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Drug Evaluations

Prepandemic H5N1 influenza vaccine adjuvanted with AS03: a review of the pre-clinical and clinical data

, MD PhD
Pages 1057-1071 | Published online: 26 Jun 2009

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Karen K. Yam, Angela Brewer, Virginie Bleau, Édith Beaulieu, Corey P. Mallett & Brian J. Ward. (2017) Low hemagglutinin antigen dose influenza vaccines adjuvanted with AS03 alter the long-term immune responses in BALB/c mice. Human Vaccines & Immunotherapeutics 13:3, pages 561-571.
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Nathalie Garçon & Alberta Di Pasquale. (2017) From discovery to licensure, the Adjuvant System story. Human Vaccines & Immunotherapeutics 13:1, pages 19-33.
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Crina Stavaru, Adrian Onu, Emilia Lupulescu, Catalin Tucureanu, Orhan Rasid, Ene Vlase, Cristin Coman, Iuliana Caras, Alina Ghiorghisor, Laurentiu Berbecila, Vlad Tofan, Richard A. Bowen, Nicole Marlenee, Airn Hartwig, Helle Bielefeldt-Ohmann, Susan L. Baldwin, Neal Van Hoeven, Thomas S. Vedvick, Chuong Huynh, Michael K. O'Hara, Diana L. Noah & Christopher B. Fox. (2016) Technology transfer of oil-in-water emulsion adjuvant manufacturing for pandemic influenza vaccine production in Romania: Preclinical evaluation of split virion inactivated H5N1 vaccine with adjuvant. Human Vaccines & Immunotherapeutics 12:4, pages 1009-1026.
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Giuseppe Del Giudice, Elena Fragapane, Giovanni Della Cioppa & Rino Rappuoli. (2013) Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza. Expert Opinion on Biological Therapy 13:1, pages 121-135.
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Hideyuki Ikematsu, Kazuyoshi Tenjinbaru, Ping Li, Anuradha Madan & David Vaughn. (2012) Evaluation of immune response following one dose of an AS03A-adjuvanted H1N1 2009 pandemic influenza vaccine in Japanese adults 65 years of age or older. Human Vaccines & Immunotherapeutics 8:8, pages 1119-1125.
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Nicola Principi & Susanna Esposito. (2012) Adjuvanted influenza vaccines. Human Vaccines & Immunotherapeutics 8:1, pages 59-66.
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Derek T O’Hagan, Rino Rappuoli, Ennio De Gregorio, Theodore Tsai & Giuseppe Del Giudice. (2011) MF59 adjuvant: the best insurance against influenza strain diversity. Expert Review of Vaccines 10:4, pages 447-462.
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Ruchi R. Shah, Luis A. Brito, Derek T. O’Hagan & Mansoor M. Amiji. 2015. Subunit Vaccine Delivery. Subunit Vaccine Delivery 59 76 .
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Christopher H. CleggRichard RoqueNeal Van HoevenLucy PerroneSusan L. BaldwinJoseph A. RiningerRichard A. Bowen & Steven G. Reed. (2012) Adjuvant solution for pandemic influenza vaccine production. Proceedings of the National Academy of Sciences 109:43, pages 17585-17590.
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Jessica A. Belser, Cynthia B. Snider, Nancy J. Cox & Frederick G. Hayden. (2011) XIth International Symposium on Respiratory Viral Infections. Influenza and Other Respiratory Viruses 5:6, pages 443-e457.
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Yuichi Harada, Ai Ninomiya-Mori, Yoshimasa Takahashi, Masayuki Shirakura, Noriko Kishida, Tsutomu Kageyama, Yoshikazu Tada, Masato Tashiro & Takato Odagiri. (2011) Inactivated and adjuvanted whole-virion clade 2.3.4 H5N1 pre-pandemic influenza vaccine possesses broad protective efficacy against infection by heterologous clades of highly pathogenic H5N1 avian influenza virus in mice. Vaccine 29:46, pages 8330-8337.
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John Steel. (2012) New Strategies for the Development of H5N1 Subtype Influenza Vaccines. BioDrugs 25:5, pages 285-298.
