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Drug Evaluations

Clozapine use in children and adolescents

, MD & , MD
Pages 459-465 | Published online: 28 Jan 2008

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Corinna Klein & Anton Bespalov. (2014) Development of novel therapy of schizophrenia in children and adolescents. Expert Opinion on Investigational Drugs 23:11, pages 1531-1540.
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Articles from other publishers (43)

Sara Jiménez-Fernández, Manuel Gurpegui, Christoph U. Correll, Jose de Leon & Georgios Schoretsanitis. (2023) A Systematic Review of Clozapine Concentration–Dose Ratio from Therapeutic Drug Monitoring Studies in Children and Adolescents Treated with Clozapine for Mental Disorders. Therapeutic Drug Monitoring.
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Virginio Salvi, Laura Orsolini, Lorenzo Maria Martino, Simone Pompili & Umberto Volpe. (2022) Recognizing, Managing and Treating Acute Agitation in Youths. Current Pharmaceutical Design 28:31, pages 2554-2568.
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Ronald J. Gurrera, Priya F. Gearin, Jonathan Love, Kevin J. Li, Ashley Xu, Faith H. Donaghey & Matthew R. Gerace. (2022) Recognition and management of clozapine adverse effects: A systematic review and qualitative synthesis. Acta Psychiatrica Scandinavica 145:5, pages 423-441.
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Antonio Vita, Stefano Barlati, Antonello Bellomo, Paolo Fusar Poli, Gabriele Masi, Lino Nobili, Gianluca Serafini, Alessandro Zuddas & Stefano Vicari. (2022) Patterns of Care for Adolescent With Schizophrenia: A Delphi-Based Consensus Study. Frontiers in Psychiatry 13.
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Rocío Paricio del Castillo, Pablo del Sol Calderón & Inmaculada Palanca Maresca. (2021) ¿Mantenimiento o retirada? Pericarditis en un paciente en tratamiento con clozapina: a propósito de un caso. Psiquiatría Biológica 28:3, pages 100334.
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David I. Driver, Shari Thomas, Nitin Gogtay & Judith L. Rapoport. (2020) Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders. Child and Adolescent Psychiatric Clinics of North America 29:1, pages 71-90.
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Jonathan M. Meyer & Stephen M. Stahl. 2021. The Clozapine Handbook. The Clozapine Handbook 276 306 .
Vivekananda Rachamallu, Benjamin W. Elberson, Emily Vutam & Manish Aligeti. (2019) Off-Label Use of Clozapine in Children and Adolescents—A Literature Review. American Journal of Therapeutics 26:3, pages e406-e416.
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Timothy RiceStephanie FriedmanJasmine TatumNaomi Weiss-GoldmanYael KufertBarbara J. Coffey. (2019) Optimizing Clozapine Benefit While Minimizing Adverse Effects with Concomitant Fluvoxamine Treatment in an Adolescent with Schizoaffective Disorder. Journal of Child and Adolescent Psychopharmacology 29:1, pages 66-71.
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Susanne Mudra, Daniel Luedecke, Maria Grafmann & Michael Schulte-Markwort. (2018) Myocarditis During Treatment With Clozapine in 2 Adolescent Cases. Journal of Clinical Psychopharmacology 38:6, pages 639-640.
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Esther S. LeeCarol VidalRobert L. Findling. (2018) A Focused Review on the Treatment of Pediatric Patients with Atypical Antipsychotics. Journal of Child and Adolescent Psychopharmacology 28:9, pages 582-605.
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Laura M. SteinauerJonathan G. LeungBetsy Walters BurkeyIan R. McGraneVictoria LettsJessica L. GorenDawn M. HoeftSandra MullenMegan MaroneyKathryn M. SchakJennifer L. Vande Voort. (2018) A Retrospective Multicenter Evaluation of Clozapine Use in Pediatric Patients Admitted for Acute Psychiatric Hospitalization. Journal of Child and Adolescent Psychopharmacology 28:9, pages 615-619.
