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Expert Opinion on Biological Therapy Volume 12, 2012 - Issue 6
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Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors

Giulia MesianoUniversity of Torino Medical School, Institute for Cancer Research and Treatment, Department of Oncological Sciences, Laboratory of Cell Therapy of Cancer, 10060 Candiolo (Torino), Italy+390119933503; +390119933522; [email protected]
,
Maja TodorovicUniversity of Torino Medical School, Institute for Cancer Research and Treatment, Department of Oncological Sciences, Laboratory of Cell Therapy of Cancer, 10060 Candiolo (Torino), Italy+390119933503; +390119933522; [email protected]
, MD,
Loretta GammaitoniUniversity of Torino Medical School, Institute for Cancer Research and Treatment, Department of Oncological Sciences, Laboratory of Cell Therapy of Cancer, 10060 Candiolo (Torino), Italy+390119933503; +390119933522; [email protected]
,
Valeria LeuciUniversity of Torino Medical School, Institute for Cancer Research and Treatment, Department of Oncological Sciences, Laboratory of Cell Therapy of Cancer, 10060 Candiolo (Torino), Italy+390119933503; +390119933522; [email protected]
, PhD,
Lidia Giraudo DiegoUniversity of Torino Medical School, Institute for Cancer Research and Treatment, Department of Oncological Sciences, Laboratory of Cell Therapy of Cancer, 10060 Candiolo (Torino), Italy+390119933503; +390119933522; [email protected]
,
Fabrizio Carnevale-SchiancaUniversity of Torino Medical School, Institute for Cancer Research and Treatment, Department of Oncological Sciences, Laboratory of Cell Therapy of Cancer, 10060 Candiolo (Torino), Italy+390119933503; +390119933522; [email protected]
, MD,
Franca FagioliRegina Margherita Children's Hospital, Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Pz. Polonia 94, 10126 Torino, Italy
, MD,
Wanda PiacibelloUniversity of Torino Medical School, Institute for Cancer Research and Treatment, Department of Oncological Sciences, Laboratory of Cell Therapy of Cancer, 10060 Candiolo (Torino), Italy+390119933503; +390119933522; [email protected]
, MD,
Massimo AgliettaUniversity of Torino Medical School, Institute for Cancer Research and Treatment, Department of Oncological Sciences, Laboratory of Cell Therapy of Cancer, 10060 Candiolo (Torino), Italy+390119933503; +390119933522; [email protected]
, MD &
Dario SangioloUniversity of Torino Medical School, Institute for Cancer Research and Treatment, Department of Oncological Sciences, Laboratory of Cell Therapy of Cancer, 10060 Candiolo (Torino), Italy+390119933503; +390119933522; [email protected]
, MD PhD show all
Pages 673-684 | Published online: 14 Apr 2012

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Haiqing Wang, Aixiang Liu, Wentao Bo, Xielin Feng, Yong Hu, Lang Tian, Hui Zhang & Xiaoli Tang. (2016) Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma patients after curative resection, a systematic review and meta-analysis. Digestive and Liver Disease 48:11, pages 1275-1282.
Crossref
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Crossref
Weng-Chee Chan & Yeh-Ching Linn. (2014) A comparison between cytokine- and bead-stimulated polyclonal T cells: the superiority of each and their possible complementary role. Cytotechnology 68:4, pages 735-748.
Crossref
Jiong-huang Chen, Jian-yang Xiang, Guo-ping Ding & Li-ping Cao. (2016) Cholangiocarcinoma-derived exosomes inhibit the antitumor activity of cytokine-induced killer cells by down-regulating the secretion of tumor necrosis factor-α and perforin胆管癌外泌体通过抑制肿瘤坏死因子α 与穿孔素分泌使细胞因子诱导的杀伤细胞抗肿瘤活性下降. Journal of Zhejiang University-SCIENCE B 17:7, pages 537-544.
