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Expert Opinion on Pharmacotherapy Volume 9, 2008 - Issue 7
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Drug Evaluations

Managing neuropathic pain with Sativex®: a review of its pros and cons

Jordi Perez Universitat de Barcelona, Department of Anaesthesiology, Pain Clinic, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain +34 93 225 5558; [email protected]
, MD &
Mª Victoria Ribera Chairman, Pain Unit, Hospital Universitari Vall d'Hebron, University Autonoma of Barcelona, Spain
, MD PhD
Pages 1189-1195 | Published online: 21 Apr 2008

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Lisa Hill & Stephan A Schug. (2009) Recent advances in the pharmaceutical management of pain. Expert Review of Clinical Pharmacology 2:5, pages 543-557.
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Jordi Pérez Martínez. (2022) Aspectos prácticos de la elección del producto y la titulación con cannabis medicinal para el dolor crónico. Revista de la Sociedad Española del Dolor.
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L. Matchett-Oates, S. Braich, G. C. Spangenberg, S. Rochfort & N. O. I. Cogan. (2021) In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation. PLOS ONE 16:9, pages e0257413.
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Brandon Yep, Nigel V. Gale & Youbin Zheng. (2020) Comparing hydroponic and aquaponic rootzones on the growth of two drug-type Cannabis sativa L. cultivars during the flowering stage. Industrial Crops and Products 157, pages 112881.
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Francesco Patti, Clara Grazia Chisari, Claudio Solaro, Maria Donata Benedetti, Eliana Berra, Assunta Bianco, Roberto Bruno Bossio, Fabio Buttari, Letizia Castelli, Paola Cavalla, Raffaella Cerqua, Gianfranco Costantino, Claudio Gasperini, Angelica Guareschi, Domenico Ippolito, Roberta Lanzillo, Giorgia Teresa Maniscalco, Manuela Matta, Damiano Paolicelli, Loredana Petrucci, Simona Pontecorvo, Isabella Righini, Margherita Russo, Francesco Saccà, Giovanna Salamone, Elisabetta Signoriello, Gabriella Spinicci, Daniele Spitaleri, Eleonora Tavazzi, Maria Trotta, Mauro Zaffaroni & Mario Zappia. (2020) Effects of THC/CBD oromucosal spray on spasticity-related symptoms in people with multiple sclerosis: results from a retrospective multicenter study. Neurological Sciences 41:10, pages 2905-2913.
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María Fernández-Trapero, Carmen Pérez-Díaz, Francisco Espejo-Porras, Eva de Lago & Javier Fernández-Ruiz. (2020) Pharmacokinetics of Sativex® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders. Biomolecules 10:2, pages 279.
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Iftach Sagy, Tal Peleg-Sagy, Leonid Barski, Lior Zeller & Alan Jotkowitz. (2018) Ethical issues in medical cannabis use. European Journal of Internal Medicine 49, pages 20-22.
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Maria Grazia Cascio, Roger G. Pertwee & Pietro Marini. 2017. Cannabis sativa L. - Botany and Biotechnology. Cannabis sativa L. - Botany and Biotechnology 207 225 .
Margherita Russo, Antonino Naro, Antonino Leo, Edoardo Sessa, Giangaetano D’Aleo, Placido Bramanti & Rocco Salvatore Calabrò. (2016) Evaluating Sativex ® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis . Pain Medicine, pages pnv080.
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Uwe K. Zettl, Paulus Rommer, Petra Hipp & Robert Patejdl. (2015) Evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management of patients with spasticity due to multiple sclerosis. Therapeutic Advances in Neurological Disorders 9:1, pages 9-30.
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Jun-Xu Li & Yanan Zhang. (2012) Emerging drug targets for pain treatment. European Journal of Pharmacology 681:1-3, pages 1-5.
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J. Michael Bostwick. (2012) Blurred Boundaries: The Therapeutics and Politics of Medical Marijuana. Mayo Clinic Proceedings 87:2, pages 172-186.
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Maria Grazia Cascio & Roger Pertwee. 2011. Marijuana and Madness. Marijuana and Madness 23 34 .
Gillian Burgess & Dic Williams. (2010) The discovery and development of analgesics: new mechanisms, new modalities. Journal of Clinical Investigation 120:11, pages 3753-3759.
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Sue Peat. (2010) Using cannabinoids in pain and palliative care. International Journal of Palliative Nursing 16:10, pages 481-485.
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Hsin-Ying Wu, An-Chi Chang, Chia-Chi Wang, Fu-Hua Kuo, Chi-Ya Lee, Der-Zen Liu & Tong-Rong Jan. (2010) Cannabidiol induced a contrasting pro-apoptotic effect between freshly isolated and precultured human monocytes. Toxicology and Applied Pharmacology 246:3, pages 141-147.
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Martin A. Javors, Thomas S. King, Brett C. Ginsburg & Lisa R. Gerak. 2011. Addiction Medicine. Addiction Medicine 283 331 .
Alessia Ligresti, Stefania Petrosino & Vincenzo Di Marzo. (2009) From endocannabinoid profiling to ‘endocannabinoid therapeutics’. Current Opinion in Chemical Biology 13:3, pages 321-331.
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Praveen Anand, Garth Whiteside, Christopher J. Fowler & Andrea G. Hohmann. (2009) Targeting CB2 receptors and the endocannabinoid system for the treatment of pain. Brain Research Reviews 60:1, pages 255-266.
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Giovanni Appendino, Anna Giana, Simon Gibbons, Massimo Maffei, Giorgio Gnavi, Gianpaolo Grassi & Olov Sterner. (2008) A Polar Cannabinoid from Cannabis Sativa Var. Carma . Natural Product Communications 3:12, pages 1934578X0800301.
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RUSSELL K. PORTENOY & MERVYN KOH. 2010. Cancer Pain. Cancer Pain 272 286 .

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