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Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction

Pages 753-764 | Published online: 23 Feb 2005

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Abel Matondo & Sung Soo Kim. (2018) Targeted-mitochondria antioxidants therapeutic implications in inflammatory bowel disease. Journal of Drug Targeting 26:1, pages 1-8.
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Sergej M. Ostojic. (2017) Mitochondria-targeted nutraceuticals in sports medicine: a new perspective. Research in Sports Medicine 25:1, pages 91-100.
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Volkmar Weissig. (2005) Targeted drug delivery to mammalian mitochondria in living cells. Expert Opinion on Drug Delivery 2:1, pages 89-102.
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Articles from other publishers (55)

Tatyana I. Rokitskaya, Ljudmila S. Khailova, Galina A. Korshunova & Yuri N. Antonenko. (2023) Efficiency of mitochondrial uncoupling by modified butyltriphenylphosphonium cations and fatty acids correlates with lipophilicity of cations: Protonophoric vs leakage mechanisms. Biochimica et Biophysica Acta (BBA) - Biomembranes 1865:7, pages 184183.
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Julia Heisig, Niels V. Heise, Sophie Hoenke, Dieter Ströhl & René Csuk. (2023) The Finally Rewarding Search for A Cytotoxic Isosteviol Derivative. Molecules 28:13, pages 4951.
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Tatyana I. Rokitskaya, Ekaterina V. Aleksandrova, Galina A. Korshunova, Ljudmila S. Khailova, Vadim N. Tashlitsky, Victor B. Luzhkov & Yuri N. Antonenko. (2022) Membrane Permeability of Modified Butyltriphenylphosphonium Cations. The Journal of Physical Chemistry B 126:2, pages 412-422.
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Mengyuan Cen, Wei Ouyang, Wanying Zhang, Liping Yang, Xiuhui Lin, Min Dai, Huiqun Hu, Huifang Tang, Hongyun Liu, Jingyan Xia & Feng Xu. (2021) MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism. Redox Biology 41, pages 101936.
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Tatyana I. Rokitskaya, Elena A. Kotova, Victor B. Luzhkov, Roman S. Kirsanov, Ekaterina V. Aleksandrova, Galina A. Korshunova, Vadim N. Tashlitsky & Yuri N. Antonenko. (2021) Lipophilic ion aromaticity is not important for permeability across lipid membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes 1863:1, pages 183483.
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Diana Guzman-Villanueva, Mark R. Mendiola, Huy X. Nguyen, Francis Yambao, Nusem Yu & Volkmar Weissig. 2019. Pharmaceutical Nanotechnology. Pharmaceutical Nanotechnology 183 189 .
Natalie E. Scholpa & Rick G. Schnellmann. (2017) Mitochondrial-Based Therapeutics for the Treatment of Spinal Cord Injury: Mitochondrial Biogenesis as a Potential Pharmacological Target. Journal of Pharmacology and Experimental Therapeutics 363:3, pages 303-313.
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Nuri Gueven, Monila Nadikudi, Abraham Daniel & Jamuna Chhetri. (2017) Targeting mitochondrial function to treat optic neuropathy. Mitochondrion 36, pages 7-14.
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. 2016. Nanotechnology in Nutraceuticals. Nanotechnology in Nutraceuticals 87 116 .
Gerard D’Souza, Paul Nguyen & Volkmar Weissig. 2016. Drug Delivery Across Physiological Barriers. Drug Delivery Across Physiological Barriers 367 389 .
Sergej M. Ostojic. (2015) Targeting molecular hydrogen to mitochondria: Barriers and gateways. Pharmacological Research 94, pages 51-53.
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Omar Ortiz-Avila, Mauricio Esquivel-Martínez, Berenice Eridani Olmos-Orizaba, Alfredo Saavedra-Molina, Alain R. Rodriguez-Orozco & Christian Cortés-Rojo. (2015) Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats. Journal of Diabetes Research 2015, pages 1-9.
