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Bispecific antibodies engage T cells for antitumor immunotherapy

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Pages 843-853 | Published online: 30 Mar 2011

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Vala Kafil, Amir Ata Saei, Mohammad Reza Tohidkia, Jaleh Barar & Yadollah Omidi. (2020) Immunotargeting and therapy of cancer by advanced multivalence antibody scaffolds. Journal of Drug Targeting 28:10, pages 1018-1033.
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Junnan Tang, Deliang Shen, Jinying Zhang, Frances S Ligler & Ke Cheng. (2015) Bispecific antibodies, nanoparticles and cells: bringing the right cells to get the job done. Expert Opinion on Biological Therapy 15:9, pages 1251-1255.
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Tanja D de Gruijl, Axel B Janssen & Victor W van Beusechem. (2015) Arming oncolytic viruses to leverage antitumor immunity. Expert Opinion on Biological Therapy 15:7, pages 959-971.
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Carter M Suryadevara, Patrick C Gedeon, Luis Sanchez-Perez, Terence Verla, Christopher Alvarez-Breckenridge, Bryan D Choi, Peter E Fecci & John H Sampson. (2015) Are BiTEs the “missing link” in cancer therapy?. OncoImmunology 4:6.
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Xiufeng Wu, Arlene J Sereno, Flora Huang, Steven M Lewis, Ricky L Lieu, Caroline Weldon, Carina Torres, Cody Fine, Micheal A Batt, Jonathan R Fitchett, Andrew L Glasebrook, Brian Kuhlman & Stephen J Demarest. (2015) Fab-based bispecific antibody formats with robust biophysical properties and biological activity. mAbs 7:3, pages 470-482.
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Mahiuddin Ahmed, Ming Cheng, Irene Y Cheung & Nai-Kong V Cheung. (2015) Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody. OncoImmunology 4:4.
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Roland B Walter. (2014) Biting back: BiTE antibodies as a promising therapy for acute myeloid leukemia. Expert Review of Hematology 7:3, pages 317-319.
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Diane L Rossi, Edmund A Rossi, Thomas M Cardillo, David M Goldenberg & Chien-Hsing Chang. (2014) A new class of bispecific antibodies to redirect T cells for cancer immunotherapy. mAbs 6:2, pages 381-391.
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Deepa Kolaseri Krishnadas, Fanqi Bai & Kenneth G Lucas. (2013) Cancer testis antigen and immunotherapy. ImmunoTargets and Therapy 2, pages 11-19.
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Bryan D Choi, Patrick C Gedeon, Luis Sanchez-Perez, Darell D Bigner & John H Sampson. (2013) Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. OncoImmunology 2:12.
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Patrick C Gedeon, Bryan D Choi, Tiffany R Hodges, Duane A Mitchell, Darell D Bigner & John H Sampson. (2013) An EGFRvIII-targeted bispecific T-cell engager overcomes limitations of the standard of care for glioblastoma. Expert Review of Clinical Pharmacology 6:4, pages 375-386.
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Divaya Bhutani & Ulka N Vaishampayan. (2013) Monoclonal antibodies in oncology therapeutics: present and future indications. Expert Opinion on Biological Therapy 13:2, pages 269-282.
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Dan Li, Xue Li, Wei-Lin Zhou, Yong Huang, Xiao Liang, Lin Jiang, Xiao Yang, Jie Sun, Zonghai Li, Wei-Dong Han & Wei Wang. (2019) Genetically engineered T cells for cancer immunotherapy. Signal Transduction and Targeted Therapy 4:1.
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Xiaolong Zhang, Yuanyuan Yang, Dongmei Fan & Dongsheng Xiong. (2017) The development of bispecific antibodies and their applications in tumor immune escape. Experimental Hematology & Oncology 6:1.
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Abbas Alibakhshi, Fatemeh Abarghooi Kahaki, Shahrzad Ahangarzadeh, Hajar Yaghoobi, Fatemeh Yarian, Roghaye Arezumand, Javad Ranjbari, Ahad Mokhtarzadeh & Miguel de la Guardia. (2017) Targeted cancer therapy through antibody fragments-decorated nanomedicines. Journal of Controlled Release 268, pages 323-334.
