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Drug Evaluation

Donepezil: an update

Pages 1011-1023 | Published online: 01 May 2007

Keep up to date with the latest research on this topic with citation updates for this article.

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Gabriel C Léger & Fadi Massoud. (2013) Novel disease-modifying therapeutics for the treatment of Alzheimer’s disease. Expert Review of Clinical Pharmacology 6:4, pages 423-442.
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Piera Sozio, Laura S Cerasa, Lisa Marinelli & Antonio Di Stefano. (2012) Transdermal donepezil on the treatment of Alzheimer’s disease. Neuropsychiatric Disease and Treatment 8, pages 361-368.
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Antonio Di Stefano, Antonio Iannitelli, Sara Laserra & Piera Sozio. (2011) Drug delivery strategies for Alzheimer's disease treatment. Expert Opinion on Drug Delivery 8:5, pages 581-603.
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Alberto Halabe Bucay. (2009) Donepezil (aricept) as a treatment for anorexia nervosa: a very feasible therapeutic possibility. Expert Opinion on Investigational Drugs 18:5, pages 569-571.
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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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Heinz Reichmann & Tjalf Ziemssen. (2009) Treatment strategies for nonmotor manifestations of Parkinson's disease. Expert Opinion on Pharmacotherapy 10:5, pages 773-784.
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Sandra A Jacobson & Marwan N Sabbagh. (2008) Donepezil: potential neuroprotective and disease-modifying effects. Expert Opinion on Drug Metabolism & Toxicology 4:10, pages 1363-1369.
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Walter J Lukiw. (2008) Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD). Expert Opinion on Emerging Drugs 13:2, pages 255-271.
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Articles from other publishers (57)

