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Review

Update on the use of aromatase inhibitors in breast cancer

Pages 1919-1930 | Published online: 04 Oct 2006

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Laxmi Banjare, Yogesh Singh, Sant Kumar Verma, Atul Kumar Singh, Pradeep Kumar, Shashank Kumar, Akhlesh Kumar Jain & Suresh Thareja. (2023) Multifaceted 3D-QSAR analysis for the identification of pharmacophoric features of biphenyl analogues as aromatase inhibitors. Journal of Biomolecular Structure and Dynamics 41:4, pages 1322-1341.
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Articles from other publishers (45)

Debashis Ghosh. (2023) Structures and functions of human placental aromatase and steroid sulfatase, two key enzymes in estrogen biosynthesis. Steroids 196, pages 109249.
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Borja Diaz de Greñu, Diego M. Fernández-Aroca, Juan A. Organero, Gema Durá, Felix Angel Jalón, Ricardo Sánchez-Prieto, M. José Ruiz-Hidalgo, Ana María Rodríguez, Lucia Santos, José L. Albasanz & Blanca R. Manzano. (2023) Ferrozoles: Ferrocenyl derivatives of letrozole with dual effects as potent aromatase inhibitors and cytostatic agents. JBIC Journal of Biological Inorganic Chemistry 28:6, pages 531-547.
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Yongmei Wang, Fanbo Jing & Haibo Wang. (2022) Role of Exemestane in the Treatment of Estrogen-Receptor-Positive Breast Cancer: A Narrative Review of Recent Evidence. Advances in Therapy 39:2, pages 862-891.
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Nilanjan Adhikari, Sandip Kumar Baidya & Tarun Jha. (2020) Effective anti-aromatase therapy to battle against estrogen-mediated breast cancer: Comparative SAR/QSAR assessment on steroidal aromatase inhibitors. European Journal of Medicinal Chemistry 208, pages 112845.
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Mahboobeh Kian & Elham Tazikeh-Lemeski. (2020) B12Y12 (Y: N, P) fullerene-like cages for exemestane-delivery; molecular modeling investigation. Journal of Molecular Structure 1217, pages 128455.
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Laxmi Banjare, Sant Kumar Verma, Akhlesh Kumar Jain & Suresh Thareja. (2020) Design and pharmacophoric identification of flavonoid scaffold‐based aromatase inhibitors. Journal of Heterocyclic Chemistry.
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Mei Jiang, Weiling Wang, Jingxuan Zhang, Chunguo Wang, Yucong Bi, Pin Li, Song Yang, Jialin Li, Yan-Tong Xu & Ting Wang. (2020) Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats. Frontiers in Pharmacology 11.
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Subhajit Makar, Abhrajyoti Ghosh, Ashok Kumar & Sushil K. Singh. (2020) Recent Studies on Aromatase and Sulfatase Involved in Breast Cancer and their Inhibitors. Current Enzyme Inhibition 16:1, pages 20-44.
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Mark Gray, James Meehan, Carlos Martínez-Pérez, Charlene Kay, Arran K. Turnbull, Linda R. Morrison, Lisa Y. Pang & David Argyle. (2020) Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer. Frontiers in Oncology 10.
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Laxmi Banjare, Sant Kumar Verma, Akhlesh Kumar Jain & Suresh Thareja. (2019) Structure Guided Molecular Docking Assisted Alignment Dependent 3DQSAR Study on Steroidal Aromatase Inhibitors (SAIs) as Anti-breast Cancer Agents. Letters in Drug Design & Discovery 16:7, pages 808-817.
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Rebeka Jójárt, Péter Traj, Édua Kovács, Ágnes Horváth, Gyula Schneider, Mihály Szécsi, Attila Pál, Gábor Paragi & Erzsébet Mernyák. (2019) Synthesis, Biological Evaluation and Docking Studies of 13-Epimeric 10-fluoro- and 10-Chloroestra-1,4-dien-3-ones as Potential Aromatase Inhibitors. Molecules 24:9, pages 1783.
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Irida Kastrati, Svetlana Semina, Benjamin Gordon & Emily Smart. (2019) Insights into how phosphorylation of estrogen receptor at serine 305 modulates tamoxifen activity in breast cancer. Molecular and Cellular Endocrinology 483, pages 97-101.
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Irida Kastrati. 2017. Resistance to Targeted Therapies in Breast Cancer. Resistance to Targeted Therapies in Breast Cancer 89 101 .
Mahder Seifu Manenda, Charles Jérémie Hamel, Loreleï Masselot--Joubert, Marie-Ève Picard & Rong Shi. (2016) Androgen-metabolizing enzymes: A structural perspective. The Journal of Steroid Biochemistry and Molecular Biology 161, pages 54-72.
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Debashis Ghosh, Jessica Lo & Chinaza Egbuta. (2016) Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure–Function Perspective. Journal of Medicinal Chemistry 59:11, pages 5131-5148.
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Mange Ram Yadav, Mahesh A. Barmade, Riyaj S. Tamboli & Prashant R. Murumkar. (2015) Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer. European Journal of Medicinal Chemistry 105, pages 1-38.
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Irshad Ahmad & Shagufta. (2015) Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer. European Journal of Medicinal Chemistry 102, pages 375-386.
