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Drug Evaluation

Rupatadine: pharmacological profile and its use in the treatment of allergic disorders

Pages 1989-2001 | Published online: 04 Oct 2006

Keep up to date with the latest research on this topic with citation updates for this article.

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Rosa Antonijoan, Jimena Coimbra, Consuelo García-Gea, Montserrat Puntes, Ignasi Gich, Cristina Campo, Román Valiente & Luis Labeaga. (2017) Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers. Current Medical Research and Opinion 33:1, pages 129-136.
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Xue Yan Wang, Margaret Lim-Jurado, Narayanan Prepageran, Pongsakorn Tantilipikorn & De Yun Wang. (2016) Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine. Therapeutics and Clinical Risk Management 12, pages 585-597.
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Vanesa González-Núñez, Claus Bachert & Joaquim Mullol. (2016) Rupatadine: global safety evaluation in allergic rhinitis and urticaria. Expert Opinion on Drug Safety 15:10, pages 1439-1448.
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Eustachio Nettis, Pantalea Delle Donne, Elisabetta Di leo, Gian Franco Calogiuri, Antonio Ferrannini & Angelo Vacca. (2013) Rupatadine for the treatment of urticaria. Expert Opinion on Pharmacotherapy 14:13, pages 1807-1813.
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Vanesa González-Núñez, Antonio Valero & Joaquim Mullol. (2013) Safety evaluation of desloratadine in allergic rhinitis. Expert Opinion on Drug Safety 12:3, pages 445-453.
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Martin Metz & Marcus Maurer. (2011) Rupatadine for the treatment of allergic rhinitis and urticaria. Expert Review of Clinical Immunology 7:1, pages 15-20.
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Arnold P Oranje, Rogier Heide, Flora B de Waard-van der Spek, Dirk Van Gysel & Bhupendra Tank. (2008) Recent advances in mast cell-related skin diseases: particular focus on mastocytosis and urticaria. Expert Review of Dermatology 3:1, pages 65-72.
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Elena Borzova & Clive Grattan. (2007) Urticaria: current and future treatments. Expert Review of Dermatology 2:3, pages 317-334.
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Vladimir V. Voronin, Mikhail V. Polynski & Maria S. Ledovskaya. (2023) 1,2,4‐Triazines and Calcium Carbide in the Catalyst‐Free Synthesis of 2,3,6‐Trisubstituted Pyridines and Their D‐, 13 C‐, and Doubly D 2 ‐ 13 C 2 ‐Labeled Analogues . Chemistry – An Asian Journal 18:23.
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Hanaa Mohamed Khalaf, Sara Mohamed Naguib Abdel Hafez, Ahlam Mohamed Abdalla, Nermeen N. Welson, Walaa Yehia Abdelzaher & Fatma Alzhraa Fouad Abdelbaky. (2022) Role of Platelet-activating factor and HO-1 in mediating the protective effect of rupatadine against 5-fluorouracil-induced hepatotoxicity in rats. Environmental Science and Pollution Research 29:26, pages 40190-40203.
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Marco Busnelli, Stefano Manzini, Alice Colombo, Fabrizia Bonacina, Giuseppe D. Norata, Elsa Franchi, Silvia Castiglioni, Christos Andronis, Eftychia Lekka, Eugenio Scanziani & Giulia Chiesa. (2021) Rupatadine Treatment Is Associated with Atherosclerosis Worsening and Altered T Lymphocyte Recruitment. Thrombosis and Haemostasis 122:05, pages 853-856.
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Mohamed A Ibrahim, Alyaa Abdelfattah Abdelmonaem, Seham A Abdel-Gaber, Heba M Hafez, Sara Mohamed Naguib Abdel Hafez & Walaa Yehia Abdelzaher. (2022) Rupatadine ameliorated ulcerative colitis in rats via modulation of platelet-activatiweng factor/interleukin-6/vascular endothelial growth factor signalling pathway. Journal of Pharmacy and Pharmacology 74:4, pages 537-546.
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Heba M. Hafez, Elshymaa A. Abdel-Hakeem & Hanaa Hassanein. (2020) Rupatadine, a dual antagonist of histamine and platelet-activating factor (PAF), attenuates experimentally induced diabetic nephropathy in rats. Naunyn-Schmiedeberg's Archives of Pharmacology 393:8, pages 1487-1500.
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Katarzyna Wasilewska, Patrycja Ciosek-Skibińska, Joanna Lenik, Stanko Srčič, Anna Basa & Katarzyna Winnicka. (2020) Utilization of Ethylcellulose Microparticles with Rupatadine Fumarate in Designing Orodispersible Minitablets with Taste Masking Effect. Materials 13:12, pages 2715.
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A. L. Guseva & M. L. Derbeneva. (2020) Antihistamines in the treatment of allergic rhinitis. Meditsinskiy sovet = Medical Council:6, pages 90-96.
