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Mesenchymal stem cells at the intersection of cell and gene therapy

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Pages 1663-1679 | Published online: 09 Nov 2010

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Xiaoyan Wang, Chichi Li, Yan Zheng, Wei Xia, Youcheng Yu & Xianjie Ma. (2012) Bone marrow mesenchymal stem cells increase skin regeneration efficiency in skin and soft tissue expansion. Expert Opinion on Biological Therapy 12:9, pages 1129-1139.
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Timothy J. Myers, Yun Yan, Froilan Granero-Molto, Jared A. Weis, Lara Longobardi, Tieshi Li, Ying Li, Clara Contaldo, Huseyin Ozkhan & Anna Spagnoli. (2012) Systemically delivered insulin-like growth factor-I enhances mesenchymal stem cell-dependent fracture healing. Growth Factors 30:4, pages 230-241.
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Articles from other publishers (73)

Agieshkumar Balakrishna Pillai, Vignesh Mariappan, Aashika Raagavi JeanPierre & S. R. Rao. (2022) Restoration of vascular endothelial integrity by mesenchymal stromal/stem cells in debilitating virus diseases. Human Cell 35:6, pages 1633-1639.
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Zhihui Zhang, Yulin Kuang, Kui Ma, Yan Li, Xiaoming Liu, Yuru Shi & Xu Wu. (2022) Gclc overexpression inhibits apoptosis of bone marrow mesenchymal stem cells through the PI3K/AKT/Foxo1 pathway to alleviate inflammation in acute lung injury. International Immunopharmacology 110, pages 109017.
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Masoumeh Rostami, Kamran Haidari, Hossein Amini & Majid Shahbazi. (2022) Genetically Engineered Mesenchymal Stem Cell Therapy Against Murine Experimental Autoimmune Encephalomyelitis. Molecular Neurobiology 59:6, pages 3449-3457.
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Feifei Huang, Tianyun Gao, Wenqing Wang, Liudi Wang, Yuanyuan Xie, Chenxun Tai, Shuo Liu, Yi Cui & Bin Wang. (2021) Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway. Stem Cell Research & Therapy 12:1.
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Yuxiang Liu & Jingai Fang. (2020) Mesenchymal Stem Cells as Therapeutic Agents and Novel Carriers for the Delivery of Candidate Genes in Acute Kidney Injury. Stem Cells International 2020, pages 1-10.
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Tahir Muhammad, Ali Sakhawat, Aamir Ali Khan, Hua Huang, Haroon Rashid Khan, Yinghui Huang & Juan Wang. (2020) Aloperine in combination with therapeutic adenoviral vector synergistically suppressed the growth of non-small cell lung cancer. Journal of Cancer Research and Clinical Oncology 146:4, pages 861-874.
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Pankaj Mandpe, Bala Prabhakar & Pravin Shende. (2019) Role of Liposomes-Based Stem Cell for Multimodal Cancer Therapy. Stem Cell Reviews and Reports 16:1, pages 103-117.
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Jibin Han, Yuxiang Liu, Hong Liu & Yuanyuan Li. (2019) Genetically modified mesenchymal stem cell therapy for acute respiratory distress syndrome. Stem Cell Research & Therapy 10:1.
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Michael T. Schweizer, Hao Wang, Trinity J. Bivalacqua, Alan W. Partin, Su Jin Lim, Carolyn Chapman, Rehab Abdallah, Oren Levy, Neil A. Bhowmick, Jeffrey M. Karp, Angelo De Marzo, John T. Isaacs, W. Nathaniel Brennen & Samuel R. Denmeade. (2019) A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer. Stem Cells Translational Medicine 8:5, pages 441-449.
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Joana SerraCláudia P.A. AlvesLiliana BritoGabriel A. MonteiroJoaquim M.S. CabralDuarte Miguel F. PrazeresCláudia L. da Silva. (2019) Engineering of Human Mesenchymal Stem/Stromal Cells with Vascular Endothelial Growth Factor–Encoding Minicircles for Angiogenic Ex Vivo Gene Therapy . Human Gene Therapy 30:3, pages 316-329.
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Jun Zhang & Ching-An Peng. (2019) Migration of mesenchymal stem cells tethered with carbon nanotubes under a chemotactic gradient. RSC Advances 9:13, pages 7156-7164.