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Dmitry B. Zorov, Magdalena Juhaszova & Steven J. Sollott. (2014) Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release. Physiological Reviews 94:3, pages 909-950.
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Pamela Boon Li Pun, Angela Logan, Victor Darley-Usmar, Balu Chacko, Michelle S. Johnson, Guang W. Huang, Sebastian Rogatti, Tracy A. Prime, Carmen Methner, Thomas Krieg, Ian M. Fearnley, Lesley Larsen, David S. Larsen, Katja E. Menger, Yvonne Collins, Andrew M. James, G.D. Kishore Kumar, Richard C. Hartley, Robin A.J. Smith & Michael P. Murphy. (2014) A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes. Free Radical Biology and Medicine 67, pages 437-450.
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Katerina Krumova, Lana E. Greene & Gonzalo Cosa. (2013) Fluorogenic α-Tocopherol Analogue for Monitoring the Antioxidant Status within the Inner Mitochondrial Membrane of Live Cells. Journal of the American Chemical Society 135:45, pages 17135-17143.
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Mohanad Mossalam, Jamie Soto, Carol S. Lim & E. Dale Abel. (2013) Solid Phase Synthesis of Mitochondrial Triphenylphosphonium-Vitamin E Metabolite Using a Lysine Linker for Reversal of Oxidative Stress. PLoS ONE 8:1, pages e53272.
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Brian D. Fink, Judith A. Herlein, Mark A. Yorek, Amanda M. Fenner, Robert J. Kerns & William I. Sivitz. (2012) Bioenergetic Effects of Mitochondrial-Targeted Coenzyme Q Analogs in Endothelial Cells. Journal of Pharmacology and Experimental Therapeutics 342:3, pages 709-719.
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Elena Galea, Nathalie Launay, Manuel Portero-Otin, Montserrat Ruiz, Reinald Pamplona, Patrick Aubourg, Isidre Ferrer & Aurora Pujol. (2012) Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822:9, pages 1475-1488.
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Carlo M.T. Marobbio, Isabella Pisano, Vito Porcelli, Francesco M. Lasorsa & Luigi Palmieri. (2012) Rapamycin reduces oxidative stress in frataxin-deficient yeast cells. Mitochondrion 12:1, pages 156-161.
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Robin A.J. SmithRichard C. HartleyMichael P. Murphy. (2011) Mitochondria-Targeted Small Molecule Therapeutics and Probes. Antioxidants & Redox Signaling 15:12, pages 3021-3038.
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M. N. Yurova, M. A. Zabezhinski, T. S. Piskunova, M. L. Tyndyk, I. G. Popovich & V. N. Anisimov. (2011) Effect of mitochondria-targeted antioxidant SkQ1 on aging, lifespan, and spontaneous carcinogenesis in three strains of mice. Advances in Gerontology 1:3, pages 260-271.
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Jeremy G. Stone, Gemma Casadesus, Kasia Gustaw-Rothenberg, Sandra L. Siedlak, Xinglong Wang, Xiongwei Zhu, George Perry, Rudy J. Castellani & Mark A. Smith. (2010) Frontiers in Alzheimer’s disease therapeutics. Therapeutic Advances in Chronic Disease 2:1, pages 9-23.
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Jun Lu, Omar M. Khdour, Jeffrey S. Armstrong & Sidney M. Hecht. (2010) Design, synthesis, and evaluation of an ?-tocopherol analogue as a mitochondrial antioxidant. Bioorganic & Medicinal Chemistry 18:21, pages 7628-7638.
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David J. Bonda, Xinglong Wang, George Perry, Akihiko Nunomura, Massimo Tabaton, Xiongwei Zhu & Mark A. Smith. (2010) Oxidative stress in Alzheimer disease: A possibility for prevention. Neuropharmacology 59:4-5, pages 290-294.
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Tamara G. Amstislavskaya, Larissa N. Maslova, Daniil V. Gladkikh, Irina I. Belousova, Natalya A. Stefanova & Natalya G. Kolosova. (2010) Effects of the mitochondria-targeted antioxidant SkQ1 on sexually motivated behavior in male rats. Pharmacology Biochemistry and Behavior 96:2, pages 211-216.