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Kimihiro Okubo, Takamasa Suzuki, Ayaka Tanaka & Hiroshi Aoki. (2019) Efficacy and safety of rupatadine in Japanese patients with seasonal allergic rhinitis: A double-blind, randomized, multicenter, placebo-controlled clinical trial. Allergology International 68:2, pages 207-215.
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Katarzyna Wasilewska, Marta Szekalska, Patrycja Ciosek-Skibinska, Joanna Lenik, Anna Basa, Julia Jacyna, Michal Markuszewski & Katarzyna Winnicka. (2019) Ethylcellulose in Organic Solution or Aqueous Dispersion Form in Designing Taste-Masked Microparticles by the Spray Drying Technique with a Model Bitter Drug: Rupatadine Fumarate. Polymers 11:3, pages 522.
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Li‐Ping Zhao & Xing‐Hua Gao. 2019. Advances in Integrative Dermatology. Advances in Integrative Dermatology 145 162 .
Ronan Lordan, Alexandros Tsoupras & Ioannis Zabetakis. (2019) The Potential Role of Dietary Platelet-Activating Factor Inhibitors in Cancer Prevention and Treatment. Advances in Nutrition 10:1, pages 148-164.
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Michihiro Hide, Takamasa Suzuki, Ayaka Tanaka & Hiroshi Aoki. (2019) Efficacy and safety of rupatadine in Japanese adult and adolescent patients with chronic spontaneous urticaria: A double-blind, randomized, multicenter, placebo-controlled clinical trial. Allergology International 68:1, pages 59-67.
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Marija R. Popović-Nikolić, Gordana V. Popović, Kristina Stojilković, Maja Dobrosavljević & Danica D. Agbaba. (2018) Acid–Base Equilibria of Rupatadine Fumarate in Aqueous Media. Journal of Chemical & Engineering Data 63:8, pages 3150-3156.
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G. K. Scadding, H. H. Kariyawasam, G. Scadding, R. Mirakian, R. J. Buckley, T. Dixon, S. R. Durham, S. Farooque, N. Jones, S. Leech, S. M. Nasser, R. Powell, G. Roberts, G. Rotiroti, A. Simpson, H. Smith & A. T. Clark. (2017) BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis (Revised Edition 2017; First edition 2007). Clinical & Experimental Allergy 47:7, pages 856-889.
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Ruben Vardanyan. 2017. Piperidine-Based Drug Discovery. Piperidine-Based Drug Discovery 223 239 .
Jörg Täubel, Georg Ferber, Sara Fernandes, Ulrike Lorch, Eva Santamaría & Iñaki Izquierdo. (2016) Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial. PLOS ONE 11:9, pages e0163020.
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Yuqing Xiong, Zhao Yuan, Jingzhi Yang, Chunhua Xia, Xinhua Li, Shibo Huang, Hong Zhang & Mingyi Liu. (2014) CYP3A5*3 and MDR1 C3435T are influencing factors of inter-subject variability in rupatadine pharmacokinetics in healthy Chinese volunteers. European Journal of Drug Metabolism and Pharmacokinetics 41:2, pages 117-124.
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Martin Metz, Karsten Weller, Claudia Neumeister, Iñaki Izquierdo, Rolf-Hasso Bödeker, Ulrich Schwantes & Marcus Maurer. (2015) Rupatadine in Established Treatment Schemes Improves Chronic Spontaneous Urticaria Symptoms and Patients’ Quality of Life: a Prospective, Non-interventional Trial. Dermatology and Therapy 5:4, pages 217-230.
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Pertti Panula, Paul L. Chazot, Marlon Cowart, Ralf Gutzmer, Rob Leurs, Wai L. S. Liu, Holger Stark, Robin L. Thurmond & Helmut L. Haas. (2015) International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacological Reviews 67:3, pages 601-655.
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J. Mullol, J. Bousquet, C. Bachert, G. W. Canonica, A. Giménez-Arnau, M. L. Kowalski, F. E. R. Simons, M. Maurer, D. Ryan & G. Scadding. (2015) Update on rupatadine in the management of allergic disorders. Allergy 70, pages 1-24.
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M A Mokronosova. (2014) RUPATADINE FUMARATE: NEW FORMULA - NEW THERAPEUTIC EFFICACY. Russian Journal of Allergy 11:6, pages 58-62.
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Erminia Ridolo, Marcello Montagni, Filippo Fassio, Ilaria Massaro, Oliviero Rossi, Cristoforo Incorvaia & Giorgio Walter Canonica. (2014) Rupatadine for the treatment of allergic rhinitis and urticaria: a look at the clinical data. Clinical Investigation 4:5, pages 453-461.
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Soja Shamizadeh, Knut Brockow & Johannes Ring. (2014) Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects. Allergo Journal International 23:3, pages 87-95.
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Soja Shamizadeh, Knut Brockow & Johannes Ring. (2014) Rupatadin — Wirksamkeit und Sicherheit eines nichtsedierenden Antihistaminikums mit PAF-antagonisierender Wirkung. Allergo Journal 23:3, pages 27-35.