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Yunlong Wu & Zhiyi Yao. (2015) Synthesis, Biological Evaluation and Molecular Docking Studies of Ferrocene Derivatives Coupling with N-heterocyclic on Human Breast Cancer. MATEC Web of Conferences 22, pages 05001.
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Debashis Ghosh, Jessica Lo & Chinaza Egbuta. 2015. Resistance to Aromatase Inhibitors in Breast Cancer. Resistance to Aromatase Inhibitors in Breast Cancer 33 61 .
Chinaza Egbuta, Jessica Lo & Debashis Ghosh. (2014) Mechanism of Inhibition of Estrogen Biosynthesis by Azole Fungicides. Endocrinology 155:12, pages 4622-4628.
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Samar BasuRachida Nachat-KappesFlorence Caldefie-ChézetMarie-Paule Vasson. (2013) Eicosanoids and Adipokines in Breast Cancer: From Molecular Mechanisms to Clinical Considerations. Antioxidants & Redox Signaling 18:3, pages 323-360.
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Debashis Ghosh, Jessica Lo, Daniel Morton, Damien Valette, Jingle Xi, Jennifer Griswold, Susan Hubbell, Chinaza Egbuta, Wenhua Jiang, Jing An & Huw M. L. Davies. (2012) Novel Aromatase Inhibitors by Structure-Guided Design. Journal of Medicinal Chemistry 55:19, pages 8464-8476.
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Aruna V. Krishnan, Srilatha Swami & David Feldman. (2012) The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer. Steroids 77:11, pages 1107-1112.
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Hareesh B. Nair, Rao P. Perla, Nameer B. Kirma, Naveen K. Krishnegowda, Manonmani Ganapathy, Rajib Rajhans, Sujit S. Nair, Pothana Saikumar, Ratna K. Vadlamudi & Rajeshwar Rao Tekmal. (2011) Estrogen Receptor-beta Mediates the Protective Effects of Aromatase Induction in the MMTV-Her-2/neu x Aromatase Double Transgenic Mice. Hormones and Cancer 3:1-2, pages 26-36.
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Debashis Ghosh, Wenhua Jiang, Jessica Lo & Chinaza Egbuta. (2011) Higher order organization of human placental aromatase. Steroids 76:8, pages 753-758.
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Karen A. Johnson & Powel H. Brown. (2010) Drug Development for Cancer Chemoprevention: Focus on Molecular Targets. Seminars in Oncology 37:4, pages 345-358.
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Aruna V. Krishnan, Srilatha Swami & David Feldman. (2010) Vitamin D and breast cancer: Inhibition of estrogen synthesis and signaling. The Journal of Steroid Biochemistry and Molecular Biology 121:1-2, pages 343-348.
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Jing Shi, Xiaoyu Zhang, Zhongjun Ma, Min Zhang & Fang Sun. (2010) Characterization of Aromatase Binding Agents from the Dichloromethane Extract of Corydalis yanhusuo Using Ultrafiltration and Liquid Chromatography Tandem Mass Spectrometry. Molecules 15:5, pages 3556-3566.
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Debashis Ghosh, Jennifer Griswold, Mary Erman & Walter Pangborn. (2010) X-ray structure of human aromatase reveals an androgen-specific active site. The Journal of Steroid Biochemistry and Molecular Biology 118:4-5, pages 197-202.
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Jiaqi Fu, Amy M. Weise, Josie L. Falany, Charles N. Falany, Bryan J. Thibodeau, Fred R. Miller, Thomas A. Kocarek & Melissa Runge-Morris. (2009) Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression. Breast Cancer Research and Treatment 120:1, pages 35-45.
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Aruna V. Krishnan, Srilatha Swami, Lihong Peng, Jining Wang, Jacqueline Moreno & David Feldman. (2010) Tissue-Selective Regulation of Aromatase Expression by Calcitriol: Implications for Breast Cancer Therapy. Endocrinology 151:1, pages 32-42.
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Marcy J. Balunas, Bin Su, Soedarsono Riswan, Harry H.S. Fong, Robert W. Brueggemeier, John M. Pezzuto & A. Douglas Kinghorn. (2009) Isolation and characterization of aromatase inhibitors from Brassaiopsis glomerulata (Araliaceae). Phytochemistry Letters 2:1, pages 29-33.
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Paul J. Fitzgerald. (2009) Is norepinephrine an etiological factor in some types of cancer?. International Journal of Cancer 124:2, pages 257-263.
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Marcy J. Balunas, Bin Su, Robert W. Brueggemeier & A. Douglas Kinghorn. (2008) Xanthones from the Botanical Dietary Supplement Mangosteen ( Garcinia mangostana ) with Aromatase Inhibitory Activity . Journal of Natural Products 71:7, pages 1161-1166.
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Udayan Dutta & Kartikeya Pant. (2007) Aromatase inhibitors: past, present and future in breast cancer therapy. Medical Oncology 25:2, pages 113-124.
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Sampo Karkola, Annamaria Lilienkampf & Kristiina Wähälä. (2008) A 3D QSAR Model of 17β-HSD1 Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core Applying Molecular Dynamics Simulations and Ligand–Protein Docking. ChemMedChem 3:3, pages 461-472.
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