Advanced search
Publication Cover
Expert Opinion on Biological Therapy Volume 9, 2009 - Issue 8
Submit an article Journal homepage
154
Views
48
CrossRef citations to date
0
Altmetric
Reviews

Therapeutic implications of cancer initiating cells

Alessandro Scopelliti PhD student, University of Palermo, Department of Surgical and Oncological Sciences, Laboratory of Cellular and Molecular Pathophysiology, Via Liborio Giuffre', 5, 90127 Palermo, Italy
,
Patrizia Cammareri PostDoc, University of Palermo, Department of General Surgery, Emergency and Organ Transplantation (GENURTO), Via Liborio Giuffre', 5, 90127 Palermo, Italy
,
Veronica Catalano PhD student, University of Palermo, International Immunopharmacology Course, Department of Surgical and Oncological Sciences, Laboratory of Cellular and Molecular Pathophysiology, Via Liborio Giuffre', 5, 90127 Palermo, Italy
,
Vitanna Saladino PhD student, University of Palermo, International Immunopharmacology Course, Department of Surgical and Oncological Sciences, Laboratory of Cellular and Molecular Pathophysiology, Via Liborio Giuffre', 5, 90127 Palermo, Italy
,
Matilde Todaro University Senior Researcher, University of Palermo, Department of Surgical and Oncological Sciences, Laboratory of Cellular and Molecular Pathophysiology, Via Liborio Giuffre', 5, 90127 Palermo, Italy
, MD &
Giorgio Stassi Professor, Group Leader, University of Palermo, Department of Surgical and Oncological Sciences, Laboratory of Cellular and Molecular Pathophysiology, Via Liborio Giuffre', 5, 90127 Palermo, Italy +39 091 6553211; +39 091 6553238; [email protected]; [email protected]
, MD
Pages 1005-1016 | Published online: 23 Jun 2009

Citations (48)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Veronica Catalano, Simone Di Franco, Flora Iovino, Francesco Dieli, Giorgio Stassi & Matilde Todaro. (2012) CD133 as a target for colon cancer. Expert Opinion on Therapeutic Targets 16:3, pages 259-267.
Read now
Theresa L. Whiteside, Deborah L. Griffin, Joanna Stanson, William Gooding, David McKenna, Darin Sumstad, Diane Kadidlo, Adrian Gee, April Durett, Robert Lindblad, Deborah Wood & David Styers. (2011) Shipping of therapeutic somatic cell products. Cytotherapy 13:2, pages 201-213.
Read now

Articles from other publishers (46)

Matteo Brindisi, Manuela Curcio, Luca Frattaruolo, Giuseppe Cirillo, Antonella Leggio, Vittoria Rago, Fiore Pasquale Nicoletta, Anna Rita Cappello & Francesca Iemma. (2022) CD44-targeted nanoparticles with GSH-responsive activity as powerful therapeutic agents against breast cancer. International Journal of Biological Macromolecules 221, pages 1491-1503.
Crossref
Vanessa Rodríguez-Fanjul, Rosa Guerrero-López, Beatriz Fernández-Varas, Rosario Perona, Ana Sastre-Perona & Leandro Sastre. (2022) Comparison of Colorectal Cancer Stem Cells and Oxaliplatin-Resistant Cells Unveils Functional Similarities. Cells 11:3, pages 511.
Crossref
Ching-Li Li, Chien-Che Wang, Hsin-Te Pai, Stan-Ley Tu, Pin-Yuan Hou, Chien-Yu Huang, Ming-Te Huang & Yu-Jia Chang. (2022) The Natural Compound Dehydrocrenatidine Attenuates Nicotine-Induced Stemness and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Regulating a7nAChR-Jak2 Signaling Pathways. Disease Markers 2022, pages 1-15.
Crossref
Yih-Giun Cherng, Yi Cheng Chu, Vijesh Kumar Yadav, Ting-Yi Huang, Ming-Shou Hsieh, Kwai-Fong Lee, Wei-Hwa Lee, Chi-Tai Yeh & Jiann Ruey Ong. (2021) Induced Mitochondrial Alteration and DNA Damage via IFNGR-JAK2-STAT1-PARP1 Pathway Facilitates Viral Hepatitis Associated Hepatocellular Carcinoma Aggressiveness and Stemness. Cancers 13:11, pages 2755.