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Michail Alevizos, Anna Karagkouni, Smaro Panagiotidou, Magdalini Vasiadi & Theoharis C. Theoharides. (2014) Stress triggers coronary mast cells leading to cardiac events. Annals of Allergy, Asthma & Immunology 112:4, pages 309-316.
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I S Gushchin. (2013) THERAPEUTIC EFFICACY OF A POLY-FUNCTIONAL ANTIALLERGIC DRUG - RUPATADINE. Russian Journal of Allergy 10:1, pages 63-77.
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Michail Alevizos, Anna Karagkouni, Magdalini Vasiadi, Nikolaos Sismanopoulos, Michael Makris, Dimitrios Kalogeromitros & Theoharis C. Theoharides. (2013) Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. Annals of Allergy, Asthma & Immunology 111:6, pages 542-547.
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Xiao-xi Lv, Xiao-xing Wang, Ke Li, Zi-yan Wang, Zhe Li, Qi Lv, Xiao-ming Fu & Zhuo-Wei Hu. (2013) Rupatadine Protects against Pulmonary Fibrosis by Attenuating PAF-Mediated Senescence in Rodents. PLoS ONE 8:7, pages e68631.
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Manpreet Kaur, Jerry P. Jasinski, Zane A. Luopa, Neeraj Kumar, Nilesh G. Patel, Omprakash Gudaparthi & H. S. Yathirajan. (2013) Rupatadine. Acta Crystallographica Section E Structure Reports Online 69:6, pages o980-o980.
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Preeti Singh, Ishwari Narayan Singh, Sambhu Charan Mondal, Lubhan Singh & Vipin Kumar Garg. (2013) Platelet-activating factor (PAF)-antagonists of natural origin. Fitoterapia 84, pages 180-201.
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Elena Yu Borzova & Clive H Grattan. (2010) TREATMENT OF URTICARIA: TODAY AND TOMORROW. Russian Journal of Allergy 7:6, pages 5-13.
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Consuelo García‐Gea, Maria Rosa Ballester, Juan Martínez, Rosa Maria Antonijoan, Esther Donado, Iñaki Izquierdo & Manuel‐José Barbanoj. (2010) Rupatadine does not potentiate the CNS depressant effects of lorazepam: randomized, double‐blind, crossover, repeated dose, placebo‐controlled study. British Journal of Clinical Pharmacology 69:6, pages 663-674.
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Ester Donado, Iñaki Izquierdo, Iñaki Pérez, Olga García, Rosa Ma Antonijoan, Ignaci Gich, Anna Solans, Juana Peña, Joel Morganroth & Manuel J. Barbanoj. (2010) No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: results from a ‘thorough QT/QTc study’ performed according to ICH guidelines. British Journal of Clinical Pharmacology 69:4, pages 401-410.
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Amanda J. DeGraw, Michael J. Keiser, Joshua D. Ochocki, Brian K. Shoichet & Mark D. Distefano. (2010) Prediction and Evaluation of Protein Farnesyltransferase Inhibition by Commercial Drugs. Journal of Medicinal Chemistry 53:6, pages 2464-2471.
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Martin Metz, Elisabeth Scholz, Marta Ferrán, Iñaki Izquierdo, Ana Giménez-Arnau & Marcus Maurer. (2010) Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. Annals of Allergy, Asthma & Immunology 104:1, pages 86-92.
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Antonio Valero, Fernando de la Torre, José Antonio Castillo, Pilar Rivas, Alfonso del Cuvillo, Ignacio Antépara, Javier Borja, Esther Donado, Oriol Molà & Iñaki Izquierdo. (2009) Safety of Rupatadine Administered Over a Period of 1 Year in the Treatment of Persistent Allergic Rhinitis. Drug Safety 32:1, pages 33-42.
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Daniele Rubert Nogueira, Maximiliano da Silva Sangoi, Lucélia Magalhães da Silva, Vítor Todeschini & Sérgio Luiz Dalmora. (2008) Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method. Journal of Separation Science 31:16-17, pages 3098-3105.
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J. Mullol, J. Bousquet, C. Bachert, W. G. Canonica, A. Gimenez-Arnau, M. L. Kowalski, E. Martí-Guadaño, M. Maurer, C. Picado, G. Scadding & P. Van Cauwenberge. (2008) Rupatadine in allergic rhinitis and chronic urticaria. Allergy 63:s87, pages 5-28.
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Daniele R. Nogueira, Felipe B. D’Avila, Clarice M. B. Rolim & Sergio L. Dalmora. (2007) Development and Validation of a Stability-Indicating LC Method for the Determination of Rupatadine in Pharmaceutical Formulations. Chromatographia 66:11-12, pages 915-919.
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Anna Solans, Marcel·lí Carbó, Juana Peña, Teresa Nadal, Iñaki Izquierdo & Manuel Merlos. (2007) Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: A single-dose, randomized, open-label, two-way crossover study. Clinical Therapeutics 29:5, pages 900-908.
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