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Drug Evaluation

The efficacy and safety of interleukin-1-receptor antagonist anakinra in the treatment of systemic juvenile idiopathic arthritis

, MD, , & , MD PhD
Pages 1743-1752 | Published online: 28 Oct 2010

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Joseph R. Berger, Clyde Markowitz, Peter A. Merkel, Rachel A. Kolster & Zissimos Mourelatos. (2021) Multifocal neutrophilic meningoencephalitis: a novel disorder responsive to anakinra. Journal of Neurology 268:8, pages 2995-2999.
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Emma Rey-Jurado & María Cecilia Poli. (2021) Functional genetics in inborn errors of immunity. Future Rare Diseases 1:2.
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Manel Mejbri, Katerina Theodoropoulou, Michael Hofer & Rolando Cimaz. (2020) Interleukin-1 Blockade in Systemic Juvenile Idiopathic Arthritis. Pediatric Drugs 22:3, pages 251-262.
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Benedetta Saccomanno, Jessica Tibaldi, Francesca Minoia, Francesca Bagnasco, Angela Pistorio, Andressa Guariento, Roberta Caorsi, Alessandro Consolaro, Marco Gattorno & Angelo Ravelli. (2019) Predictors of Effectiveness of Anakinra in Systemic Juvenile Idiopathic Arthritis. The Journal of Rheumatology 46:4, pages 416-421.
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Petros Efthimiou & Sujani Yadlapati. 2019. Auto-Inflammatory Syndromes. Auto-Inflammatory Syndromes 261 276 .
Katherine A. Lyseng-Williamson. (2018) Anakinra in Still’s disease: a profile of its use. Drugs & Therapy Perspectives 34:12, pages 543-553.
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Baris Afsar, Adrian Covic, Alberto Ortiz, Rengin Elsurer Afsar & Mehmet Kanbay. (2018) The Future of IL-1 Targeting in Kidney Disease. Drugs 78:11, pages 1073-1083.
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Gabriella Giancane, Francesca Minoia, Sergio Davì, Giulia Bracciolini, Alessandro Consolaro & Angelo Ravelli. (2016) IL-1 Inhibition in Systemic Juvenile Idiopathic Arthritis. Frontiers in Pharmacology 7.
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Brian A. BaldoBrian A. Baldo. 2016. Safety of Biologics Therapy. Safety of Biologics Therapy 217 261 .
Shweta Pasi, Ravi Kant, Sarika Gupta & Avadhesha Surolia. (2015) Novel multimeric IL-1 receptor antagonist for the treatment of rheumatoid arthritis. Biomaterials 42, pages 121-133.
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Sebastiaan J. Vastert, Wilco de Jager, Bo Jan Noordman, Dirk Holzinger, Wietse Kuis, Berent J. Prakken & Nico M. Wulffraat. (2014) Effectiveness of First-Line Treatment With Recombinant Interleukin-1 Receptor Antagonist in Steroid-Naive Patients With New-Onset Systemic Juvenile Idiopathic Arthritis: Results of a Prospective Cohort Study. Arthritis & Rheumatology 66:4, pages 1034-1043.
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Charles A. Dinarello & Jos W.M. van der Meer. (2013) Treating inflammation by blocking interleukin-1 in humans. Seminars in Immunology 25:6, pages 469-484.
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Marieke H Otten, Janneke Anink, Sandra Spronk & Lisette W A van Suijlekom-Smit. (2013) Efficacy of biological agents in juvenile idiopathic arthritis: a systematic review using indirect comparisons. Annals of the Rheumatic Diseases 72:11, pages 1806-1812.
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Sarah Ringold, Pamela F. Weiss, Timothy Beukelman, Esi Morgan DeWitt, Norman T. Ilowite, Yukiko Kimura, Ronald M. Laxer, Daniel J. Lovell, Peter A. Nigrovic, Angela Byun Robinson & Richard K. Vehe. (2013) 2013 Update of the 2011 American College of Rheumatology Recommendations for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for the Medical Therapy of Children With Systemic Juvenile Idiopathic Arthritis and Tuberculosis Screening Among C. Arthritis & Rheumatism 65:10, pages 2499-2512.
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Sarah Ringold, Pamela F. Weiss, Timothy Beukelman, Esi Morgan DeWitt, Norman T. Ilowite, Yukiko Kimura, Ronald M. Laxer, Daniel J. Lovell, Peter A. Nigrovic, Angela Byun Robinson & Richard K. Vehe. (2013) 2013 Update of the 2011 American College of Rheumatology Recommendations for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for the Medical Therapy of Children With Systemic Juvenile Idiopathic Arthritis and Tuberculosis Screening Among C. Arthritis Care & Research 65:10, pages 1551-1563.
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Femke H. M. Prince & Lisette W. A. van Suijlekom-Smit. (2013) Cost of Biologics in the Treatment of Juvenile Idiopathic Arthritis: A Factor not to be Overlooked. Pediatric Drugs 15:4, pages 271-280.
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Jeremy J. Edmunds. 2013. Drug Discovery. Drug Discovery 337 388 .
Joost F Swart, Sytze de Roock & Nico M Wulffraat. (2013) What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis?. Arthritis Research & Therapy 15:3, pages 213.
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Hu-Yuan Tsai, Jyh-Hong Lee, Hsin-Hui Yu, Li-Chieh Wang, Yao-Hsu Yang & Bor-Luen Chiang. (2012) Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study. Journal of the Formosan Medical Association 111:10, pages 542-549.
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Charles A. Dinarello, Anna Simon & Jos W. M. van der Meer. (2012) Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nature Reviews Drug Discovery 11:8, pages 633-652.
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D. Spoerl & Andreas J. Bircher. 2012. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 579 607 .
Robert S. Woodrick & Eric M. Ruderman. (2011) Safety of biologic therapy in rheumatoid arthritis. Nature Reviews Rheumatology 7:11, pages 639-652.
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NICO M. WULFFRAAT. (2011) Defining Criteria for Macrophage Activation Syndrome, a Process Towards Early Recognition and Treatment. The Journal of Rheumatology 38:4, pages 593-594.
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