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Marimuthu Jeya, Hee-Jung Moon, Jeong-Lim Lee, In-Won Kim & Jung-Kul Lee. (2009) Current state of coenzyme Q10 production and its applications. Applied Microbiology and Biotechnology 85:6, pages 1653-1663.
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Josef Finsterer. (2010) Treatment of mitochondrial disorders. European Journal of Paediatric Neurology 14:1, pages 29-44.
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David Bonda, Xinglong Wang, Katarzyna Gustaw-Rothenberg, George Perry, Mark Smith & Xiongwei Zhu. (2009) Mitochondrial Drugs for Alzheimer Disease. Pharmaceuticals 2:3, pages 287-298.
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Kosta Steliou, Susan P. Perrine & Douglas V. Faller. (2009) Lactic acid in cancer and mitochondrial disease. Drug Development Research 70:7, pages 499-511.
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Viduranga Y. Waisundara, Annie Hsu, Benny Kwong-Huat Tan & Dejian Huang. (2009) Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats. Diabetes/Metabolism Research and Reviews 25:7, pages 671-677.
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Brian D. Fink, Yunxia O'Malley, Brian L. Dake, Nicolette C. Ross, Thomas E. Prisinzano & William I. Sivitz. (2009) Mitochondrial Targeted Coenzyme Q, Superoxide, and Fuel Selectivity in Endothelial Cells. PLoS ONE 4:1, pages e4250.
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Sara Leo, György Szabadkai & Rosario Rizzuto. (2008) The Mitochondrial Antioxidants MitoE2 and MitoQ10 Increase Mitochondrial Ca2+ Load upon Cell Stimulation by Inhibiting Ca2+ Efflux from the Organelle. Annals of the New York Academy of Sciences 1147:1, pages 264-274.
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Robin A.J. Smith, Victoria J. Adlam, Frances H. Blaikie, Abdul-Rahman B. Manas, Carolyn M. Porteous, Andrew M. James, Meredith F. Ross, Angela Logan, Helena M. Cochemé, Jan Trnka, Tracy A. Prime, Irina Abakumova, Bruce A. Jones, Aleksandra Filipovska & Michael P. Murphy. (2008) Mitochondria-Targeted Antioxidants in the Treatment of Disease. Annals of the New York Academy of Sciences 1147:1, pages 105-111.
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Michael P. Murphy. 2008. Drug‐Induced Mitochondrial Dysfunction. Drug‐Induced Mitochondrial Dysfunction 575 587 .
Michael P. Murphy. (2008) Targeting lipophilic cations to mitochondria. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1777:7-8, pages 1028-1031.
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Chao LuDawei ZhangMatthew WhitemanJeffrey S. Armstrong. (2008) Is Antioxidant Potential of the Mitochondrial Targeted Ubiquinone Derivative MitoQ Conserved in Cells Lacking mtDNA?. Antioxidants & Redox Signaling 10:3, pages 651-660.
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Helena M. Cochemé, Geoffrey F. Kelso, Andrew M. James, Meredith F. Ross, Jan Trnka, Thabo Mahendiran, Jordi Asin-Cayuela, Frances H. Blaikie, Abdul-Rahman B. Manas, Carolyn M. Porteous, Victoria J. Adlam, Robin A.J. Smith & Michael P. Murphy. (2007) Mitochondrial targeting of quinones: Therapeutic implications. Mitochondrion 7, pages S94-S102.
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Michael P. MurphyRobin A.J. Smith. (2007) Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations. Annual Review of Pharmacology and Toxicology 47:1, pages 629-656.
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J. Finsterer. (2006) Central nervous system manifestations of mitochondrial disorders. Acta Neurologica Scandinavica 114:4, pages 217-238.
