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The importance of examining the proportion of circulating DNA originating from tumor, microenvironment and normal cells in colorectal cancer patients

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Pages S209-S215 | Published online: 18 May 2012

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Zuzana Kubiritova, Jan Radvanszky & Roman Gardlik. (2019) Cell-Free Nucleic Acids and their Emerging Role in the Pathogenesis and Clinical Management of Inflammatory Bowel Disease. International Journal of Molecular Sciences 20:15, pages 3662.
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Sahar Alimirzaie, Maryam Bagherzadeh & Mohammad R. Akbari. (2019) Liquid biopsy in breast cancer: A comprehensive review. Clinical Genetics 95:6, pages 643-660.
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Judit Szilvia Keserű, Beáta Soltész, János Lukács, Éva Márton, Melinda Szilágyi-Bónizs, András Penyige, Róbert Póka & Bálint Nagy. (2019) Detection of cell-free, exosomal and whole blood mitochondrial DNA copy number in plasma or whole blood of patients with serous epithelial ovarian cancer. Journal of Biotechnology 298, pages 76-81.
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Eveline E. Vietsch & Anton Wellstein. 2019. Oncogenomics. Oncogenomics 207 218 .
Tae Won Kim, Marc Peeters, Anne Thomas, Peter Gibbs, Kristina Hool, Jianqi Zhang, Agnes Lee Ang, Bruce Allen Bach & Timothy Price. (2018) Impact of Emergent Circulating Tumor DNA RAS Mutation in Panitumumab-Treated Chemoresistant Metastatic Colorectal Cancer . Clinical Cancer Research 24:22, pages 5602-5609.
Crossref
Ondrej Pös, Orsolya Biró, Tomas Szemes & Bálint Nagy. (2018) Circulating cell-free nucleic acids: characteristics and applications. European Journal of Human Genetics 26:7, pages 937-945.
Crossref
Ivana Bratić Hench, Jürgen Hench & Markus Tolnay. (2018) Liquid Biopsy in Clinical Management of Breast, Lung, and Colorectal Cancer. Frontiers in Medicine 5.
Crossref
Hao Xu, Liang Chen, Yang Shao, Dongqin Zhu, Xiaofei Zhi, Qiang Zhang, Fengyuan Li, Jianghao Xu, Xisheng Liu & Zekuan Xu. (2018) Clinical Application of Circulating Tumor DNA in the Genetic Analysis of Patients with Advanced GIST. Molecular Cancer Therapeutics 17:1, pages 290-296.
Crossref
A. Creemers, S. Krausz, M. Strijker, M.J. van der Wel, E.C. Soer, R.J. Reinten, M.G. Besselink, J.W. Wilmink, M.J. van de Vijver, C.J.M. van Noesel, J. Verheij, S.L. Meijer, F. Dijk, M.F. Bijlsma, M.G.H. van Oijen & H.W.M. van Laarhoven. (2017) Clinical value of ctDNA in upper-GI cancers: A systematic review and meta-analysis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:2, pages 394-403.
Crossref
Thaiz Rivera Vargas & Lionel Apetoh. (2017) Danger signals: Chemotherapy enhancers?. Immunological Reviews 280:1, pages 175-193.
Crossref
Ana García-Casas, Dolores C García-Olmo & Damián García-Olmo. (2017) Further the liquid biopsy: Gathering pieces of the puzzle of genometastasis theory. World Journal of Clinical Oncology 8:5, pages 378-388.
Crossref
Anne Winther-Larsen, Christina Demuth, Joan Fledelius, Anne Tranberg Madsen, Karin Hjorthaug, Peter Meldgaard & Boe Sandahl Sorensen. (2017) Correlation between circulating mutant DNA and metabolic tumour burden in advanced non-small cell lung cancer patients. British Journal of Cancer 117:5, pages 704-709.
Crossref
Brian S Sorg, Sarfraz Memon, Kelly Y Kim, Aniruddha Ganguly, Tracy Lively, James Tricoli, Magdalena Thurin, Lokesh Agrawal, Tawnya C McKee, Barbara A Conley & J Milburn Jessup. 2017. Biomarkers in Cancer Screening and Early Detection. Biomarkers in Cancer Screening and Early Detection 231 244 .
Wei Wang, Peng Kong, Ge Ma, Li Li, Jin Zhu, Tiansong Xia, Hui Xie, Wenbin Zhou & Shui Wang. (2017) Characterization of the release and biological significance of cell-free DNA from breast cancer cell lines. Oncotarget 8:26, pages 43180-43191.
Crossref
Stella Maris Ranuncolo. (2017) Liquid Biopsy in Liquid Tumors. Journal of Cancer Therapy 08:03, pages 302-320.
Crossref
Andrea Sartore-Bianchi, Salvatore Siena, Giuseppe Tonini, Alberto Bardelli & Daniele Santini. (2016) Overcoming dynamic molecular heterogeneity in metastatic colorectal cancer: Multikinase inhibition with regorafenib and the case of rechallenge with anti-EGFR. Cancer Treatment Reviews 51, pages 54-62.
