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Original Research

Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults

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Pages 339-343 | Published online: 04 Jan 2013

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Jonathan C. L. Chua, John D. F. Hale, Pat Silcock & Phil J. Bremer. (2020) Bacterial survival and adhesion for formulating new oral probiotic foods. Critical Reviews in Food Science and Nutrition 60:17, pages 2926-2937.
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Giulia Marini, Emanuela Sitzia, Maria Laura Panatta & Giovanni Carlo De Vincentiis. (2019) Pilot study to explore the prophylactic efficacy of oral probiotic Streptococcus salivarius K12 in preventing recurrent pharyngo-tonsillar episodes in pediatric patients. International Journal of General Medicine 12, pages 213-217.
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Seraj Zohurul Haque & Mainul Haque. (2017) The ecological community of commensal, symbiotic, and pathogenic gastrointestinal microorganisms – an appraisal. Clinical and Experimental Gastroenterology 10, pages 91-103.
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Win-Yan Chan, Jonathan M Cohen & Jeremy S Brown. (2016) The new first-line defense: the potential of nasopharyngeal colonization in vaccine strategies. Vaccine: Development and Therapy 6, pages 47-57.
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Francesco Di Pierro, Maria Colombo, Alberto Zanvit & Amilcare S Rottoli. (2016) Positive clinical outcomes derived from using Streptococcus salivarius K12 to prevent streptococcal pharyngotonsillitis in children: a pilot investigation. Drug, Healthcare and Patient Safety 8, pages 77-81.
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Francesco Di Pierro, Daniele Di Pasquale & Maurizio Di Cicco. (2015) Oral use of Streptococcus salivarius K12 in children with secretory otitis media: preliminary results of a pilot, uncontrolled study. International Journal of General Medicine 8, pages 303-308.
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Francesco Di Pierro, Alberto Zanvit, Piero Nobili, Paolo Risso & Carlo Fornaini. (2015) Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study. Clinical, Cosmetic and Investigational Dentistry 7, pages 107-113.
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Francesco Di Pierro, Maria Colombo, Alberto Zanvit, Paolo Risso & Amilcare S Rottoli. (2014) Use of Streptococcus salivarius K12 in the prevention of streptococcal and viral pharyngotonsillitis in children. Drug, Healthcare and Patient Safety 6, pages 15-20.
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Stephen M Vindigni, Elizabeth K Broussard & Christina M Surawicz. (2013) Alteration of the intestinal microbiome: fecal microbiota transplant and probiotics for Clostridium difficile and beyond. Expert Review of Gastroenterology & Hepatology 7:7, pages 615-628.
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V. V. Bobyr, O. A. Nazarchuk, V. G. Paliy, A. V. Kryzhanovska, N. A. Bobyr, I. G. Vlasenko & N. A. Zhemera. (2023) The human microbiome and modern approaches to its preservation (analytical review). Reports of Vinnytsia National Medical University 27:3, pages 495-500.
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Shanthala B Mallikarjun, Henna Palampadiyan Salim, Shashidara Raju & Austin R Surendranath. (2023) Randomized Clinical Trial of Oral Probiotic Streptococcus salivarius M18 on Salivary Streptococcus mutans in Preprimary Children. International Journal of Clinical Pediatric Dentistry 16:2, pages 259-263.
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Xi Fu, Bingqian Du, Yi Meng, Yanling Li, Xunhua Zhu, Zheyuan Ou, Mei Zhang, Huarong Wen, Aminnuddin Ma'pol, Jamal Hisham Hashim, Zailina Hashim, Gunilla Wieslander, Qingmei Chen, Jun Jiang, Juan Wang, Dan Norbäck, Yun Xia, Qingsong Chen & Yu Sun. (2023) Associations between environmental characteristics, high-resolution indoor microbiome, metabolome and allergic and non-allergic rhinitis symptoms for junior high school students. Environmental Science: Processes & Impacts 25:4, pages 791-804.
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John R. Tagg, Liam K. Harold, Rohit Jain & John D. F. Hale. (2023) Beneficial modulation of human health in the oral cavity and beyond using bacteriocin-like inhibitory substance-producing streptococcal probiotics. Frontiers in Microbiology 14.
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O. V. Zaytseva, T. I. Rychkova, E. E. Lokshina, N. K. Shumeiko & E. V. Kulikova. (2023) Variable and insidious respiratory infections: can they be prevented?. Meditsinskiy sovet = Medical Council:1, pages 39-45.