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Thekkeparambil Chandrabose Srijaya, Sandhya Sriram, Noor Hayaty Abu Kasim & Shigeki Sugii. 2019. A Roadmap to Non-Hematopoietic Stem Cell-based Therapeutics. A Roadmap to Non-Hematopoietic Stem Cell-based Therapeutics 395 418 .
Xiaoyan Sun, Hua Qin, Siming Yang & Xiaobing Fu. 2019. Severe Trauma and Sepsis. Severe Trauma and Sepsis 357 389 .
Taha Umair Wani, Hasham S. Sofi, Nisar Ahmad Khan & Faheem A. Sheikh. 2020. Stem Cell Nanotechnology. Stem Cell Nanotechnology 77 84 .
Masoumeh Rostami, Kamran Haidari & Majid Shahbazi. (2018) The Human IL-23 Decoy Receptor Inhibits T-Cells Producing IL-17 by Genetically Engineered Mesenchymal Stem Cells. International Journal of Cell Biology 2018, pages 1-14.
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Masoumeh RostamiKamran HaidariMajid Shahbazi. (2018) Genetically Engineered Adipose Mesenchymal Stem Cells Using HIV-Based Lentiviral Vectors as Gene Therapy for Autoimmune Diseases. Cellular Reprogramming 20:6, pages 337-346.
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Yubao Liu, Rui Zou, Zhen Wang, Chuanyang Wen, Fan Zhang & Fuqing Lin. (2018) Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis. Biochemical Journal 475:22, pages 3629-3638.
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Jiahui Huo, Sujing Sun, Zhijun Geng, Wei Sheng, Runkai Chen, Kui Ma, Xiaoyan Sun & Xiaobing Fu. (2018) Bone Marrow-Derived Mesenchymal Stem Cells Promoted Cutaneous Wound Healing by Regulating Keratinocyte Migration via β 2 -Adrenergic Receptor Signaling . Molecular Pharmaceutics 15:7, pages 2513-2527.
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Luminita Labusca, Dumitru Daniel Herea & Kaveh Mashayekhi. (2018) Stem cells as delivery vehicles for regenerative medicine-challenges and perspectives. World Journal of Stem Cells 10:5, pages 43-56.
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Wei WangHao GuoHongyue LiYongjia YanChao WuXiaodong WangXianghui HeNa Zhao. (2018) Interleukin-35 Gene-Modified Mesenchymal Stem Cells Protect Concanavalin A–Induced Fulminant Hepatitis by Decreasing the Interferon Gamma Level. Human Gene Therapy 29:2, pages 234-241.
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Sang-Soo Han, Hong Yeol Yoon, Ji Young Yhee, Myeong Ok Cho, Hye-Eun Shim, Ji-Eun Jeong, Dong-Eun Lee, Kwangmeyung Kim, Hwanuk Guim, John Hwan Lee, Kang Moo Huh & Sun-Woong Kang. (2018) In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering . Polymer Chemistry 9:1, pages 20-27.
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Jaitip Tipanee, Yoke Chin Chai, Thierry VandenDriessche & Marinee K. Chuah. (2017) Preclinical and clinical advances in transposon-based gene therapy. Bioscience Reports 37:6.
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Nan Wang, Wei Liu, Tao Tan, Chao-Qun Dong, Duan-Yang Lin, Jun Zhao, Chang Yu & Xiao-Ji Luo. (2017) Notch signaling negatively regulates BMP9-induced osteogenic differentiation of mesenchymal progenitor cells by inhibiting JunB expression. Oncotarget 8:65, pages 109661-109674.
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Ainsley M. Robinson, Ahmed A. Rahman, Sarah Miller, Rhian Stavely, Samy Sakkal & Kulmira Nurgali. (2017) The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis. Stem Cell Research & Therapy 8:1.
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Jaitip TipaneeThierry VandenDriesscheMarinee K. Chuah. (2017) Transposons: Moving Forward from Preclinical Studies to Clinical Trials. Human Gene Therapy 28:11, pages 1087-1104.
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Yufeng Wang, Qiaoling Feng, Caixia Ji, Xiaohua Liu, Li Li & Jinyong Luo. (2017) RUNX3 plays an important role in mediating the BMP9-induced osteogenic differentiation of mesenchymal stem cells. International Journal of Molecular Medicine.