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Andrew T. Olagunju, Scott R. Clark & Bernhard T. Baune. (2018) Clozapine and Psychosocial Function in Schizophrenia: A Systematic Review and Meta-Analysis. CNS Drugs 32:11, pages 1011-1023.
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Stephen M. Stahl. 2021. Prescriber's Guide – Children and Adolescents. Prescriber's Guide – Children and Adolescents.
Yong Kee Choi, Matthew P. Gardner & Frank I. Tarazi. (2017) Developmental effects of antipsychotic drugs on serotonin receptor subtypes. Synapse 71:10, pages e21988.
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Vivekananda Rachamallu, Ayman Haq, Michael M. Song & Manish Aligeti. (2017) Clozapine-Induced Microseizures, Orofacial Dyskinesia, and Speech Dysfluency in an Adolescent with Treatment Resistant Early Onset Schizophrenia on Concurrent Lithium Therapy. Case Reports in Psychiatry 2017, pages 1-7.
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Ozhan YalcinGizem KaymakAyten ErdoganCanan TanidirGul KaracetinAli Guven KilicogluCaner MutluHilal AdaletliHatice GunesKayhan BahaliBasak AyikOzden Sukran Uneri. (2016) A Retrospective Investigation of Clozapine Treatment in Autistic and Nonautistic Children and Adolescents in an Inpatient Clinic in Turkey. Journal of Child and Adolescent Psychopharmacology 26:9, pages 815-821.
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Fernando Espi Forcen, Konstantina Matsoukas & Yesne Alici. (2015) Antipsychotic-induced akathisia in delirium: A systematic review. Palliative and Supportive Care 14:1, pages 77-84.
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John Lally & Robert J. Flanagan. 2016. Life-Threatening Effects of Antipsychotic Drugs. Life-Threatening Effects of Antipsychotic Drugs 105 148 .
Megan Elizabeth Rich & Heather Kingsley Caldwell. (2015) A Role for Oxytocin in the Etiology and Treatment of Schizophrenia. Frontiers in Endocrinology 6.
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Jessica Memarzia, Derek Tracy & Giovanni Giaroli. (2014) The use of antipsychotics in preschoolers: A veto or a sensible last option?. Journal of Psychopharmacology 28:4, pages 303-319.
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Yael MidbariTanya EbertIra KosovMoshe KotlerAbraham WeizmanAnca Ram. (2013) Hematological and Cardiometabolic Safety of Clozapine in the Treatment of Very Early Onset Schizophrenia: A Retrospective Chart Review. Journal of Child and Adolescent Psychopharmacology 23:8, pages 516-521.
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Silvio Caccia. (2013) Safety and Pharmacokinetics of Atypical Antipsychotics in Children and Adolescents. Pediatric Drugs 15:3, pages 217-233.
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Lewis Couchman, Sally V.J. Bowskill, Simon Handley, Maxine X. Patel & Robert J. Flanagan. (2013) Plasma clozapine and norclozapine in relation to prescribed dose and other factors in patients aged <18 years: data from a therapeutic drug monitoring service, 1994-2010. Early Intervention in Psychiatry 7:2, pages 122-130.
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A Eltas, Ş Kartalcı, ŞD Eltas, S Dündar & MO Uslu. (2013) An assessment of periodontal health in patients with schizophrenia and taking antipsychotic medication. International Journal of Dental Hygiene 11:2, pages 78-83.
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N. Toepfner, A. Wohlfarth, J. Naue, V. Auwärter, R. Berner & M. Hermanns-Clausen. (2013) Accidental clozapine intoxication in a toddler: clinical and pharmacokinetic lessons learnt. Journal of Clinical Pharmacy and Therapeutics 38:2, pages 165-168.
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Kristin N. MaherMarcus TanJulia W. TossellBrian WeisingerPeter GochmanRachel MillerDeanna GreensteinGerald P. OvermanJudith L. RapoportNitin Gogtay. (2013) Risk Factors for Neutropenia in Clozapine-Treated Children and Adolescents with Childhood-Onset Schizophrenia. Journal of Child and Adolescent Psychopharmacology 23:2, pages 110-116.