Crossref
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Crossref
Congqi Dai, Fengjuan Lin, Ruixuan Geng, Xiaoxiao Ge, Wenbo Tang, Jinjia Chang, Zheng Wu, Xinyang Liu, Ying Lin, Zhe Zhang & Jin Li. (2016) Implication of combined PD-L1/PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal cancer. Oncotarget 7:9, pages 10332-10344.
Crossref
Yu Chen, Wan-song Lin, Wei-feng Zhu, Jing Lin, Zhi-feng Zhou, Chuan-zhong Huang, Gang Chen, Yi Shi, Zeng-qing Guo & Yun-bin Ye. (2015) Tumor MICA status predicts the efficacy of immunotherapy with cytokine-induced killer cells for patients with gastric cancer. Immunologic Research 64:1, pages 251-259.
Crossref
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Crossref
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Crossref
Satoshi Kokura. 2016. Hyperthermic Oncology from Bench to Bedside. Hyperthermic Oncology from Bench to Bedside 261 274 .
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Crossref
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Qiang Zhang, Xiao-yan Liu, Teng Zhang, Xin-feng Zhang, Lin Zhao, Fei Long, Zhuang-kai Liu & En-hua Wang. (2015) The dual-functional capability of cytokine-induced killer cells and application in tumor immunology. Human Immunology 76:5, pages 385-391.
Crossref
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Hui Liu, Jianyu Li, Fengmei Wang, Yingtang Gao, Ying Luo, Peng Wang, Chenglong Li & Zhengyan Zhu. (2014) Comparative study of different procedures for the separation of peripheral blood mononuclear cells in cytokine-induced killer cell immunotherapy for hepatocarcinoma. Tumor Biology 36:4, pages 2299-2307.
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Xiaoxiang Rong, Fang Wei, Aimin Li, Dong Xiao & Rongcheng Luo. (2015) Effective activity of cytokine induced killer cells against hepatocellular carcinoma including tumor-initiating cells. Medical Hypotheses 84:3, pages 159-161.
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Da-Peng Li, Wei Li, Jun Feng, Kai Chen & Min Tao. (2015) Adjuvant Chemotherapy With Sequential Cytokine-Induced Killer (CIK) Cells in Stage IB Non-Small Cell Lung Cancer. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 22:2, pages 67-74.
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Yu-Peng Hong. (2015) Immunotherapy for hepatocellular carcinoma: From basic research to clinical use. World Journal of Hepatology 7:7, pages 980.
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Bruce Lyday, Tony Chen, Santosh Kesari & Boris Minev. (2015) Overcoming tumor immune evasion with an unique arbovirus. Journal of Translational Medicine 13:1, pages 3.
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Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park & Si Young Song. (2014) Phase II clinical trial of ex vivo-expanded cytokine-induced killer cells therapy in advanced pancreatic cancer. Cancer Immunology, Immunotherapy 63:9, pages 939-946.
Crossref
Yukai He, Yuan Hong & Gerald J Mizejewski. (2014) Engineering α-fetoprotein-based gene vaccines to prevent and treat hepatocellular carcinoma: review and future prospects. Immunotherapy 6:6, pages 725-736.
Crossref
Ke Pan, Xun-Xing Guan, Yong-Qiang Li, Jing-Jing Zhao, Jian-Jun Li, Hui-Juan Qiu, De-Sheng Weng, Qi-Jing Wang, Qing Liu, Li-Xi Huang, Jia He, Shi-Ping Chen, Miao-La Ke, Yi-Xin Zeng & Jian-Chuan Xia. (2014) Clinical Activity of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Post-Mastectomy Triple-Negative Breast Cancer. Clinical Cancer Research 20:11, pages 3003-3011.
Crossref
Ying Pan, Qianshan Tao, Huiping Wang, Shudao Xiong, Rui Zhang, Tianping Chen, Lili Tao & Zhimin Zhai. (2014) Dendritic Cells Decreased the Concomitant Expanded Tregs and Tregs Related IL-35 in Cytokine-Induced Killer Cells and Increased Their Cytotoxicity against Leukemia Cells. PLoS ONE 9:4, pages e93591.