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O. Yu. Pletjushkina, E. K. Fetisova, K. G. Lyamzaev, O. Yu. Ivanova, L. V. Domnina, M. Yu. Vyssokikh, A. V. Pustovidko, A. V. Alexeevski, D. A. Alexeevski, J. M. Vasiliev, M. P. Murphy, B. V. Chernyak & V. P. Skulachev. (2006) Hydrogen peroxide produced inside mitochondria takes part in cell-to-cell transmission of apoptotic signal. Biochemistry (Moscow) 71:1, pages 60-67.
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O Yu Pletjushkina, E K Fetisova, K G Lyamzaev, O Yu Ivanova, L V Domnina, M Yu Vyssokikh, A V Pustovidko, J M Vasiliev, M P Murphy, B V Chernyak & V P Skulachev. (2005) Long-distance apoptotic killing of cells is mediated by hydrogen peroxide in a mitochondrial ROS-dependent fashion. Cell Death and Differentiation 12:11, pages 1442-1444.
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Andrew M. James, Helena M. Cochemé & Michael P. Murphy. (2005) Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing. Mechanisms of Ageing and Development 126:9, pages 982-986.
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Andrew M. James, Helena M. Cochemé, Robin A.J. Smith & Michael P. Murphy. (2005) Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species. Journal of Biological Chemistry 280:22, pages 21295-21312.
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Aleksandra Filipovska, Geoffrey F. Kelso, Stephanie E. Brown, Samantha M. Beer, Robin A.J. Smith & Michael P. Murphy. (2005) Synthesis and Characterization of a Triphenylphosphonium-conjugated Peroxidase Mimetic. Journal of Biological Chemistry 280:25, pages 24113-24126.
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M. F. Ross, G. F. Kelso, F. H. Blaikie, A. M. James, H. M. Cochemé, A. Filipovska, T. Da Ros, T. R. Hurd, R. A. J. Smith & M. P. Murphy. (2005) Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology. Biochemistry (Moscow) 70:2, pages 222-230.
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M.P. Murphy. (2004) Investigating mitochondrial radical production using targeted probes. Biochemical Society Transactions 32:6, pages 1011-1014.
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Jordi Asin-Cayuela, Abdul-Rahman B. Manas, Andrew M. James, Robin A.J. Smith & Michael P. Murphy. (2004) Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Letters 571:1-3, pages 9-16.
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Volkmar Weissig, Shing-Ming Cheng & Gerard G.M D'Souza. (2004) Mitochondrial pharmaceutics. Mitochondrion 3:4, pages 229-244.
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Katherine Green, Martin D. Brand & Michael P. Murphy. (2004) Prevention of Mitochondrial Oxidative Damage as a Therapeutic Strategy in Diabetes. Diabetes 53:suppl_1, pages S110-S118.
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Aleksandra Filipovska, Michael R Eccles, Robin A.J Smith & Michael P Murphy. (2004) Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation. FEBS Letters 556:1-3, pages 180-186.
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Hervé Seznec, Robert B Wilson & Hélène Puccio. (2004) 2003 International Friedreich's Ataxia Research Conference, 14–16 February 2003, Bethesda, MD, USA. Neuromuscular Disorders 14:1, pages 70-82.
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Robin A.J Smith, Geoffrey F Kelso, Andrew M James & Michael P Murphy. 2004. Quinones and Quinone Enzymes, Part B. Quinones and Quinone Enzymes, Part B 45 67 .
Matthias L. Jauslin, Thomas Meier, Robin A. J. Smith & P. Michael Murphy. (2003) Mitochondria‐targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. The FASEB Journal 17:13, pages 1-10.
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Andrew M. James, Frances H. Blaikie, Robin A. J. Smith, Robert N. Lightowlers, Paul M. Smith & Michael P. Murphy. (2003) Specific targeting of a DNA‐alkylating reagent to mitochondria. European Journal of Biochemistry 270:13, pages 2827-2836.
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Andrew M. James & Michael P. Murphy. (2002) How mitochondrial damage affects cell function. Journal of Biomedical Science 9:6, pages 475-487.
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