183
Views
39
CrossRef citations to date
0
Altmetric
Miscellaneous

IL-12/IL-2 combination cytokine therapy for solid tumours: translation from bench to bedside

&
Pages 513-524 | Published online: 23 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Kyoung-Won Seo, Hee-Woo Lee, Ye-In Oh, Jin-Ok Ahn, Ye-Rin Koh, Seung-Hyun Oh, Sung-Keun Kang & Hwa-Young Youn. (2011) Anti-tumor effects of canine adipose tissue-derived mesenchymal stromal cell-based interferon-β gene therapy and cisplatin in a mouse melanoma model. Cytotherapy 13:8, pages 944-955.
Read now
Jonathan M Weiss, Jeff J Subleski, Jon M Wigginton & Robert H Wiltrout. (2007) Immunotherapy of cancer by IL-12-based cytokine combinations. Expert Opinion on Biological Therapy 7:11, pages 1705-1721.
Read now
Ruth Cordoba-Rodriguez & David M Frucht. (2003) IL-23 and IL-27: new members of the growing family of IL-12-related cytokines with important implications for therapeutics. Expert Opinion on Biological Therapy 3:5, pages 715-723.
Read now

Articles from other publishers (35)

Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T. Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu J. F. Crupi, Huy-Dung Hoang, Abolfazl Nik-Akhtar, Mahsa Ahmadi, Nika Kooshki Zamani, Ashkan Golshani, Tommy Alain, Peter Greer, Michele Ardolino, Bryan C. Dickinson, Lee-Hwa Tai, Carolina S. Ilkow & John C. Bell. (2023) Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies. Nature Communications 14:1.
Crossref
Yinan Shen, Wei Song, Danni Lin, Xiaozhen Zhang, Meng Wang, Yuwei Li, Zifan Yang, Sida Guo, Zijun Wang, Jianpeng Sheng, Yanal Murad, Jun Ding, Yufeng Lou, Xinping Pan, Zongsong Wu, Ronghua Zhao, Weiguo Jia, Xueli Bai & Tingbo Liang. (2022) VG161 activates systemic antitumor immunity in pancreatic cancer models as a novel oncolytic herpesvirus expressing multiple immunomodulatory transgenes. Journal of Medical Virology 95:1.
Crossref
A-Rum Yoon, Cosette Rivera-Cruz, Jeffrey M. Gimble, Chae-Ok Yun & Marxa L. Figueiredo. (2022) Immunotherapy by mesenchymal stromal cell delivery of oncolytic viruses for treating metastatic tumors. Molecular Therapy - Oncolytics 25, pages 78-97.
Crossref
T. Komel, M. Bosnjak, S. Kranjc Brezar, M. De Robertis, M. Mastrodonato, G. Scillitani, G. Pesole, E. Signori, G. Sersa & M. Cemazar. (2021) Gene electrotransfer of IL-2 and IL-12 plasmids effectively eradicated murine B16.F10 melanoma. Bioelectrochemistry 141, pages 107843.
Crossref
Yoo-Jin Lee & Jongsun Kim. (2020) Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation. International Journal of Molecular Sciences 21:24, pages 9575.
Crossref
Dmitry V. Chouljenko, Jun Ding, I-Fang Lee, Yanal M. Murad, Xuexian Bu, Guoyu Liu, Zahid Delwar, Yi Sun, Sheng Yu, Ismael Samudio, Ronghua Zhao & William Wei-Guo Jia. (2020) Induction of Durable Antitumor Response by a Novel Oncolytic Herpesvirus Expressing Multiple Immunomodulatory Transgenes. Biomedicines 8:11, pages 484.
Crossref
Noor Momin, Naveen K. Mehta, Nitasha R. Bennett, Leyuan Ma, Joseph R. Palmeri, Magnolia M. Chinn, Emi A. Lutz, Byong Kang, Darrell J. Irvine, Stefani Spranger & K. Dane Wittrup. (2019) Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy. Science Translational Medicine 11:498.
Crossref
Grégoire Altan-Bonnet & Ratnadeep Mukherjee. (2019) Cytokine-mediated communication: a quantitative appraisal of immune complexity. Nature Reviews Immunology 19:4, pages 205-217.
Crossref
Jinyu Zhang, Haochen Jiang & Haiyun Zhang. (2018) In situ administration of cytokine combinations induces tumor regression in mice. EBioMedicine 37, pages 38-46.