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G. Kuether, B. Dietrich, T. Smith, C. Peter & S. Gruessner. (2011) Atraumatic osteonecrosis of the humeral head after influenza A-(H1N1) v-2009 vaccination. Vaccine 29:40, pages 6830-6833.
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Joanne M. Langley, George Risi, Michael Caldwell, Larry Gilderman, Bruce Berwald, Charles Fogarty, Terry Poling, Dennis Riff, Mira Baron, Louise Frenette, Eric Sheldon, Harry Collins, Marc Shepard, Marc Dionne, Daniel Brune, Linda Ferguson, David Vaughn, Ping Li & Louis Fries. (2011) Dose-Sparing H5N1 A/Indonesia/05/2005 Pre-pandemic Influenza Vaccine in Adults and Elderly Adults: A Phase III, Placebo-Controlled, Randomized Study. The Journal of Infectious Diseases 203:12, pages 1729-1738.
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Garry L. Morefield. (2011) A Rational, Systematic Approach for the Development of Vaccine Formulations. The AAPS Journal 13:2, pages 191-200.
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Alexander Batista-Duharte, Erik B. Lindblad & Ernesto Oviedo-Orta. (2011) Progress in understanding adjuvant immunotoxicity mechanisms. Toxicology Letters 203:2, pages 97-105.
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Sven Meyer, Matti Adam, Brunhilde Schweiger, Corina Ilchmann, Christine Eulenburg, Edgar Sattinger, Hendrik Runte, Michael Schlüter, Tobias Deuse, Hermann Reichenspurner & Angelika Costard-Jäckle. (2011) Antibody Response After a Single Dose of an AS03-Adjuvanted Split-Virion Influenza A (H1N1) Vaccine in Heart Transplant Recipients. Transplantation 91:9, pages 1031-1035.
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Heng Liu, Laura Bungener, Wouter ter Veer, Beth-Ann Coller, Jan Wilschut & Anke Huckriede. (2011) Preclinical evaluation of the saponin derivative GPI-0100 as an immunostimulating and dose-sparing adjuvant for pandemic influenza vaccines. Vaccine 29:11, pages 2037-2043.
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Beno?t Baras, Koert J. Stittelaar, Thijs Kuiken, Val?rie Jacob, Roger Bernhard, Sandra Giannini, Leon de Waal, Geert van Amerongen, James H. Simon, Albert D.M.E. Osterhaus, Emmanuel Hanon & Sally P. Mossman. (2011) Longevity of the protective immune response induced after vaccination with one or two doses of AS03A-adjuvanted split H5N1 vaccine in ferrets. Vaccine 29:11, pages 2092-2099.
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Maja Folkenberg, Torbj?rn Callr?us, Henrik Svanstr?m, Palle Valentiner-Branth & Anders Hviid. (2011) Spontaneous reporting of adverse events following immunisation against pandemic influenza in Denmark November 2009?March 2010. Vaccine 29:6, pages 1180-1184.
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Giuseppe Del Giudice & Rino Rappuoli. 2011. Influenza Vaccines for the Future. Influenza Vaccines for the Future 401 423 .
Derek T. O’Hagan, Theodore Tsai & Steven Reed. 2011. Influenza Vaccines for the Future. Influenza Vaccines for the Future 327 357 .
Felix Geeraedts & Anke Huckriede. 2011. Crossroads between Innate and Adaptive Immunity III. Crossroads between Innate and Adaptive Immunity III 161 174 .
Ari Balofsky, Nancy Agmon-Levin & Yehuda Shoenfeld. (2010) The new H1N1 and HPV vaccines and old fears. Current Opinion in Rheumatology 22:4, pages 431-436.
Crossref
Alenka Kraigher & Veronika Učakar. (2010) Surveillance of adverse events following immunization against pandemic influenza in Slovenia in season 2009/10. Vaccine 28:33, pages 5467-5472.
Crossref
M Lamine Mbow, Ennio De Gregorio, Nicholas M Valiante & Rino Rappuoli. (2010) New adjuvants for human vaccines. Current Opinion in Immunology 22:3, pages 411-416.
Crossref

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