Crossref
Louise Rasmussen, Michael Wilhelmsen, Ib Jarle Christensen, Jens Andersen, Lars Nannestad Jørgensen, Morten Rasmussen, Jakob W Hendel, Mogens R Madsen, Jesper Vilandt, Thore Hillig, Michael Klærke, Anna-Marie Bloch Münster, Lars M Andersen, Berit Andersen, Nete Hornung, Erland J Erlandsen, Ali Khalid & Hans Jørgen Nielsen. (2016) Protocol Outlines for Parts 1 and 2 of the Prospective Endoscopy III Study for the Early Detection of Colorectal Cancer: Validation of a Concept Based on Blood Biomarkers. JMIR Research Protocols 5:3, pages e182.
Crossref
A. R. Thierry, S. El Messaoudi, P. B. Gahan, P. Anker & M. Stroun. (2016) Origins, structures, and functions of circulating DNA in oncology. Cancer and Metastasis Reviews 35:3, pages 347-376.
Crossref
Mikhail Fedyanin, Elizaveta Polyanskaya & Sergei Tjulandin. (2016) Circulating tumor cells and circulating tumor DNA in colon cancerZirkulierende Tumorzellen und zirkulierende Tumor-DNA bei Kolonkarzinom. memo - Magazine of European Medical Oncology 9:2, pages 88-92.
Crossref
Hongbiao Lu, Jonas Busch, Monika Jung, Silke Rabenhorst, Bernhard Ralla, Ergin Kilic, Steffen Mergemeier, Nils Budach, Annika Fendler & Klaus Jung. (2016) Diagnostic and prognostic potential of circulating cell-free genomic and mitochondrial DNA fragments in clear cell renal cell carcinoma patients. Clinica Chimica Acta 452, pages 109-119.
Crossref
B A Boone, L Orlichenko, N E Schapiro, P Loughran, G C Gianfrate, J T Ellis, A D Singhi, R Kang, D Tang, M T Lotze & H J Zeh. (2015) The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer. Cancer Gene Therapy 22:6, pages 326-334.
Crossref
Dalong Pang, Alain R. Thierry & Anatoly Dritschilo. (2015) DNA studies using atomic force microscopy: capabilities for measurement of short DNA fragments. Frontiers in Molecular Biosciences 2.
Crossref
Eleonora Zonta, Philippe Nizard & Valérie Taly. 2015. 197 246 .
Celine Lewis & Lyn S. Chitty. 2015. Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring. Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring 381 398 .
Lisa Hui, Jill L. Maron & Peter B. Gahan. 2015. Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring. Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring 295 323 .
Florent Mouliere, Safia El Messaoudi, Dalong Pang, Anatoly Dritschilo & Alain R. Thierry. (2014) Multi‐marker analysis of circulating cell‐free DNA toward personalized medicine for colorectal cancer. Molecular Oncology 8:5, pages 927-941.
Crossref
Alain R Thierry, Florent Mouliere, Safia El Messaoudi, Caroline Mollevi, Evelyne Lopez-Crapez, Fanny Rolet, Brigitte Gillet, Celine Gongora, Pierre Dechelotte, Bruno Robert, Maguy Del Rio, Pierre-Jean Lamy, Frederic Bibeau, Michelle Nouaille, Virginie Loriot, Anne-Sophie Jarrousse, Franck Molina, Muriel Mathonnet, Denis Pezet & Marc Ychou. (2014) Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA. Nature Medicine 20:4, pages 430-435.
Crossref
W. SUN, Y. SUN, M. ZHU, Z. WANG, H. ZHANG, Y. XIN, G. JIANG, X. GUO, Z. ZHANG & Y. LIU. (2014) The role of plasma cell-free DNA detection in predicting preoperative chemoradiotherapy response in rectal cancer patients. Oncology Reports 31:3, pages 1466-1472.
Crossref
Christoph Kahlert, Sonia A. Melo, Alexei Protopopov, Jiabin Tang, Sahil Seth, Moritz Koch, Jianhua Zhang, Juergen Weitz, Lynda Chin, Andrew Futreal & Raghu Kalluri. (2014) Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer. Journal of Biological Chemistry 289:7, pages 3869-3875.
Crossref
GABRIELA B. GELALETI, ADRIANA GRANZOTTO, CAMILA LEONEL, BRUNA V. JARDIM, MARINA G. MOSCHETTA, CLAUDIA M.A. CARARETO & DEBORA AP.P.C. ZUCCARI. (2014) Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia. Oncology Reports 31:1, pages 435-441.
Crossref
Francois-Clement BidardBritta WeigeltJorge S. Reis-Filho. (2013) Going with the Flow: From Circulating Tumor Cells to DNA. Science Translational Medicine 5:207.
Crossref
Safia El Messaoudi, Fanny Rolet, Florent Mouliere & Alain R. Thierry. (2013) Circulating cell free DNA: Preanalytical considerations. Clinica Chimica Acta 424, pages 222-230.
Crossref

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