Crossref
Biagio Armentano, Rosita Curcio, Matteo Brindisi, Raffaella Mancuso, Vittoria Rago, Ida Ziccarelli, Luca Frattaruolo, Marco Fiorillo, Vincenza Dolce, Bartolo Gabriele & Anna Rita Cappello. (2020) 5-(Carbamoylmethylene)-oxazolidin-2-ones as a Promising Class of Heterocycles Inducing Apoptosis Triggered by Increased ROS Levels and Mitochondrial Dysfunction in Breast and Cervical Cancer. Biomedicines 8:2, pages 35.
Crossref
Yan-Jiun Huang, Vijesh Kumar Yadav, Prateeti Srivastava, Alexander TH Wu, Thanh-Tuan Huynh, Po-Li Wei, Chi-Ying F. Huang & Tse-Hung Huang. (2019) Antrodia cinnamomea Enhances Chemo-Sensitivity of 5-FU and Suppresses Colon Tumorigenesis and Cancer Stemness via Up-Regulation of Tumor Suppressor miR-142-3p. Biomolecules 9:8, pages 306.
Crossref
Alpna Tyagi, Sushil Kumar, Komal Raina, Michael F. Wempe, Paul D. Maroni, Rajesh Agarwal & Chapla Agarwal. (2019) Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″-di- O -gallate against prostate cancer stem cells . Molecular Carcinogenesis 58:7, pages 1105-1117.
Crossref
Chen Wang, Wang Zheng, Dan Yao, Qianping Chen, Lin Zhu, Junlin Zhang, Yan Pan, Jianghong Zhang & Chunlin Shao. (2019) Upregulation of DNA Metabolism-Related Genes Contributes to Radioresistance of Glioblastoma. Human Gene Therapy Clinical Development 30:2, pages 74-87.
Crossref
Lanlan Liu, Jiansheng Liu, Haiwei Wang, Hui Zhao & Yanzhi Du. (2018) Fenretinide targeting of human colon cancer sphere cells through cell cycle regulation and stress‑responsive activities. Oncology Letters.
Crossref
Bela Ozsvari, Federica Sotgia & Michael P. Lisanti. (2018) Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs). Aging 10:2, pages 229-240.
Crossref
Xiaofeng Yu, Lin Mi, Jie Dong & Jian Zou. (2017) Long intergenic non-protein-coding RNA 1567 (LINC01567) acts as a “sponge” against microRNA-93 in regulating the proliferation and tumorigenesis of human colon cancer stem cells. BMC Cancer 17:1.
Crossref
Patrick M. Reeves, Mojgan A. Abbaslou, Farah R.W. Kools, Kritchai Vutipongsatorn, Xiaoyun Tong, Christina Gavegnano, Raymond F. Schinazi & Mark C. Poznansky. (2017) Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice. Oncotarget 8:55, pages 94040-94053.
Crossref
Shobana Raghunath, Raghavendra Sumanth Pudupakam, Adria Allen, Moanaro Biswas & Nammalwar Sriranganathan. (2017) Genetically engineered oncolytic Newcastle disease virus mediates cytolysis of prostate cancer stem like cells. Journal of Biotechnology 260, pages 91-97.
Crossref
Ernestina Marianna De Francesco, Gloria Bonuccelli, Marcello Maggiolini, Federica Sotgia & Michael P. Lisanti. (2017) Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs). Oncotarget 8:40, pages 67269-67286.
Crossref
Lanfang Zhang, Xiaohe Guo, Dezhong Zhang, Yingying Fan, Lei Qin, Shuping Dong & Lanfang Zhang. (2017) Upregulated miR-132 in Lgr5 + gastric cancer stem cell-like cells contributes to cisplatin-resistance via SIRT1/CREB/ABCG2 signaling pathway . Molecular Carcinogenesis 56:9, pages 2022-2034.
Crossref
Yu-kai Su, Ping-Hsiao Shih, Wei-Hwa Lee, Oluwaseun Adebayo Bamodu, Alexander T.H. Wu, Chun-Chih Huang, Yew-Min Tzeng, Michael Hsiao, Chi-Tai Yeh & Chien-Min Lin. (2017) Antrodia cinnamomea sensitizes radio-/chemo-therapy of cancer stem-like cells by modulating microRNA expression. Journal of Ethnopharmacology 207, pages 47-56.
Crossref
Yun Wang, Nanxin Huang, Hongli Li, Shubao Liu, Xianjun Chen, Shichang Yu, Nan Wu, Xiu-Wu Bian, Hai-Ying Shen, Chengren Li & Lan Xiao. (2017) Promoting oligodendroglial-oriented differentiation of glioma stem cell: a repurposing of quetiapine for the treatment of malignant glioma. Oncotarget 8:23, pages 37511-37524.