Crossref
Daiqing Gao, Changyou Li, Xihe Xie, Peng Zhao, Xiaofang Wei, Weihong Sun, Hsin-Chen Liu, Aris T. Alexandrou, Jennifer Jones, Ronghua Zhao & Jian Jian Li. (2014) Autologous Tumor Lysate-Pulsed Dendritic Cell Immunotherapy with Cytokine-Induced Killer Cells Improves Survival in Gastric and Colorectal Cancer Patients. PLoS ONE 9:4, pages e93886.
Crossref
Aaron J. Smith, John Oertle & Dino Prato. (2014) Immunotherapy in Cancer Treatment. Open Journal of Medical Microbiology 04:03, pages 178-191.
Crossref
Natalie Vandeven & Paul Nghiem. (2014) Pathogen-Driven Cancers and Emerging Immune Therapeutic Strategies. Cancer Immunology Research 2:1, pages 9-14.
Crossref
Dario Sangiolo, Giulia Mesiano, Loretta Gammaitoni, Valeria Leuci, Maja Todorovic, Lidia Giraudo, Cristina Cammarata, Carmine Dell'Aglio, Lorenzo D'Ambrosio, Alberto Pisacane, Ivana Sarotto, Sara Miano, Ivana Ferrero, Fabrizio Carnevale-Schianca, Ymera Pignochino, Francesco Sassi, Andrea Bertotti, Wanda Piacibello, Franca Fagioli, Massimo Aglietta & Giovanni Grignani. (2014) Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas. Cancer Research 74:1, pages 119-129.
Crossref
Meriem Messaoudene, Giulia Fregni, Emmanuelle Fourmentraux-Neves, Johan Chanal, Eve Maubec, Sarra Mazouz-Dorval, Benoit Couturaud, Angelique Girod, Xavier Sastre-Garau, Sebastien Albert, Charles Guédon, Lydia Deschamps, Delphine Mitilian, Isabelle Cremer, Nicolas Jacquelot, Sylvie Rusakiewicz, Laurence Zitvogel, Marie-Francoise Avril & Anne Caignard. (2014) Mature Cytotoxic CD56bright/CD16 + Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma . Cancer Research 74:1, pages 81-92.
Crossref
Hui Zhu, Xuejing Yang, Jiali Li, Yanjie Ren, Tianyu Zhang, Chunze Zhang, Jintai Zhang, Jing Li & Yan Pang. (2014) Immune Response, Safety, and Survival and Quality of Life Outcomes for Advanced Colorectal Cancer Patients Treated with Dendritic Cell Vaccine and Cytokine-Induced Killer Cell Therapy. BioMed Research International 2014, pages 1-5.
Crossref
Xiaomeng Wang, Wenwen Yu, Hui Li, Jinpu Yu, Xinwei Zhang, Xiubao Ren & Shui Cao. (2014) Can the dual-functional capability of CIK cells be used to improve antitumor effects?. Cellular Immunology 287:1, pages 18-22.
Crossref
Ke Pan, Qi-Jing Wang, Qing Liu, Hai-Xia Zheng, Yong-Qiang Li, De-Sheng Weng, Jian-Jun Li, Li-Xi Huang, Jia He, Shi-Ping Chen, Miao-La Ke, Yi-Xin Zeng & Jian-Chuan Xia. (2013) The phenotype of ex vivo generated cytokine-induced killer cells is associated with overall survival in patients with cancer. Tumor Biology 35:1, pages 701-707.
Crossref
Andreas A Hombach, Gunter Rappl & Hinrich Abken. (2013) Arming Cytokine-induced Killer Cells With Chimeric Antigen Receptors: CD28 Outperforms Combined CD28–OX40 “Super-stimulation”. Molecular Therapy 21:12, pages 2268-2277.
