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Antibody-based therapy in Alzheimer's disease

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Pages 343-357 | Published online: 25 Jan 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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Susmitha Ambadipudi & Markus Zweckstetter. (2016) Targeting intrinsically disordered proteins in rational drug discovery. Expert Opinion on Drug Discovery 11:1, pages 65-77.
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Francesco Panza, Vincenzo Solfrizzi, Bruno P Imbimbo, Michele Giannini, Andrea Santamato, Davide Seripa & Giancarlo Logroscino. (2014) Efficacy and safety studies of gantenerumab in patients with Alzheimer’s disease. Expert Review of Neurotherapeutics 14:9, pages 973-986.
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Francesco Panza, Vincenzo Solfrizzi, Bruno P Imbimbo, Rosanna Tortelli, Andrea Santamato & Giancarlo Logroscino. (2014) Amyloid-based immunotherapy for Alzheimer's disease in the time of prevention trials: the way forward. Expert Review of Clinical Immunology 10:3, pages 405-419.
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Geovanny Rivera-Hernández, Marta Marín-Argany, Bernat Blasco-Moreno, Jaume Bonet, Baldomero Oliva & Sandra Villegas. (2013) Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency. mAbs 5:5, pages 678-689.
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Bared Safieh-Garabedian, Yunis Mayasi & Nayef E Saadé. (2012) Targeting neuroinflammation for therapeutic intervention in neurodegenerative pathologies: a role for the peptide analogue of thymulin (PAT). Expert Opinion on Therapeutic Targets 16:11, pages 1065-1073.
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Bruno P Imbimbo, Simone Ottonello, Vincenza Frisardi, Vincenzo Solfrizzi, Antonio Greco, Davide Seripa, Alberto Pilotto & Francesco Panza. (2012) Solanezumab for the treatment of mild-to-moderate Alzheimer’s disease. Expert Review of Clinical Immunology 8:2, pages 135-149.
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Steven S. Plotkin & Neil R. Cashman. (2020) Passive immunotherapies targeting Aβ and tau in Alzheimer's disease. Neurobiology of Disease 144, pages 105010.
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Jeffrey Cummings, Aaron Ritter & Kate Zhong. (2018) Clinical Trials for Disease-Modifying Therapies in Alzheimer’s Disease: A Primer, Lessons Learned, and a Blueprint for the Future. Journal of Alzheimer's Disease 64:s1, pages S3-S22.
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D’Artagnan Greene, Theodora Po, Jennifer Pan, Tanya Tabibian & Ray Luo. (2018) Computational Analysis for the Rational Design of Anti-Amyloid Beta (Aβ) Antibodies. The Journal of Physical Chemistry B 122:16, pages 4521-4536.
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Das Bhaskar C. (2018) The Role of Tau Protein in Diseases. Annals of Advances in Chemistry, pages 001-016.
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Nuzhat Ahsan, Ibrar Ahmed Siddique, Sarika Gupta & Avadhesha Surolia. (2018) A routinely used protein staining dye acts as an inhibitor of wild type and mutant alpha-synuclein aggregation and modulator of neurotoxicity. European Journal of Medicinal Chemistry 143, pages 1174-1184.
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Leah K. Cuddy, Claudia Seah, Stephen H. Pasternak & R. Jane Rylett. (2017) Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT. Frontiers in Molecular Neuroscience 10.
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Francesco A. AprilePietro SormanniMichele PerniPaolo ArosioSara Linse, Tuomas P. J. KnowlesChristopher M. DobsonMichele Vendruscolo. (2017) Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method. Science Advances 3:6.
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Tara P. Hurst, Caroline Coleman-Vaughan, Indu Patwal & Justin V. McCarthy. (2016) Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease. AIMS Molecular Science 3:2, pages 138-157.
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Lenka Hromadkova, Michala Kolarova, Barbora Jankovicova, Ales Bartos, Jan Ricny, Zuzana Bilkova & Daniela Ripova. (2015) Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product. Journal of Neuroimmunology 289, pages 121-129.
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Paul J. Lucassen, Edwin H. Jacobs, Lianne Hoeijmakers, Sylvie Lesuis, Harm Krugers, Aniko Korosi, H. Georg Kuhn & Karin Boekhoorn. 2015. Neural Stem Cells in Development, Adulthood and Disease. Neural Stem Cells in Development, Adulthood and Disease 53 78 .
Francesco Panza, Giancarlo Logroscino, Bruno P. Imbimbo & Vincenzo Solfrizzi. (2014) Is there still any hope for amyloid-based immunotherapy for Alzheimer's disease?. Current Opinion in Psychiatry 27:2, pages 128-137.
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Paolo Arosio, Michele Vendruscolo, Christopher M. Dobson & Tuomas P.J. Knowles. (2014) Chemical kinetics for drug discovery to combat protein aggregation diseases. Trends in Pharmacological Sciences 35:3, pages 127-135.
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Elvira Valera & Eliezer Masliah. (2013) Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies. Pharmacology & Therapeutics 138:3, pages 311-322.
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Elias Akoury, Michal Gajda, Marcus Pickhardt, Jacek Biernat, Pornsuwan Soraya, Christian Griesinger, Eckhard Mandelkow & Markus Zweckstetter. (2013) Inhibition of Tau Filament Formation by Conformational Modulation. Journal of the American Chemical Society 135:7, pages 2853-2862.
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Thomas Appl, Linda Kaltenbach, Donald C. Lo & Georg C. Terstappen. (2012) Targeting mutant huntingtin for the development of disease-modifying therapy. Drug Discovery Today 17:21-22, pages 1217-1223.
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Damien Hall & Herman Edskes. (2012) Computational modeling of the relationship between amyloid and disease. Biophysical Reviews 4:3, pages 205-222.
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Torleif Härd & Christofer Lendel. (2012) Inhibition of Amyloid Formation. Journal of Molecular Biology 421:4-5, pages 441-465.
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Zhiping Zhang, Tom Goldschmidt & Hugh Salter. (2012) Possible allelic structure of IgG2a and IgG2c in mice. Molecular Immunology 50:3, pages 169-171.
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Francesco PanzaVincenza Frisardi, Vincenzo Solfrizzi, Bruno P Imbimbo, Giancarlo Logroscino, Andrea Santamato, Antonio Greco, Davide Seripa & Alberto Pilotto. (2012) Immunotherapy for Alzheimer’s disease: from anti-β-amyloid to tau-based immunization strategies. Immunotherapy 4:2, pages 213-238.
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