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Ju Yang, Jing Yan & Baorui Liu. (2017) Targeting EGFRvIII for glioblastoma multiforme. Cancer Letters 403, pages 224-230.
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Feifei Luo, Jiawen Qian, Jiao Yang, Yuting Deng, Xiujuan Zheng, Jie Liu & Yiwei Chu. (2016) Bifunctional αHER2/CD3 RNA-engineered CART-like human T cells specifically eliminate HER2+ gastric cancer. Cell Research 26:7, pages 850-853.
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Daniel Regan, Amanda Guth, Jonathan Coy & Steven Dow. (2016) Cancer immunotherapy in veterinary medicine: Current options and new developments. The Veterinary Journal 207, pages 20-28.
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J.M. Redman, E.M. Hill, D. AlDeghaither & L.M. Weiner. (2015) Mechanisms of action of therapeutic antibodies for cancer. Molecular Immunology 67:2, pages 28-45.
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G S Laszlo, C J Gudgeon, K H Harrington & R B Walter. (2015) T-cell ligands modulate the cytolytic activity of the CD33/CD3 BiTE antibody construct, AMG 330. Blood Cancer Journal 5:8, pages e340-e340.
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Jianxuan Zou, Dan Chen, Yunhui Zong, Sisi Ye, Jinle Tang, Huimin Meng, Gangli An, Xingding Zhang & Lin Yang. (2015) Immunotherapy based on bispecific T‐cell engager with hIgG 1 Fc sequence as a new therapeutic strategy in multiple myeloma . Cancer Science 106:5, pages 512-521.
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Kenneth M. Prentice, Alison Wallace & Catherine M. Eakin. (2015) Inline Protein A Mass Spectrometry for Characterization of Monoclonal Antibodies. Analytical Chemistry 87:4, pages 2023-2028.
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D. A. Reardon, G. Freeman, C. Wu, E. A. Chiocca, K. W. Wucherpfennig, P. Y. Wen, E. F. Fritsch, W. T. Curry, J. H. Sampson & G. Dranoff. (2014) Immunotherapy advances for glioblastoma. Neuro-Oncology 16:11, pages 1441-1458.
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Takao Hamakubo, Osamu Kusano-Arai & Hiroko Iwanari. (2014) Generation of antibodies against membrane proteins. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1844:11, pages 1920-1924.
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Weizao Chen, Yang Feng, Ponraj Prabakaran, Tianlei Ying, Yanping Wang, Jianping Sun, Camila D. S. Macedo, Zhongyu Zhu, Yuxian He, Victoria R. Polonis & Dimiter S. Dimitrov. (2014) Exceptionally Potent and Broadly Cross-Reactive, Bispecific Multivalent HIV-1 Inhibitors Based on Single Human CD4 and Antibody Domains. Journal of Virology 88:2, pages 1125-1139.
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Steven M Albelda & Steve H Thorne. (2014) Giving Oncolytic Vaccinia Virus More BiTE. Molecular Therapy 22:1, pages 6-8.
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Lei Wang, Yanran He, Ge Zhang, Juan Ma, Changzhen Liu, Wen He, Wei Wang, Huamin Han, Bhargavi M. Boruah & Bin Gao. (2013) Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody. PLoS ONE 8:9, pages e75589.
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Bryan D. Choi, Patrick C. Gedeon, James E. HerndonIIII, Gary E. Archer, Elizabeth A. Reap, Luis Sanchez-Perez, Duane A. Mitchell, Darell D. Bigner & John H. Sampson. (2013) Human Regulatory T Cells Kill Tumor Cells through Granzyme-Dependent Cytotoxicity upon Retargeting with a Bispecific Antibody. Cancer Immunology Research 1:3, pages 163-167.
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Bryan D. Choi, Patrick C. Gedeon, Chien-Tsun Kuan, Luis Sanchez-Perez, Gary E. Archer, Darell D. Bigner & John H. Sampson. (2013) Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis. Journal of Immunological Methods 395:1-2, pages 14-20.
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