Crossref
Cheng Du, Zhaozhe Liu, Zhenyu Ding, Fang Guo, Dongchu Ma & Xiaodong Xie. (2013) Autologous cytokine-induced killer cells combined with chemotherapy in the treatment of advanced colorectal cancer: a randomized control study. The Chinese-German Journal of Clinical Oncology 12:10, pages 487-491.
Crossref
Loretta Gammaitoni, Lidia Giraudo, Valeria Leuci, Maja Todorovic, Giulia Mesiano, Franco Picciotto, Alberto Pisacane, Alessandro Zaccagna, Maria Giuseppa Volpe, Susanna Gallo, Daniela Caravelli, Elena Giacone, Tiziana Venesio, Antonella Balsamo, Ymera Pignochino, Giovanni Grignani, Fabrizio Carnevale-Schianca, Massimo Aglietta & Dario Sangiolo. (2013) Effective Activity of Cytokine-Induced Killer Cells against Autologous Metastatic Melanoma Including Cells with Stemness Features. Clinical Cancer Research 19:16, pages 4347-4358.
Crossref
Yeh-Ching Linn. (2013) Adoptive immunotherapy with polyclonal T cells and natural killer cells for hematological malignancies: current status and future prospects. International Journal of Hematologic Oncology 2:4, pages 325-338.
Crossref
E Rettinger, H Bonig, S Wehner, G Lucchini, A Willasch, A Jarisch, J Soerensen, R Esser, C Rossig, T Klingebiel & P Bader. (2013) Feasibility of IL-15-activated cytokine-induced killer cell infusions after haploidentical stem cell transplantation. Bone Marrow Transplantation 48:8, pages 1141-1143.
Crossref
Qiuling Liu, Yafeng Wang, Han Wang, Yingying Liu, Tao Liu & Patricia Elena Kunda. (2013) Tandem therapy for retinoblastoma: immunotherapy and chemotherapy enhance cytotoxicity on retinoblastoma by increasing apoptosis. Journal of Cancer Research and Clinical Oncology 139:8, pages 1357-1372.
Crossref
Yu Chen, Gen Lin, Zeng-qing Guo, Zhi-feng Zhou, Zhi-yong He & Yun-bin Ye. (2013) Effects of MICA Expression on the Prognosis of Advanced Non-Small Cell Lung Cancer and the Efficacy of CIK Therapy. PLoS ONE 8:7, pages e69044.
Crossref
Alicia Sawdon & Ching-An Peng. (2013) Engineering antiphagocytic biomimetic drug carriers. Therapeutic Delivery 4:7, pages 825-839.
Crossref
M Sarah S Bovenberg, M Hannah Degeling & Bakhos A Tannous. (2013) Cell-based Immunotherapy Against Gliomas: From Bench to Bedside. Molecular Therapy 21:7, pages 1297-1305.
Crossref
Xiao-Pu Wang, Meng Xu, Hong-Fei Gao, Jian-Fu Zhao & Ke-Cheng Xu. (2013) Intraperitoneal perfusion of cytokine-induced killer cells with local hyperthermia for advanced hepatocellular carcinoma. World Journal of Gastroenterology 19:19, pages 2956-2962.
Crossref
WEI LI, LIN PING XU, LING DI ZHAO, LI WANG, YONG ZHANG, QUAN LI GAO & LING MAI. (2013) Cytokine-induced killer cell therapy for advanced pancreatic adenocarcinoma: A case report and review of the literature. Oncology Letters 5:4, pages 1427-1429.
Crossref
Kathleen F. BensonJoni L. BeamanBoxin OuAdemola OkubenaOlajuwon OkubenaGitte S. Jensen. (2013) West African Sorghum bicolor Leaf Sheaths Have Anti-Inflammatory and Immune-Modulating Properties In Vitro . Journal of Medicinal Food 16:3, pages 230-238.
Crossref
Tao Liu. (2013) Cytokine-induced killer cells co-cultured with complete tumor antigen-loaded dendritic cells, have enhanced selective cytotoxicity on carboplatin-resistant retinoblastoma cells. Oncology Reports.
Crossref

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