossref
Vassil St. Georgiev. 2009. National Institute of Allergy and Infectious Diseases, NIH. National Institute of Allergy and Infectious Diseases, NIH 415 514 .
Louise Doyon, Robert Elston & Pierre R. Bonneau. 2009. Antimicrobial Drug Resistance. Antimicrobial Drug Resistance 477 492 .
Patrick T. Ronaldson, Yuri Persidsky & Reina Bendayan. (2008) Regulation of ABC membrane transporters in glial cells: Relevance to the pharmacotherapy of brain HIV‐1 infection. Glia 56:16, pages 1711-1735.
Crossref
Yong-Li Zhong, Brenda Pipik, Jaemoon Lee, Yoshinori Kohmura, Shigemitsu Okada, Kazunobu Igawa, Chie Kadowaki, Akihiro Takezawa, Shinji Kato, David A. Conlon, Hua Zhou, Anthony O. King, Robert A. Reamer, Donald R. Gauthier, Jr. & David Askin. (2008) Practical Synthesis of a HIV Integrase Inhibitor. Organic Process Research & Development 12:6, pages 1245-1252.
Crossref
Rebecca F. TurcotteRonald T. Raines. (2008) Design and Characterization of an HIV-Specific Ribonuclease Zymogen. AIDS Research and Human Retroviruses 24:11, pages 1357-1363.
Crossref
Bjoern Habermann, Christian Eberhardt & Andreas A. Kurth. (2008) Total joint replacement in HIV positive patients. Journal of Infection 57:1, pages 41-46.
Crossref
Kimberley Evason, James J. Collins, Cheng Huang, Stacie Hughes & Kerry Kornfeld. (2008) Valproic acid extends Caenorhabditis elegans lifespan. Aging Cell 7:3, pages 305-317.
Crossref
Petra Schlick & Tim Skern. (2008) Investigating human immunodeficiency virus-1 proteinase specificity at positions P4 to P2 using a bacterial screening system. Analytical Biochemistry 377:2, pages 162-169.
Crossref
Patcharawee Nunthanavanit, Nahoum G. Anthony, Blair F. Johnston, Simon P. Mackay & Jiraporn Ungwitayatorn. (2008) 3D‐QSAR Studies on Chromone Derivatives as HIV‐1 Protease Inhibitors: Application of Molecular Field Analysis. Archiv der Pharmazie 341:6, pages 357-364.
Crossref
Karem L Ortega, Alejandro Ceballos-Salobreña, Luis A Gaitán-Cepeda & Marina G Magalhães. (2008) Oral Manifestations after Immune Reconstitution in HIV Patients on Haart. International Journal of STD & AIDS 19:5, pages 305-308.
Crossref
Jane M. Sayer, Fengling Liu, Rieko Ishima, Irene T. Weber & John M. Louis. (2008) Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease. Journal of Biological Chemistry 283:19, pages 13459-13470.
Crossref
Diane E Bennett, Silvia Bertagnolio, Donald Sutherland & Charles F Gilks. (2008) The World Health Organization's global strategy for prevention and assessment of HIV drug resistance. Antiviral Therapy 13:2_suppl, pages 1-13.
Crossref
N Sarapa, D J Nickens, S R Raber, R R Reynolds & M A Amantea. (2007) Ritonavir 100 mg Does Not Cause QTc Prolongation in Healthy Subjects: A Possible Role as CYP3A Inhibitor in Thorough QTc Studies. Clinical Pharmacology & Therapeutics 83:1, pages 153-159.
Crossref
A.W. Neuman & D.C. Liotta. 2008. Encyclopedia of Virology. Encyclopedia of Virology 505 517 .
Sebastian Biglione, Sarah A Byers, Jason P Price, Van Trung Nguyen, Olivier Bensaude, David H Price & Wendy Maury. (2007) Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex. Retrovirology 4:1.
Crossref
Kristin H. S. Busse & Scott R. Penzak. (2007) Darunavir: A second-generation protease inhibitor. American Journal of Health-System Pharmacy 64:15, pages 1593-1602.
Crossref
Rieko Ishima, Dennis A. Torchia & John M. Louis. (2007) Mutational and Structural Studies Aimed at Characterizing the Monomer of HIV-1 Protease and Its Precursor. Journal of Biological Chemistry 282:23, pages 17190-17199.
Crossref
Welkin E Johnson. (2007) Assisted suicide for retroviruses. Nature Biotechnology 25:6, pages 643-644.
Crossref
Daniel M. Held, Jay D. Kissel, Sarah J. Thacker, Daniel Michalowski, Dayal Saran, Jianfei Ji, Richard W. Hardy, John J. Rossi & Donald H. Burke. (2007) Cross-Clade Inhibition of Recombinant Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus SIVcpz Reverse Transcriptases by RNA Pseudoknot Aptamers. Journal of Virology 81:10, pages 5375-5384.
Crossref
Alok Mulky, B. Christie Vu, Joan A. Conway, Stephen H. Hughes & John C. Kappes. (2007) Analysis of Amino Acids in the β7–β8 Loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase for their Role in Virus Replication. Journal of Molecular Biology 365:5, pages 1368-1378.
Crossref
Catherine S. Adamson & Eric O. Freed. 2007. HIV‐1: Molecular Biology and Pathogenesis Viral Mechanisms, Second Edition. HIV‐1: Molecular Biology and Pathogenesis Viral Mechanisms, Second Edition 347 387 .
John M. Louis, Rieko Ishima, Dennis A. Torchia & Irene T. Weber. 2007. HIV‐1: Molecular Biology and Pathogenesis Viral Mechanisms, Second Edition. HIV‐1: Molecular Biology and Pathogenesis Viral Mechanisms, Second Edition 261 298 .
Diane E Bennett. (2006) The requirement for surveillance of HIV drug resistance within antiretroviral rollout in the developing world. Current Opinion in Infectious Diseases 19:6, pages 607-614.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.