Jing-Jing Xu, Jiao Luo, Heng Xi, Jin-Bu Xu & Lin-Xi Wan. (2023) Palladium-catalyzed synthesis and anti-AD biological activity evaluation of N-aryl-debenzeyldonepezil analogues. Frontiers in Chemistry 11.
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Ahmed M. Salem, Nada M. Mostafa, Eman Al‐Sayed, Iten M. Fawzy & Abdel Nasser B. Singab. (2023) Insights into the Role of Erythrina corallodendron L. in Alzheimer's Disease: in Vitro and in Silico Approach . Chemistry & Biodiversity 20:7.
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Sanghee Choi, Wang-Seob Shim, Jiyoung Yoon, Doowon Choi, Eunseo Song, Yeo Jin Choi, Soo-Heui Paik & Kyung-Tae Lee. (2023) Method Development and Validation for the Simultaneous Quantitation of Pentoxifylline, Its Pharmacologically Active Metabolites, and Donepezil Using LC-MS/MS in Rat Plasma: Its Application to a Pharmacokinetic Study. Separations 10:5, pages 276.
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Astik Kumar, Sachithra Thazhathuveedu Sudevan, Aathira Sujathan Nair, Ashutosh Kumar Singh, Sunil Kumar, Jobin Jose, Tapan Behl, Sabitha Mangalathillam, Bijo Mathew & Hoon Kim. (2023) Current and Future Nano-Carrier-Based Approaches in the Treatment of Alzheimer’s Disease. Brain Sciences 13:2, pages 213.
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Shuainan Zheng, Long Pan, Jianguang Hou, Aimei Liao, Yinchen Hou, Guanghai Yu, Xiaoxiao Li, Yongjian Yuan, Yuqi Dong, Penghui Zhao, Jie Zhang, Zheyuan Hu, Ming Hui, Jian Cao & Ji-Hong Huang. (2022) The role of wheat embryo globulin nutrients in improving cognitive dysfunction in AD rats. Food & Function 13:19, pages 9856-9867.
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Rouchan Ali, Ghanshyam Das Gupta & Pooja A. Chawla. (2022) Aducanumab: A new hope in Alzheimer's disease. Health Sciences Review 4, pages 100039.
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Parham Pooladgar, Mehdi Sakhabakhsh, Arsia Taghva & Saeed Soleiman-Meigooni. (2022) Donepezil Beyond Alzheimer's Disease? A Narrative Review of Therapeutic Potentials of Donepezil in Different Diseases. Iranian Journal of Pharmaceutical Research 21:1.
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Philippe Delbreil, Jean-Michel Rabanel, Xavier Banquy & Davide Brambilla. (2022) Therapeutic nanotechnologies for Alzheimer’s disease: A critical analysis of recent trends and findings. Advanced Drug Delivery Reviews 187, pages 114397.
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Teresa Pardo-Moreno, Anabel González-Acedo, Antonio Rivas-Domínguez, Victoria García-Morales, Francisco Jose García-Cozar, Juan Jose Ramos-Rodríguez & Lucía Melguizo-Rodríguez. (2022) Therapeutic Approach to Alzheimer’s Disease: Current Treatments and New Perspectives. Pharmaceutics 14:6, pages 1117.
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Keshireddy AnjiReddy & S. Karpagam Subramanian. (2022) A New Mode of Thinfilm and Nanofiber for Burst Release of the Drug for Alzheimer Disease; A Complete Scenario from Dispersible Polymer to Formulation Methodology. Mini-Reviews in Medicinal Chemistry 22:6, pages 949-966.
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Yuan Li, Xiuzhen Sun, Jianqun Zhuang, Junzhi Wang & Chunqiang Yang. (2022) Donepezil ameliorates oxygen‑glucose deprivation/reoxygenation‑induced cardiac microvascular endothelial cell dysfunction through PARP1/NF‑κB signaling. Molecular Medicine Reports 25:4.
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Wei Xiong, Xiaoqin Zhao, Qing Xu, Guihua Wei, Liudai Zhang, Yuqing Fan, Lingmiao Wen, Yanjun Liu, Tinglan Zhang, Li Zhang, Yan Tong, Qiaozhi Yin, Tian-e Zhang & Zhiyong Yan. (2022) Qisheng Wan formula ameliorates cognitive impairment of Alzheimer's disease rat via inflammation inhibition and intestinal microbiota regulation. Journal of Ethnopharmacology 282, pages 114598.
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Lin-Xi Wan, Shi-Xing Miao, Zhen-Xiang He, Xiaohuan Li, Xian-Li Zhou & Feng Gao. (2021) Pd-Catalyzed Direct Modification of an Anti-Alzheimer’s Disease Drug: Synthesis and Biological Evaluation of α-Aryl Donepezil Analogues. ACS Omega 6:36, pages 23347-23354.
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Ana CVV Giacomini, Barbara W Bueno, Leticia Marcon, Naiara Scolari, Rafael Genario, Konstantin A Demin, Tatyana O Kolesnikova, Allan V Kalueff & Murilo S de Abreu. (2020) An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish. Journal of Psychopharmacology 34:12, pages 1449-1456.
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Cindy Juliet Cristancho Ortiz, Caio Miranda Damasio, Letizia Pruccoli, Nathália Fonseca Nadur, Luciana Luiza de Azevedo, Isabella Alvim Guedes, Laurent Emmanuel Dardenne, Arthur Eugen Kümmerle, Andrea Tarozzi & Claudio ViegasJr.Jr.. (2020) Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases. Neurochemical Research 45:12, pages 3003-3020.
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Stephen M. Stahl. 2021. Prescriber's Guide. Prescriber's Guide 243 248 .
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Niloufar Choubdar & Sara Avizheh. (2020) Nanotechnology Based Delivery Systems of Drugs Currently Used to Treat Alzheimer’s Disease. Nanoscience & Nanotechnology-Asia 10:3, pages 228-247.
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Kowthavarapu Venkata Krishna, Geetika Wadhwa, Amit Alexander, Neha Kanojia, Ranendra Narayan Saha, Ritushree Kukreti, Gautam Singhvi & Sunil Kumar Dubey. (2019) Design and Biological Evaluation of Lipoprotein-Based Donepezil Nanocarrier for Enhanced Brain Uptake through Oral Delivery. ACS Chemical Neuroscience 10:9, pages 4124-4135.
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Pablo Zambrano, Mario Suwalsky, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka, Benjamin Sepúlveda, María J. Gallardo & Luis F. Aguilar. (2019) The acetylcholinesterase (AChE) inhibitor and anti-Alzheimer drug donepezil interacts with human erythrocytes. Biochimica et Biophysica Acta (BBA) - Biomembranes 1861:6, pages 1078-1085.
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James T. BrewsterIIII, Simone Dell’Acqua, Danny Q. Thach & Jonathan L. Sessler. (2018) Classics in Chemical Neuroscience: Donepezil. ACS Chemical Neuroscience 10:1, pages 155-167.
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Jana Zdarova Karasova, Vit Sestak, Jan Korabecny, Eva Mezeiova, Vladimir Palicka, Kamil Kuca & Martin Mzik. (2018) 1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats. Journal of Chromatography B 1092, pages 350-358.
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Chang Yell Shin, Hae-Sun Kim, Kwang-Ho Cha, Dong Han Won, Ji-Yun Lee, Sun Woo Jang & Uy Dong Sohn. (2018) The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents. Biomolecules & Therapeutics 26:3, pages 274-281.
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Christopher WilkeDavid GrosshansJoseph DumanPaul BrownJing Li. (2018) Radiation-induced cognitive toxicity: pathophysiology and interventions to reduce toxicity in adults. Neuro-Oncology 20:5, pages 597-607.
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Zhengping Zhang, Rong Chen, Wenji An, Chunmei Wang, Gaoyong Liao, Xiaoliang Dong, Aijing Bi, Zhimin Yin & Lan Luo. (2015) A novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improves Aβ25–35-impaired mouse cognitive function. Psychopharmacology 233:4, pages 599-613.
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Maviye Galipoğlu, Meryem Sedef Erdal & Sevgi Güngör. (2014) Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment. AAPS PharmSciTech 16:2, pages 284-292.
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Yoon-Sang Oh, Joong-Seok Kim, Dong Woo Ryu & Kwang-Soo Lee. (2012) Donepezil induced antecollis in a patient with Parkinson’s disease dementia. Neurological Sciences 34:9, pages 1685-1686.
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Matthias Vandesquille, Mathieu Baudonnat, Laurence Decorte, Caroline Louis, Pierre Lestage & Daniel Béracochéa. (2013) Working memory deficits and related disinhibition of the cAMP/PKA/CREB are alleviated by prefrontal α4β2*-nAChRs stimulation in aged mice. Neurobiology of Aging 34:6, pages 1599-1609.
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Soad A Yehia, Ahmed H Elshafeey & Ibrahim Elsayed. (2012) Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation. Journal of Pharmacy and Pharmacology 64:10, pages 1425-1437.
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Ramakrishna Nirogi, Gopinadh Bhyrapuneni, Vishwottam Kandikere, Vijay Benade, Nageswararao Muddana, Ramanatha Saralaya, Shantaveer Irappanavar, Ranjithkumar Ponnamaneni & K. Mukkanti. (2012) Concurrent administration of atypical antipsychotics and donepezil: drug interaction study in rats. European Journal of Drug Metabolism and Pharmacokinetics 37:3, pages 155-161.
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Joonho Choi, Min-Koo Choi, Saeho Chong, Suk-Jae Chung, Chang-Koo Shim & Dae-Duk Kim. (2012) Effect of fatty acids on the transdermal delivery of donepezil: In vitro and in vivo evaluation. International Journal of Pharmaceutics 422:1-2, pages 83-90.
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