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Fengqi Yan, Xia Li, Nan Li, Rui Zhang, Qinhao Wang, Yi Ru, Xiaoke Hao, Jianxin Ni, He Wang & Guojun Wu. (2017) Immunoproapoptotic molecule scFv-Fdt-tBid modified mesenchymal stem cells for prostate cancer dual-targeted therapy. Cancer Letters 402, pages 32-42.
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Caixia Ji, Xiaohua Liu, Li Xu, Tingting Yu, Chaoqun Dong & Jinyong Luo. (2017) RUNX1 Plays an Important Role in Mediating BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Line C3H10T1/2, Murine Multi-Lineage Cells Lines C2C12 and MEFs. International Journal of Molecular Sciences 18:7, pages 1348.
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Xue-Qin Hou, Lei Wang, Fu-Gang Wang, Xiao-Min Zhao & Han-Ting Zhang. (2017) Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases. Genes 8:5, pages 135.
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Xiaomin Lu, Jibin Han, Xiuping Xu, Jingyuan Xu, Ling Liu, Yingzi Huang, Yi Yang & Haibo Qiu. (2017) PGE2 Promotes the Migration of Mesenchymal Stem Cells through the Activation of FAK and ERK1/2 Pathway. Stem Cells International 2017, pages 1-11.
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J.W. Kim, J. Murphy, A.L. Chang, D.A. Spencer, J.R. Kane, D. Kanojia, A. Rashidi, J.S. Young & M.S. Lesniak. 2017. Mesenchymal Stromal Cells as Tumor Stromal Modulators. Mesenchymal Stromal Cells as Tumor Stromal Modulators 475 499 .
Yaning Li, Guo‐Yuan Yang & Yongting Wang. 2016. Stem Cells in Toxicology and Medicine. Stem Cells in Toxicology and Medicine 347 362 .
Julie R. Beegle, Jan A. Nolta & Fernando A. Fierro. 2016. The Biology and Therapeutic Application of Mesenchymal Cells. The Biology and Therapeutic Application of Mesenchymal Cells 873 891 .
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Chrisna Durandt, Fiona A. van Vollenstee, Carla Dessels, Karlien Kallmeyer, Danielle de Villiers, Candice Murdoch, Marnie Potgieter & Michael S. Pepper. (2016) Novel flow cytometric approach for the detection of adipocyte subpopulations during adipogenesis. Journal of Lipid Research 57:4, pages 729-742.
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Min Li, Fangrong Zhang, Kerong Chen, Cheng Wang, Yujie Su, Yuan Liu, Jianping Zhou & Wei Wang. (2016) Nanoparticles and mesenchymal stem cells: a win-win alliance for anticancer drug delivery. RSC Advances 6:43, pages 36910-36922.
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Amit N. Patel & Thomas E. Ichim. 2016. Stem Cell and Gene Therapy for Cardiovascular Disease. Stem Cell and Gene Therapy for Cardiovascular Disease 225 231 .
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Matthew L. Skiles, Brandon Hanna, Lindsay Rucker, Allison Tipton, Aidan Brougham-Cook, Ehsan Jabbarzadeh & James O. Blanchette. (2015) ASC Spheroid Geometry and Culture Oxygenation Differentially Impact Induction of Preangiogenic Behaviors in Endothelial Cells. Cell Transplantation 24:11, pages 2323-2335.
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Stella Alimperti & Stelios T. Andreadis. (2015) CDH2 and CDH11 act as regulators of stem cell fate decisions. Stem Cell Research 14:3, pages 270-282.
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Andrzej SteplewskiJolanta FertalaPedro BeredjiklianMark L. WangAndrzej Fertala. (2015) Matrix-Specific Anchors: A New Concept for Targeted Delivery and Retention of Therapeutic Cells. Tissue Engineering Part A 21:7-8, pages 1207-1216.
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Feng Tian, Xiang-lu Ji, Wan-an Xiao, Bin Wang & Fei Wang. (2015) CXCL13 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Inhibiting miR-23a Expression. Stem Cells International 2015, pages 1-8.