Crossref
Marco Fiorillo, Rebecca Lamb, Herbert B. Tanowitz, Luciano Mutti, Marija Krstic-Demonacos, Anna Rita Cappello, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2016) Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells. Oncotarget 7:23, pages 34084-34099.
Crossref
Piernicola Pedicini, Lidia Strigari, Luigi Spiazzi, Alba Fiorentino, Paolo Tini & Luigi Pirtoli. 2016. Radiobiology of Glioblastoma. Radiobiology of Glioblastoma 87 100 .
Gillian Farnie, Federica Sotgia & Michael P. Lisanti. (2015) High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant. Oncotarget 6:31, pages 30472-30486.
Crossref
Arianna De Luca, Marco Fiorillo, Maria Peiris-Pagès, Bela Ozsvari, Duncan L. Smith, Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Anna Rita Cappello, Vincenzo Pezzi, Michael P. Lisanti & Federica Sotgia. (2015) Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells. Oncotarget 6:17, pages 14777-14795.
Crossref
Michele Cioffi, Crescenzo D’Alterio, Rosalba Camerlingo, Virginia Tirino, Claudia Consales, Anna Riccio, Caterina Ieranò, Sabrina Chiara Cecere, Nunzia Simona Losito, Stefano Greggi, Sandro Pignata, Giuseppe Pirozzi & Stefania Scala. (2015) Identification of a distinct population of CD133+CXCR4+ cancer stem cells in ovarian cancer. Scientific Reports 5:1.
Crossref
Myoung-Eun Han, Su-Jin Baek, Seon-Young Kim, Chi-Dug Kang & Sae-Ock Oh. (2015) ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem Cells. PLOS ONE 10:5, pages e0126085.
Crossref
Rebecca Lamb, Hannah Harrison, Duncan L. Smith, Paul A. Townsend, Thomas Jackson, Bela Ozsvari, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Michael P. Lisanti & Federica Sotgia. (2015) Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction. Oncotarget 6:7, pages 4585-4601.
Crossref
Marco Fiorillo, Andrea F. Verre, Maria Iliut, Maria Peiris-Pagés, Bela Ozsvari, Ricardo Gandara, Anna Rita Cappello, Federica Sotgia, Aravind Vijayaraghavan & Michael P. Lisanti. (2015) Graphene oxide selectively targets cancer stem cells, across multiple tumor types: Implications for non-toxic cancer treatment, via “differentiation-based nano-therapy”. Oncotarget 6:6, pages 3553-3562.
Crossref
Rahel Philip, Sarah Heiler, Wei Mu, Markus W. Büchler, Margot Zöller & Florian Thuma. (2014) Claudin-7 promotes the epithelial - mesenchymal transition in human colorectal cancer. Oncotarget 6:4, pages 2046-2063.
Crossref
Mark Noble, Margot Mayer-Pröschel, Zaibo Li, Tiefei Dong, Wanchang Cui, Christoph Pröschel, Ibro Ambeskovic, Joerg Dietrich, Ruolan Han, Yin Miranda Yang, Christopher Folts, Jennifer Stripay, Hsing-Yu Chen & Brett M. Stevens. (2015) Redox biology in normal cells and cancer: Restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment. Free Radical Biology and Medicine 79, pages 300-323.
Crossref
Rebecca Lamb, Hannah Harrison, James Hulit, Duncan L. Smith, Michael P. Lisanti & Federica Sotgia. (2014) Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition. Oncotarget 5:22, pages 11029-11037.
Crossref
Yi Wang, Yang Jiang, Jun‐ichiro Ikeda, Tian Tian, Atsushi Sato, Hiroshi Ohtsu & Eiichi Morii. (2014) Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line. Cancer Medicine 3:5, pages 1126-1135.
Crossref
Yong-tong Zhu, Zhen Zhao, Xin-yang Fu, Yang Luo, Cheng-yong Lei, Wei Chen, Fei Li, Shi-yu Pang, San-san Chen & Wan-long Tan. (2014) The granulocyte macrophage?colony stimulating factor surface modified MB49 bladder cancer stem cells vaccine against metastatic bladder cancer. Stem Cell Research 13:1, pages 111-122.
Crossref
Kyung-Won Yoon, Seon-Young Park, Ji-Young Kim, Su-Mi Lee, Chang‑Hwan Park, Sung-Bum Cho, Wan-Sik Lee, Young-Eun Joo, Jae‑Hyuk Lee, Hyun‑Soo Kim, Sung-Kyu Choi & Jong-Sun Rew. (2014) Leptin-induced adhesion and invasion in colorectal cancer cell lines. Oncology Reports.