Crossref
Roberto De Luca & Dario Neri. (2018) Potentiation of PD-L1 blockade with a potency-matched dual cytokine–antibody fusion protein leads to cancer eradication in BALB/c-derived tumors but not in other mouse strains. Cancer Immunology, Immunotherapy 67:9, pages 1381-1391.
Crossref
Roberto De Luca, Alex Soltermann, Francesca Pretto, Catherine Pemberton-Ross, Giovanni Pellegrini, Sarah Wulhfard & Dario Neri. (2017) Potency-matched Dual Cytokine–Antibody Fusion Proteins for Cancer Therapy. Molecular Cancer Therapeutics 16:11, pages 2442-2451.
Crossref
Eonju Oh, Il-Kyu Choi, JinWoo Hong & Chae-Ok Yun. (2016) Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model. Oncotarget 8:3, pages 4730-4746.
Crossref
Hyo Min Ahn, JinWoo Hong & Chae-Ok Yun. (2016) Oncolytic adenovirus coexpressing interleukin-12 and shVEGF restores antitumor immune function and enhances antitumor efficacy. Oncotarget 7:51, pages 84965-84980.
Crossref
Elisabetta Radice, Graziella Bellone & Vincenzo Miranda. (2015) Enhancement of the Immunostimulatory Functions of Ex Vivo–Generated Dendritic Cells from Early-Stage Colon Cancer Patients by Consecutive Exposure to Low Doses of Sequential-Kinetic-Activated IL-4 and IL-12. A Preliminary Study. Translational Oncology 8:4, pages 327-338.
Crossref
Julia K. TietzeDanice E. C. WilkinsGail D. SckiselMyriam N. BouchlakaKory L. AldersonJonathan M. WeissErik AmesKevin W. BruhnNoah CraftRobert H. WiltroutDan L. LongoLewis L. LanierBruce R. Blazar, Doug Redelman & William J. Murphy. (2012) Delineation of antigen-specific and antigen-nonspecific CD8+ memory T-cell responses after cytokine-based cancer immunotherapy. Blood 119:13, pages 3073-3083.
Crossref
Tim Chan, Timothy C. Back, Jeffrey J. Subleski, Jonathan M. Weiss, John R. Ortaldo & Robert H. Wiltrout. (2012) Systemic IL-12 Administration Alters Hepatic Dendritic Cell Stimulation Capabilities. PLoS ONE 7:3, pages e33303.
Crossref
Sid P. Kerkar, Romina S. Goldszmid, Pawel Muranski, Dhanalakshmi Chinnasamy, Zhiya Yu, Robert N. Reger, Anthony J. Leonardi, Richard A. Morgan, Ena Wang, Francesco M. Marincola, Giorgio Trinchieri, Steven A. Rosenberg & Nicholas P. Restifo. (2011) IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. Journal of Clinical Investigation 121:12, pages 4746-4757.
Crossref
I-K Choi, J-S Lee, S-N Zhang, J Park, K-M Lee, C H Sonn & C-O Yun. (2011) Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rβ2 or IL-18Rα. Gene Therapy 18:9, pages 898-909.
Crossref
Y Qu, J L Taylor, A Bose & W J Storkus. (2011) Therapeutic effectiveness of intratumorally delivered dendritic cells engineered to express the pro-inflammatory cytokine, interleukin (IL)-32. Cancer Gene Therapy 18:9, pages 663-673.
Crossref
Marganit Benish & Shamgar Ben-Eliyahu. (2010) Surgery as a Double-Edged Sword: A Clinically Feasible Approach to Overcome the Metastasis-Promoting Effects of Surgery by Blunting Stress and Prostaglandin Responses. Cancers 2:4, pages 1929-1951.
Crossref
Sid P. Kerkar, Pawel Muranski, Andrew Kaiser, Andrea Boni, Luis Sanchez-Perez, Zhiya Yu, Douglas C. Palmer, Robert N. Reger, Zachary A. Borman, Ling Zhang, Richard A. Morgan, Luca Gattinoni, Steven A. Rosenberg, Giorgio Trinchieri & Nicholas P. Restifo. (2010) Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts. Cancer Research 70:17, pages 6725-6734.
