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Expert Opinion on Biological Therapy Volume 10, 2010 - Issue 1
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Drug Evaluations

Glucarpidase following high-dose methotrexate: update on development

Daniel M Patterson UCL Cancer Institute and University College Hospital, Department of Oncology, 250 Euston Road, London NW1 2PG, UK +44 (0)207 380 9091;+44 (0)207 380 9321;[email protected]
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Siow Ming Lee
Pages 105-111 | Published online: 20 Nov 2009

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Berna Demiralp, Lane Koenig, Jaya Kala, Chaoling Feng, Elizabeth G Hamlett, Marie Steele-Adjognon & Suzanne Ward. (2019) Length of stay, mortality, and readmissions among Medicare cancer patients treated with glucarpidase and conventional care: a retrospective study. ClinicoEconomics and Outcomes Research 11, pages 129-144.
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Seham M. Ragab & Eman A. Badr. (2016) Evaluation of serum and urine fetuin-A levels in children with acute lymphoblastic leukemia during and after high-dose methotrexate therapy: Relation to toxicity. Hematology 21:2, pages 78-91.
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Articles from other publishers (14)

Mudit Bhargava, Chirag Rajkumar Kopp, Shankar Naidu, Deba Prasad Dhibar, Atul Saroch, Alka Khadwal, Tarun Narang, Siddharth Jain, Aastha Khullar, Bidya Leishangthem, Aman Sharma, Susheel Kumar, Shefali Sharma, Sanjay Jain & Varun Dhir. (2023) Comparison of two doses of leucovorin in severe low-dose methotrexate toxicity – a randomized controlled trial. Arthritis Research & Therapy 25:1.
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Astra Heywood & Iain L Lamont. (2020) Cell envelope proteases and peptidases of Pseudomonas aeruginosa : multiple roles, multiple mechanisms . FEMS Microbiology Reviews 44:6, pages 857-873.
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Zachary L. Taylor, Tomoyuki Mizuno, Nieko C. Punt, Balaji Baskaran, Adriana Navarro Sainz, William Shuman, Nicholas Felicelli, Alexander A. Vinks, Jesper Heldrup & Laura B. Ramsey. (2020) MTXPK.org: A Clinical Decision Support Tool Evaluating High‐Dose Methotrexate Pharmacokinetics to Inform Post‐Infusion Care and Use of Glucarpidase. Clinical Pharmacology & Therapeutics 108:3, pages 635-643.
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Qianfen Liu, Xiaocui Zhong, Ying Zhang, Xinya Li, Guanhua Qian & Tinghe Yu. (2020) Ultrasound Enhances ZD2767P–Carboxypeptidase G2 against Chemoresistant Ovarian Cancer Cells by Altering the Intracellular Pharmacokinetics of ZD2767D. Molecular Pharmaceutics 17:6, pages 1922-1932.
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Jennifer H. Foster, Patrick A. Thompson, M. Brooke Bernhardt, Judith F. Margolin, Susan G. Hilsenbeck, Eunji Jo, Deborah A. Marquez-Do, Michael E. Scheurer & Eric S. Schafer. (2018) A prospective study of a simple algorithm to individually dose high-dose methotrexate for children with leukemia at risk for methotrexate toxicities. Cancer Chemotherapy and Pharmacology 83:2, pages 349-360.
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David Gervais. 2019. Therapeutic Enzymes: Function and Clinical Implications. Therapeutic Enzymes: Function and Clinical Implications 55 80 .
Jeffrey R. Scott, Yinmei Zhou, Cheng Cheng, Deborah A. Ward, Hope D. Swanson, Alejandro R. Molinelli, Clinton F. Stewart, Fariba Navid, Sima Jeha, Mary V. Relling & Kristine R. Crews. (2015) Comparable efficacy with varying dosages of glucarpidase in pediatric oncology patients. Pediatric Blood & Cancer 62:9, pages 1518-1522.
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Brigitte C. Widemann, Stefan Schwartz, Nalini Jayaprakash, Robbin Christensen, Ching-Hon Pui, Nikhil Chauhan, Claire Daugherty, Thomas R. King, Janet E. Rush & Scott C. Howard. (2014) Efficacy of Glucarpidase (Carboxypeptidase G2) in Patients with Acute Kidney Injury After High-Dose Methotrexate Therapy. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 34:5, pages 427-439.
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G. Adam Campbell, Daniel Hu & Mark D. Okusa. (2014) Acute Kidney Injury in the Cancer Patient. Advances in Chronic Kidney Disease 21:1, pages 64-71.
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Mark A. Perazella. (2012) Onco-Nephrology. Clinical Journal of the American Society of Nephrology 7:10, pages 1713-1721.
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Victor Tuan Giam Chuang & Manabu Suno. (2012) Levoleucovorin as Replacement for Leucovorin in Cancer Treatment. Annals of Pharmacotherapy 46:10, pages 1349-1357.
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Jennifer M. Belavic. (2012) Voraxaze treats toxic methotrexate levels. The Nurse Practitioner 37:9, pages 15-16.
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Anthony M. Christensen, Jennifer L. Pauley, Alejandro R. Molinelli, John C. Panetta, Deborah A. Ward, Clinton F. Stewart, James M. Hoffman, Scott C. Howard, Ching‐Hon Pui, Alberto S. Pappo, Mary V. Relling & Kristine R. Crews. (2012) Resumption of high‐dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patients. Cancer 118:17, pages 4321-4330.
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Rameez Qudsi, Ola Abdulhadi & Iyad Sultan. (2010) Low-dose carboxypeptidase-G2 for methotrexate toxicity in a child. Pediatric Blood & Cancer 55:7, pages 1439-1440.
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