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Alice Wong, Ehssan Ghassemi & Clare E Yellowley. (2014) Nestin expression in mesenchymal stromal cells: regulation by hypoxia and osteogenesis. BMC Veterinary Research 10:1.
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Joaquim Casañas, Jaime de la Torre, Francesc Soler, Felix García, Clementina Rodellar, Martí Pumarola, Jana Climent, Robert Soler & Lluís Orozco. (2014) Peripheral nerve regeneration after experimental section in ovine radial and tibial nerves using synthetic nerve grafts, including expanded bone marrow mesenchymal cells: morphological and neurophysiological results. Injury 45, pages S2-S6.
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Valentina UliviRoberta TassoRanieri CanceddaFiorella Descalzi. (2014) Mesenchymal Stem Cell Paracrine Activity Is Modulated by Platelet Lysate: Induction of an Inflammatory Response and Secretion of Factors Maintaining Macrophages in a Proinflammatory Phenotype. Stem Cells and Development 23:16, pages 1858-1869.
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M. Paradisi, F. Alviano, S. Pirondi, G. Lanzoni, M. Fernandez, G. Lizzo, L. Giardino, A. Giuliani, R. Costa, C. Marchionni, L. Bonsi & L. Calzà. (2014) Human Mesenchymal Stem Cells Produce Bioactive Neurotrophic Factors: Source, Individual Variability and Differentiation Issues. International Journal of Immunopathology and Pharmacology 27:3, pages 391-402.
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Onju Ham, Chang Youn Lee, Byeong-Wook Song, Se-Yeon Lee, Ran Kim, Jun-Hee Park, Jiyun Lee, Hyang-Hee Seo, Chae Yoon Lee, Byeong-Wook Song, Yong-An Chung, Lee-So Maeng, Min Young Lee, Jongmin Kim, Byeong-Wook Song, Jihwan Hwang, Dong Kyun Woo & Woochul Chang. (2014) Upregulation of miR-23b Enhances the Autologous Therapeutic Potential for Degenerative Arthritis by Targeting PRKACB in Synovial Fluid-Derived Mesenchymal Stem Cells from Patients. Molecules and Cells 37:6, pages 449-456.
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Evgeny K Shevchenko, Pavel I Makarevich, Zoya I Tsokolaeva, Maria A Boldyreva, Veronika Yu Sysoeva, Vsevolod A Tkachuk & Yelena V Parfyonova. (2013) Transplantation of modified human adipose derived stromal cells expressing VEGF165 results in more efficient angiogenic response in ischemic skeletal muscle. Journal of Translational Medicine 11:1.
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Linda N. Liu, Gang Wang, Kyle Hendricks, Keunmyoung Lee, Ernst Bohnlein, Uwe Junker & Joseph D. Mosca. (2013) Comparison of Drug and Cell-Based Delivery: Engineered Adult Mesenchymal Stem Cells Expressing Soluble Tumor Necrosis Factor Receptor II Prevent Arthritis in Mouse and Rat Animal Models. STEM CELLS Translational Medicine 2:5, pages 362-375.
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Marién Cobo, Per Anderson, Karim Benabdellah, Miguel G. Toscano, Pilar Muñoz, Angélica García-Pérez, Iván Gutierrez, Mario Delgado & Francisco Martin. (2013) Mesenchymal Stem Cells Expressing Vasoactive Intestinal Peptide Ameliorate Symptoms in a Model of Chronic Multiple Sclerosis. Cell Transplantation 22:5, pages 839-854.
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Tao SONG, Juan-Wen HE, Jin WANG, Min TANG & Jin-Yong LUO. (2013) Inhibition of ERK1/2 Kinase Enhances BMP9-induced Osteogenic Differentiation of Mesenchymal Stem Cells*. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39:12, pages 1197-1206.
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Froilán Granero-Moltó, Timothy J. Myers, Jared A. Weis, Lara Longobardi, Tieshi Li, Yun Yan, Natasha Case, Janet Rubin & Anna Spagnoli. (2011) Mesenchymal Stem Cells Expressing Insulin-like Growth Factor-I (MSCIGF) Promote Fracture Healing and Restore New Bone Formation in Irs1 Knockout Mice: Analyses of MSCIGF Autocrine and Paracrine Regenerative Effects. Stem Cells 29:10, pages 1537-1548.
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