Crossref
Deborah L. S. Goetz & William J. Murphy. 2010. Natural Killer Cells. Natural Killer Cells 199 219 .
H Komita, X Zhao, A K Katakam, P Kumar, M Kawabe, H Okada, J M Braughler & W J Storkus. (2009) Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity. Cancer Gene Therapy 16:12, pages 883-891.
Crossref
Yukari Shinozaki, Sen Wang, Yoshiyuki Miyazaki, Kohji Miyazaki, Hisakata Yamada, Yasunobu Yoshikai, Hiromitsu Hara & Hiroki Yoshida. (2009) Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity. International Journal of Cancer 124:6, pages 1372-1378.
Crossref
Thomas Ebensen & Carlos A. Guzmán. 2009. Pharmaceutical Biotechnology. Pharmaceutical Biotechnology 171 188 .
Antonio Daga, Anna Maria Orengo, Rosaria Maria Rita Gangemi, Daniela Marubbi, Marzia Perera, Alberto Comes, Silvano Ferrini & Giorgio Corte. (2007) Glioma immunotherapy by IL‐21 gene‐modified cells or by recombinant IL‐21 involves antibody responses. International Journal of Cancer 121:8, pages 1756-1763.
Crossref
Ronald B. Smeltz. (2007) Profound Enhancement of the IL-12/IL-18 Pathway of IFN-γ Secretion in Human CD8+ Memory T Cell Subsets via IL-15. The Journal of Immunology 178:8, pages 4786-4792.
Crossref
Charles F. Eisenbeis, Gregory B. Lesinski, Mirela Anghelina, Robin Parihar, Daniel Valentino, Jing Liu, Padma Nadella, Poongothai Sundaram, Donn C. Young, Mario Sznol, Michael J. Walker & William E. CarsonIIIIII. (2005) Phase I Study of the Sequential Combination of Interleukin-12 and Interferon Alfa-2b in Advanced Cancer: Evidence for Modulation of Interferon Signaling Pathways by Interleukin-12. Journal of Clinical Oncology 23:34, pages 8835-8844.
Crossref
John R. Ortaldo, Robin T. Winkler-Pickett, Earl W. BereJrJr, Morihiro Watanabe, William J. Murphy & Robert H. Wiltrout. (2005) In Vivo Hydrodynamic Delivery of cDNA Encoding IL-2: Rapid, Sustained Redistribution, Activation of Mouse NK Cells, and Therapeutic Potential in the Absence of NKT Cells. The Journal of Immunology 175:2, pages 693-699.
Crossref
Jinhai Wang, Raymond Alvarez, Gregory Roderiquez, Ennan Guan, Quincy Caldwell, Jiun Wang, Michael Phelan & Michael A. Norcross. (2005) CpG-Independent Synergistic Induction of β-Chemokines and a Dendritic Cell Phenotype by Orthophosphorothioate Oligodeoxynucleotides and Granulocyte-Macrophage Colony-Stimulating Factor in Elutriated Human Primary Monocytes. The Journal of Immunology 174:10, pages 6113-6121.
Crossref
Nai-Kong V. Cheung & Paul M. Sondel. 2005. Neuroblastoma. Neuroblastoma 223 242 .
Rosalba Salcedo, Jimmy K. Stauffer, Erin Lincoln, Timothy C. Back, Julie A. Hixon, Cynthia Hahn, Kimberly Shafer-Weaver, Anatoli Malyguine, Robert Kastelein & Jon M. Wigginton. (2004) IL-27 Mediates Complete Regression of Orthotopic Primary and Metastatic Murine Neuroblastoma Tumors: Role for CD8+ T Cells. The Journal of Immunology 173:12, pages 7170-7182.
Crossref
Malcolm A Smith & Barry D Anderson. (2004) Commentary on “European collaboration in trials of new agents for children with cancer” by Ablett et al.. European Journal of Cancer 40:12, pages 1893-1895.
Crossref
David E Spaner. (2004) Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cells. Journal of Leukocyte Biology 76:2, pages 338-351.
Crossref
Tian-Geng You, Hong-Shun Wang, Jia-He Yang, Qi-Jun Qian, Rui-Fang Fan & Meng-Chao Wu. (2004) Transfection of IL-2 and/or IL-12 genes into spleen in treatment of rat liver cancer. World Journal of Gastroenterology 10:15, pages 2190.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.