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Expert Opinion on Biological Therapy Volume 12, 2012 - Issue 9
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Drug Evaluations

The role of tocilizumab in the management of rheumatoid arthritis

Zoe AshUniversity of Leeds, Leeds Institute of Molecular Medicine, Leeds Teaching Hospitals, Section of Musculoskeletal Disease, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK
, BMedSci BMBS MRCP &
Paul EmeryDivision of Rheumatic and Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals, Leeds, UK+0044 113 3924884;+0044 113 3924991; [email protected]
, MA MD FRCP
Pages 1277-1289 | Published online: 31 Jul 2012

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Kohei Mizuno, Yuri Ikeuchi-Takahashi, Yoshiyuki Hattori & Hiraku Onishi. (2021) Preparation and evaluation of conjugate nanogels of glycyl-prednisolone with natural anionic polysaccharides as anti-arthritic delivery systems. Drug Delivery 28:1, pages 136-144.
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Özgül Muştu Koryürek & Göknur Kalkan. (2016) A new alternative therapy in dermatology: tocilizumab. Cutaneous and Ocular Toxicology 35:2, pages 145-152.
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Maeve McLaughlin & Andrew Östör’s. (2015) Safety of subcutaneous versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. Expert Opinion on Drug Safety 14:3, pages 429-437.
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Emilio Besada. (2014) Potential patient benefit of a subcutaneous formulation of tocilizumab for the treatment of rheumatoid arthritis: a critical review. Patient Preference and Adherence 8, pages 1051-1059.
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Luca Semerano, Allan Thiolat, Emeline Minichiello, Gaëlle Clavel, Natacha Bessis & Marie-Christophe Boissier. (2014) Targeting IL-6 for the treatment of rheumatoid arthritis: Phase II investigational drugs. Expert Opinion on Investigational Drugs 23:7, pages 979-999.
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Emma Guttman-Yassky, Nikhil Dhingra & Donald YM Leung. (2013) New era of biologic therapeutics in atopic dermatitis. Expert Opinion on Biological Therapy 13:4, pages 549-561.
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Luca MASTORINO, Gianluca AVALLONE, Paolo DAPAVO, Martina MERLI, Andrea AGOSTINI, Damiano GRANDINETTI, Maria T. FIERRO, Pietro QUAGLINO & Simone RIBERO. (2022) Tocilizumab and its usage for skin diseases. Italian Journal of Dermatology and Venereology 157:1.
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Yasar Karatas, Mehmet Fatih Erdi, Bülent Kaya, Fatih Keskin, Gökhan Cüce, Ibrahim Kılınc, Mehmet Uyar, Emir Kaan Izci & Erdal Kalkan. (2019) Neuroprotective Effects of Tocilizumab on Experimentally-Induced Spinal Cord Ischemia-Reperfusion Injury. World Neurosurgery 124, pages e208-e213.
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Pablo R. G. Cardoso, Katherine A. Matias, Andrea T. Dantas, Claudia D. L. Marques, Michelly C. Pereira, Angela L. B. P. Duarte, Moacyr Jesus Barreto de Melo Rego, Ivan da Rocha Pitta & Maira Galdino da Rocha Pitta. (2018) Losartan, but not Enalapril and Valsartan, Inhibits the Expression of IFN-γ, IL-6, IL-17F and IL-22 in PBMCs from Rheumatoid Arthritis Patients. The Open Rheumatology Journal 12:1, pages 160-170.
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Michela Rusconi, Francesca Gerardi, William Santus, Andrea Lizio, Valeria Ada Sansone, Christian Lunetta, Ivan Zanoni & Francesca Granucci. (2017) Inflammatory role of dendritic cells in Amyotrophic Lateral Sclerosis revealed by an analysis of patients’ peripheral blood. Scientific Reports 7:1.
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Masaru Ishii. (2017) Immunology proves a great success for treating systemic autoimmune diseases - a perspective on immunopharmacology: IUPHAR Review 23. British Journal of Pharmacology 174:13, pages 1875-1880.
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Kris Janssens, Helena Slaets & Niels Hellings. (2015) Immunomodulatory properties of the IL-6 cytokine family in multiple sclerosis. Annals of the New York Academy of Sciences 1351:1, pages 52-60.
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Michele Barone, Antonella Notarnicola, Giuseppe Lopalco, Maria Teresa Viggiani, Francesco Sebastiani, Michele Covelli, Florenzo Iannone, Alfonso W. Avolio, Alfredo Di Leo, Luca Cantarini & Giovanni Lapadula. (2015) Safety of long‐term biologic therapy in rheumatologic patients with a previously resolved hepatitis B viral infection. Hepatology 62:1, pages 40-46.
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Dan Qu, Jian Liu, Chi Wai Lau & Yu Huang. (2014) IL-6 in diabetes and cardiovascular complications. British Journal of Pharmacology 171:15, pages 3595-3603.
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Karim C. El Kasmi, Steven C. Pugliese, Suzette R. Riddle, Jens M. Poth, Aimee L. Anderson, Maria G. Frid, Min Li, Soni S. Pullamsetti, Rajkumar Savai, Maria A. Nagel, Mehdi A. Fini, Brian B. Graham, Rubin M. Tuder, Jacob E. Friedman, Holger K. Eltzschig, Ronald J. Sokol & Kurt R. Stenmark. (2014) Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension. The Journal of Immunology 193:2, pages 597-609.
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H Wang, J Zhao, H Zhang, Y Huang, S Wang, Q Tu & N Yang. (2014) CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response. Clinical and Experimental Immunology 176:2, pages 238-245.
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Corneliu Sima & Michael Glogauer. (2013) Macrophage subsets and osteoimmunology: tuning of the immunological recognition and effector systems that maintain alveolar bone. Periodontology 2000 63:1, pages 80-101.
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Sean O. Ryan, Jenny L. Johnson & Brian A. Cobb. (2013) Neutrophils Confer T Cell Resistance to Myeloid-Derived Suppressor Cell–Mediated Suppression To Promote Chronic Inflammation. The Journal of Immunology 190:10, pages 5037-5047.
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. (2013) Current World Literature. Current Opinion in Rheumatology 25:3, pages 398-409.
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Md Yuzaiful Md Yusof & Paul Emery. (2013) Targeting Interleukin-6 in Rheumatoid Arthritis. Drugs 73:4, pages 341-356.
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Katia Boniface. (2013) Role of Th17 cells in the pathogenesis of rheumatoid arthritis. World Journal of Rheumatology 3:3, pages 25.
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Jonathan P Sherlock, Andrew D Filer, John D Isaacs & Christopher D Buckley. (2013) What can rheumatologists learn from translational cancer therapy?. Arthritis Research & Therapy 15:3, pages 114.
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Min Yang, Xiaomin Cen, Qibing Xie, Chuan Zuo, Guixiu Shi & Geng Yin. (2013) Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis. Clinical and Developmental Immunology 2013, pages 1-4.
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Marie-Elise Truchetet, M. Djavad Mossalayi & Katia Boniface. (2013) IL-17 in the Rheumatologist’s Line of Sight. BioMed Research International 2013, pages 1-18.
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