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Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR antibodies: overcoming the mechanisms of cancer cell resistance

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Pages 241-255 | Published online: 03 Jan 2013

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Miguel Jhonatan Sotelo Lezama, Javier Sastre Valera & Eduardo Díaz-Rubio García. (2014) Impact of cetuximab in current treatment of metastatic colorectal cancer. Expert Opinion on Biological Therapy 14:3, pages 387-399.
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Shanshan Chen, Xuechun Li, Rongming Chen, Mingang Yin & Qiuhong Zheng. (2016) Cetuximab intensifies the ADCC activity of adoptive NK cells in a nude mouse colorectal cancer xenograft model. Oncology Letters 12:3, pages 1868-1876.
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Guang-jun Zhang, Jian-shui Li, He Zhou, Hua-xu Xiao, Yu Li & Tong Zhou. (2015) MicroRNA-106b promotes colorectal cancer cell migration and invasion by directly targeting DLC1. Journal of Experimental & Clinical Cancer Research 34:1.
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Julianne D. Twomey, Su-Ryun Kim, Liqun Zhao, William P. Bozza & Baolin Zhang. (2015) Spatial dynamics of TRAIL death receptors in cancer cells. Drug Resistance Updates 19, pages 13-21.
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Bo Gong. (2015) MiR-21/RASA1 axis affects malignancy of colon cancer cells via RAS pathways . World Journal of Gastroenterology 21:5, pages 1488.
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Onat Kadioglu, Ean Jeong Seo & Thomas Efferth. 2014. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies 823 850 .
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Siddhartha Deb & Stephen B Fox. (2014) Molecular profiling in colorectal cancer: current state of play and future directions. Colorectal Cancer 3:1, pages 41-56.
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Wenhao Weng, Junlan Feng, Huanlong Qin & Yanlei Ma. (2014) Molecular therapy of colorectal cancer: Progress and future directions. International Journal of Cancer, pages n/a-n/a.
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Sing Yu Moorcraft, Elizabeth C. Smyth & David Cunningham. (2013) The role of personalized medicine in metastatic colorectal cancer: an evolving landscape. Therapeutic Advances in Gastroenterology 6:5, pages 381-395.
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Santu Kumar Saha & Anisur Rahman Khuda-Bukhsh. (2013) Molecular approaches towards development of purified natural products and their structurally known derivatives as efficient anti-cancer drugs: Current trends. European Journal of Pharmacology 714:1-3, pages 239-248.
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Crossref
Jan B VermorkenChristian RolfoGiuseppe BronteAntonio RussoMarc Peeters. 2013. Monoclonal Antibodies Targeting EGFR/HER2 and Clinical Outcomes in Cancer Treatment. Monoclonal Antibodies Targeting EGFR/HER2 and Clinical Outcomes in Cancer Treatment 10 26 .
Lei Zhu, Lin Zhao, Meizhi Wu, Zhange Chen & Huangjin Li. (2013) B-cell epitope peptide vaccination targeting dimer interface of epidermal growth factor receptor (EGFR). Immunology Letters 153:1-2, pages 33-40.
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