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Eduardo Henrique Teixeira, Antonio Jacintho, Heloisa Valler Celeri & Paulo Dalgalarrondo. (2013) Atypical antipsychotics in the treatment of pathological aggression in children and adolescents: literature review and clinical recommendations. Trends in Psychiatry and Psychotherapy 35:3, pages 151-159.
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Itziar Flamarique, Josefina Castro-Fornieles, Juan Miguel Garrido, Elena de la Serna, Alexandre Pons, Miguel Bernardo & Inmaculada Baeza. (2012) Electroconvulsive Therapy and Clozapine in Adolescents With Schizophrenia Spectrum Disorders. Journal of Clinical Psychopharmacology 32:6, pages 756-766.
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C. Lindsay Devane. 2012. Pharmacotherapy of Child and Adolescent Psychiatric Disorders. Pharmacotherapy of Child and Adolescent Psychiatric Disorders 25 38 .
Rebecca Rendleman & John T. Walkup. 2012. Swaiman's Pediatric Neurology. Swaiman's Pediatric Neurology 664 702 .
Ariane Wohlfarth, Nicole Toepfner, Maren Hermanns-Clausen & Volker Auwärter. (2011) Sensitive quantification of clozapine and its main metabolites norclozapine and clozapine-N-oxide in serum and urine using LC-MS/MS after simple liquid–liquid extraction work-up. Analytical and Bioanalytical Chemistry 400:3, pages 737-746.
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Patty M. M. Nooijen, Felix Carvalho & Robert J. Flanagan. (2011) Haematological toxicity of clozapine and some other drugs used in psychiatry. Human Psychopharmacology: Clinical and Experimental 26:2, pages 112-119.
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Anand K Mattai, Julia L Hill & Rhoshel K Lenroot. (2010) Treatment of early-onset schizophrenia. Current Opinion in Psychiatry 23:4, pages 304-310.
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Laure Ragonnet, Pascale Abadie & Sonia Dollfus. (2010) Use of Clozapine in an Adolescent With Refractory First-Episode Psychosis and Neutropenia. Journal of Clinical Psychopharmacology 30:3, pages 336-338.
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Laurel A. WeaverDiva D. De LeónKarin Borgmann-WinterBarbara J. Coffey. (2010) Use of Metformin to Control Clozapine-Associated Weight Gain in an Adolescent with Schizoaffective Disorder. Journal of Child and Adolescent Psychopharmacology 20:2, pages 153-157.
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Anthony C. James. (2018) Prescribing antipsychotics for children and adolescents. Advances in Psychiatric Treatment 16:1, pages 63-75.
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Anand Mattai, Alex Chavez, Deanna Greenstein, Liv Clasen, Jennifer Bakalar, Reva Stidd, Judith Rapoport & Nitin Gogtay. (2010) Effects of clozapine and olanzapine on cortical thickness in childhood-onset schizophrenia. Schizophrenia Research 116:1, pages 44-48.
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Chad A. Noggle & Raymond S. Dean. (2009) Atypical and typical antipsychotics in the schools. Psychology in the Schools 46:9, pages 869-884.
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Anand Mattai, Lawrence Fung, Jennifer Bakalar, Gerald Overman, Julia Tossell, Rachel Miller, Judith Rapoport & Nitin Gogtay. (2009) Adjunctive use of lithium carbonate for the management of neutropenia in clozapine‐treated children. Human Psychopharmacology: Clinical and Experimental 24:7, pages 584-589.
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Yeni Kim, Boong‐Nyun Kim, Soo‐Churl Cho, Jae‐Won Kim & Min‐Sup Shin. (2008) Long‐term sustained benefits of clozapine treatment in refractory early onset schizophrenia: A retrospective study in Korean children and adolescents. Human Psychopharmacology: Clinical and Experimental 23:8, pages 715-722.
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Anthony James. (2008) Paediatric psychopharmacology in schizophrenia. Psychiatry 7:11, pages 458-462.
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Iliyan Ivanov & Alexander Charney. (2008) Treating pediatric patients with antipsychotic drugs: balancing benefits and safety. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 75:3, pages 276-286.
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