Crossref
Kevin Leder, Ken Pitter, Quincey LaPlant, Dolores Hambardzumyan, Brian?D. Ross, Timothy?A. Chan, Eric?C. Holland & Franziska Michor. (2014) Mathematical Modeling of PDGF-Driven Glioblastoma Reveals Optimized Radiation Dosing Schedules. Cell 156:3, pages 603-616.
Crossref
Yong-tong Zhu, Cheng-yong Lei, Yang Luo, Na Liu, Cheng-wu He, Wei Chen, Fei Li, Yong-jian Deng & Wan-long Tan. (2013) A modified method for isolation of bladder cancer stem cells from a MB49 murine cell line. BMC Urology 13:1.
Crossref
Nicholas J Giacalone, Robert B Den, Rosana Eisenberg, Heidi Chen, Sandra J Olson, Pierre P Massion, David P Carbone & Bo Lu. (2013) ALDH7A1 expression is associated with recurrence in patients with surgically resected non-small-cell lung carcinoma. Future Oncology 9:5, pages 737-745.
Crossref
XIA SHENG, ZENG LI, DE-LIN WANG, WEN-BIN LI, ZHAO LUO, KE-HONG CHEN, JIAN-JIA CAO, CHAO YU & WU-JIANG LIU. (2013) Isolation and enrichment of PC-3 prostate cancer stem-like cells using MACS and serum-free medium. Oncology Letters 5:3, pages 787-792.
Crossref
Kate Lewis & Claudia Petritsch. (2013) Asymmetric cell division: Implications for glioma development and treatment. Translational Neuroscience 4:4.
Crossref
Xinlan Fan, Shanying Liu, Fang Su, Qiuhui Pan & Tianxin Lin. (2012) Effective enrichment of prostate cancer stem cells from spheres in a suspension culture system. Urologic Oncology: Seminars and Original Investigations 30:3, pages 314-318.
Crossref
Myoung-Eun Han, Tae-Yong Jeon, Sun-Hwi Hwang, Young-Suk Lee, Hyun-Jung Kim, Hye-Eun Shim, Sik Yoon, Sun-Yong Baek, Bong-Seon Kim, Chi-Dug Kang & Sae-Ock Oh. (2011) Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell research. Cellular and Molecular Life Sciences 68:21, pages 3589-3605.
Crossref
Xinlan Fan, Nengyong Ouyang, Hong Teng & Herui Yao. (2011) Isolation and characterization of spheroid cells from the HT29 colon cancer cell line. International Journal of Colorectal Disease 26:10, pages 1279-1285.
Crossref
Sze-Ue Luk, Terence Kin-Wah Lee, Ji Liu, Davy Tak-Wing Lee, Yung-Tuen Chiu, Stephanie Ma, Irene Oi-Lin Ng, Yong-Chuan Wong, Franky Leung Chan & Ming-Tat Ling. (2011) Chemopreventive Effect of PSP Through Targeting of Prostate Cancer Stem Cell-Like Population. PLoS ONE 6:5, pages e19804.
Crossref
Flora Iovino, Serena Meraviglia, Marisa Spina, Valentina Orlando, Vitanna Saladino, Francesco Dieli, Giorgio Stassi & Matilde Todaro. (2011) Immunotherapy targeting colon cancer stem cells. Immunotherapy 3:1, pages 97-106.
Crossref
Margot Zöller & Thorsten Jung. 2011. Liver Metastasis: Biology and Clinical Management. Liver Metastasis: Biology and Clinical Management 89 127 .
A.B. Di Stefano, F. Iovino, Y. Lombardo, V. Eterno, T. Höger, F. Dieli, G. Stassi & M. Todaro. (2010) Survivin is regulated by interleukin‐4 in colon cancer stem cells. Journal of Cellular Physiology 225:2, pages 555-561.
Crossref
Diponkar Banerjee. (2010) Reinventing Diagnostics for Personalized Therapy in Oncology. Cancers 2:2, pages 1066-1091.
Crossref
Shalmoli Bhattacharyya & Kishan Lal Khanduja. (2010) New hope in the horizon: cancer stems cells. Acta Biochimica et Biophysica Sinica 42:4, pages 237-242.
Crossref
Candace A. Gilbert & Alonzo H. Ross. (2009) Cancer stem cells: Cell culture, markers, and targets for new therapies. Journal of Cellular Biochemistry 108:5, pages 1031-1038.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.