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Alexander Bertuccioli, Marco Gervasi, Giosuè Annibalini, Beatrice Binato, Fabrizio Perroni, Marco B. L. Rocchi, Davide Sisti & Stefano Amatori. (2023) Use of Streptococcus salivarius K12 in supporting the mucosal immune function of active young subjects: A randomised double-blind study. Frontiers in Immunology 14.
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M V Nasserallah, N M de Silva, V Tobin, W M Rozen & D J Hunter-Smith. (2022) Can probiotic gargles reduce post-tonsillectomy morbidity in adult patients? A pilot, triple-blind, randomised, controlled trial and feasibility study. The Journal of Laryngology & Otology 137:3, pages 323-341.
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Vania Arboleda, Kawther N Elsouri, Samantha E Heiser, Isabel Bernal, Marc M Kesselman & Michelle Demory Beckler. (2023) Oral Microbiome as a Tool of Systemic Disease on Cleft Patients: A New Landscape. Cureus.
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Medana Zamfir, Iulia-Roxana Angelescu & Silvia-Simona Grosu-Tudor. (2023) In Vitro Evaluation of Commercial Probiotic Products Containing Streptococcus salivarius K12 by Assessment of Probiotic Viability and Inhibitory Potency against Respiratory Pathogens. Processes 11:2, pages 622.
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Francesco Di Pierro, Somia Iqtadar, Sami Ullah Mumtaz, Alexander Bertuccioli, Martino Recchia, Nicola Zerbinati & Amjad Khan. (2022) Clinical Effects of Streptococcus salivarius K12 in Hospitalized COVID-19 Patients: Results of a Preliminary Study. Microorganisms 10:10, pages 1926.
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Dmitry I. Trukhan, Anatoly F. Sulimov & Larissa Yu. Trukhan. (2022) Changes in the organs and tissues of the oral cavity in the new coronavirus infection (COVID-19): A review. Consilium Medicum 24:5, pages 349-357.
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Arianna Zangrilli, Laura Diluvio, Arianna Di Stadio & Stefano Di Girolamo. (2022) Improvement of Psoriasis Using Oral Probiotic Streptococcus salivarius K-12: a Case–Control 24-Month Longitudinal Study. Probiotics and Antimicrobial Proteins 14:3, pages 573-578.
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M. Dzhafarov, U. B. Edisherashvili, A. A. Dolgalev, S. N. Garaza, G. S. Shulga & A. B. Dymnikov. (2022) Perspectives for the use of probiotics in the treatment of peri-implantitis. Literature reviewe. Medical alphabet:2, pages 7-10.
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Young-Gyun Song & Sung-Hoon Lee. (2021) Characteristics of antimicrobial activity of Streptococcus salivarius K 12 by culture condition . Journal of Dental Rehabilitation and Applied Science 37:4, pages 244-250.
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Kyle W. MacDonald, Ryan M. Chanyi, Jean M. Macklaim, Peter A. Cadieux, Gregor Reid & Jeremy P. Burton. (2021) Streptococcus salivarius inhibits immune activation by periodontal disease pathogens. BMC Oral Health 21:1.
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S.O. Kramarov, V.V. Yevtushenko, I.Yu. Seryakova & T.N. Kaminskaya. (2021) Применение пробиотического штамма Streptococcus salivarius К12 в лечении острых тонзиллофарингитов у детей. ACTUAL INFECTOLOGY 8:3-4, pages 29-34.
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S.A. Kramarev & V.V. Yevtushenko. (2021) Бактоблис® (Streptococcus salivarius K12) — инновационная терапия и профилактика острых респираторных инфекций и их осложнений. ACTUAL INFECTOLOGY 8:1, pages 50-53.
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Francesco Di Pierro, Valeria Sagheddu, Serena Galletti, Mara Forti, Marina Elli, Alexander Bertuccioli & Simone Gaeta. (2021) Antibacterial Activity of a Fractionated Pistacia lentiscus Oil Against Pharyngeal and Ear Pathogens, Alone or in Combination With Antibiotics. Frontiers in Microbiology 12.
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Yan Wang, Jiatong Li, Haonan Zhang, Xin Zheng, Jiantao Wang, Xiaoyue Jia, Xian Peng, Qian Xie, Jing Zou, Liwei Zheng, Jiyao Li, Xuedong Zhou & Xin Xu. (2021) Probiotic Streptococcus salivarius K12 Alleviates Radiation-Induced Oral Mucositis in Mice. Frontiers in Immunology 12.
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Suvi Sarlin, Mysore V. Tejesvi, Jenni Turunen, Petri Vänni, Tytti Pokka, Marjo Renko & Terhi Tapiainen. (2020) Impact of Streptococcus salivarius K12 on Nasopharyngeal and Saliva Microbiome: A Randomized Controlled Trial. Pediatric Infectious Disease Journal 40:5, pages 394-402.
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Shanthala B Mallikarjun, Srihari Nirguna Chandrasekhar & Henna P Salim. (2020) Comparative Evaluation of Antibacterial Activity of Probiotics SK12 and SM18: An In Vitro Study. International Journal of Clinical Pediatric Dentistry 13:6, pages 611-616.
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